{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T11:32:53Z","timestamp":1782387173565,"version":"3.54.5"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T00:00:00Z","timestamp":1049155200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"published-print":{"date-parts":[[2003,4]]},"DOI":"10.1007\/bf03345186","type":"journal-article","created":{"date-parts":[[2014,4,10]],"date-time":"2014-04-10T18:41:16Z","timestamp":1397155276000},"page":"364-371","source":"Crossref","is-referenced-by-count":23,"title":["The emerging role of peripheral corticotropin-releasing hormone (CRH)"],"prefix":"10.1007","volume":"26","author":[{"given":"I.","family":"Ilias","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Mastorakos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,3,18]]},"reference":[{"key":"BF03345186_CR1","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1056\/NEJM199505183322008","volume":"332","author":"GP Chrousos","year":"1995","unstructured":"Chrousos G.P. The Hypothalamic-Pituitary-Adrenal axis and the immune\/inflammatory reaction. N. Engl. J. Med. 1995, 332: 1351\u20131362.","journal-title":"N. Engl. J. Med."},{"key":"BF03345186_CR2","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1056\/NEJM199309303291423","volume":"329","author":"S Reichlin","year":"1993","unstructured":"Reichlin S. Neuroendocrine-immune interactions. N. Engl. J. Med. 1993, 329: 1246\u20131253.","journal-title":"N. Engl. J. Med."},{"key":"BF03345186_CR3","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1159\/000319385","volume-title":"Neuroimmunoendocrinology","author":"HM Johnson","year":"1992","unstructured":"Johnson H.M. Neuroendocrine peptide hormone regulation of immunity. In: Blalock J.E. ed. Neuroimmunoendocrinology. 2nd ed. Basel: Karger. 1992, 49\u201383.","edition":"2nd ed"},{"key":"BF03345186_CR4","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1210\/endo-110-1-272","volume":"110","author":"C Rivier","year":"1982","unstructured":"Rivier C., Brownstein M., Spiess J., et al. In vivo corticotropin-releasing factor-induced secretion of adrenocorticotropin, \u03b2-endorphin and corticosterone. Endocrinology 1982, 110: 272\u2013278.","journal-title":"Endocrinology"},{"key":"BF03345186_CR5","first-page":"245","volume":"39","author":"W Vale","year":"1983","unstructured":"Vale W., Rivier C., Brown M.R., et al. Chemical and biological characterization of corticotropin releasing factor. Recent Prog. Horm. Res. 1983, 39: 245\u2013270.","journal-title":"Recent Prog. Horm. Res."},{"key":"BF03345186_CR6","doi-asserted-by":"crossref","first-page":"6517","DOI":"10.1073\/pnas.78.10.6517","volume":"78","author":"J Spiess","year":"1981","unstructured":"Spiess J., Rivier J., Rivier C., Vale W. Primary structure of corticotropin-releasing factor from ovine hypothalamus. Proc. Natl. Acad. Sci. USA 1981, 78: 6517\u20136521.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BF03345186_CR7","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1210\/endo.137.5.8612563","volume":"137","author":"CJ Donaldson","year":"1996","unstructured":"Donaldson C.J., Sutton S.W., Perrin M.H., et al. Cloning and characterization of human urocortin. Endocrinology 1996, 137: 2167\u20132170.","journal-title":"Endocrinology"},{"key":"BF03345186_CR8","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1002\/j.1460-2075.1983.tb01499.x","volume":"2","author":"S Shibahara","year":"1983","unstructured":"Shibahara S., Morimoto Y., Furutani Y., et al. Isolation and sequence analysis of the human corticotropin-releasing factor precursor gene. EMBO J. 1983, 2:775\u2013779.","journal-title":"EMBO J."},{"key":"BF03345186_CR9","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1159\/000123454","volume":"36","author":"LW Swanson","year":"1983","unstructured":"Swanson L.W., Sawchenko P.E., Rivier J., Vale W.W. Organization of ovine corticotropin-releasing factor immunoreactive cells and fibers in the rat brain: An immunohistochemical study. Neuroendocrinology 1983, 36: 165\u2013186.","journal-title":"Neuroendocrinology"},{"key":"BF03345186_CR10","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1172\/JCI443","volume":"101","author":"FP Giraldi","year":"1998","unstructured":"Giraldi F.P., Cavagnini F. Corticotropin-releasing hormone is produced by rat corticotropes and modulates ACTH secretion in a paracrine\/autocrine fashion. J. Clin. Invest. 1998, 101: 2478\u20132484.","journal-title":"J. Clin. Invest."},{"key":"BF03345186_CR11","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1523\/JNEUROSCI.04-04-01118.1984","volume":"4","author":"PE Sawchenko","year":"1984","unstructured":"Sawchenko P.E., Swanson L.W., Vale W.W. Corticotropinreleasing factors: Coexpression within distinct subsets of oxytocin-, vasopressin-, and neurotensin-immunoreactive neurons in the hypothalamus of the male rat. J. Neurosci. 1984, 4: 1118\u20131129.","journal-title":"J. Neurosci."},{"key":"BF03345186_CR12","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1210\/jcem-59-6-1103","volume":"59","author":"TH Schurmeyer","year":"1984","unstructured":"Schurmeyer T.H., Avgerinos P.C., Gold P.W., et al. Human corticotropin-releasing factor in man: pharmacokinetic properties and dose-response of plasma adrenocorticotropin and cortisol secretion. J. Clin. Endocrinol. Metab. 1984, 59: 1103\u20131108.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03345186_CR13","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1210\/jcem-58-3-463","volume":"58","author":"JV Conaglen","year":"1984","unstructured":"Conaglen J.V., Donld R.A., Espiner E.A., et al. The effect of ovine corticotropin-releasing factor on catecholamine, vasopressin, and aldosterone secretion in normal man. J. Clin. Endocrinol. Metab. 1984, 58: 463\u2013466.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03345186_CR14","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1210\/jcem-62-4-767","volume":"62","author":"EP Pavlov","year":"1986","unstructured":"Pavlov E.P., Harman S.M., Chrousos G.P., et al. Responses of plasma adrenocorticotropin, cortisol, and dehydroepiandrosterone to ovine corticotropin-releasing hormone in healthy aging men. J. Clin. Endocrinol. Metab. 1986, 62: 767\u2013772.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03345186_CR15","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1210\/jcem-61-2-273","volume":"61","author":"GS DeCherney","year":"1985","unstructured":"DeCherney G.S., DeBold C.R., Jackson R.V., et al. Diurnal variation in the response of plasma adrenocorticotropin and cortisol to intravenous ovine corticotropin-releasing hormone. J. Clin. Endocrinol. Metab. 1985, 61: 273\u2013279.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03345186_CR16","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/S0006-291X(87)80261-9","volume":"148","author":"M Grino","year":"1987","unstructured":"Grino M., Chrousos G.P., Margioris A.N. The corticotropin releasing hormone gene is expressed in human placenta. Biochem. Biophys. Res. Commun. 1987, 148: 1208\u20131214.","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BF03345186_CR17","first-page":"1046","volume":"81","author":"G Mastorakos","year":"1996","unstructured":"Mastorakos G., Scopa C.D., Kao L.C., et al. Presence of immunoreactive corticotropin-releasing hormone in human endometrium. J. Clin. Endocrinol. Metab. 1996, 81: 1046\u20131050.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03345186_CR18","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0960-0760(95)00142-M","volume":"54","author":"A Ferrari","year":"1995","unstructured":"Ferrari A., Petraglia F., Gurpide E. Corticotropin releasing factor decidualizes human endometrial stromal cells in vitro. Interaction with progestin. J. Steroid. Biochem. Mol. Biol. 1995, 54: 251\u2013255.","journal-title":"J. Steroid. Biochem. Mol. Biol."},{"key":"BF03345186_CR19","first-page":"1427","volume":"74","author":"F Petraglia","year":"1992","unstructured":"Petraglia F., Tabanelli S., Galassi M.C., et al. Human decidua and in vitro decidualized endometrial stromal cells at term contain immunoreactive corticotropin-releasing factor (CRF) and CRF messenger ribonucleic acid. J. Clin. Endocrinol. Metab. 1992, 74: 1427\u20131431.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03345186_CR20","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1210\/endo-127-3-1541","volume":"127","author":"A Fabbri","year":"1990","unstructured":"Fabbri A., Tinajero J.C., Dufau M.L. Corticotropin-releasing factor is produced by rat Leydig cells and has a major local antireproductive role in the testis. Endocrinology 1990, 127: 1541\u20131543.","journal-title":"Endocrinology"},{"key":"BF03345186_CR21","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1016\/S0021-9258(18)94155-4","volume":"264","author":"S Ulisse","year":"1989","unstructured":"Ulisse S., Fabbri A., Dufau M.L. Corticotropin-releasing factor receptors and actions in rat Leydig cells. J. Biol. Chem. 1989, 264: 2156\u20132163.","journal-title":"J. Biol. Chem."},{"key":"BF03345186_CR22","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1172\/JCI116672","volume":"92","author":"G Mastorakos","year":"1993","unstructured":"Mastorakos G., Webster E.L., Friedman T.C., Chrousos G.P. Immunoreactive corticotropin releasing hormone (CRH) and its binding sites in the rat ovary. J. Clin. Invest. 1993, 92: 961\u2013968.","journal-title":"J. Clin. Invest."},{"key":"BF03345186_CR23","first-page":"1191","volume":"79","author":"G Mastorakos","year":"1994","unstructured":"Mastorakos G., Scopa C.D., Vryonidou A., et al. Presence of immunoreactive corticotropin releasing hormone (CRH) in normal and polycystic human ovaries. J. Clin. Endocrinol. Metab. 1994, 79: 1191\u20131197.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03345186_CR24","first-page":"1159","volume":"145","author":"G Mastorakos","year":"1994","unstructured":"Mastorakos G., Scopa C.D., Friedman T.C., et al. Presence of immunoreactive corticotropin releasing hormone (CRH) in thyroid lesions. Am. J. Pathol. 1994, 145: 1159\u20131167.","journal-title":"Am. J. Pathol."},{"key":"BF03345186_CR25","doi-asserted-by":"crossref","first-page":"4650","DOI":"10.1210\/endo.136.10.7664685","volume":"136","author":"G Mastorakos","year":"1995","unstructured":"Mastorakos G., Bouzas E.A., et al. Immune corticotropinreleasing hormone is present in the eyes of and promotes experimental autoimmune uveoretinitis in rodents. Endocrinology 1995, 136: 4650\u20134658.","journal-title":"Endocrinology"},{"key":"BF03345186_CR26","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1210\/jcem-64-2-224","volume":"64","author":"A Sasaki","year":"1987","unstructured":"Sasaki A., Shinkawa O., Margioris A.N., et al. Immunoreactive corticotropin-releasing hormone in human plasma during pregnancy, labor, and delivery. J. Clin. Endocrinol. Metab. 1987, 64: 224\u2013229.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03345186_CR27","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1530\/acta.0.1220711","volume":"122","author":"W Jeske","year":"1990","unstructured":"Jeske W., Soszynski P., Lukaszewicz E., et al. Enhancement of plasma corticotropin-releasing hormone in pregnancy-induced hypertension. Acta Endocrinol. 1990, 122: 711\u2013714.","journal-title":"Acta Endocrinol"},{"key":"BF03345186_CR28","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1365-2265.1988.tb01218.x","volume":"28","author":"EA Linton","year":"1988","unstructured":"Linton E.A., Wolfe C.D., Behan D.P., Lowry P.J. A specific carrier substance for human corticotropin releasing factor in late gestational maternal plasma which could mask the ACTH-releasing activity. Clin. Endocrinol. (Oxf) 1988, 28: 315\u2013324.","journal-title":"Clin. Endocrinol. (Oxf)"},{"key":"BF03345186_CR29","doi-asserted-by":"crossref","first-page":"8967","DOI":"10.1073\/pnas.90.19.8967","volume":"90","author":"R Chen","year":"1993","unstructured":"Chen R., Lewis K.A., Perrin M.H., Vale W.W. Expression cloning of a human corticotropin-releasing-factor receptor. Proc. Natl. Acad. Sci. USA 1993, 90: 8967\u20138971.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BF03345186_CR30","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/BF01552870","volume":"2","author":"NC Vamvakopoulos","year":"1994","unstructured":"Vamvakopoulos N.C., Sioutopoulou T.O. Human corticotropin-releasing hormone receptor gene (CRHR) is located on the long arm of chromosome 17 (17q12-qter). Chromosome Res. 1994, 2: 471\u2013473.","journal-title":"Chromosome Res."},{"key":"BF03345186_CR31","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1096\/fj.00-0850rev","volume":"15","author":"A Slominski","year":"2001","unstructured":"Slominski A., Wortsman J., Pisarchik A., et al. Cutaneous expression of corticotropin-releasing hormone (CRH), urocortin, and CRH receptors. FASEB J. 2001, 15: 1678\u20131693.","journal-title":"FASEB J."},{"key":"BF03345186_CR32","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1210\/endo-121-3-1133","volume":"121","author":"T Watanabe","year":"1987","unstructured":"Watanabe T., Orth D.N. Detailed kinetic analysis of adrenocorticotropin secretion by dispersed rat anterior pituitary cells in a microperfusion system: Effects of ovine corticotropin-releasing factor and arginine vasopressin. Endocrinology 1987, 121: 1133\u20131145.","journal-title":"Endocrinology"},{"key":"BF03345186_CR33","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1210\/edrv-9-1-135","volume":"9","author":"JR Lundblad","year":"1988","unstructured":"Lundblad J.R., Roberts J.L. Regulation of proopiomelanocortin gene expression in pituitary. Endocr. Rev. 1988, 9: 135\u2013158.","journal-title":"Endocr. Rev."},{"key":"BF03345186_CR34","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1210\/endo-116-4-1653","volume":"116","author":"PC Wynn","year":"1985","unstructured":"Wynn P.C., Harwood J.P., Catt K.J., Aguilera G. Regulation of corticotropin-releasing factor (CRF) receptors in the rat pituitary gland: Effect of adrenalectomy on CRF receptors and corticotropin responses. Endocrinology 1985, 116: 1653\u20131659.","journal-title":"Endocrinology"},{"key":"BF03345186_CR35","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1210\/endo.133.4.8404613","volume":"133","author":"RL Hauger","year":"1993","unstructured":"Hauger R.L., Aguilera G. Regulation of pituitary corticotropin releasing hormone (CRH) receptors by CRH: Interaction with vasopressin. Endocrinology 1993, 133: 1708\u20131714.","journal-title":"Endocrinology"},{"key":"BF03345186_CR36","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0092-8674(94)90332-8","volume":"76","author":"WE Paul","year":"1994","unstructured":"Paul W.E., Seder R.A. Lymphocyte responses and cytokines. Cell 1994, 76: 241\u2013251.","journal-title":"Cell"},{"key":"BF03345186_CR37","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.7326\/0003-4819-119-12-199312150-00007","volume":"119","author":"DT Boumpas","year":"1993","unstructured":"Boumpas D.T., Chrousos G.P., Wilder R.I., Cupps T.R., Balow J.E. Glococorticoid therapy for immune-mediated diseases: basic and clinical correlates. Ann. Intern. Med. 1993, 119: 1198\u20131208.","journal-title":"Ann. Intern. Med."},{"key":"BF03345186_CR38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.1999.tb07618.x","volume":"876","author":"IJ Elenkov","year":"1999","unstructured":"Elenkov I.J., Webster E.L., Torpy D.J., Chrousos G.P. Stress, corticotropin releasing hormone, glucocorticoids, and the immune\/inflammatory response: acute and chronic effects. Ann. NY Acad. Sci. 1999, 876: 1\u201313.","journal-title":"Ann. NY Acad. Sci."},{"key":"BF03345186_CR39","first-page":"934","volume":"79","author":"G Mastorakos","year":"1994","unstructured":"Mastorakos G., Weber J.S., Magiakou M.A., Gunn H., Chrousos G.P. Hypothalamic-pituitary-adrenal axis activation and stimulation of systemic vasopressin secretion by recombinant interleukin-6 in humans: potential implications for the syndrome of inappropriate vasopressin secretion. J. Clin. Endocrinol. Metab. 1994, 79: 934\u2013939.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03345186_CR40","first-page":"1690","volume":"77","author":"G Mastorakos","year":"1993","unstructured":"Mastorakos G., Chrousos G.P., Weber J.S. Recombinant interleukin-6 activates the hypothalamic-pituitary-adrenal axis in humans. J. Clin. Endocrinol. Metab. 1993, 77: 1690\u20131694.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03345186_CR41","unstructured":"Gionis D., Ilias I., Moustaki M., et al. Hypothalamic-pituitary-adrenal axis & interleukin-6 activity in children with head trauma and syndrome of inappropriate secretion of antidiuretic hormone. J. Pediatr. Endocr. Metab. (in press.)"},{"key":"BF03345186_CR42","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1210\/endo-57-5-599","volume":"57","author":"R Guillemin","year":"1995","unstructured":"Guillemin R., Rosenberg B. Humoral hypothalamic control of anterior pituitary: A study with combined tissue cultures. Endocrinology 1995, 57: 599\u2013607.","journal-title":"Endocrinology"},{"key":"BF03345186_CR43","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1210\/endo-126-2-759","volume":"126","author":"A Kavelaars","year":"1990","unstructured":"Kavelaars A., Berkenbosch F., Croiset G., Ballieux R.E., Heijnen C.J. Induction of beta-endorphin secretion by lymphocytes after subcutaneous administration of corticotropinreleasing hormone. Endocrinology 1990, 126: 759\u2013764.","journal-title":"Endocrinology"},{"key":"BF03345186_CR44","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1126\/science.1925600","volume":"254","author":"K Karalis","year":"1991","unstructured":"Karalis K., Sano H., Redwine J., Listwak S., Wilder R.L., Chrousos G.P. Autocrine or paracrine inflammatory actions of corticotropin-releasing hormone in vivo. Science 1991, 254: 421\u2013423.","journal-title":"Science"},{"key":"BF03345186_CR45","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1172\/JCI117193","volume":"93","author":"K Karalis","year":"1994","unstructured":"Karalis K., Mastorakos G., Chrousos G.P., Tolis G. Somatostatin analogues suppress the inflammatory reaction in vivo. J. Clin. Invest. 1994, 93: 2000\u20132006.","journal-title":"J. Clin. Invest."},{"key":"BF03345186_CR46","doi-asserted-by":"crossref","first-page":"4133","DOI":"10.1210\/endo.136.9.7544277","volume":"136","author":"K Karalis","year":"1995","unstructured":"Karalis K., Mastorakos G., Sano H., Wilder R.L., Chrousos G.P. Somatostatin may participate in the anti-inflammatory actions of glucocorticoids. Endocrinology 1995, 136: 4133\u20134138.","journal-title":"Endocrinology"},{"key":"BF03345186_CR47","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0196-9781(89)90096-X","volume":"10","author":"AE Calogero","year":"1989","unstructured":"Calogero A.E., Bernardini R., Margioris A.N, et al. Effects of serotonergic agonists ant antagonists on corticotropinreleasing hormone secretion by explanted rat hypothalami. Peptides 1989, 10: 189\u2013200.","journal-title":"Peptides"},{"key":"BF03345186_CR48","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1210\/jcem-58-5-919","volume":"58","author":"T Suda","year":"1984","unstructured":"Suda T., Tomori N., Tozawa F., et al. Immunoreactive corticotropin and corticotropin-releasing factor in human hypothalamus, adrenal, lung cancer and pheochromocytoma. J. Clin. Endocrinol. Metab. 1984, 58: 919\u2013924.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03345186_CR49","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1172\/JCI116150","volume":"90","author":"LJ Crofford","year":"1992","unstructured":"Crofford L.J., Sano H., Karalis K., et al. Local secretion of corticotropin-releasing hormone in the joints of Lewis rats with inflammatory arthritis. J. Clin. Invest. 1992, 90: 2555\u20132564.","journal-title":"J. Clin. Invest."},{"key":"BF03345186_CR50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4049\/jimmunol.151.3.1587","volume":"151","author":"LJ Crofford","year":"1993","unstructured":"Crofford L.J., Sano H., Karalis K., et al. Corticotropin-releasing hormone in synovial fluids and tissues of patients with rheumatoid arhtritis and osteoarthritis. J. Immunol. 1993, 151: 1\u201310.","journal-title":"J. Immunol."},{"key":"BF03345186_CR51","first-page":"933","volume":"33","author":"G Mastorakos","year":"1992","unstructured":"Mastorakos G., Silver P.B., Bouzas E.A., Caspi R.R., Chan C.C., Chrousos G.P. Immunoreactive corticotropin releasing hormone in experimental uveitis. Inv. Ophthalmol. Vis. Sci. 1992, 33: 933.","journal-title":"Inv. Ophthalmol. Vis. Sci."},{"key":"BF03345186_CR52","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1006\/exer.2001.0992","volume":"72","author":"V Poulaki","year":"2001","unstructured":"Poulaki V., Mitsiades N., Mastorakos G., Caspi R.R., Chrousos G.P., Bouzas E. Fas\/fas ligand-associated apoptosis in experimental autoimmune uveoretinitis in rodents: role of proinflammatory corticotropin-releasing hormone. Exp. Eye Res. 2001, 72: 623\u2013629.","journal-title":"Exp. Eye Res."},{"key":"BF03345186_CR53","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1159\/000123942","volume":"38","author":"G Scofitsch","year":"1984","unstructured":"Scofitsch G., Hamill G.S., Jacobowitz D.M. Capsaicin depletes corticotropin-releasing factor-like immunoreactive neurons in the rat spinal cord and medulla oblongata. Neuroendocrinology 1984, 38: 514\u2013517.","journal-title":"Neuroendocrinology"},{"key":"BF03345186_CR54","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0006-8993(83)91001-6","volume":"275","author":"I Merchenthaler","year":"1983","unstructured":"Merchenthaler I., Hynes M.A., Vigh S., Schally A.V., Petrusz P. Immunocytochemical localization of corticotropin releasing factor (CRF) in the rat spinal cord. Brain Res. 1983, 275: 373\u2013377.","journal-title":"Brain Res"},{"key":"BF03345186_CR55","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/319147a0","volume":"319","author":"R Udelsman","year":"1986","unstructured":"Udelsman R., Harwood J.P., Millan M.A., et al. Functional corticotropin releasing factor receptors in the primate peripheral sympathetic nervous system. Nature 1986, 319: 147\u2013150.","journal-title":"Nature"},{"key":"BF03345186_CR56","first-page":"4806","volume":"138","author":"L Ghizzoni","year":"1997","unstructured":"Ghizzoni L., Mastorakos G., Vottero A., et al. Corticotropinreleasing hormone (CRH) inhibits steroid biosynthesis by cultured human granulose-lutein cells in a CRH and interleukin-1 receptor-mediated fashion. J. Clin. Endocr. Metab. 1997, 138: 4806\u20134811.","journal-title":"J. Clin. Endocr. Metab."},{"key":"BF03345186_CR57","doi-asserted-by":"crossref","first-page":"10477","DOI":"10.1073\/pnas.93.19.10477","volume":"93","author":"DW Schulz","year":"1996","unstructured":"Schulz D.W., Mansbach R.S., Sprouse J., et al. CP-I54,526: A potent and selective nonpeptide antagonist of corticotropin releasing factor receptors. Proc. Natl. Acad. Sci. USA 1996, 93: 10477\u201310482.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BF03345186_CR58","doi-asserted-by":"crossref","first-page":"5747","DOI":"10.1210\/endo.137.12.8940412","volume":"137","author":"EL Webster","year":"1996","unstructured":"Webster E.L., Lewis D.B., Torpy D.J., Zachman E.K., Rice K.C., Chrousos G.P. In vivo characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: Suppression of pituitary ACTH release and peripheral inflammation. Endocrinology 1996, 137: 5747\u20135750.","journal-title":"Endocrinology"},{"key":"BF03345186_CR59","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/ni719","volume":"2","author":"A Makrigiannakis","year":"2001","unstructured":"Makrigiannakis A., Zoumakis E., Kalantaridou S., et al. Corticotropin-releasing hormone promotes blastocyst implantation and early maternal tolerance. Nature Immunology 2001, 2: 1018\u20131024.","journal-title":"Nature Immunology"},{"key":"BF03345186_CR60","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1677\/joe.0.1110469","volume":"111","author":"EM Wintour","year":"1986","unstructured":"Wintour E.M., Bell R.J., Carson R.S., et al. Effect of longterm infusion of CRF in the immature ovine fetus. J. Endocrinol. 1986, 111: 469\u2013475.","journal-title":"J. Endocrinol."},{"key":"BF03345186_CR61","doi-asserted-by":"crossref","first-page":"3357","DOI":"10.1210\/endo.139.7.6189","volume":"139","author":"EC Chan","year":"1998","unstructured":"Chan E.C., Falconer J., Madsen G., et al. A corticotropinreleasing hormone type I receptor antagonist delays parturition in sheep. Endocrinology 1998, 139: 3357\u20133360.","journal-title":"Endocrinology"},{"key":"BF03345186_CR62","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1210\/endo.139.4.5938","volume":"139","author":"SR Bornstein","year":"1998","unstructured":"Bornstein S.R., Webster E.L., Torpy D.J., et al. Chronic effects of a nonpeptide corticotropin-releasing hormone type I receptor antagonist on pituitary adrenal function, body weight, and metabolic regulation. Endocrinology 1998, 139: 1546\u20131555.","journal-title":"Endocrinology"},{"key":"BF03345186_CR63","first-page":"PL53","volume":"65","author":"ML Wong","year":"1999","unstructured":"Wong M.L., Webster E.L., Spokes H., et al. Chronic administration of the non-peptide CRH type 1 receptor antagonist antalarmin does not blunt hypothalamic-pituitaryadrenal axis responses to acute immobilization stress. Life Sci. 1999, 65, PL53\u201358.","journal-title":"Life Sci."},{"key":"BF03345186_CR64","doi-asserted-by":"crossref","first-page":"6079","DOI":"10.1073\/pnas.97.11.6079","volume":"97","author":"KE Habib","year":"2000","unstructured":"Habib K.E., Weld K.P., Rice K.C., et al. Oral administration of a corticotropin-releasing hormone receptor antagonist significantly attenuates behavioral, neuroendocrine, and autonomic responses to stress in primates. Proc. Natl Acad. Sci. USA 2000, 97: 6079\u20136084.","journal-title":"Proc. Natl Acad. Sci. USA"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03345186.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF03345186\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03345186","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T01:26:07Z","timestamp":1689125167000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF03345186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4]]},"references-count":64,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003,4]]}},"alternative-id":["BF03345186"],"URL":"https:\/\/doi.org\/10.1007\/bf03345186","relation":{},"ISSN":["0391-4097","1720-8386"],"issn-type":[{"value":"0391-4097","type":"print"},{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,4]]}}}