{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:29:29Z","timestamp":1760189369905},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T00:00:00Z","timestamp":1049155200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"published-print":{"date-parts":[[2003,4]]},"DOI":"10.1007\/bf03345177","type":"journal-article","created":{"date-parts":[[2014,4,10]],"date-time":"2014-04-10T18:41:16Z","timestamp":1397155276000},"page":"305-311","source":"Crossref","is-referenced-by-count":7,"title":["Insulin and GH secretion in adolescent girls with irregular cycles: Polycystic vs multifollicular ovaries"],"prefix":"10.1007","volume":"26","author":[{"given":"Paola","family":"Villa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Rossodivita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. M.","family":"Fulghesu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Cucinelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Barini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Apa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Belosi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Lanzone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,3,18]]},"reference":[{"key":"BF03345177_CR1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1159\/000180567","volume":"24","author":"S Venturoli","year":"1986","unstructured":"Venturoli S., Porcu E., Fabbri R., et al. Menstrual irregularities in adolescents: hormonal pattern and ovarian morphology. Horm. Res. 1986, 24: 269\u2013279.","journal-title":"Horm. Res."},{"key":"BF03345177_CR2","first-page":"119","volume":"79","author":"D Apter","year":"1994","unstructured":"Apter D., B\u00f9tzow T., Laughlin G.A., Yen S.S.C. Accelerated 24-hour luteinizing hormone pulsatile activity in adolescent girls with ovarian hyperandrogenism: relevance to the developmental phase of polycystic ovarian syndrome. J. Clin. Endocrinol. Metab. 1994, 79: 119\u2013125.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03345177_CR3","first-page":"2966","volume":"80","author":"D Apter","year":"1995","unstructured":"Apter D., B\u00f9tzow T., Laughlin G.A., Yen S.S.C. Metabolic features of polycystic ovary syndrome are found in adolescent girls with hyperandrogenism. J. Clin. Endocrinol. Metab. 1995, 80: 2966\u20132973.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03345177_CR4","first-page":"310","volume":"53","author":"JI Mechanick","year":"1986","unstructured":"Mechanick J.I., Futterweit W. The aberrant puberty hyphotesis of the polycystic ovarian disease: a review. Mount Sinai J. Med. 1986, 53: 310\u2013314.","journal-title":"Mount Sinai J. Med."},{"key":"BF03345177_CR5","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1210\/jcem-68-5-932","volume":"68","author":"CP Smith","year":"1989","unstructured":"Smith C.P., Dunger D.B., Williams A.J., et al. Relationship between insulin, insulin-like growth factor I, and dehydroepiandrosterone sulfate concentrations during childhood, puberty and adult life. J. Clin. Endocrinol. Metab. 1989, 68: 932\u2013937.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03345177_CR6","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1056\/NEJM198607243150402","volume":"315","author":"S Amiel","year":"1986","unstructured":"Amiel S., Sherwin R., Simonson D.C., Lauritano A.A., Tamborlane W.V. Impaired insulin action in puberty a contribuiting factor to poor glycaemic control in adolescent with diabetes. N. Engl. J. Med. 1986, 315: 215\u2013219.","journal-title":"N. Engl. J. Med."},{"key":"BF03345177_CR7","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/S0022-3476(89)80438-X","volume":"114","author":"S Caprio","year":"1989","unstructured":"Caprio S., Plewe G., Diamond M.P., et al. Increased insulin secretion in puberty a compensatory response to reduction in insulin sensitivity. J. Ped. 1989, 114: 963\u2013967.","journal-title":"J. Ped."},{"key":"BF03345177_CR8","first-page":"725","volume":"77","author":"JS Cook","year":"1993","unstructured":"Cook J.S., Hoffman R.P., Stene M.A., Hansen J.R. Effects of maturational stage on insulin sensitivity during puberty. J. Clin. Endocrinol. Metab. 1993, 77: 725\u2013730.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03345177_CR9","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1530\/acta.0.1230007","volume":"123","author":"EM Rutanen","year":"1990","unstructured":"Rutanen E.M., Pekonen F. Insulin-like growth factors and their binding proteins. Acta Endocrinol. (Copenh.) 1990, 123: 7\u201313.","journal-title":"Acta Endocrinol. (Copenh.)"},{"key":"BF03345177_CR10","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1677\/joe.0.124R001","volume":"24","author":"A Singh","year":"1990","unstructured":"Singh A., Hamilton-Farley D., Koistinen R., et al. Effects of insulin-like growth factor type I (IGF-I) and insulin on the secretion of sex hormone binding globulin and IGF-I binding protein (IBP-I) by human hepatoma cells. J. Endocrinol. 1990, 24: R1.","journal-title":"J. Endocrinol."},{"key":"BF03345177_CR11","doi-asserted-by":"crossref","first-page":"13238","DOI":"10.1016\/S0021-9258(18)51620-3","volume":"264","author":"CP Moxham","year":"1989","unstructured":"Moxham C.P., Duronio V., Jacobs S. Insulin-like growth factor I receptor beta-subunit heterogeneity. Evidence for hybrid tetramers composed of insulin-like growth factor I and insulin receptor heterodimers. J. Biol. Chem. 1989, 264: 13238\u201313244.","journal-title":"J. Biol. Chem."},{"key":"BF03345177_CR12","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1093\/humrep\/14.9.2223","volume":"14","author":"MH Hooff Van","year":"1999","unstructured":"Van Hooff M.H., Voorhorst F.J., Kaptein M.B., Hirasing R.A., Koppenaal C., Schoemaker J. Endocrine features of polycystic ovary syndrome in a random population sample of 14\u201316 year old adolescents. Hum. Reprod. 1999, 14: 2223\u20132229.","journal-title":"Hum. Reprod."},{"key":"BF03345177_CR13","first-page":"13","volume":"44","author":"W Marshall","year":"1969","unstructured":"Marshall W., Tanner J. Variation in the pattern of pubertal changes in girls. Arch. Dis. Childhood 1969, 44: 13\u201323.","journal-title":"Arch. Dis. Childhood"},{"key":"BF03345177_CR14","first-page":"320","volume":"56","author":"MI New","year":"1986","unstructured":"New M.I., Lorenzen F., Lerner A.J., et al. Genotyping steroid 21-hydroxylase deficiency: hormonal reference data. J. Clin. Endocrinol. Metab. 1986, 56: 320\u2013325.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03345177_CR15","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0002-9378(77)90464-1","volume":"127","author":"P Gohary","year":"1977","unstructured":"Gohary P., Berkowitz R.L., Hobbins J.C. Prediction of intrauterine growth retardation by determination of total intrauterine volume. Am. J. Obstet. Gynecol. 1977, 127: 255\u2013260.","journal-title":"Am. J. Obstet. Gynecol."},{"key":"BF03345177_CR16","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1203\/00006450-199512000-00024","volume":"38","author":"S Venturoli","year":"1995","unstructured":"Venturoli S., Porcu E., Fabbri R., et al. Longitudinal changes of ovarian aspects and endocrine parameters in irregular cycles of adolescence. Ped. Res. 1995, 38: 974\u2013980.","journal-title":"Ped. Res."},{"key":"BF03345177_CR17","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S","volume":"15","author":"KGMM Alberti","year":"1998","unstructured":"Alberti K.G.M.M., Zymmet P.Z. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1. Diagnosis and classifications of diabetes mellitus. Provisional report of WHO Consultation. Diabetic Med. 1998, 15: 539\u2013553.","journal-title":"Diabetic Med."},{"key":"BF03345177_CR18","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/S0015-0282(16)54353-2","volume":"55","author":"Y Ardaens","year":"1991","unstructured":"Ardaens Y., Robert Y., Lemaitre L., Fossati P., Dewailly D. Polycystic ovarian syndrome: contribution of vaginal endosonography and reassessment of ultrasonic diagnosis. Fertil. Steril. 1991, 55: 1062\u20131068.","journal-title":"Fertil. Steril."},{"key":"BF03345177_CR19","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/(SICI)1097-0096(199606)24:5<243::AID-JCU3>3.0.CO;2-E","volume":"24","author":"LD Herter","year":"1996","unstructured":"Herter L.D., Magalhaes J.A., Spritzer M.P. Relevance of the determination of ovarian volume in adolescent girls with menstrual disorders. J. Clin. Ultrasound 1996, 24: 243\u2013248.","journal-title":"J. Clin. Ultrasound"},{"key":"BF03345177_CR20","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0015-0282(16)57728-0","volume":"64","author":"Y Robert","year":"1995","unstructured":"Robert Y., Dubrulle F., Gaillandre L., et al. Ultrasound assessment of ovarian stroma hypertrophy in hyperan-drogenism and ovulation disorders: visual analysis versus computerized quantification. Fertil. Steril. 1995, 64: 307\u2013312.","journal-title":"Fertil. Steril."},{"key":"BF03345177_CR21","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/S0015-0282(01)01919-7","volume":"76","author":"AM Fulghesu","year":"2001","unstructured":"Fulghesu A.M., Ciampelli M., Belosi C., Apa R., Pavone V., Lanzone A. A new ultrasound criterion for the diagnosis of polycystic ovary syndrome: the ovarian stroma \/ total area ratio. Fertil. Steril. 2001, 76: 326\u2013331.","journal-title":"Fertil. Steril."},{"key":"BF03345177_CR22","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1365-2265.1988.tb03669.x","volume":"28","author":"P Hindmarsh","year":"1988","unstructured":"Hindmarsh P., Di Silvio L., Pringle P.J., Kurtz A.B., Brook C.G. Changes in serum insulin concentration during puberty and their relathionship to growth hormone. Clin. Endocrinol. (Oxf.) 1988, 28: 381\u2013388.","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"BF03345177_CR23","first-page":"1237","volume":"81","author":"L Ibanez","year":"1996","unstructured":"Ibanez L., Potau N., Zampolli M., Prat N., Virdis R., Vincens-Calvet E. Hyperinsulinemia in post-pubertal girls with a history of premature pubarche and functional ovarian hyperandrogenism. J. Clin. Endocrinol. Metab. 1996, 81: 1237\u20131243.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03345177_CR24","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1365-2265.1980.tb02132.x","volume":"12","author":"SSC Yen","year":"1980","unstructured":"Yen S.S.C. The polycystic ovarian syndrome. Clin. Endocrinol. (Oxf.) 1980, 12: 177\u2013207.","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"BF03345177_CR25","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0015-0282(16)56879-4","volume":"62","author":"M Filicori","year":"1994","unstructured":"Filicori M., Flamigni C., Cognini G., Dellai P., Michelacci L., Arnone R. Increased insulin secretion in patients with multifollicular and polycystic ovaries and its impact on ovulation induction. Fertil. Steril. 1994, 62: 279\u2013285.","journal-title":"Fertil. Steril."},{"key":"BF03345177_CR26","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1093\/oxfordjournals.humrep.a136150","volume":"10","author":"A Lanzone","year":"1995","unstructured":"Lanzone A., Villa P., Fulghesu A.M., Pavone V., Caruso A., Mancuso S. The growth hormone response to growth-hormone-releasing hormone is blunted in polycystic ovary syndrome: relationship with obesity and hyperinsulinemia. Hum. Reprod. 1995, 10: 1653\u20131657.","journal-title":"Hum. Reprod."},{"key":"BF03345177_CR27","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1111\/j.1365-2265.1995.tb02691.x","volume":"42","author":"GP Piaditis","year":"1995","unstructured":"Piaditis G.P., Kounadi T.G., Rangou D.B., et al. Dysfunction of the growth hormone\/insulin-like growth factor-1 axis in women with polycystic ovarian syndrome. Clin. Endocrinol. (Oxf.) 1995, 42: 635\u2013640.","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"BF03345177_CR28","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0015-0282(98)00405-1","volume":"71","author":"P Villa","year":"1999","unstructured":"Villa P., Valle D., Mancini A., et al. Effect of opiod blockade on insulin and growth hormone (GH) secretion in patients with polycystic ovary syndrome: the heterogeneity of impaired GH secretion is related to both obesity and hyper-insulinism. Fertil. Steril. 1999, 71: 115\u2013121.","journal-title":"Fertil. Steril."}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03345177.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF03345177\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03345177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T10:29:28Z","timestamp":1648808968000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF03345177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003,4]]}},"alternative-id":["BF03345177"],"URL":"https:\/\/doi.org\/10.1007\/bf03345177","relation":{},"ISSN":["0391-4097","1720-8386"],"issn-type":[{"value":"0391-4097","type":"print"},{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,4]]}}}