{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:02:19Z","timestamp":1790193739009,"version":"4.1.0"},"reference-count":86,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging Clin Exp Res"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1007\/bf03324947","type":"journal-article","created":{"date-parts":[[2014,1,17]],"date-time":"2014-01-17T02:35:09Z","timestamp":1389926109000},"page":"3-10","source":"Crossref","is-referenced-by-count":49,"title":["Environmental and genetic factors in age-related hearing impairment"],"prefix":"10.1007","volume":"23","author":[{"given":"Roberto","family":"Bovo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Ciorba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Martini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,7,26]]},"reference":[{"key":"BF03324947_CR1","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/S0140-6736(05)67423-5","volume":"366","author":"GA Gates","year":"2005","unstructured":"Gates GA, Mills JH. Presbycusis. Lancet 2005; 366: 1111\u201320.","journal-title":"Lancet"},{"key":"BF03324947_CR2","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1093\/geront\/43.5.661","volume":"43","author":"DS Dalton","year":"2003","unstructured":"Dalton DS, Cruickshanks KJ, Klein BE, Klein R, Wiley TL, Nondahl DM. The impact of hearing loss on quality of life in older adults. Gerontologist 2003; 43: 661\u20138.","journal-title":"Gerontologist"},{"key":"BF03324947_CR3","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1080\/09638280210129162","volume":"24","author":"C Heine","year":"2002","unstructured":"Heine C, Browning CJ. Communication and psychosocial consequences of sensory loss in older adults: overview and rehabilitation directions. Disabil Rehabil 2002; 24: 763\u201373.","journal-title":"Disabil Rehabil"},{"key":"BF03324947_CR4","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1159\/000106478","volume":"12","author":"E Eyken Van","year":"2007","unstructured":"Van Eyken E, Van Camp G, Van Laer L. The complexity of agerelated hearing impairment: contributing environmental and genetic factors. Audiol Neurootol 2007; 12: 345\u201358.","journal-title":"Audiol Neurootol"},{"key":"BF03324947_CR5","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.heares.2004.09.009","volume":"201","author":"E Emmerich","year":"2005","unstructured":"Emmerich E, Richter F, Linss V, Linss W. Frequency-specific cochlear damage in guinea pig after exposure to different types of realistic industrial noise. Hear Res 2005; 201: 90\u20138.","journal-title":"Hear Res"},{"key":"BF03324947_CR6","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0378-5955(97)00181-0","volume":"115","author":"MJ Mulroy","year":"1998","unstructured":"Mulroy MJ, Henry WR, McNeil PL. Noise-induced transient microlesions in the cell membranes of auditory hair cells. Hear Res 1998; 115: 93\u2013100.","journal-title":"Hear Res"},{"key":"BF03324947_CR7","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.1121\/1.1513364","volume":"112","author":"FA Boettcher","year":"2002","unstructured":"Boettcher FA. Susceptibility to acoustic trauma in young and aged gerbils. J Acoust Soc Am 2002; 112: 2948\u201355.","journal-title":"J Acoust Soc Am"},{"key":"BF03324947_CR8","volume-title":"Acoustic \u2014 Threshold of Hearing by Air Conduction as a Function of Age and Sex for Otologically Normal Persons","author":"International Organization of Standardization","year":"2000","unstructured":"International Organization of Standardization: Acoustic \u2014 Threshold of Hearing by Air Conduction as a Function of Age and Sex for Otologically Normal Persons. Geneva, International Organization of Standardization, 2000, ISO 7029."},{"key":"BF03324947_CR9","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1749-6632.1999.tb08646.x","volume":"884","author":"R Pujol","year":"1999","unstructured":"Pujol R, Puel JL. Excitotoxicity, synaptic repair, and functional recovery in the mammalian cochlea: a review of recent findings. Ann NY Acad Sci 1999; 884: 249\u201354.","journal-title":"Ann NY Acad Sci"},{"key":"BF03324947_CR10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.aud.0000191942.36672.f3","volume":"27","author":"D Henderson","year":"2006","unstructured":"Henderson D, Bielefeld EC, Harris KC, Hu BH. The role of oxidative stress in noise-induced hearing loss. Ear Hear 2006; 27: 1\u201319.","journal-title":"Ear Hear"},{"key":"BF03324947_CR11","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3109\/00016489509121877","volume":"519","author":"H Yamane","year":"1995","unstructured":"Yamane H, Nakai Y, Takayama M et al. The emergence of free radicals after acoustic trauma and strial blood flow. Acta Otolaryngol Suppl 1995; 519: 87\u201392.","journal-title":"Acta Otolaryngol Suppl"},{"key":"BF03324947_CR12","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1159\/000013846","volume":"4","author":"K Ohlemiller","year":"1999","unstructured":"Ohlemiller K, Wright JS, Dugan LL. Early elevation of cochlear reactive oxygen species following noise exposure. Audiol Neurootol 1999; 4: 229\u201336.","journal-title":"Audiol Neurootol"},{"key":"BF03324947_CR13","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0006-8993(00)02733-5","volume":"878","author":"Y Ohinata","year":"2000","unstructured":"Ohinata Y, Miller JM, Altschuler RA, Schacht J. Intense noise induces formation of vasoactive lipid peroxidation products in the cochlea. Brain Res 2000; 878: 163\u201373.","journal-title":"Brain Res"},{"key":"BF03324947_CR14","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/000164800760370774","volume":"120","author":"BH Hu","year":"2000","unstructured":"Hu BH, Guo W, Wang PY, Henderson D, Jiang SC. Intense noise-induced apoptosis in hair cells of guinea pig cochleae. Acta Otolaryngol 2000; 120: 19\u201324.","journal-title":"Acta Otolaryngol"},{"key":"BF03324947_CR15","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0378-5955(00)00005-8","volume":"141","author":"K Lamm","year":"2000","unstructured":"Lamm K, Arnold W. The effect of blood flow promoting drugs on cochlear blood flow, perilymphatic pO(2) and auditory function in the normal and noise-damaged hypoxic and ischemic guinea pig inner ear. Hear Res 2000; 141: 199\u201319.","journal-title":"Hear Res"},{"key":"BF03324947_CR16","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1159\/000071061","volume":"8","author":"JM Miller","year":"2003","unstructured":"Miller JM, Brown JN, Schacht J. Iso-prostaglandin F(2alpha), a product of noise exposure, reduces inner ear blood flow. Audiol Neuro-otol 2003; 8: 207\u201321.","journal-title":"Audiol Neuro-otol"},{"key":"BF03324947_CR17","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/sj.ki.5002434","volume":"72","author":"LP Rybak","year":"2007","unstructured":"Rybak LP, Ramkumar V. Ototoxicity. Kidney Int 2007; 72: 931\u20135.","journal-title":"Kidney Int"},{"key":"BF03324947_CR18","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2174\/138161207779313731","volume":"13","author":"E Selimoglu","year":"2007","unstructured":"Selimoglu E. Aminoglycoside-induced ototoxicity. Curr Pharm Des 2007; 13: 119\u201326.","journal-title":"Curr Pharm Des"},{"key":"BF03324947_CR19","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.heares.2006.05.008","volume":"226","author":"Y Chen","year":"2007","unstructured":"Chen Y, Huang WG, Zha DJ et al. Aspirin attenuates gentamycin ototoxicity: from the laboratory to the clinic. Hear Res 2007; 226: 178\u201382.","journal-title":"Hear Res"},{"key":"BF03324947_CR20","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1159\/000013861","volume":"5","author":"A Forge","year":"2000","unstructured":"Forge A, Schacht J. Aminoglycoside antibiotics. Audiol Neuro-otol 2000; 5: 3\u201322.","journal-title":"Audiol Neuro-otol"},{"key":"BF03324947_CR21","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1097\/01.jom.0000071507.96740.70","volume":"45","author":"TC Morata","year":"2003","unstructured":"Morata TC. Chemical exposure as a risk factor for hearing loss. J Occup Environ Med 2003; 45: 676\u201382.","journal-title":"J Occup Environ Med"},{"key":"BF03324947_CR22","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1289\/ehp.8959","volume":"114","author":"SJ Chang","year":"2006","unstructured":"Chang SJ, Chen CJ, Lien CH, Sung FC. Hearing loss in workers exposed to toluene and noise. Environ Health Perspect 2006; 114: 1283\u20136.","journal-title":"Environ Health Perspect"},{"key":"BF03324947_CR23","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1159\/000026182","volume":"17","author":"SG Wannamethee","year":"1998","unstructured":"Wannamethee SG, Shaper AG. Alcohol, coronary heart disease and stroke: an examination of the J-shaped curve. Neuroepidemiology 1998; 17: 288\u201395.","journal-title":"Neuroepidemiology"},{"key":"BF03324947_CR24","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1111\/j.1532-5415.2000.tb02601.x","volume":"48","author":"MM Popelka","year":"2000","unstructured":"Popelka MM, Cruickshanks KJ, Wiley TL et al. Moderate alcohol consumption and hearing loss: a protective effect. J Am Geriatr Soc 2000; 48: 1273\u20138.","journal-title":"J Am Geriatr Soc"},{"key":"BF03324947_CR25","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s10162-008-0123-1","volume":"9","author":"E Fransen","year":"2008","unstructured":"Fransen E, Topsakal V, Hendrickx JJ et al. Occupational noise, smoking, and a high body mass index are risk factors for age-related hearing impairment and moderate alcohol consumption is protective: a European population-based multicenter study. J Assoc Res Otolaryngol 2008; 9: 264\u201376.","journal-title":"J Assoc Res Otolaryngol"},{"key":"BF03324947_CR26","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1044\/1092-4388(2009\/08-0026)","volume":"52","author":"SR Pratt","year":"2009","unstructured":"Pratt SR, Kuller L, Talbott EO, McHugh-Pemu K, Buhari AM, Xu X. Prevalence of hearing loss in black and white elders: results of the Cardiovascular Health Study. J Speech Lang Hear Res 2009; 52: 973\u201389.","journal-title":"J Speech Lang Hear Res"},{"key":"BF03324947_CR27","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1093\/oxfordjournals.aje.a009713","volume":"48","author":"KJ Cruickshanks","year":"1998","unstructured":"Cruickshanks KJ, Wiley TL, Tweed TS et al. Prevalence of hearing loss in older adults in Beaver Dam, Wisconsin. The Epidemiology of Hearing Loss Study. Am J Epidemiol 1998; 48: 879\u201386.","journal-title":"Am J Epidemiol"},{"key":"BF03324947_CR28","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1159\/000099016","volume":"12","author":"V Danielidis","year":"2007","unstructured":"Danielidis V, Tsimpiris N, Balatsouras DG et al. Short-term pathophysiologic changes and histopathologic findings of the auditory pathway after closed head injury, using a rabbit model. Audiol Neuro-otol 2007; 12: 145\u201354.","journal-title":"Audiol Neuro-otol"},{"key":"BF03324947_CR29","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/sj.bmt.1703152","volume":"28","author":"H Iwai","year":"2001","unstructured":"Iwai H, Lee S, Inaba M et al. Prevention of accelerated presbycusis by bone marrow transplantation in senescence-accelerated mice. Bone Marrow Transplant 2001; 28: 323\u20138.","journal-title":"Bone Marrow Transplant"},{"key":"BF03324947_CR30","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0531-5565(02)00177-8","volume":"38","author":"H Iwai","year":"2003","unstructured":"Iwai H, Lee S, Inaba M et al. Correlation between accelerated presbycusis and decreased immune functions. Exp Gerontol 2003; 38: 319\u201325.","journal-title":"Exp Gerontol"},{"key":"BF03324947_CR31","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1017\/S0022215100108345","volume":"103","author":"M Kurien","year":"1989","unstructured":"Kurien M, Thomas K, Bhanu TS. Hearing threshold in patients with diabetes mellitus. J Laryngol Otol 1989; 103: 164\u20138.","journal-title":"J Laryngol Otol"},{"key":"BF03324947_CR32","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1097\/00129492-200305000-00006","volume":"24","author":"V Kakarlapudi","year":"2003","unstructured":"Kakarlapudi V, Sawyer R, Staecker H. The effect of diabetes on sensorineural hearing loss. Otol Neurotol 2003; 24: 382\u20136.","journal-title":"Otol Neurotol"},{"key":"BF03324947_CR33","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.heares.2005.09.002","volume":"211","author":"ST Frisina","year":"2006","unstructured":"Frisina ST, Mapes F, Kim S, Frisina DR, Frisina RD. Characterization of hearing loss in aged type II diabetics. Hear Res 2006; 211: 103\u201313.","journal-title":"Hear Res"},{"key":"BF03324947_CR34","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1001\/archotol.132.9.934","volume":"132","author":"H Fukushima","year":"2006","unstructured":"Fukushima H, Cureoglu S, Schachern PA, Paparella MM, Harada T, Oktay MF. Effects of type 2 diabetes mellitus on cochlear structure in humans. Arch Otolaryngol Head Neck Surg 2006; 132: 934\u20138.","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"BF03324947_CR35","doi-asserted-by":"crossref","first-page":"29744","DOI":"10.1074\/jbc.274.42.29744","volume":"274","author":"GM Janssen","year":"1999","unstructured":"Janssen GM, Maassen JA, van Den Ouweland JM. The diabetes- associated 3243 mutation in the mitochondrial tRNA(Leu(UUR)) gene causes severe mitochondrial dysfunction without a strong decrease in protein synthesis rate. J Biol Chem 1999; 274: 29744\u20138.","journal-title":"J Biol Chem"},{"key":"BF03324947_CR36","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1097\/MAO.0b013e31818a0906","volume":"29","author":"R Nomiya","year":"2008","unstructured":"Nomiya R, Nomiya S, Kariya S et al. Generalized arteriosclerosis and changes of the cochlea in young adults. Otol Neurotol 2008; 29: 1193\u20137.","journal-title":"Otol Neurotol"},{"key":"BF03324947_CR37","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1177\/000348947508400404","volume":"84","author":"MM Paparella","year":"1975","unstructured":"Paparella MM, Hanson DG, Rao KN, Ulvestad R. Genetic sensorineural deafness in adults. Ann Otol Rhinol Laryngol 1975; 84: 459\u201372.","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"BF03324947_CR38","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1001\/archotol.1953.00710040399001","volume":"58","author":"HF Schuknecht","year":"1953","unstructured":"Schuknecht HF. Techniques for study of cochlear function and pathology in experimental animals: development of the anatomical frequency scale of the cat. Arch Otolaryngol 1953; 58: 377\u201397.","journal-title":"Arch Otolaryngol"},{"key":"BF03324947_CR39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/000348949310200101","volume":"102","author":"HF Schuknecht","year":"1993","unstructured":"Schuknecht HF, Gacek MR. Cochlear pathology in presbycusis. Ann Otol Rhinol Laryngol 1993; 102: 1\u201316.","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"BF03324947_CR40","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1097\/01.moo.0000134450.99615.22","volume":"12","author":"KK Ohlemiller","year":"2004","unstructured":"Ohlemiller KK.Age-related hearing loss: the status of Schuknecht\u2019s typology. Curr Opin Otolaryngol Head Neck Surg 2004; 12: 439\u201343.","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"BF03324947_CR41","first-page":"171","volume":"115","author":"CR Jennings","year":"2001","unstructured":"Jennings CR, Jones NS. Presbyacusis. J Laryngol Otol 2001; 115: 171\u20138.","journal-title":"J Laryngol Otol"},{"key":"BF03324947_CR42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.mlg.0000236089.44566.62","volume":"116","author":"EG Nelson","year":"2006","unstructured":"Nelson EG, Hinojosa R. Presbycusis: a human temporal bone study of individuals with downward sloping audiometric patterns of hearing loss and review of the literature. Laryngoscope 2006; 116: 1\u201312.","journal-title":"Laryngoscope"},{"key":"BF03324947_CR43","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1097\/00005537-200310000-00006","volume":"113","author":"EG Nelson","year":"2003","unstructured":"Nelson EG, Hinojosa R. Presbycusis: A human temporal bone study of individuals with flat audiometric patterns of hearing loss using a new method to quantify stria vascularis volume. Laryngoscope 2003; 113: 1672\u201386.","journal-title":"Laryngoscope"},{"key":"BF03324947_CR44","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/00003446-199704000-00003","volume":"18","author":"KK Karlsson","year":"1997","unstructured":"Karlsson KK, Harris JR, Svartengren M. Description and primary results from an audiometric study of male twins. Ear Hear 1997; 18: 114\u201320.","journal-title":"Ear Hear"},{"key":"BF03324947_CR45","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1001\/archotol.125.6.654","volume":"125","author":"GA Gates","year":"1999","unstructured":"Gates GA, Couropmitree NN, Myers RH. Genetic associations in age-related hearing thresholds. Arch Otolaryngol Head Neck Surg 1999; 125: 654\u20139.","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"BF03324947_CR46","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1046\/j.1532-5415.2001.4911245.x","volume":"49","author":"K Christensen","year":"2001","unstructured":"Christensen K, Frederiksen H, Hoffman HJ. Genetic and environmental influences on self-reported reduced hearing in the old and oldest old. J Am Geriatr Soc 2001; 49: 1512\u20137.","journal-title":"J Am Geriatr Soc"},{"key":"BF03324947_CR47","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0378-5955(97)00155-X","volume":"114","author":"KR Johnson","year":"1997","unstructured":"Johnson KR, Erway LC, Cook SA, Willott JF, Zheng QY. A major gene affecting age-related hearing loss in C57BL\/6J mice. Hear Res 1997; 114: 83\u201392.","journal-title":"Hear Res"},{"key":"BF03324947_CR48","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1006\/geno.2002.6858","volume":"80","author":"KR Johnson","year":"2002","unstructured":"Johnson KR, Zheng QY. Ahl2, a second locus affecting age-related hearing loss in mice. Genomics 2002; 80: 461\u20134.","journal-title":"Genomics"},{"key":"BF03324947_CR49","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.bbrc.2004.09.186","volume":"324","author":"M Nemoto","year":"2004","unstructured":"Nemoto M, Morita Y, Mishima Y et al. Ahl3, a third locus on mouse chromosome 17 affecting age-related hearing loss. Biochem Biophys Res Commun 2004; 324: 1283\u20138.","journal-title":"Biochem Biophys Res Commun"},{"key":"BF03324947_CR50","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/j.neurobiolaging.2007.12.011","volume":"30","author":"QY Zheng","year":"2009","unstructured":"Zheng QY, Ding D, Yu H, Salvi RJ, Johnson KR. A locus on distal chromosome 10 (ahl4) affecting age-related hearing loss in A\/J mice. Neurobiol Aging 2009; 30: 1693\u2013705.","journal-title":"Neurobiol Aging"},{"key":"BF03324947_CR51","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1006\/geno.1997.4869","volume":"44","author":"K Noben-Trauth","year":"1997","unstructured":"Noben-Trauth K, Zheng QY, Johnson KR, Nishina PM. mdfw: a deafness susceptibility locus that interacts with deaf waddler (dfw). Genomics 1997; 44: 266\u201372.","journal-title":"Genomics"},{"key":"BF03324947_CR52","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/83660","volume":"27","author":"F Palma Di","year":"2001","unstructured":"Di Palma F, Holme RH, Bryda EC et al. Mutations in Cdh23, encoding a new type of cadherin, cause stereocilia disorganization in waltzer, the mouse model for Usher syndrome type 1D. Nat Genet 2001; 27: 103\u20137.","journal-title":"Nat Genet"},{"key":"BF03324947_CR53","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0378-5955(97)00155-X","volume":"114","author":"KR Johnson","year":"1997","unstructured":"Johnson KR, Erway LC, Cook SA, Willott JF, Zheng QY. A major gene affecting age-related hearing loss in C57BL\/6J mice. Hear Res 1997; 114: 83\u201392.","journal-title":"Hear Res"},{"key":"BF03324947_CR54","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/ng1226","volume":"35","author":"K Noben-Trauth","year":"2003","unstructured":"Noben-Trauth K, Zheng QY, Johnson KR. Association of cadherin 23 with polygenic inheritance and genetic modification of sensorineural hearing loss. Nat Genet 2003; 35: 21\u20133.","journal-title":"Nat Genet"},{"key":"BF03324947_CR55","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0378-5955(89)90176-7","volume":"41","author":"JO Pickles","year":"1989","unstructured":"Pickles JO, Brix J, Comis SD et al. The organization of tip links and stereocilia on hair cells of bird and lizard basilar papillae. Hear Res 1989; 41: 31\u201342.","journal-title":"Hear Res"},{"key":"BF03324947_CR56","first-page":"19","volume":"5","author":"RR Davis","year":"2003","unstructured":"Davis RR, Kozel P, Erway LC. Genetic influences in individual susceptibility to noise: a review. Noise Health 2003; 5: 19\u201328.","journal-title":"Noise Health"},{"key":"BF03324947_CR57","doi-asserted-by":"crossref","first-page":"7127","DOI":"10.1073\/pnas.95.12.7127","volume":"95","author":"A Fridberger","year":"1998","unstructured":"Fridberger A, Flock A, Ulfendahl M, Flock B. Acoustic overstimulation increases outer hair cell Ca2+ concentrations and causes dynamic contractions of the hearing organ. Proc Natl Acad Sci USA 1998; 95: 7127\u201332.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF03324947_CR58","doi-asserted-by":"crossref","first-page":"18693","DOI":"10.1074\/jbc.273.30.18693","volume":"273","author":"PJ Kozel","year":"1998","unstructured":"Kozel PJ, Friedman RA, Erway LC et al. Balance and hearing deficits in mice with a null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2. J Biol Chem 1998; 273: 18693\u20136.","journal-title":"J Biol Chem"},{"key":"BF03324947_CR59","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/1284","volume":"19","author":"VA Street","year":"1998","unstructured":"Street VA, McKee-Johnson JW, Fonseca RC, Tempel BL, Noben-Trauth K. Mutations in a plasma membrane Ca2+- ATPase gene cause deafness in deafwaddler mice. Nat Genet 1998; 19: 390\u20134.","journal-title":"Nat Genet"},{"key":"BF03324947_CR60","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1001\/archotol.129.3.285","volume":"129","author":"AL DeStefano","year":"2003","unstructured":"DeStefano AL, Gates GA, Heard-Costa N, Myers RH, Baldwin CT. Genome-wide linkage analysis to presbycusis in the Framingham Heart Study. Arch Otolaryngol Head Neck Surg 2003; 129: 285\u20139.","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"BF03324947_CR61","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1001\/archotol.132.5.506","volume":"132","author":"HJ Garringer","year":"2006","unstructured":"Garringer HJ, Pankratz ND, Nichols WC, Reed T. Hearing impairment susceptibility in elderly men and the DFNA18 locus. Arch Otolaryngol Head Neck Surg 2006; 132: 506\u201310.","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"BF03324947_CR62","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1002\/humu.20375","volume":"27","author":"E Eyken Van","year":"2006","unstructured":"Van Eyken E, Van Laer L, Fransen E et al. KCNQ4: a gene for age-related hearing impairment? Hum Mutat 2006; 27: 1007\u201316.","journal-title":"Hum Mutat"},{"key":"BF03324947_CR63","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0092-8674(00)80556-5","volume":"96","author":"C Kubisch","year":"1999","unstructured":"Kubisch C, Schroeder BC, Friedrich T et al. KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness. Cell 1999; 96: 437\u201346.","journal-title":"Cell"},{"key":"BF03324947_CR64","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1097\/00001756-200105250-00042","volume":"12","author":"Y Takumi","year":"2001","unstructured":"Takumi Y, Matsubara A, Tsuchida S, Ottersen OP, Shinkawa H, Usami S. Various glutathione S-transferase isoforms in the rat cochlea. Neuroreport 2001; 12: 1513\u20136.","journal-title":"Neuroreport"},{"key":"BF03324947_CR65","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0378-5955(97)00154-8","volume":"114","author":"J Lautermann","year":"1997","unstructured":"Lautermann J, Crann SA, McLaren J, Schacht J. Glutathione-dependent antioxidant systems in the mammalian inner ear: effects of aging, ototoxic drugs and noise. Hear Res 1997; 114: 75\u201382.","journal-title":"Hear Res"},{"key":"BF03324947_CR66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-5955(01)00224-6","volume":"155","author":"SH Sha","year":"2001","unstructured":"Sha SH, Taylor R, Forge A, Schacht J. Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals. Hear Res 2001; 155: 1\u20138.","journal-title":"Hear Res"},{"key":"BF03324947_CR67","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1097\/01.mlg.0000183694.10583.12","volume":"115","author":"M Unal","year":"2005","unstructured":"Unal M, Tamer L, Do\u011druer ZN, Yildirim H, Vayiso\u011dlu Y, Camdeviren H. N-acetyltransferase 2 gene polymorphism and presbycusis. Laryngoscope 2005; 115: 2238\u201341.","journal-title":"Laryngoscope"},{"key":"BF03324947_CR68","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1136\/jmg.2007.049205","volume":"44","author":"E Eyken Van","year":"2007","unstructured":"Van Eyken E, Van Camp G, Fransen E et al. The N-acetyltransferase 2 polymorphism NAT2_6A is a causative factor for age related hearing impairment. J Med Genet 2007; 44: 570\u20138.","journal-title":"J Med Genet"},{"key":"BF03324947_CR69","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1080\/14992020601145294","volume":"46","author":"G O\u2019Grady","year":"2007","unstructured":"O\u2019Grady G, Boyles AL, Speer M, DeRuyter F, Strittmatter W, Worley G. Apolipoprotein E alleles and sensorineural hearing loss. Int J Audiol 2007; 46: 183\u20136.","journal-title":"Int J Audiol"},{"key":"BF03324947_CR70","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/scientificamerican0897-40","volume":"277","author":"DC Wallace","year":"1997","unstructured":"Wallace DC. Mitochondrial DNA in aging and disease. Sci Am 1997; 277: 40\u20137.","journal-title":"Sci Am"},{"key":"BF03324947_CR71","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0378-5955(97)00077-4","volume":"110","author":"N Fischel-Ghodsian","year":"1997","unstructured":"Fischel-Ghodsian N, Bykhovskaya Y, Taylor K et al. Temporal bone analysis of patients with presbycusis reveals high frequency of mitochondrial mutations. Hear Res 1997; 110: 147\u201354.","journal-title":"Hear Res"},{"key":"BF03324947_CR72","first-page":"449","volume":"18","author":"U Bai","year":"1997","unstructured":"Bai U, Seidman MD, Hinojosa R, Quirk WS. Mitochondrial DNA deletions associated with aging and possibly presbycusis: a human archival temporal bone study. Am J Otol 1997; 18: 449\u201353.","journal-title":"Am J Otol"},{"key":"BF03324947_CR73","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1002\/lary.20218","volume":"119","author":"A Markaryan","year":"2009","unstructured":"Markaryan A, Nelson EG, Hinojosa R. Quantification of the mitochondrial DNA common deletion in presbycusis. Laryngoscope 2009; 119: 1184\u20139.","journal-title":"Laryngoscope"},{"key":"BF03324947_CR74","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1097\/00005537-199606000-00021","volume":"106","author":"MD Seidman","year":"1996","unstructured":"Seidman MD, Bai U, Khan MJ et al. Association of mitochondrial DNA deletions and cochlear pathology: a molecular biologic tool. Laryngoscope 1996; 106: 777\u201383.","journal-title":"Laryngoscope"},{"key":"BF03324947_CR75","doi-asserted-by":"crossref","first-page":"780","DOI":"10.3109\/00016480903397702","volume":"130","author":"A Markaryan","year":"2010","unstructured":"Markaryan A, Nelson EG, Hinojosa R. Major arc mitochondrial DNA deletions in cytochrome c oxidase deficient human cochlear spiral ganglion cells. Acta Otolaryngol 2010; 130: 780\u20137.","journal-title":"Acta Otolaryngol"},{"key":"BF03324947_CR76","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.heares.2008.12.005","volume":"249","author":"KK Ohlemiller","year":"2009","unstructured":"Ohlemiller KK, Rice ME, Lett JM, Gagnon PM. Absence of strial melanin coincides with age-associated marginal cell loss and endocochlear potential decline. Hear Res 2009; 249: 1\u201314.","journal-title":"Hear Res"},{"key":"BF03324947_CR77","first-page":"59","volume-title":"Advances in Noise Research. Biological effect of noise","author":"M B\u00e4rrenas","year":"1998","unstructured":"B\u00e4rrenas M. Pigmentation and noise-induced hearing loss: is the relationship between pigmentation and noise-induced hearing loss due to an ototoxic pheolamin interaction or to otoprotective eumelan effects. In Prasher D, Luxon L, Eds. Advances in Noise Research. Biological effect of noise. London: Whurr Ed, 1998: 59\u201370."},{"key":"BF03324947_CR78","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1034\/j.1600-0749.2002.00039.x","volume":"15","author":"J Voisey","year":"2002","unstructured":"Voisey J, van Daal A. Agouti: from mouse to man, from skin to fat. Pigment Cell Res 2002; 15: 10\u20138.","journal-title":"Pigment Cell Res"},{"key":"BF03324947_CR79","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1093\/hmg\/ddn402","volume":"18","author":"RA Friedman","year":"2009","unstructured":"Friedman RA, Van Laer L, Huentelman MJ et al. GRM7 variants confer susceptibility to age-related hearing impairment. Hum Mol Genet 2009; 18: 785\u201396.","journal-title":"Hum Mol Genet"},{"key":"BF03324947_CR80","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/hmg\/ddm292","volume":"17","author":"L Laer Van","year":"2008","unstructured":"Van Laer L, Van Eyken E, Fransen E et al. The grainyhead like 2 gene (GRHL2), alias TFCP2L3, is associated with age-related hearing impairment. Hum Mol Genet 2008; 17: 159\u201369.","journal-title":"Hum Mol Genet"},{"key":"BF03324947_CR81","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.1093\/hmg\/11.23.2877","volume":"11","author":"LM Peters","year":"2002","unstructured":"Peters LM, Anderson DW, Griffith AJ et al. Mutation of a transcription factor, TFCP2L3, causes progressive autosomal dominant hearing loss, DFNA28. Hum Mol Genet 2002; 11: 2877\u201385.","journal-title":"Hum Mol Genet"},{"key":"BF03324947_CR82","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1523\/JNEUROSCI.4985-05.2006","volume":"26","author":"SG Kujawa","year":"2006","unstructured":"Kujawa SG, Liberman MC. Acceleration of age-related hearing loss by early noise exposure: evidence of a misspent youth. J Neurosci 2006; 26: 2115\u201323.","journal-title":"J Neurosci"},{"key":"BF03324947_CR83","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1746-1561.2002.tb06514.x","volume":"72","author":"RL Folmer","year":"2002","unstructured":"Folmer RL, Griest SE, Martin WH. Hearing conservation education programs for children: a review. School Health 2002; 72: 51\u20137.","journal-title":"School Health"},{"key":"BF03324947_CR84","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1038\/nm925","volume":"9","author":"H Li","year":"2003","unstructured":"Li H, Liu H, Heller S. Pluripotent stem cells from the adult mouse inner ear. Nat Med 2003; 9: 1293\u20139.","journal-title":"Nat Med"},{"key":"BF03324947_CR85","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.heares.2009.09.001","volume":"264","author":"EC Bielefeld","year":"2010","unstructured":"Bielefeld EC, Tanaka C, Chen GD, Henderson D. Age-related hearing loss: Is it a preventable condition? Hear Res 2010; 264: 98\u2013107","journal-title":"Hear Res"},{"key":"BF03324947_CR86","doi-asserted-by":"crossref","first-page":"665","DOI":"10.3727\/096368908786092685","volume":"17","author":"RP Revoltella","year":"2008","unstructured":"Revoltella RP, Papini S, Rosellini A. Cochlear repair by transplantation of human cord blood CD133+ cells to nod-scid mice made deaf with kanamycin and noise. Cell Transplant 2008; 17: 665\u201378.","journal-title":"Cell Transplant"}],"container-title":["Aging Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03324947.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF03324947\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03324947","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T18:37:57Z","timestamp":1565116677000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF03324947"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":86,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["BF03324947"],"URL":"https:\/\/doi.org\/10.1007\/bf03324947","relation":{},"ISSN":["1594-0667","1720-8319"],"issn-type":[{"value":"1594-0667","type":"print"},{"value":"1720-8319","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2]]}}}