{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:13:30Z","timestamp":1761560010174},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2002,7,1]],"date-time":"2002-07-01T00:00:00Z","timestamp":1025481600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"published-print":{"date-parts":[[2002,7]]},"DOI":"10.1007\/bf03345087","type":"journal-article","created":{"date-parts":[[2014,3,31]],"date-time":"2014-03-31T12:47:23Z","timestamp":1396270043000},"page":"624-630","source":"Crossref","is-referenced-by-count":32,"title":["Temporal relationship between the appearance of thyroid autoantibodies and development of destructive thyroiditis in patients undergoing treatment with two different type-1 interferons for HCV-related chronic hepatitis: A prospective study"],"prefix":"10.1007","volume":"25","author":[{"given":"G.","family":"Mazziotti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Sorvillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Stornaiuolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Rotondi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Morisco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ruberto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Cioffi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Amato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Caporaso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. B.","family":"Gaeta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Carella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,3,18]]},"reference":[{"key":"BF03345087_CR1","first-page":"47","volume":"28","author":"G Tossing","year":"2001","unstructured":"Tossing G. New developments in interferon therapy. Eur. J. Med. Res. 2001, 28: 47\u201365.","journal-title":"Eur. J. Med. Res."},{"key":"BF03345087_CR2","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1200\/JCO.1986.4.2.234","volume":"4","author":"JR Quesada","year":"1986","unstructured":"Quesada J.R., Talpaz M., Rios A., Kurzrock R., Gutterman J.U. Clinical toxicity of interferons in cancer patients: a review. J. Clin. Oncol. 1986, 4: 234\u2013243.","journal-title":"J. Clin. Oncol."},{"key":"BF03345087_CR3","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/S0140-6736(85)92475-4","volume":"1","author":"IS Fentiman","year":"1985","unstructured":"Fentiman I.S., Thomas B.S., Balkwill F.R. Rubens R.D., Hayward J.L. Primary hypothyroidism associated with interferon therapy of breast cancer. Lancet 1985, 1: 1166.","journal-title":"Lancet"},{"key":"BF03345087_CR4","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1016\/0016-5085(92)90348-3","volume":"102","author":"M Lisker-Melman","year":"1992","unstructured":"Lisker-Melman M., Di Bisceglie A.M., Usala S.J., Weintraub B., Murray L.M., Weissel M. Development of thyroid disease during therapy of chronic viral hepatitis with interferon alfa. Gastroenterology 1992, 102: 2155\u20132160.","journal-title":"Gastroenterology"},{"key":"BF03345087_CR5","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1159\/000184606","volume":"44","author":"C Carella","year":"1995","unstructured":"Carella C., Amato G., Biondi B., et al. Longitudinal study of antibodies against thyroid in patients undergoing interferon alfa therapy for HCV chronic hepatitis. Horm. Res. 1995, 44: 110\u2013114.","journal-title":"Horm. Res."},{"key":"BF03345087_CR6","first-page":"922","volume":"80","author":"A Imagawa","year":"1995","unstructured":"Imagawa A., Itoh N., Hanafusa T., et al. Autoimmune endocrine disease induced by recombinant interferon alfa therapy for chronic active type C hepatitis. J. Clin. Endocrinol. Metab. 1995, 80: 922\u2013926.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03345087_CR7","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/S0002-9343(96)00259-8","volume":"101","author":"E Roti","year":"1996","unstructured":"Roti E., Minelli R., Giuberti T., et al. Multiple changes in thyroid function in patients with chronic active HCV hepatitis treated with recombinant interferon-alpha. Am. J. Med. 1996, 101: 482\u2013487.","journal-title":"Am. J. Med."},{"key":"BF03345087_CR8","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1046\/j.1365-2265.1996.751768.x","volume":"44","author":"M Marazuela","year":"1996","unstructured":"Marazuela M., Garcia-Buey L., Fernandez-Gonzalez B., et al. Thyroid autoimmune disorders in patients with chronic hepatitis C before and during interferon-a therapy. Clin. Endocrinol. 1996, 44: 635\u2013642.","journal-title":"Clin. Endocrinol."},{"key":"BF03345087_CR9","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1007\/BF03348040","volume":"21","author":"M Rotondi","year":"1998","unstructured":"Rotondi M., Oliviero A., Profice P., et al. Occurrence of thyroid autoimmunity and dysfunction throughout a ninemonth follow-up in patients undergoing interferon-b therapy for multiple sclerosis. J. Endocrinol. Invest. 1998, 21: 748\u2013752.","journal-title":"J. Endocrinol. Invest."},{"key":"BF03345087_CR10","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/BF03343730","volume":"23","author":"M Rotondi","year":"2000","unstructured":"Rotondi M., Mazziotti G., Biondi B., et al. Long-term treatment with interferon-beta therapy for multiple sclerosis and occurrence of Graves\u2019 disease. J. Endocrinol. Invest. 2000, 23: 321\u2013324.","journal-title":"J. Endocrinol. Invest."},{"key":"BF03345087_CR11","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S1590-8658(01)80715-5","volume":"33","author":"F Morisco","year":"2001","unstructured":"Morisco F., Mazziotti G., Rotondi M., et al. Interferonrelated thyroid autoimmunity and long-term clinical outcome of chronic hepatitis C. Dig. Liver Dis. 2001, 33: 247\u2013253.","journal-title":"Dig. Liver Dis."},{"key":"BF03345087_CR12","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1089\/thy.1997.7.891","volume":"7","author":"LKH Koh","year":"1997","unstructured":"Koh L.K.H., Greenspan F.S., Yeo P.P.B. Interferon-a induced thyroid dysfunction: three clinical presentations and review of the literature. Thyroid 1997, 7: 891\u2013896.","journal-title":"Thyroid"},{"key":"BF03345087_CR13","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1046\/j.1365-2893.2000.00247.x","volume":"7","author":"R Parana","year":"2000","unstructured":"Parana R., Cruz M., Lyra L., Cruz T. Subacute thyroiditis during treatment with combination therapy (interferon plus ribavirin) for hepatitis C virus. J. Vir. Hepat. 2000, 7: 393\u2013395.","journal-title":"J. Vir. Hepat."},{"key":"BF03345087_CR14","first-page":"1925","volume":"86","author":"C Carella","year":"2001","unstructured":"Carella C., Mazziotti G., Morisco M., et al. Long-term outcome of interferon-a-induced thyroid autoimmunity and prognostic influence of thyroid autoantibody pattern at the end of treatment. J. Clin. Endocrinol. Metab. 2001, 86: 1925\u20131929.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03345087_CR15","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1365-2265.1995.tb01894.x","volume":"43","author":"MPJ Vanderpump","year":"1995","unstructured":"Vanderpump M.P.J., Tunbridge W.M.G., French J.M., et al. The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham survey. Clin. Endocrinol. 1995, 43: 55\u201368.","journal-title":"Clin. Endocrinol."},{"key":"BF03345087_CR16","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1007\/BF03347987","volume":"20","author":"N Custro","year":"1997","unstructured":"Custro N., Montalto G., Scafidi V., et al. Prospective study on thyroid autoimmunity and dysfunction related to chronic hepatitis C and interferon therapy. J. Endocrinol. Invest. 1997, 20: 374\u2013380.","journal-title":"J. Endocrinol. Invest."},{"key":"BF03345087_CR17","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1210\/jcem-63-5-1086","volume":"63","author":"P Burman","year":"1986","unstructured":"Burman P., Totterman T.H., Oberg K., Karlsson F.A. Thyroid autoimmunity in patients on long term therapy with leukocity-derived interferon. J. Clin. Endocrinol. Metab. 1986, 63: 1086\u20131090.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03345087_CR18","doi-asserted-by":"crossref","first-page":"178","DOI":"10.7326\/0003-4819-115-3-178","volume":"115","author":"LE Ronnblom","year":"1991","unstructured":"Ronnblom L.E., Alm G.V., Oberg K.E. Autoimmunity after alpha-interferon therapy for malignant carcinoid tumors. Ann. Intern. Med. 1991, 115: 178\u2013183.","journal-title":"Ann. Intern. Med."},{"key":"BF03345087_CR19","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/0002-9343(92)90278-J","volume":"92","author":"NP Sauter","year":"1992","unstructured":"Sauter N.P., Atkins M.B., Mier J.W., Lechan R.M. Transient thyrotoxicosis and persistent hypothyroidism due to acute autoimmune thyroiditis after interleukin-2 and interferona therapy for metastatic carcinoma: a case report. Am. J. Med. 1992, 92: 441\u2013444.","journal-title":"Am. J. Med."},{"key":"BF03345087_CR20","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1016\/S0140-6736(89)90157-8","volume":"1","author":"M Schultz","year":"1989","unstructured":"Schultz M., Muller R., von zur Muhlen A., Brabant G. Induction of hyperthyroidism by interferon-alpha-2b. Lancet 1989, 1: 1452.","journal-title":"Lancet"},{"key":"BF03345087_CR21","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1007\/BF00577739","volume":"72","author":"H Monig","year":"1994","unstructured":"Monig H., Hauschild A., Lange S., Folsch UR. Suppressed thyroid-stimulating hormone secretion in patients treated with interleukin-2 and interferon-alpha 2b for metastatic melanoma. Clin. Investig. 1994, 72: 975\u2013978.","journal-title":"Clin. Investig."},{"key":"BF03345087_CR22","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1046\/j.1365-2249.1999.01020.x","volume":"118","author":"A Kaser","year":"1999","unstructured":"Kaser A., Enrich B., Ludwiczek O., Vogel W., Tilg H. Interferon-alpha (IFN-a) enhances cytotoxicity in healthy volunteers and chronic hepatitis C infection mainly by the perforin pathway. Clin. Exp. Immunol. 1999, 118: 71\u201377.","journal-title":"Clin. Exp. Immunol."},{"key":"BF03345087_CR23","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1089\/jir.1996.16.489","volume":"16","author":"LM Blatt","year":"1996","unstructured":"Blatt L.M., Davis J.M., Kein S.B., Taylor M.W. The biologic activity and molecular characterization of a novel synthetic interferon-alpha species, consensus interferon. J. Interferon. Cytokine. Res. 1996, 16: 489\u2013499.","journal-title":"J. Interferon. Cytokine. Res."},{"key":"BF03345087_CR24","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1089\/jir.1992.12.55","volume":"12","author":"ON Ozes","year":"1992","unstructured":"Ozes O.N., Reiter Z., Klein S., Blatt L.S., Taylor M.W. A comparison of interferon-Con1 with natural recombinant interferons-a: antiviral, antiproliferative, and natural killerinducing activities. J. Interferon Cytokine Res. 1992, 12: 55\u201359.","journal-title":"J. Interferon Cytokine Res."},{"key":"BF03345087_CR25","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1210\/jcem-46-6-859","volume":"46","author":"H Yoshida","year":"1978","unstructured":"Yoshida H., Amino N., Yagawa K., et al. Association of serum antitiroid antibodies with linphocytic infiltration of the thyroid gland: studies of seventy autopsied cases. J. Clin. Endocrinol. Metab. 1978, 46: 859\u2013862.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03345087_CR26","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1089\/thy.1998.8.1101","volume":"8","author":"J Takamatsu","year":"1998","unstructured":"Takamatsu J., Yoshida S., Yokozawa T., et al. Correlation of antithyroglobulin and antithyroid-peroxidase antibody profile with clinical and ultrasound characteristics of chronic thyroiditis. Thyroid 1998, 8: 1101\u20131106.","journal-title":"Thyroid"},{"key":"BF03345087_CR27","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1089\/thy.1996.6.445","volume":"6","author":"K Kasagy","year":"1996","unstructured":"Kasagy K., Kousaka T., Higuchi K., et al. Clinical significance of measurements of antithyroid antibodies in the diagnosis of Hashimoto\u2019s thyroiditis: comparison with histological findings. Thyroid 1996, 6: 445\u2013450.","journal-title":"Thyroid"},{"key":"BF03345087_CR28","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1530\/eje.0.1460743","volume":"146","author":"C Carella","year":"2002","unstructured":"Carella C., Mazziotti G., Morisco F., et al. The addition of ribavirin to interferon-a therapy in patients with HCV-related chronic hepatitis does not modify the thyroid autoantibody pattern but increases the risk to develop hypothyroidism. Eur. J. Endocrinol. 2002, 146, 743\u2013749.","journal-title":"Eur. J. Endocrinol."},{"key":"BF03345087_CR29","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0168-8278(99)80093-2","volume":"30","author":"RC Tam","year":"1999","unstructured":"Tam R.C., Pai B., Bard J., et al. Ribavirin polarizes human T cell responses toward a type 1 cytokine profile. J. Hepatol. 1999, 30: 376\u2013382.","journal-title":"J. Hepatol."},{"key":"BF03345087_CR30","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/0167-5699(95)80068-9","volume":"16","author":"RL Liblau","year":"1995","unstructured":"Liblau R.L., Singer S.M., McDevitt H.O. Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune disease. Immunol. Today 1995, 16: 34\u201338.","journal-title":"Immunol. Today"},{"key":"BF03345087_CR31","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1126\/science.272.5258.50","volume":"272","author":"TF Douglas","year":"1996","unstructured":"Douglas T.F. The instructive role of innate immunity in the acquired immune response. Science 1996, 272: 50\u201354.","journal-title":"Science"},{"key":"BF03345087_CR32","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/79792","volume":"1","author":"FD Shi","year":"2000","unstructured":"Shi F.D., Wang H.B., Li H., et al. Natural killer cells determine the outcome of B cell-mediated autoimmunity. Nat. Immunol. 2000, 1: 245\u2013251.","journal-title":"Nat. Immunol."}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03345087.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF03345087\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03345087","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T02:40:07Z","timestamp":1565318407000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF03345087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,7]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2002,7]]}},"alternative-id":["BF03345087"],"URL":"https:\/\/doi.org\/10.1007\/bf03345087","relation":{},"ISSN":["0391-4097","1720-8386"],"issn-type":[{"value":"0391-4097","type":"print"},{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,7]]}}}