{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T19:44:50Z","timestamp":1771875890285,"version":"3.50.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"published-print":{"date-parts":[[2009,1]]},"DOI":"10.1007\/bf03345685","type":"journal-article","created":{"date-parts":[[2014,4,10]],"date-time":"2014-04-10T14:55:48Z","timestamp":1397141748000},"page":"83-84","source":"Crossref","is-referenced-by-count":10,"title":["Low-dose flutamide for women with androgen excess: Anti-androgenic efficacy and hepatic safety"],"prefix":"10.1007","volume":"32","author":[{"given":"F.","family":"de Zegher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Ib\u00e1\u00f1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,3,22]]},"reference":[{"key":"BF03345685_CR1","first-page":"41","volume":"260","author":"F Labrie","year":"1988","unstructured":"Labrie F, Dupont A, Giguere M, et al. Combination therapy with flutamide and castration (orchiectomy or LHRH agonist): the minimal endocrine therapy in both untreated and previously treated patients with advanced prostate cancer. Prog Clin Biol Res 1988, 260: 41\u201362.","journal-title":"Prog Clin Biol Res"},{"key":"BF03345685_CR2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0022-5347(01)66596-0","volume":"155","author":"DK Wysowski","year":"1996","unstructured":"Wysowski DK, Fourcroy JL. Flutamide hepatotoxicity. J Urol 1996, 155: 209\u201312.","journal-title":"J Urol"},{"key":"BF03345685_CR3","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1093\/humrep\/dei004","volume":"20","author":"L Ib\u00e1\u00f1ez","year":"2005","unstructured":"Ib\u00e1\u00f1ez L, Jaramillo A, Ferrer A, de Zegher F. Absence of hepatotoxicity after long-term, low-dose flutamide in hyperandrogenic girls and young women. Hum Reprod 2005, 20: 1833\u20136.","journal-title":"Hum Reprod"},{"key":"BF03345685_CR4","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1056\/NEJMcp033496","volume":"353","author":"RL Rosenfield","year":"2005","unstructured":"Rosenfield RL. Hirsutism. N Engl J Med 2005, 353: 2578\u201388.","journal-title":"N Engl J Med"},{"key":"BF03345685_CR5","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1210\/jc.2007-2437","volume":"93","author":"KA Martin","year":"2008","unstructured":"Martin KA, Chang RJ, Ehrmann DA, et al. Evaluation and treatment of hirsutism in premenopausal women: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 2008, 93: 1105\u201320.","journal-title":"J Clin Endocrinol Metab"},{"key":"BF03345685_CR6","doi-asserted-by":"crossref","first-page":"3446","DOI":"10.1210\/jc.2006-2798","volume":"92","author":"J Calaf","year":"2007","unstructured":"Calaf J, L\u00f3pez E, Millet A, et al; the Spanish Working Group for Hirsutism. Long-term efficacy and tolerability of flutamide combined with oral contraception in moderate to severe hirsutism. A 12-month, double-blind, parallel clinical trial. J Clin Endocrinol Metab 2007, 92: 3446\u201352.","journal-title":"J Clin Endocrinol Metab"},{"key":"BF03345685_CR7","doi-asserted-by":"crossref","first-page":"4716","DOI":"10.1210\/jc.2004-0047","volume":"89","author":"L Ib\u00e1\u00f1ez","year":"2004","unstructured":"Ib\u00e1\u00f1ez L, Valls C, Cabr\u00e9 S, de Zegher F. Flutamide-metformin plus ethinylestradiol-drospirenone for lipolysis and anti-atherogenesis in young women with ovarian hyperandrogenism: the key role of early, low-dose flutamide. J Clin Endocrinol Metab 2004, 89: 4716\u201320.","journal-title":"J Clin Endocrinol Metab"},{"key":"BF03345685_CR8","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/S0140-6736(06)68498-5","volume":"367","author":"A Osculati","year":"2006","unstructured":"Osculati A, Castiglioni C. Fatal liver complications with flutamide. Lancet 2006, 367: 1140\u20131.","journal-title":"Lancet"},{"key":"BF03345685_CR9","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0015-0282(16)57785-1","volume":"64","author":"P Moghetti","year":"1995","unstructured":"Moghetti P, Castello R, Negri C, et al. Flutamide in the treatment of hirsutism: long-term clinical effects, endocrine changes, and androgen receptor behavior. Fertil Steril 1995, 64: 511\u20137.","journal-title":"Fertil Steril"},{"key":"BF03345685_CR10","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/S0015-0282(97)00266-5","volume":"68","author":"II Muderris","year":"1997","unstructured":"Muderris II, Bayram F, Sahin Y, Kelestimur F. A comparison between two doses of flutamide (250 mg\/d and 500 mg\/d) in the treatment of hirsutism. Fertil Steril 1997, 68: 644\u20137.","journal-title":"Fertil Steril"},{"key":"BF03345685_CR11","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1530\/eje.0.1410361","volume":"141","author":"L Falsetti","year":"1999","unstructured":"Falsetti L, Gambera A, Legrenzi L, Iacobello C, Bugari G. Comparison of finasteride versus flutamide in the treatment of hirsutism. Eur J Endocrinol 1999, 141: 361\u20137.","journal-title":"Eur J Endocrinol"},{"key":"BF03345685_CR12","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3109\/09513590009167658","volume":"14","author":"II Muderris","year":"2000","unstructured":"Muderris II, Bayram F, Guven M. Treatment of hirsutism with lowest-dose flutamide (62.5 mg\/day). Gynecol Endocrinol 2000, 14: 38\u201341.","journal-title":"Gynecol Endocrinol"},{"key":"BF03345685_CR13","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1159\/000048086","volume":"56","author":"S Venturoli","year":"2001","unstructured":"Venturoli S, Paradisi R, Bagnoli A, et al. Low-dose flutamide (125 mg\/day) as maintenance therapy in the treatment of hirsutism. Horm Res 2001, 56: 25\u201331.","journal-title":"Horm Res"},{"key":"BF03345685_CR14","doi-asserted-by":"crossref","first-page":"3970","DOI":"10.1210\/jc.2005-2250","volume":"91","author":"A Gambineri","year":"2006","unstructured":"Gambineri A, Patton L, Vaccina A, et al. Treatment with flutamide, metformin, and their combination added to a hypocaloric diet in overweight-obese women with polycystic ovary syndrome: a randomized, 12-month, placebo-controlled study. J Clin Endocrinol Metab 2006, 91: 3970\u201380.","journal-title":"J Clin Endocrinol Metab"},{"key":"BF03345685_CR15","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1111\/j.1365-2265.2007.02952.x","volume":"67","author":"K Ong","year":"2007","unstructured":"Ong K, de Zegher F, Valls C, Dunger DB, Ib\u00e1\u00f1ez L. Persisting benefits 12\u201318 months beyond discontinuation of pubertal metformin therapy in low-birthweight girls. Clin Endocrinol 2007, 67: 468\u201371.","journal-title":"Clin Endocrinol"},{"key":"BF03345685_CR16","doi-asserted-by":"crossref","unstructured":"Castelo-Branco C, Moyano D, G\u00f3mez O, Balasch J. Long-term safety and tolerability of flutamide forthe treatment of hirsutism. Fertil Steril 2008, Mar 11 [Epub ahead of print]; doi: 10.1016\/j.fertnstert.2008.01.046.","DOI":"10.1016\/j.fertnstert.2008.01.046"},{"key":"BF03345685_CR17","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1365-2265.2007.03137.x","volume":"68","author":"L Ib\u00e1\u00f1ez","year":"2008","unstructured":"Ib\u00e1\u00f1ez L, L\u00f3pez-Bermejo A, Diaz M, Enr\u00edquez G, Valls C, de Zegher F. Pioglitazone (7.5 mg\/d) added to flutamide-metformin in women with androgen excess: additional increments of visfatin and high-molecular-weight adiponectin. Clin Endocrinol 2008, 68: 317\u201320.","journal-title":"Clin Endocrinol"},{"key":"BF03345685_CR18","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s00404-008-0719-z","volume":"279","author":"E Dikensoy","year":"2009","unstructured":"Dikensoy E, Balat O, Pence S, Akcali C, Cicek H. The risk of hepatotoxicity during long-term and low-dose flutamide treatment in hirsutism. Arch Gynecol Obstet 2009, 279: 321\u20137.","journal-title":"Arch Gynecol Obstet"},{"key":"BF03345685_CR19","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1093\/humupd\/dmi054","volume":"12","author":"L Ib\u00e1\u00f1ez","year":"2006","unstructured":"Ib\u00e1\u00f1ez L, de Zegher F. Low-dose flutamide-metformin therapy for hyperinsulinemic hyperandrogenism in non-obese adolescents and women. Hum Reprod Update 2006, 12: 243\u201352.","journal-title":"Hum Reprod Update"},{"key":"BF03345685_CR20","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1210\/jc.2006-2684","volume":"92","author":"L Ib\u00e1\u00f1ez","year":"2007","unstructured":"Ib\u00e1\u00f1ez L, L\u00f3pez-Bermejo A, del Rio L, Enr\u00edquez G, Valls C, de Zegher F. Combined low-dose pioglitazone, flutamide, and metformin for women with androgen excess. J Clin Endocrinol Metab 2007, 92: 1710\u20134.","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03345685.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF03345685\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03345685","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T06:25:55Z","timestamp":1558506355000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF03345685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["BF03345685"],"URL":"https:\/\/doi.org\/10.1007\/bf03345685","relation":{},"ISSN":["0391-4097","1720-8386"],"issn-type":[{"value":"0391-4097","type":"print"},{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1]]}}}