{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:17:27Z","timestamp":1791281847016,"version":"4.1.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2010,6,11]],"date-time":"2010-06-11T00:00:00Z","timestamp":1276214400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1007\/bf03347039","type":"journal-article","created":{"date-parts":[[2014,4,10]],"date-time":"2014-04-10T18:50:59Z","timestamp":1397155859000},"page":"106-110","source":"Crossref","is-referenced-by-count":16,"title":["The effects of native and synthetic estrogenic compounds as well as vitamin D less-calcemic analogs on adipocytes content in rat bone marrow"],"prefix":"10.1007","volume":"34","author":[{"given":"D.","family":"Somjen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Katzburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Kohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Gayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. H.","family":"Posner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Yoles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Livne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,6,11]]},"reference":[{"key":"BF03347039_CR1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/8756-3282(87)90015-9","volume":"8","author":"R Burkhardt","year":"1987","unstructured":"Burkhardt R, Kettner G, Bohm W, et al. Changes in trabecular bone, hematopoiesis and bone marrow vessels in aplastic anemia, primary osteoporosis, and old age: a comparative histomorphometric study. Bone 1987, 8: 157\u201364.","journal-title":"Bone"},{"key":"BF03347039_CR2","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/00003086-197110000-00021","volume":"80","author":"P Meunier","year":"1971","unstructured":"Meunier P, Aaron J, Edouard C, Vignon G. Osteoporosis and the replacement of cell populations of the marrow by adipose tissue. A quantitative study of 84 iliac bone biopsies. Clin Orthop Relat Res 1971, 80: 147\u201354.","journal-title":"Clin Orthop Relat Res"},{"key":"BF03347039_CR3","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/BF02556007","volume":"45","author":"TJ Wronski","year":"1989","unstructured":"Wronski TJ, Dann LM, Scott KS, Cintr\u00f3n M. Long-term effects of ovariectomy and aging on the rat skeleton. Calcif Tissue Int 1989, 45: 360\u20136.","journal-title":"Calcif Tissue Int"},{"key":"BF03347039_CR4","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1210\/en.2006-1704","volume":"148","author":"V David","year":"2007","unstructured":"David V, Martin A, Lafage-Proust MH, et al. Mechanical loading down-regulates peroxisome proliferator-activated receptor gamma in bone marrow stromal cells and favors osteoblastogenesis at the expense of adipogenesis. Endocrinology 2007, 148: 2553\u201362.","journal-title":"Endocrinology"},{"key":"BF03347039_CR5","first-page":"34","volume":"17","author":"C Rozman","year":"1989","unstructured":"Rozman C, Feliu E, Berga L, Reverter JC, Climent C, Ferr\u00e1n MJ. Age-related variations of fat tissue fraction in normal human bone marrow depend both on size and number of adipocytes: a stereo-logical study. Exp Hematol 1989, 17: 34\u20137.","journal-title":"Exp Hematol"},{"key":"BF03347039_CR6","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1677\/joe.0.1730387","volume":"173","author":"JE Compston","year":"2002","unstructured":"Compston JE. Bone marrow and bone: a functional unit. J Endocrinol 2002, 173: 387\u201394.","journal-title":"J Endocrinol"},{"key":"BF03347039_CR7","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/8756-3282(91)90011-7","volume":"12","author":"RB Martin","year":"1991","unstructured":"Martin RB, Zissimos SL Relationships between marrow fat and bone turnover in ovariectomized and intact rats. Bone 1991, 12: 123\u201331.","journal-title":"Bone"},{"key":"BF03347039_CR8","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev.cellbio.16.1.145","volume":"16","author":"ED Rosen","year":"2000","unstructured":"Rosen ED, Spiegelman BM. Molecular regulation of adipogenesis. Annu Rev Cell Dev Biol 2000, 16: 145\u201371.","journal-title":"Annu Rev Cell Dev Biol"},{"key":"BF03347039_CR9","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1159\/000048929","volume":"48","author":"GK Chan","year":"2002","unstructured":"Chan GK, Duque G. Age-related bone loss: old bone, new facts. Gerontology 2002, 48: 62\u201371.","journal-title":"Gerontology"},{"key":"BF03347039_CR10","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1210\/endo.139.6.6087","volume":"139","author":"R Pacifici","year":"1998","unstructured":"Pacifici R. Cytokines, estrogen and postmenopausal osteoporosis\u2014the second decade. Endocrinology 1998, 139: 2659\u201361.","journal-title":"Endocrinology"},{"key":"BF03347039_CR11","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1359\/jbmr.1998.13.5.763","volume":"13","author":"BL Riggs","year":"1998","unstructured":"Riggs BL, Khosla S, Melton III LJ. A unitary model for involutional osteoporosis: Estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men. J Bone Miner Res 1998, 13: 763\u201373.","journal-title":"J Bone Miner Res"},{"key":"BF03347039_CR12","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1210\/edrv.23.3.0465","volume":"23","author":"BL Riggs","year":"2002","unstructured":"Riggs BL, Khosla S, Melton LJ 3rd. Sex steroids and the construction and conservation of the adult skeleton. Endocr Rev 2002, 23: 279\u2013302.","journal-title":"Endocr Rev"},{"key":"BF03347039_CR13","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0960-0760(03)00252-8","volume":"86","author":"D Somjen","year":"2003","unstructured":"Somjen D, Yoles I. DT56a (Tofupill\/Femarelle) selectively stimulates creatine kinase specific activity in skeletal tissues of rats but not in the uterus. J Steroid Biochem Mol Biol 2003, 86: 93\u20138.","journal-title":"J Steroid Biochem Mol Biol"},{"key":"BF03347039_CR14","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1111\/j.1471-0528.2005.00573.x","volume":"112","author":"D Somjen","year":"2005","unstructured":"Somjen D, Katzburg S, Livne E, Yoles I. DT56a (Femarelle) stimulates bone formation in female rats. BJOG 2005, 112: 981\u20135.","journal-title":"BJOG"},{"key":"BF03347039_CR15","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1002\/jcb.21143","volume":"100","author":"D Somjen","year":"2007","unstructured":"Somjen D, Katzburg S, Posner GH, Livne E, Kaye AM. Systemic treatments with the low-calcemic 1,25(OH)(2)D(3) analogs JKF or QW increaseboth the morphological and biochemical responses to estradiol-17\u03b2in rat tibiae. J Cell Biochem 2007, 100: 1406\u201314.","journal-title":"J Cell Biochem"},{"key":"BF03347039_CR16","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1002\/jcb.21565","volume":"103","author":"D Somjen","year":"2007","unstructured":"Somjen D, Katzburg S, Kohen F, Gayer B, Livne E. Daidzein unlike other isolated isoflavones, preserves bone architecture in ovariectomized female rats in vivo. J Cell Biochem 2007,103: 1826\u201332.","journal-title":"J Cell Biochem"},{"key":"BF03347039_CR17","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1096\/fasebj.10.8.8666168","volume":"10","author":"M Sato","year":"1996","unstructured":"Sato M, Rippy MK, Bryant HU. Raloxifene, tamoxifen, nafoxidine or estrogen effects on reproductive and nonreproductive tissues in ovariectomized rats. FASEB J 1996, 10: 905\u201312.","journal-title":"FASEB J"},{"key":"BF03347039_CR18","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1359\/jbmr.2000.15.1.138","volume":"15","author":"JC Sharp","year":"2000","unstructured":"Sharp JC, Copps JC, Liu Q, et al. Analysis of ovariectomy and estrogen effects on body composition in rats by X-ray and magnetic resonance imaging techniques. J Bone Miner Res 2000, 15: 138\u201346.","journal-title":"J Bone Miner Res"},{"key":"BF03347039_CR19","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/1097-4644(20001201)79:3<407::AID-JCB60>3.0.CO;2-8","volume":"79","author":"D Benayahu","year":"2000","unstructured":"Benayahu D, Shur I, Ben-Eliyahu S. Hormonal changes affect the boneand bone marrow cells in a rat model. J Cell Biochem 79, 2000: 407\u201315.","journal-title":"J Cell Biochem"},{"key":"BF03347039_CR20","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1615\/CritRevEukarGeneExpr.v17.i2.30","volume":"17","author":"D Somjen","year":"2007","unstructured":"Somjen D. Vitamin D modulation of the activity of estrogenic compounds in bone cells in vitro and in vivo. Crit Rev Eukaryot Gene Expr 2007, 17: 115\u201347.","journal-title":"Crit Rev Eukaryot Gene Expr"},{"key":"BF03347039_CR21","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1359\/jbmr.1997.12.11.1772","volume":"12","author":"O Kajkenova","year":"1997","unstructured":"Kajkenova O, Lecka-Czernik B, Gubrij I, et al. Increased adipogenesis and myelopoiesis in the bone marrow of SAMP6, a murine model of defective osteoblastogenesis and low turnover osteopenia. J Bone Miner Res 1997, 12: 1772\u20139.","journal-title":"J Bone Miner Res"},{"key":"BF03347039_CR22","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1148\/radiology.175.1.2315484","volume":"175","author":"SG Moore","year":"1990","unstructured":"Moore SG, Dawson KL Red and yellow marrow in the femur: age-related changes in appearance at MR imaging. Radiology 1990, 175: 219\u201323.","journal-title":"Radiology"},{"key":"BF03347039_CR23","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1474-9728.2004.00127.x","volume":"3","author":"EJ Moerman","year":"2004","unstructured":"Moerman EJ, Teng K, Lipschitz DA, Lecka-Czernik B. Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma\/stem cells: the role of PPAR-gamma2 transcription factor and TGF-beta\/BMP signaling pathways. Aging Cell 2004, 3: 379\u201389.","journal-title":"Aging Cell"},{"key":"BF03347039_CR24","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1002\/(SICI)1097-4644(19980915)70:4<478::AID-JCB5>3.0.CO;2-G","volume":"70","author":"D Gazit","year":"1998","unstructured":"Gazit D, Zilberman Y, Ebner R, Kahn A. Bone loss (osteopenia) in old male mice results from diminished activity and availability of TGF-\u03b2. J Cell Biochem 1998, 70: 478\u201388.","journal-title":"J Cell Biochem"},{"key":"BF03347039_CR25","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1210\/endo.143.6.8834","volume":"143","author":"B Lecka-Czernik","year":"2002","unstructured":"Lecka-Czernik B, Moerman EJ, Grant DF, Lehmann JM, Manolagas SC, Jilka RL. Divergent effects of selective peroxisome proliferator-activated receptor-gamma 2 ligands on adipocyte versus osteoblast differentiation. Endocrinology 2002, 143: 2376\u201384.","journal-title":"Endocrinology"},{"key":"BF03347039_CR26","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S8756-3282(96)00258-X","volume":"19","author":"JM Gimble","year":"1996","unstructured":"Gimble JM, Robinson CE, Wu X, Kelly KA. The function of adipocytes in the bone marrow stroma: an update. Bone 1996, 19: 421\u20138.","journal-title":"Bone"},{"key":"BF03347039_CR27","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0531-5565(02)00014-1","volume":"37","author":"JL Kirkland","year":"2002","unstructured":"Kirkland JL, Tchkonia T, Pirtskhalava T, Han J, Karagiannides I. Adipogenesis and aging: does aging make fat go MAD? Exp Gerontol 2002, 37: 757\u201367.","journal-title":"Exp Gerontol"},{"key":"BF03347039_CR28","doi-asserted-by":"crossref","unstructured":"Elbaz A, Rivas D, Duque G. Effect of estrogens on bone marrow adipogenesis and Sirt1 in aging C57BL\/6J mice. Biogerontology 2009, March 31 [Epub ahead of print]; doi: 10.1007\/s10522-009-9221-7.","DOI":"10.1007\/s10522-009-9221-7"},{"key":"BF03347039_CR29","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1359\/jbmr.2002.17.3.394","volume":"17","author":"ZC Dang","year":"2002","unstructured":"Dang ZC, van Bezooijen RL, Karperien M, Papapoulos SE, L\u00f6wik CW. Exposure of KS483 cells to estrogen enhances osteogenesis and inhibits adipogenesis. J Bone Miner Res 2002, 17: 394\u2013405.","journal-title":"J Bone Miner Res"},{"key":"BF03347039_CR30","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/jcb.20087","volume":"92","author":"ZC Dang","year":"2004","unstructured":"Dang ZC, Lowik CW. Differential effects of PD98059 and U0126 on osteogenesis and adipogenesis. J Cell Biochem 2004, 92: 525\u201333.","journal-title":"J Cell Biochem"},{"key":"BF03347039_CR31","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1210\/en.2003-1014","volume":"145","author":"M Heim","year":"2004","unstructured":"Heim M, Frank O, Kampmann G, et al. The phytoestrogen genistein enhances osteogenesis and represses adipogenic differentiation of human primary bone marrow stromal cells. Endocrinology 2004, 145: 848\u201359.","journal-title":"Endocrinology"},{"key":"BF03347039_CR32","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jsbmb.2005.08.016","volume":"98","author":"D Somjen","year":"2006","unstructured":"Somjen D, Katzburg S, Kohen F, et al. Responsiveness to phytoestrogens in primary human osteoblasts is modulated differentially by a \u201cless-calcemic\u201d analog of 1,25 dihydroxyvitamin D(3): JK 1624F(2)-2 (JKF). J Steroid Biochem Mol Biol 2006, 98: 139\u201346.","journal-title":"J Steroid Biochem Mol Biol"},{"key":"BF03347039_CR33","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/s001980050065","volume":"8","author":"P Fanti","year":"1998","unstructured":"Fanti P, Monier-Faugere MC, Geng Z, et al. The phytoestrogen genistein reduces bone loss in short-term ovariectomized rats. Osteoporos Int 1998, 8: 274\u201381.","journal-title":"Osteoporos Int"},{"key":"BF03347039_CR34","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1210\/endo.140.4.6663","volume":"140","author":"Y Ishimi","year":"1999","unstructured":"Ishimi Y, Miyaura C, Ohmura M, et al. selective effects of genistein, a soybean isoflavone, on b-lymphopoiesis and bone loss caused by estrogen deficiency. Endocrinology 1999, 140: 1893\u2013900.","journal-title":"Endocrinology"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03347039.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF03347039\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03347039","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T07:55:01Z","timestamp":1565337301000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF03347039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,11]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["BF03347039"],"URL":"https:\/\/doi.org\/10.1007\/bf03347039","relation":{},"ISSN":["0391-4097","1720-8386"],"issn-type":[{"value":"0391-4097","type":"print"},{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,11]]}}}