{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T16:25:00Z","timestamp":1780503900255,"version":"3.54.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"published-print":{"date-parts":[[2009,1]]},"DOI":"10.1007\/bf03345676","type":"journal-article","created":{"date-parts":[[2014,4,10]],"date-time":"2014-04-10T18:55:48Z","timestamp":1397156148000},"page":"37-40","source":"Crossref","is-referenced-by-count":15,"title":["A comparison between finasteride, flutamide, and finasteride plus flutamide combination in the treatment of hirsutism"],"prefix":"10.1007","volume":"32","author":[{"given":"K.","family":"Unluhizarci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Ozel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Tanriverdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Karaca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Kelestimur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,3,22]]},"reference":[{"key":"BF03345676_CR1","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/S0029-7844(02)02725-4","volume":"101","author":"R Azziz","year":"2003","unstructured":"Azziz R. The evaluation and management of hirsutism. Obstet Gynecol 2003, 101: 995\u20131007.","journal-title":"Obstet Gynecol"},{"key":"BF03345676_CR2","first-page":"429","volume":"1","author":"K Unluhizarci","year":"2005","unstructured":"Unluhizarci K, Sahin Y, Kelestimur F. The evaluation and treatment of hirsute women. Women\u2019s Health 2005, 1: 429\u201335.","journal-title":"Women\u2019s Health"},{"key":"BF03345676_CR3","first-page":"810","volume":"78","author":"R Azziz","year":"1994","unstructured":"Azziz R, Dewailly D, Owerbach D. Nonclassic adrenal hyperplasia: current concepts. J Clin Endocrinol Metab 1994, 78: 810\u20135.","journal-title":"J Clin Endocrinol Metab"},{"key":"BF03345676_CR4","first-page":"347","volume":"21","author":"R Azziz","year":"2000","unstructured":"Azziz R, Carmina E, Sawaya ME. Idiopathic hirsutism. Endocr Rev 2000, 21: 347\u201362.","journal-title":"Endocr Rev"},{"key":"BF03345676_CR5","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1055\/s-2004-821307","volume":"112","author":"K Unluhizarci","year":"2004","unstructured":"Unluhizarci K, Gokce C, Atmaca H, Bayram F, Kelestimur F. A detailed investigation of hirsutism in a Turkish population: Idiopathic hyperandrogenemia as a perplexing issue. Exp Clin Endocrinol Diabetes 2004, 112: 504\u20139.","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"BF03345676_CR6","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1093\/humrep\/dei004","volume":"20","author":"L Ib\u00e1\u00f1ez","year":"2005","unstructured":"Ib\u00e1\u00f1ez L, Jaramillo A, Ferrer A, de Zegher F. Absence of hepatotoxicity after long term, low-dose flutamide in hyperandrogenic girls and young women. Hum Reprod 2005, 20: 1833\u20136.","journal-title":"Hum Reprod"},{"key":"BF03345676_CR7","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0015-0282(98)00486-5","volume":"71","author":"F Fruzzetti","year":"1999","unstructured":"Fruzzetti F, Bersi C, Parrini D, Ricci C, Genazzani AR. Treatment of hirsutism: comparisons between different antiandrogenswith central and peripheral effects. Fertil Steril 1999, 71: 445\u201351.","journal-title":"Fertil Steril"},{"key":"BF03345676_CR8","first-page":"89","volume":"85","author":"P Moghetti","year":"2000","unstructured":"Moghetti P, Tosi F, Tosti A, et al. Comparison of spironolactone, flutamide, and finasteride efficacy in the treatment of hirsutism: a randomized, double blind, placebo-controlled trial. J Clin Endocrinol Metab 2000, 85: 89\u201394.","journal-title":"J Clin Endocrinol Metab"},{"key":"BF03345676_CR9","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/S0015-0282(02)04927-0","volume":"79","author":"F Lumachi","year":"2003","unstructured":"Lumachi F, Rondinone R. Use of cyproterone acetate, finasteride, and spironolactone to treat idiopathic hirsutism. Fertil Steril 2003, 79: 942\u20136.","journal-title":"Fertil Steril"},{"key":"BF03345676_CR10","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/S1472-6483(10)61100-5","volume":"8","author":"Y Sahin","year":"2004","unstructured":"Sahin Y, Kelestimur F. Medical treatment regimens of hirsutism. Reprod BioMed Online 2004, 8: 538\u201346.","journal-title":"Reprod BioMed Online"},{"key":"BF03345676_CR11","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1530\/eje.0.1500351","volume":"150","author":"F Kelestimur","year":"2004","unstructured":"Kelestimur F, Everest H, Unluhizarci K, Bayram F, Sahin Y. A comparison between spironolactone plus finasteride and spironolactone in the treatment of hirsutism. Eur J Endocrinol 2004, 150: 351\u20134.","journal-title":"Eur J Endocrinol"},{"key":"BF03345676_CR12","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/S0015-0282(99)00383-0","volume":"72","author":"R Azziz","year":"1999","unstructured":"Azziz R, Hincapie LA, Knochenhauer ES, Dewailly D, Fox L, Boots LR. Screening for 21-hydroxylase-deficient nonclassic adrenal hyperplasia among hyperandrogenic women: a prospective study. Fertil Steril 1999, 72: 915\u201325.","journal-title":"Fertil Steril"},{"key":"BF03345676_CR13","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/0002-9378(81)90746-8","volume":"140","author":"R Hatch","year":"1981","unstructured":"Hatch R, Rosenfield RL, Kim MH, Tredway D. Hirsutism: implications, etiology, and management. Am J Obtet Gynecol 1981, 140: 815\u201330.","journal-title":"Am J Obtet Gynecol"},{"key":"BF03345676_CR14","first-page":"19","volume":"81","author":"Rotterdam ESHRE\/ASRM-Sponsored PCOS Consensus Workshop Group.","year":"2004","unstructured":"Rotterdam ESHRE\/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long term health risks related to polycystic ovary syndrome. Fertil Steril 2004, 81: 19\u201325.","journal-title":"Fertil Steril"},{"key":"BF03345676_CR15","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S0015-0282(98)00414-2","volume":"71","author":"F Pazos","year":"1999","unstructured":"Pazos F, Escobar-Morreale HF, Balsa J, Sancho JM, Varela C. Prospective randomized study comparing the long-acting gonadotropin-releasing hormone agonist triptorelin, flutamide, and cyproterone acetate, used in combination with an oral contaceptive, in the treatment of hirsutism. Fertil Steril 1999, 71: 122\u20138.","journal-title":"Fertil Steril"},{"key":"BF03345676_CR16","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S0015-0282(97)00427-5","volume":"69","author":"F Kelestimur","year":"1998","unstructured":"Kelestimur F, Sahin Y. Comparison of Diane 35 and Diane 35 plus spironolactone in the treatment of hirsutism. Fertil Steril 1998, 69: 66\u20139.","journal-title":"Fertil Steril"},{"key":"BF03345676_CR17","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/S0015-0282(00)01764-7","volume":"75","author":"Y Sahin","year":"2001","unstructured":"Sahin Y, Dilber S, Kelestimur F. Comparison of Diane 35 and Diane 35 plus finasteride in the treatment of hirsutism. Fertil Steril 2001, 75: 496\u2013500.","journal-title":"Fertil Steril"},{"key":"BF03345676_CR18","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1055\/s-0029-1212097","volume":"107","author":"F Bayram","year":"1999","unstructured":"Bayram F, M\u00fcderris II, Sahin Y, Kelestimur F. Finasteride treatment for one year in 35 hirsute patients. Exp Clin Endocrinol Diabetes 1999, 107: 195\u20137.","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"BF03345676_CR19","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1080\/09513590312331290328","volume":"17","author":"F Bayram","year":"2003","unstructured":"Bayram F, M\u00fcderris I, G\u00fcven M, Oz\u00e7elik B, Kele\u015ftimur F. Low dose (2.5 mg\/day) finasteride treatment in hirsutism. Gynecol Endocrinol 2003, 17: 419\u201322.","journal-title":"Gynecol Endocrinol"},{"key":"BF03345676_CR20","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S0015-0282(16)56634-5","volume":"61","author":"M Erenus","year":"1994","unstructured":"Erenus M, G\u00fcrb\u00fcz O, Durmu\u015fo\u011flu F, Demir\u00e7ay Z, Pekin S. Comparison of the efficacy of spironolactone versus flutamide in the treatment of hirsutism. Fertil Steril 1994, 61: 613\u20136.","journal-title":"Fertil Steril"},{"key":"BF03345676_CR21","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1530\/eje.0.1410361","volume":"141","author":"L Falsetti","year":"1999","unstructured":"Falsetti L, Gambera A. Comparison of finaseride versus flutamide in the treatment of hirsutism. Eur J Endocrinol 1999, 141: 361\u20137.","journal-title":"Eur J Endocrinol"},{"key":"BF03345676_CR22","first-page":"3251","volume":"85","author":"L Ib\u00e1\u00f1ez","year":"2000","unstructured":"Ib\u00e1\u00f1ez L, Potau N, Marcos MV, de Zegher F. Treatment of hirsutism, hyperandrogenism, oligomenorrhea, dyslipidemia, and hyperinsulinism in non-obese, adolescent girls: effect of flutamide. J Clin Endocrinol Metab 2000, 85: 3251\u20135.","journal-title":"J Clin Endocrinol Metab"},{"key":"BF03345676_CR23","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/S0015-0282(97)00266-5","volume":"68","author":"II M\u00fcderris","year":"1997","unstructured":"M\u00fcderris II, Bayram F, Sahin Y, Keletimur F. A comparison between two doses of flutamide (250 mg\/d and 500 mg\/d) in the treatment of hirsutism. Fertil Steril 1997, 68: 644\u20137.","journal-title":"Fertil Steril"},{"key":"BF03345676_CR24","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/BF03343536","volume":"22","author":"II M\u00fcderris","year":"1999","unstructured":"M\u00fcderris II, Bayram F. Clinical efficacy of lower dose flutamide 125 mg\/d in the treatment of hirsutism. J Endocrinol Invest 1999, 22: 165\u20138.","journal-title":"J Endocrinol Invest"},{"key":"BF03345676_CR25","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3109\/09513590009167658","volume":"14","author":"II M\u00fcderris","year":"2000","unstructured":"M\u00fcderris II, Bayram F, G\u00fcven M. Treatment of hirsutism with lowest-dose flutamide (62.5 mg\/day). Gynecol Endocrinol 2000, 14: 38\u201341.","journal-title":"Gynecol Endocrinol"},{"key":"BF03345676_CR26","first-page":"845","volume":"78","author":"E Carmina","year":"1991","unstructured":"Carmina E, Lobo RA. Peripheral andorgen blockade versus glandular androgen suppression in the treatment of hirsutism. Obstet Gynecol 1991, 78: 845\u20139.","journal-title":"Obstet Gynecol"},{"key":"BF03345676_CR27","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0303-7207(86)90132-2","volume":"44","author":"J Simard","year":"1986","unstructured":"Simard J, Luthy I, Guay J, B\u00e9langer A, Labrie F. Characteristics of interaction of the anti-androgen flutamide with androgen receptor in various target tissues. Mol Cell Endocrinol 1986, 44: 261\u201370.","journal-title":"Mol Cell Endocrinol"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03345676.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF03345676\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03345676","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T10:25:55Z","timestamp":1558520755000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF03345676"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["BF03345676"],"URL":"https:\/\/doi.org\/10.1007\/bf03345676","relation":{},"ISSN":["0391-4097","1720-8386"],"issn-type":[{"value":"0391-4097","type":"print"},{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1]]}}}