{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T13:46:06Z","timestamp":1751031966469},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[1999,12,1]],"date-time":"1999-12-01T00:00:00Z","timestamp":944006400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging Clin Exp Res"],"published-print":{"date-parts":[[1999,12]]},"DOI":"10.1007\/bf03339817","type":"journal-article","created":{"date-parts":[[2014,1,16]],"date-time":"2014-01-16T21:40:48Z","timestamp":1389908448000},"page":"383-389","source":"Crossref","is-referenced-by-count":3,"title":["Calorie restriction modulates Th-1 and Th-2 cytokine-induced immunoglobulin secretion in young and old C57BL\/6 cultured submandibular glands"],"prefix":"10.1007","volume":"11","author":[{"given":"C. A.","family":"Jolly","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Fernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. R.","family":"Muthukumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,1,7]]},"reference":[{"key":"BF03339817_CR1","first-page":"1313","volume-title":"Mucosal immunity","author":"SJ Challacombe","year":"1999","unstructured":"Challacombe S.J., Shirlaw P.J.: Immunology of diseases of the oral cavity. In: Ogra P.L., Mestecky J., Lamm M.E., Strober W., Bienenstock J., McGhee J.R. (Eds.), Mucosal immunity. Academic Press, San Diego, CA, 1999, pp. 1313\u20131337."},{"key":"BF03339817_CR2","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1177\/10454411960070020301","volume":"7","author":"PC Fox","year":"1996","unstructured":"Fox P.C., Speight P.M.: Current concepts of autoimmune exocrinopathy: Immunologic mechanisms in the salivary pathology of Sjogren\u2019s Syndrome. Crit. Rev. Oral Biol. Med. 7: 144\u2013158, 1996.","journal-title":"Crit. Rev. Oral Biol. Med."},{"key":"BF03339817_CR3","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1754-4505.1996.tb00842.x","volume":"16","author":"A Vissink","year":"1996","unstructured":"Vissink A., Spijkervet F.K., Amerongen V.N.: Aging and saliva: a review of the literature. Spec. Care Dentist. 16: 95\u2013103, 1996.","journal-title":"Spec. Care Dentist."},{"key":"BF03339817_CR4","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1177\/00220345950740080301","volume":"74","author":"DA Johnson","year":"1995","unstructured":"Johnson D.A., Lopez H., Lopez J.M.: Effects of protein deficiency and diet consistency on the parotid gland and parotid saliva of rats. J. Dent. Res. 74: 1444\u20131452, 1995.","journal-title":"J. Dent. Res."},{"key":"BF03339817_CR5","first-page":"459","volume":"18","author":"S Murai","year":"1996","unstructured":"Murai S., Saito H., Nakamura K., Masuda Y., Itoh T.: The effects of a long-term powdered diet on the amounts of two principal neurotransmitters in the major salivary glands and on stimulated salivary secretion in mice. Methods Find. Exp. Clin. Pharmacol. 18: 459\u2013463, 1996.","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"key":"BF03339817_CR6","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0952-3278(94)90097-3","volume":"50","author":"SM Abdel-Hakim","year":"1994","unstructured":"Abdel-Hakim S.M., Alam B.S., Alam S.Q.: Prostaglandin E2 production in submandibular salivary glands of rats in essential fatty acid deficiency. Prostaglandins Leukot. Essent. Fatty Acids 50: 141\u2013145, 1994.","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"BF03339817_CR7","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0003-9969(97)00071-X","volume":"42","author":"SQ Alam","year":"1997","unstructured":"Alam S.Q., Shi Y.Y.: The effect of essential fatty acid deficiency on the fatty acid composition of different salivary glands and saliva in rats. Arch. Oral Biol. 42: 727\u2013734, 1997.","journal-title":"Arch. Oral Biol."},{"key":"BF03339817_CR8","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1007\/BF02535974","volume":"26","author":"SQ Alam","year":"1991","unstructured":"Alam S.Q., Bergens B.M., Alam B.S.: Arachidonic acid, prostaglandin E2 and leukotriene C4 levels in gingiva and submandibular salivary glands of rats fed diets containing n-3 fatty acids. Lipids 26: 895\u2013900, 1991.","journal-title":"Lipids"},{"key":"BF03339817_CR9","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1006\/clin.1995.1128","volume":"76","author":"B Chandrasekar","year":"1995","unstructured":"Chandrasekar B., McGuff H.S., Aufdermorte T.B., Aufdermorte D.A., Talal N., Fernandes G.: Effects of calorie restriction on transforming growth factor \u03b21 and proinflammatory cytokines in murine Sjogren\u2019s Syndrome. Clin. Immunol. Immunopathol. 76: 291\u2013296, 1995.","journal-title":"Clin. Immunol. Immunopathol."},{"key":"BF03339817_CR10","doi-asserted-by":"crossref","first-page":"2960","DOI":"10.1093\/jn\/126.12.2960","volume":"126","author":"NN Gangopadhyay","year":"1996","unstructured":"Gangopadhyay N.N., Moldoveanu Z., Stephensen C.B.: Vitamin A deficiency has different effects on immunoglobulin A production and transport during influenza A infection in BALB\/c mice. J. Nutr. 126: 2960\u20132967, 1996.","journal-title":"J. Nutr."},{"key":"BF03339817_CR11","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0065-2776(08)60342-9","volume":"37","author":"AN Theofilopoulos","year":"1985","unstructured":"Theofilopoulos A.N., Dixon F.J.: Murine models of systemic lupus erythematosus. Adv. Immunol. 37: 269\u2013290, 1985.","journal-title":"Adv. Immunol."},{"key":"BF03339817_CR12","first-page":"12","volume":"19","author":"MH Foster","year":"1998","unstructured":"Foster M.H.: Relevance of systemic lupus erythematosus nephritis animal models to human disease. Semin. Nephrol. 19: 12\u201324, 1998.","journal-title":"Semin. Nephrol."},{"key":"BF03339817_CR13","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1615\/CritRevImmunol.v18.i4.10","volume":"18","author":"PA Morel","year":"1998","unstructured":"Morel P.A., Oriss T.B.: Crossregulation between Th1 and Th2 cells. Crit. Rev. Immunol. 18: 275\u2013303, 1998.","journal-title":"Crit. Rev. Immunol."},{"key":"BF03339817_CR14","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1073\/pnas.73.4.1279","volume":"73","author":"G Fernandes","year":"1976","unstructured":"Fernandes G., Yunis E.J., Good R.A.: Influence of diet on survival of mice. Proc. Natl. Acad. Sci. USA 73: 1279\u20131283, 1976.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BF03339817_CR15","first-page":"13","volume":"5","author":"JT Venkatraman","year":"1994","unstructured":"Venkatraman J.T., Attwood V.G., Turturro A., Hart R.W., Fernandes G.: Maintenance of virgin T cells and immune functions by food restriction during aging in long-lived B6D2F1 female mice. Aging: Immunol. Infect. Dis. 5: 13\u201326, 1994.","journal-title":"Aging: Immunol. Infect. Dis."},{"key":"BF03339817_CR16","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1023\/A:1027344730553","volume":"17","author":"G Fernandes","year":"1997","unstructured":"Fernandes G., Venkatraman J.T., Turturro A., Attwood V.G., Hart R.W.: Effect of food restriction on life span and immune functions in long-lived Fischer-344 X Brown Norway F1 rats. J. Clin. Immunol. 17: 85\u201395, 1997.","journal-title":"J. Clin. Immunol."},{"key":"BF03339817_CR17","first-page":"179","volume-title":"The retardation of aging and disease by dietary restriction","author":"R Weindruch","year":"1988","unstructured":"Weindruch R., Walford R.L.: Dietary restriction: Effects on biological parameters. In: Weindruch R. (Ed.), The retardation of aging and disease by dietary restriction. Charles C. Thomas, Springfield, 1988, pp. 179\u2013229."},{"key":"BF03339817_CR18","first-page":"555","volume-title":"Handbook of Physiology: Section 11 Aging","author":"RA Miller","year":"1995","unstructured":"Miller R.A.: Immune System. In: Masoro E.J. (Ed.), Handbook of Physiology: Section 11 Aging. Oxford University Press, New York, 1995, pp. 555\u2013590."},{"key":"BF03339817_CR19","first-page":"331","volume-title":"Handbook of nutrition in the aged","author":"G Fernandes","year":"1994","unstructured":"Fernandes G., Venkatraman J.T.: Effect of food restriction on immunoregulation and aging. In: Watson R.R. (Ed.), Handbook of nutrition in the aged. CRC Press, Baton Rouge, 1994, pp. 331\u2013346."},{"key":"BF03339817_CR20","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0047-6374(95)01609-4","volume":"83","author":"IM Goonewardene","year":"1995","unstructured":"Goonewardene I.M., Murasko D.M.: Age-associated changes in mitogen-induced lymphoproliferation and lymphokine production in the long-lived Brown-Norway rat: effect of caloric restriction. Mech. Ageing Dev. 83: 103\u2013116, 1995.","journal-title":"Mech. Ageing Dev."},{"key":"BF03339817_CR21","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1023\/A:1020503727157","volume":"19","author":"CA Jolly","year":"1999","unstructured":"Jolly C.A., Fernandes G.: Diet modulates Th-1 and Th-2 cytokine production in the peripheral blood of lupus-prone mice. J. Clin. Immunol. 19: 171\u2013177, 1999.","journal-title":"J. Clin. Immunol."},{"key":"BF03339817_CR22","first-page":"242","volume":"3","author":"AG Pockley","year":"1991","unstructured":"Pockley A.G., Montgomery P.C.: The effects of interleukins 5 and 6 on immunoglobulin production in rat lacrimal glands. Reg. Immunol. 3: 242\u2013246, 1991.","journal-title":"Reg. Immunol."},{"key":"BF03339817_CR23","first-page":"550","volume-title":"Methods in aging research","author":"G Fernandes","year":"1999","unstructured":"Fernandes G.: Methods for the study of immune cells in aging. In: Yu B.P. (Ed.), Methods in aging research. CRC Press, Baton Rouge, 1999, pp. 550\u2013567."},{"key":"BF03339817_CR24","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","volume":"162","author":"P Chomczynski","year":"1987","unstructured":"Chomczynski P., Sacchi N.: Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156\u2013159, 1987.","journal-title":"Anal. Biochem."},{"key":"BF03339817_CR25","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0378-1119(97)00447-2","volume":"201","author":"MG Martin","year":"1997","unstructured":"Martin M.G., Gutierrez E.M., Lam J.T., Li T.M.H., Wang J.: Genomic cloning and structural analysis of the murine polymeric receptor (pIgR) gene and promoter region. Gene 201: 189\u2013197, 1997.","journal-title":"Gene"},{"key":"BF03339817_CR26","first-page":"181","volume-title":"Mucosal immunity","author":"K Mostov","year":"1999","unstructured":"Mostov K., Kaetzel C.S.: Immunoglobulin transport and the polymeric immunoglobulin receptor. In: Ogra P.L., Mestecky J., Lamm M.E., Strober W., Bienenstock J., McGhee J.R. (Eds.), Mucosal immunity. Academic Press, San Diego, CA, 1999, pp. 181\u2013211."},{"key":"BF03339817_CR27","unstructured":"Ha C.L., Woodward B.: Reduction in the quantity of the polymeric immunoglobulin receptor is sufficient to account for the low concentration of intestinal secretory immunoglobulin A in a weanling mouse model of wasting protein-energy malnutrition. J. Nutr.: 427\u2013435, 1997."},{"key":"BF03339817_CR28","first-page":"629","volume":"38","author":"PS Friend","year":"1978","unstructured":"Friend P.S., Fernandes G., Good R.A., Michael A.F., Yunis E.J.: Dietary restrictions early and late: Effects on the nephropathy of the NZB \u00d7 NZW mouse. Lab. Invest. 38: 629\u2013632, 1978.","journal-title":"Lab. Invest."},{"key":"BF03339817_CR29","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1084\/jem.154.4.1116","volume":"154","author":"S Izui","year":"1981","unstructured":"Izui S., Fernandes G., Hara I., McConahey P.J., Jensen F.C., Dixon F.J., Good R.A.: Low-calorie diet selectively reduces expression of retroviral envelope glycoprotein gp70 in sera of NZB \u00d7 NZW F1 hybrid mice. J. Exp. Med. 154: 1116\u20131124, 1981.","journal-title":"J. Exp. Med."},{"key":"BF03339817_CR30","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0090-1229(82)90192-1","volume":"25","author":"LK Jung","year":"1982","unstructured":"Jung L.K., Palladino M.A., Calvano S., Mark D.A., Good R.A., Fernandes G.: Effect of calorie restriction on the production and responsiveness to interleukin-2 in (NZB \u00d7 NZW)F1 mice. Clin. Immunol. Immunopathol. 25: 295\u2013301, 1982.","journal-title":"Clin. Immunol. Immunopathol."},{"key":"BF03339817_CR31","doi-asserted-by":"crossref","first-page":"B103","DOI":"10.1093\/gerona\/52A.2.B103","volume":"52A","author":"C Chen","year":"1997","unstructured":"Chen C., Noland K.A., Kalu D.K.: Effects of aging and food restriction on \u03b11-adrenergic receptors and G-protein in the rat parotid gland. J. Gerontol. 52A: B103\u2013B110, 1997.","journal-title":"J. Gerontol."},{"key":"BF03339817_CR32","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/BF03339624","volume":"9","author":"MA Salih","year":"1997","unstructured":"Salih M.A., Kalu D.N., Smith T.C.: Effects of age and food restriction on calcium signaling in parotid acinar cells of Fischer 344 rats. Aging Clin. Exp. Res. 9: 419\u2013427, 1997.","journal-title":"Aging Clin. Exp. Res."},{"key":"BF03339817_CR33","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1126\/science.7063854","volume":"215","author":"R Weindruch","year":"1982","unstructured":"Weindruch R., Walford R.L.: Dietary restriction in mice beginning at 1 year of age: effect on life span and spontaneous cancer incidence. Science 215: 1415\u20131418, 1982.","journal-title":"Science"},{"key":"BF03339817_CR34","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/263504b0","volume":"7","author":"G Fernandes","year":"1976","unstructured":"Fernandes G., Yunis E.J., Good R.A.: Suppression of adenocarcinoma by the immunological consequences of calorie restriction. Nature 7: 504\u2013507, 1976.","journal-title":"Nature"},{"key":"BF03339817_CR35","doi-asserted-by":"crossref","first-page":"6494","DOI":"10.1073\/pnas.92.14.6494","volume":"92","author":"G Fernandes","year":"1995","unstructured":"Fernandes G., Chandrasekar B., Troyer D.A., Venkatraman J.T., Good R.A.: Dietary lipids and calorie restriction affect mammary tumor incidence and gene expression in mouse mammary tumor virus\/v-Ha-ras transgenic mice. Proc. Natl. Acad. Sci. USA 92: 6494\u20136498, 1995.","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Aging Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03339817.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF03339817\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03339817","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T14:38:29Z","timestamp":1565102309000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF03339817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,12]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1999,12]]}},"alternative-id":["BF03339817"],"URL":"https:\/\/doi.org\/10.1007\/bf03339817","relation":{},"ISSN":["1594-0667","1720-8319"],"issn-type":[{"value":"1594-0667","type":"print"},{"value":"1720-8319","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,12]]}}}