{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T16:47:51Z","timestamp":1780678071329,"version":"3.54.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T00:00:00Z","timestamp":1049155200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"published-print":{"date-parts":[[2003,4]]},"DOI":"10.1007\/bf03345178","type":"journal-article","created":{"date-parts":[[2014,4,10]],"date-time":"2014-04-10T18:41:16Z","timestamp":1397155276000},"page":"312-315","source":"Crossref","is-referenced-by-count":20,"title":["Apolipoprotein E 4 allele is associated with low bone density in postmenopausal women"],"prefix":"10.1007","volume":"26","author":[{"given":"K.","family":"Zaj\u00ed\u010dkov\u00e1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"\u017dofkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Ho\u0159\u00ednek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Nov\u00e1kov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,3,18]]},"reference":[{"key":"BF03345178_CR1","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1172\/JCI113125","volume":"80","author":"NA Pocock","year":"1987","unstructured":"Pocock N.A., Eisman J.A., Hopper J.L., Yeats M.G., Sambrook P.N., Ebert S. Genetic determinants of bone mass in adults: A twin study. J. Clin. Invest. 1987, 80: 706\u2013710.","journal-title":"J. Clin. Invest."},{"key":"BF03345178_CR2","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1056\/NEJM198903023200903","volume":"320","author":"E Seeman","year":"1989","unstructured":"Seeman E., Hopper J.L., Bach L.A., et al. Reduced bone mass in daughters of women with osteoporosis. N. Engl. J. Med. 1989, 320: 554\u2013558.","journal-title":"N. Engl. J. Med."},{"key":"BF03345178_CR3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/01.ATV.8.1.1","volume":"8","author":"J Davignon","year":"1988","unstructured":"Davignon J., Gregg R.E., Sing C.F. Apolipoprotein E polymorphisms and atherosclerosis. Arteriosclerosis 1988, 8: 1\u201321.","journal-title":"Arteriosclerosis"},{"key":"BF03345178_CR4","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","volume":"261","author":"EH Corder","year":"1993","unstructured":"Corder E.H., Saunders A.M., Strittmatter W.J., et al. Gene dose of apolipoprotein E type 4 allele and risk of Alzheimer\u2019s disease in late onset families. Science 1993, 261: 921\u2013923.","journal-title":"Science"},{"key":"BF03345178_CR5","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1359\/jbmr.1997.12.9.1438","volume":"12","author":"M Shiraki","year":"1997","unstructured":"Shiraki M., Shiraki Y., Aoki Ch., et al. Association of Bone Mineral Density with Apolipoprotein E Phenotype. J. Bone Miner. Res. 1997, 12: 1438\u20131445.","journal-title":"J. Bone Miner. Res."},{"key":"BF03345178_CR6","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/s001980170124","volume":"12","author":"DG M\u00fchlen","year":"2001","unstructured":"M\u00fchlen D.G., Barrett-Connor E., Schneider D.L., Morin P.A., Parry P. Osteoporosis and Apolipoprotein E Genotype in Older Adults: The Rancho Bernardo Study. Osteoporos. Int. 2001, 12: 332\u2013335.","journal-title":"Osteoporos. Int."},{"key":"BF03345178_CR7","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1359\/jbmr.1999.14.7.1175","volume":"14","author":"JA Cauley","year":"1999","unstructured":"Cauley J.A., Zmuda J.M., Yaffe K., et al. Apolipoprotein E Polymorphism: A New Genetic Marker of Hip Fracture Risk \u2014The Study of Osteoporotic Fractures. J. Bone Miner. Res. 1999, 14: 1175\u20131181.","journal-title":"J. Bone Miner. Res."},{"key":"BF03345178_CR8","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1359\/jbmr.2000.15.2.308","volume":"15","author":"LM Salamone","year":"2000","unstructured":"Salamone L.M., Cauley J.A., Zmuda J., et al. Apoliprotein E Gene Polymorphism and Bone Loss: Estrogen Status Modifies the Influence of Apoliprotein E on Bone Loss. J. Bone Miner. Res. 2000, 15: 308\u2013314.","journal-title":"J. Bone Miner. Res."},{"key":"BF03345178_CR9","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1359\/jbmr.1997.12.2.283","volume":"12","author":"MT Vogt","year":"1997","unstructured":"Vogt M.T., Cauley J.A., Kuller L.H., Nevitt M.C. Bone mineral density and blood flow to the lower extremities: the study of osteoporotic fractures. J. Bone Miner. Res. 1997, 12: 283\u2013289.","journal-title":"J. Bone Miner. Res."},{"key":"BF03345178_CR10","first-page":"278","volume":"23","author":"DP Kiel","year":"1998","unstructured":"Kiel D.P., Cupples L.A., Myers R.H., et al. Bone mineral density, hip fracture and apolipoprotein E genotype Bone 1998, 23: S278.","journal-title":"Bone"},{"key":"BF03345178_CR11","doi-asserted-by":"crossref","first-page":"435","DOI":"10.33549\/physiolres.930000.49.435","volume":"49","author":"T \u0160tulc","year":"2000","unstructured":"\u0160tulc T., \u010ce\u0161ka R., Ho\u0159\u00ednek A., \u0160t\u011bp\u00e1n J. Bone Mineral Density in patients with Apolipoprotein E Type 2\/2 and 4\/4 Genotype. Physiol. Res. 2000, 49: 435\u2013439.","journal-title":"Physiol. Res."},{"key":"BF03345178_CR12","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0378-5122(99)00084-5","volume":"34","author":"AM Heikinen","year":"2000","unstructured":"Heikinen A.M., Kroger H., Niskanen L., et al. Does apolipoprotein E genotype relate to BMD and bone markers in postmenopausal women? Maturitas 2000, 34: 33\u201341.","journal-title":"Maturitas"},{"key":"BF03345178_CR13","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/nar\/16.3.1215","volume":"16","author":"SA Miler","year":"1988","unstructured":"Miler S.A., Dykes D.D., Polesky H.F. A simple salting out procedure for extracting DNA from human nucleated cells. Nucl. Acid. Res. 1988, 16: 1215.","journal-title":"Nucl. Acid. Res."},{"key":"BF03345178_CR14","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0022-2275(20)43176-1","volume":"1","author":"JE Hixson","year":"1990","unstructured":"Hixson J.E., Vernier D.T. Restriction isotyping of human apoliporotein E by gene amplification and cleavage with Hhal. J. Lipid. Res. 1990, 1: 545\u2013548.","journal-title":"J. Lipid. Res."},{"key":"BF03345178_CR15","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0165-0270(94)90168-6","volume":"53","author":"R Crook","year":"1994","unstructured":"Crook R., Hardy J., Duff K. Single-day Apolipoprotein E genotyping. J. Neurosci. methods 1994, 53: 125\u2013127.","journal-title":"J. Neurosci. methods"},{"key":"BF03345178_CR16","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/oso\/9780195052886.001.0001","volume-title":"Foundamental of genetic epidemiology","author":"AM Khoury","year":"1993","unstructured":"Khoury A.M., Beaty T.H., Cohen B.H. Foundamental of genetic epidemiology. Oxford University Press, New York, 1993, p. 49\u201354."},{"key":"BF03345178_CR17","first-page":"268","volume":"37","author":"CF Sing","year":"1985","unstructured":"Sing C.F., Davignon J. Role of the apolipoprotein E polymorphism in determining normal plasma lipid and lipoprotein variation. Am. J. Hum. Genet. 1985, 37: 268\u2013285.","journal-title":"Am. J. Hum. Genet."},{"key":"BF03345178_CR18","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1093\/ajcn\/58.2.204","volume":"58","author":"J Saupe","year":"1993","unstructured":"Saupe J., Shearer M.J., Kohlmeier M. Phylloquinone transport and its influence on gamma-carboxyglutamate residues of osteocalcin in patients on maintenance hemodialysis. Am. J. Clin. Nutr. 1993, 58: 204\u2013208.","journal-title":"Am. J. Clin. Nutr."},{"key":"BF03345178_CR19","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1042\/bj2660625","volume":"266","author":"C Vermeer","year":"1990","unstructured":"Vermeer C. Gamma-carboxyglutamate-containing proteins and the vitamin K-dependent carboxylase. Biochem. J. 1990, 266: 625\u2013635.","journal-title":"Biochem. J."},{"key":"BF03345178_CR20","doi-asserted-by":"crossref","first-page":"9077","DOI":"10.1016\/S0021-9258(19)52510-8","volume":"256","author":"KH Weisgraber","year":"1981","unstructured":"Weisgraber K.H., Rall S.Jr., Mahley R.W. Human E apoprotein heterogenity: Cystein-arginine interchanges in the amino acid sequence of apo E isoforms. J. Biol. Chem. 1981, 256: 9077\u20139083.","journal-title":"J. Biol. Chem."},{"key":"BF03345178_CR21","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1093\/jn\/126.suppl_4.1192S","volume":"126","author":"M Kohlmeier","year":"1996","unstructured":"Kohlmeier M., Salamon A., Saupe J., Shearer M. Transport of Vitamin K to Bone in Humans. J. Nutr. 1996, 126: 1192\u20131196.","journal-title":"J. Nutr."},{"key":"BF03345178_CR22","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1007\/s002239900430","volume":"62","author":"M Kohlmeier","year":"1998","unstructured":"Kohlmeier M., Saupe J., Schaefer K., Asmus G. Bone Fracture History and Prospective bone fracture Risk of Hemodialysis Patients are related to Apolipoprotein E Genotype. Calcif. Tissue Int. 1998, 62: 278\u2013281.","journal-title":"Calcif. Tissue Int."},{"key":"BF03345178_CR23","first-page":"011","volume":"13","author":"SR Beaven","year":"1998","unstructured":"Beaven S.R., Prentice A., Stirling D.M. Apoliporotein E (Apo E) genotype and osteocalcin carboxylation post-menopause. J. Bone Miner. Res. 1998, 13: 011 (abstract).","journal-title":"J. Bone Miner. Res."}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03345178.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF03345178\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03345178","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T10:07:33Z","timestamp":1746180453000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF03345178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003,4]]}},"alternative-id":["BF03345178"],"URL":"https:\/\/doi.org\/10.1007\/bf03345178","relation":{},"ISSN":["0391-4097","1720-8386"],"issn-type":[{"value":"0391-4097","type":"print"},{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,4]]}}}