{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:17:32Z","timestamp":1791890252982,"version":"4.3.4"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2002,4,1]],"date-time":"2002-04-01T00:00:00Z","timestamp":1017619200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"published-print":{"date-parts":[[2002,4]]},"DOI":"10.1007\/bf03344013","type":"journal-article","created":{"date-parts":[[2014,3,11]],"date-time":"2014-03-11T07:11:28Z","timestamp":1394521888000},"page":"329-333","source":"Crossref","is-referenced-by-count":31,"title":["Impairment of GH secretion in adults with primary empty sella"],"prefix":"10.1007","volume":"25","author":[{"given":"M.","family":"Gasperi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Aimaretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Cecconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Colao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Di Somma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Cannav\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Baffoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Cosottini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Curt\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Trimarchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Lombardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Grasso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Ghigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Martino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,3,11]]},"reference":[{"key":"BF03344013_CR1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3171\/jns.1968.28.2.0093","volume":"28","author":"RM Bergland","year":"1968","unstructured":"Bergland R.M., Ray B.S., Torack R.M. Anatomical variations in the pituitary gland and adjacent structures in 225 human autopsy cases. J. Neurosurg. 1968, 28: 93\u201399.","journal-title":"J. Neurosurg."},{"key":"BF03344013_CR2","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1148\/90.5.931","volume":"90","author":"B Kaufman","year":"1968","unstructured":"Kaufman B. The \u201cempty\u201d sella turcica: a manifestation of the intrasellar subarachnoid space. Radiology 1968, 90: 931\u2013941.","journal-title":"Radiology"},{"key":"BF03344013_CR3","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/BF03350724","volume":"12","author":"M Lambert","year":"1989","unstructured":"Lambert M., Gaillard R.C., Vallotton M.B., Megret M., Delavelle J. Empty sella syndrome associated with diabetes insipidus: case report and review of the literature. J. Endocrinol. Invest. 1989, 12: 433\u2013437.","journal-title":"J. Endocrinol. Invest."},{"key":"BF03344013_CR4","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/j.1365-2265.1992.tb01484.x","volume":"37","author":"E Gallardo","year":"1992","unstructured":"Gallardo E., Schacter D., Caceres E., et al. The empty sella: results of treatment in 76 successive cases and high frequency of endocrine and neurological disturbances. Clin. Endocrinol. (Oxf.) 1992, 37: 529\u2013533.","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"BF03344013_CR5","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1159\/000123133","volume":"32","author":"K Brismar","year":"1981","unstructured":"Brismar K., Efendic S. Pituitary function in the empty sella syndrome. Neuroendocrinology 1981, 32: 70\u201377.","journal-title":"Neuroendocrinology"},{"key":"BF03344013_CR6","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1055\/s-2007-1009290","volume":"21","author":"M Buchfelder","year":"1989","unstructured":"Buchfelder M., Brockmeier S., Pichl J., Schrell U., Fahlbush R. Results of dynamic endocrine testing of hypothalamic pituitary function in patients with a primary \u201cempty\u201d sella syndrome. Horm. Metab. Res. 1989, 21: 573\u2013576.","journal-title":"Horm. Metab. Res."},{"key":"BF03344013_CR7","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1507\/endocrj1954.35.665","volume":"35","author":"S Ishikawa","year":"1988","unstructured":"Ishikawa S., Furuse M., Saito T., Okada K., Kuzuya T. Empty sella in control subjects and patients with hypopituitarism. Endocrinol. Jpn. 1988, 35: 665\u2013674.","journal-title":"Endocrinol. Jpn."},{"key":"BF03344013_CR8","first-page":"505","volume":"63","author":"M Impallomeni","year":"1987","unstructured":"Impallomeni M., Yeo T., Rudd A., Carr D., Aber V. Investigation of anterior pituitary function in elderly patients over the age of 75. Quart. J. Med. 1987, 63: 505\u2013515.","journal-title":"Quart. J. Med."},{"key":"BF03344013_CR9","first-page":"295","volume":"43","author":"M Pocecco","year":"1989","unstructured":"Pocecco M., De Campo C., Marinoni S., et al. High frequency of empty sella syndrome in children with growth hormone deficiency. Helv. Paediatr. Acta 1989, 43: 295\u2013301.","journal-title":"Helv. Paediatr. Acta"},{"key":"BF03344013_CR10","first-page":"767","volume":"78","author":"E Cacciari","year":"1994","unstructured":"Cacciari E., Zucchini S., Ambrosetto P., et al. Empty sella in children and adolescents with possible hypothalamic-pituitary disorders. J. Clin. Endocrinol. Metab. 1994, 78: 767\u2013771.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03344013_CR11","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1210\/er.16.1.63","volume":"16","author":"H Boer De","year":"1995","unstructured":"De Boer H., Block G., van Der Veen E.A. Clinical aspects of growth hormone deficiency in adults. Endocr. Rev. 1995, 16: 63\u201386.","journal-title":"Endocr. Rev."},{"key":"BF03344013_CR12","first-page":"379","volume":"83","author":"Growth Hormone Research Society GRS.","year":"1998","unstructured":"Growth Hormone Research Society (GRS). Consensus guidelines for diagnosis and treatment of adults with GH deficiency: summary statement of Growth Hormone Research Society workshop on adult growth hormone deficiency. J. Clin. Endocrinol. Metab. 1998, 83: 379\u2013381.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03344013_CR13","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/S0140-6736(94)90181-3","volume":"1","author":"DM Hoffman","year":"1994","unstructured":"Hoffman D.M., O\u2019Sullivan A.J., Baxter R.C., Ho K.Y. Diagnosis of growth hormone deficiency in adults. Lancet. 1994, 1: 1064\u20131068.","journal-title":"Lancet"},{"key":"BF03344013_CR14","first-page":"3097","volume":"80","author":"MO Thorner","year":"1995","unstructured":"Thorner M.O., Bentsson B.A., Ho K.Y., et al. Diagnosis of growth hormone deficiency in adults. J. Clin. Endocrinol. Metab. 1995, 80: 3097\u20133098.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03344013_CR15","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1046\/j.1365-2265.1997.1851001.x","volume":"46","author":"J Svensson","year":"1997","unstructured":"Svensson J., Johannsson G., Bengtsson B.A. Insulin-like growth factor-I in growth hormone-deficient adults: relationship to population-based normal value, body composition and insulin tolerance test. Clin. Endocrinol. (Oxf.) 1997, 46: 579\u2013586.","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"BF03344013_CR16","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1365-2265.1994.tb03793.x","volume":"41","author":"SL Jones","year":"1994","unstructured":"Jones S.L., Trainer P.J., Perry L., Wass J.A.H., Besser G.M., Grossman A. An audit of the insulin tolerance test in adult subjects in an acute investigation unit over one year. Clin. Endocrinol. (Oxf.) 1994, 41: 123\u2013128.","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"BF03344013_CR17","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1210\/jcem-67-6-1186","volume":"67","author":"J Alba-Roth","year":"1988","unstructured":"Alba-Roth J., Muller O.A., Schopohl J., von Werder K. Arginine stimulates growth hormone secretion by suppressing endogenous somatostatin secretion. J. Clin. Endocrinol. Metab. 1988, 67: 1186\u20131189.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03344013_CR18","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1530\/eje.0.1340352","volume":"134","author":"E Ghigo","year":"1996","unstructured":"Ghigo E., Aimaretti G., Gianotti L., Bellone J., Arvat E., Camanni F. New approch to the diagnosis of growth hormone deficiency in adults. Eur. J. Endocrinol. 1996, 134: 352\u2013356.","journal-title":"Eur. J. Endocrinol."},{"key":"BF03344013_CR19","first-page":"1615","volume":"83","author":"G Aimaretti","year":"1998","unstructured":"Aimaretti G., Corneli G., Razzore P., et al. Comparison between insulin-induced hypoglicemia and growth hormone (GH)-releasing hormone plus arginine as provocative test for the diagnosis of GH deficiency in adults. J. Clin. Endocrinol. Metab. 1998, 83: 1615\u20131618.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03344013_CR20","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/BF03343686","volume":"23","author":"J Bellone","year":"2000","unstructured":"Bellone J., Aimaretti G., Bellone S., et al. Sequential administration of arginine and arginine plus GHRH to test somatotroph function in short children. J. Endocrinol. Invest. 2000, 23: 97\u2013101.","journal-title":"J. Endocrinol. Invest."},{"key":"BF03344013_CR21","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1530\/eje.0.1350568","volume":"135","author":"MR Valetto","year":"1996","unstructured":"Valetto M.R., Bellone J., Baffoni C., et al. Reproducibility of the growth hormone response to stimulation with growth hormone-releasing hormone plus arginine during lifespan. Eur. J. Endocrinol. 1996, 135: 568\u2013572.","journal-title":"Eur. J. Endocrinol."},{"key":"BF03344013_CR22","first-page":"2633","volume":"84","author":"M Gasperi","year":"1999","unstructured":"Gasperi M., Aimaretti G., Scarcello G., et al. Low dose hexarelin and growth hormone (GH)-releasing hormone as a diagnostic tool for the diagnosis of GH deficiency in adults: comparison with insulin-induced hypoglycemia test. J. Clin. Endocrinol. Metab. 1999, 84: 2633\u20132637.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03344013_CR23","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1007\/BF03343638","volume":"22","author":"A Liotta","year":"1999","unstructured":"Liotta A., Maggio C., Giuffr\u00e8 M., Carta M., Manfr\u00e8 L.J. Sequential contrast-enhanced magnetic resonance imaging in the diagnosis of growth hormone deficiencies. J. Endocrinol. Invest. 1999, 22: 740\u2013746.","journal-title":"J. Endocrinol. Invest."},{"key":"BF03344013_CR24","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/BF03345478","volume":"22","author":"K Hall","year":"1999","unstructured":"Hall K., Hilding A., Thoren M. Determinants of circulating insulin-like growth factor-I. J. Endocrinol. Invest. 1999, 22: 48\u201357.","journal-title":"J. Endocrinol. Invest."},{"key":"BF03344013_CR25","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1007\/BF03343588","volume":"22","author":"JPT Span","year":"1999","unstructured":"Span J.P.T., Pieters G.F.F.M., Sweep C.G.J., Swinkels L.M.J.W., Smals A.G.H. Plasma IGF-I is a useful marker of growth hormone deficiency in adults. J. Endocrinol. Invest. 1999, 22: 446\u2013450.","journal-title":"J. Endocrinol. Invest."},{"key":"BF03344013_CR26","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1007\/BF03343585","volume":"22","author":"M Maccario","year":"1999","unstructured":"Maccario M., Gauna C., Procopio M., et al. Assessment of GH-IGF-I axis in obesity by evaluation of IGF-I levels and the GH response to GHRH+arginine test. J. Endocrinol. Invest. 1999, 22: 424\u2013429.","journal-title":"J. Endocrinol. Invest."},{"key":"BF03344013_CR27","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1210\/jcem-65-4-634","volume":"65","author":"FF Casanueva","year":"1987","unstructured":"Casanueva F.F., Villanueva L., Dieguez C, et al. Free fatty acids block growth hormone (GH) releasing hormone-stimulated GH secretion in man directly at the pituitary. J. Clin. Endocrinol. Metab. 1987, 65: 634\u2013642.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03344013_CR28","first-page":"22","volume":"22","author":"M Pombo","year":"1999","unstructured":"Pombo M., Pombo C.M., Astorga R., et al. Regulation of growth hormone secretion by signals produced by the adipose tissue. J. Endocrinol. Invest. 1999, 22: 22\u201326.","journal-title":"J. Endocrinol. Invest."},{"key":"BF03344013_CR29","first-page":"145","volume":"70","author":"MD Littley","year":"1989","unstructured":"Littley M.D., Shalet S.M., Beardwell C.G., Ahmed S.R., Applegate G., Sutton M.L. Hypopituitarism following external radiotherapy for pituitary tumours in adults. Q. J. Med. 1989, 70: 145\u2013160.","journal-title":"Q. J. Med."}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03344013.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF03344013\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03344013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T06:26:20Z","timestamp":1558506380000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF03344013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,4]]}},"alternative-id":["BF03344013"],"URL":"https:\/\/doi.org\/10.1007\/bf03344013","relation":{},"ISSN":["0391-4097","1720-8386"],"issn-type":[{"value":"0391-4097","type":"print"},{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,4]]}}}