{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:50:53Z","timestamp":1760100653132,"version":"3.40.4"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2010,10,4]],"date-time":"2010-10-04T00:00:00Z","timestamp":1286150400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"published-print":{"date-parts":[[2011,3]]},"DOI":"10.1007\/bf03347068","type":"journal-article","created":{"date-parts":[[2014,4,2]],"date-time":"2014-04-02T12:41:52Z","timestamp":1396442512000},"page":"206-215","source":"Crossref","is-referenced-by-count":2,"title":["Differential action of two prolactin isoforms on ischemia-and re-perfusion-induced arrhythmias in rats in vivo"],"prefix":"10.1007","volume":"34","author":[{"given":"T. F.","family":"Krzemi\u00f1ski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Mitr\u0119ga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Porc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"\u017borniak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Ryszka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Ostrowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Kos-Kud\u0142a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,10,4]]},"reference":[{"key":"BF03347068_CR1","first-page":"1523","volume":"80","author":"ME Freeman","year":"2000","unstructured":"Freeman ME, Kanyicska B, Lerant A, Nagy G. Prolactin: structure, function and regulation of secretion. Physiol Res 2000, 80: 1523\u2013631.","journal-title":"Physiol Res"},{"key":"BF03347068_CR2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1146\/annurev.physiol.64.081501.131049","volume":"64","author":"V Goffin","year":"2002","unstructured":"Goffin V, Binart N, Touraine P, Kelly PA. Prolactin: the new biology of an old hormone. Annu Rev Physiol 2002, 64: 47\u201367.","journal-title":"Annu Rev Physiol"},{"key":"BF03347068_CR3","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1161\/CIRCGENETICS.109.853572","volume":"2","author":"AQ Reuwer","year":"2009","unstructured":"Reuwer AQ, Twickler MT, Hutten BA, et al. Prolactin levels and risk of future coronary artery disease in apparently healthy men and women. Circ Cardiovasc Genet 2009, 2: 389\u201395.","journal-title":"Circ Cardiovasc Genet"},{"key":"BF03347068_CR4","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1210\/edrv-12-3-235","volume":"12","author":"PA Kelly","year":"1991","unstructured":"Kelly PA, Djiane J, Postel-Vinay MC, Edery M. The prolactin\/growth hormone receptor family. Endocrine Rev 1991, 12: 235\u201351.","journal-title":"Endocrine Rev"},{"key":"BF03347068_CR5","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1210\/edrv.19.3.0334","volume":"19","author":"C Bole-Feysot","year":"1998","unstructured":"Bole-Feysot C, Goffin V, Edery M, Binart N, Kelly PA. Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice. Endocr Rev 1998, 19: 225\u201368.","journal-title":"Endocr Rev"},{"key":"BF03347068_CR6","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.3168\/jds.S0022-0302(85)80972-3","volume":"68","author":"DE Bauman","year":"1985","unstructured":"Bauman DE, Eppard PJ, DeGeeter MJ, Lanza GM. Responses of high producing dairy cows to long treatment with pituitary somatotropin and recombinant somatotropin. J Dairy Sci 1985, 68: 1352\u201362.","journal-title":"J Dairy Sci"},{"key":"BF03347068_CR7","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1210\/en.2008-1023","volume":"150","author":"A Blume","year":"2009","unstructured":"Blume A, Torner L, Liu Y, Subburaju S, Aguilera G, Neumann ID. Prolactin activates mitogen-activated protein kinase signaling and corticotrophin realizing hormone transcription in rat hypothalamic neurons. Endocrinology 2009, 150: 1841\u20139.","journal-title":"Endocrinology"},{"key":"BF03347068_CR8","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1046\/j.1365-2826.2001.00725.x","volume":"13","author":"BE T\u00f2th","year":"2001","unstructured":"T\u00f2th BE, Homicsk\u00f2 K, Radnai B, et al. Salsolinol is a putative endogenous neuro-intermediate lobe prolactin-releasing factor. J Neuroendocrinol 2001, 13: 1042\u201350.","journal-title":"J Neuroendocrinol"},{"key":"BF03347068_CR9","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1111\/j.1365-2826.2009.01875.x","volume":"21","author":"T Yamada","year":"2009","unstructured":"Yamada T, Mochiduki A, Sugimoto Y, Itoi K, Inoue K. Prolactin-releasing peptide regulates the cardiovascular system via corticotrophin-releasing hormone. J Neuroendocrinol 2009, 21: 586\u201393.","journal-title":"J Neuroendocrinol"},{"key":"BF03347068_CR10","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/00004872-198704000-00010","volume":"5","author":"I Os","year":"1987","unstructured":"Os I, Kjeldsen SE, Westheim A, et al. Decreased central dopaminergic activity in essential hypertension. J Hypertens 1987, 5: 191\u20137.","journal-title":"J Hypertens"},{"key":"BF03347068_CR11","first-page":"22","volume":"31","author":"G Hudziak","year":"1988","unstructured":"Hudziak G, Kuska J. [Effect of bromocriptine on arterial blood pressure and serum prolactin level in patients with essential arterial hypertension]. Kardiol Pol 1988, 31: 22\u20139.","journal-title":"Kardiol Pol"},{"key":"BF03347068_CR12","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/S0140-6736(73)90997-5","volume":"302","author":"DF Horrobin","year":"1973","unstructured":"Horrobin DF, McNeilly AS, Jackson FS, et al. Prolactin and myocardial infarction. Lancet 1973, 302: 1261.","journal-title":"Lancet"},{"key":"BF03347068_CR13","first-page":"24","volume":"239","author":"DF Horrobin","year":"1974","unstructured":"Horrobin DF, Manku MS, Nassar BA, Reed JD, Tynan M. Actions of prolactin and frusemide on cardiac rate and rhythm. J Physiol 1974, 239: 24P-5P.","journal-title":"J Physiol"},{"key":"BF03347068_CR14","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1177\/000331979004100504","volume":"41","author":"I Saito","year":"1990","unstructured":"Saito I, Takeshita E, Hayashi S, et al. Effects of captopril on plasma prolactin in patients with essential hypertension. Angiology 1990, 41: 377\u201381.","journal-title":"Angiology"},{"key":"BF03347068_CR15","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1055\/s-2007-1001741","volume":"26","author":"IC Haznedaro\u011flu","year":"1994","unstructured":"Haznedaro\u011flu IC, Tokg\u00f6zo\u011flu L, Ca\u011flar M, et al. The effect of chronic angiotensin converting enzyme inhibition on circulating prolactin in systemic hypertension. Horm Metab Res 1994, 26: 491\u20133.","journal-title":"Horm Metab Res"},{"key":"BF03347068_CR16","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0140-6736(77)92832-X","volume":"2","author":"K Stumpe","year":"1977","unstructured":"Stumpe K, Higuchi M, Kolloch R, Kruck F. Hyperprolactinaemia and antihypertensive effect of bromocriptine in essential hypertension. Identification of abnormal central dopamine control. Lancet 1977, 2: 211\u20134.","journal-title":"Lancet"},{"key":"BF03347068_CR17","first-page":"1334","volume-title":"Goodman and Gilman\u2019s The pharmacological basis of therapeutics","author":"JA Kuret","year":"1990","unstructured":"Kuret JA, Murad F. Adenophyseal hormones and related substances. In: Gilman AG, Rall TW, Nies AS, Taylor P (ed) Goodman and Gilman\u2019s The pharmacological basis of therapeutics. Pergamon Press, New York 1990, 1334\u201361."},{"key":"BF03347068_CR18","doi-asserted-by":"crossref","first-page":"6502","DOI":"10.1016\/S0021-9258(18)43768-4","volume":"255","author":"NE Cooke","year":"1980","unstructured":"Cooke NE, Coit D, Weiner RI, Baxter JD, Martial JA. Structure of cloned DNA complementary to rat prolactin messenger rRNA. J Biol Chem 1980, 255: 6502\u201310.","journal-title":"J Biol Chem"},{"key":"BF03347068_CR19","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1177\/000331976001100505","volume":"11","author":"H Selye","year":"1960","unstructured":"Selye H, Bajusz E, Grasso S, Mendell P. Simple techniques for the surgical occlusion of coronary vessels in the rat. Angiology 1960, 11: 398\u2013407.","journal-title":"Angiology"},{"key":"BF03347068_CR20","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/0160-5402(80)90077-7","volume":"3","author":"C Clark","year":"1980","unstructured":"Clark C, Foreman MI, Kane KA, McDonald FM, Parratt JR. Coronary artery ligation in anesthetized rats as a method for the production of experimental dysrhythmias and for the determination of infarct size. J Pharmacol Meth 1980, 3: 357\u201368.","journal-title":"J Pharmacol Meth"},{"key":"BF03347068_CR21","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1097\/00005344-198611000-00023","volume":"8","author":"R Crome","year":"1986","unstructured":"Crome R, Hearse DJ, Manning AS. Ischemia- and reperfusion-induced arrhythmias: beneficial actions of nifedipine. J Cardiovasc Pharmacol 1986, 8: 1249\u201356.","journal-title":"J Cardiovasc Pharmacol"},{"key":"BF03347068_CR22","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ejphar.2006.08.002","volume":"549","author":"TF Krzemi ski","year":"2006","unstructured":"Krzemi ski TF, Grzyb J, Porc MP, Chatterjee SS. Anti-arrhythmic cardio-protective effects of furnidipine in rat model: A dose response study. Eur J Pharmacol 2006, 549: 91\u20137.","journal-title":"Eur J Pharmacol"},{"key":"BF03347068_CR23","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1093\/cvr\/22.7.447","volume":"22","author":"MJ Walker","year":"1988","unstructured":"Walker MJ, Curtis MJ, Hearse DJ, et al. The Lambeth Conventions: guidelines for the study of arrhythmias in ischaemia, infarction, and re-perfusion. Cardiovasc Res 1988, 22: 447\u201355.","journal-title":"Cardiovasc Res"},{"key":"BF03347068_CR24","first-page":"215","volume":"35","author":"F Ryszka","year":"1984","unstructured":"Ryszka F, Ludyga K, Strokowska M, Krupej, Gaus I, Zych F. Hypotensive action of prolactin in rats with spontaneous hypertension. Acta Physiol Pol 1984, 35: 215\u20137.","journal-title":"Acta Physiol Pol"},{"key":"BF03347068_CR25","volume-title":"The rat electrocardiogram in pharmacology and toxicology","author":"R Budden","year":"1981","unstructured":"Budden R, Detweiler DK, Zbinden G. The rat electrocardiogram in pharmacology and toxicology. Oxford: Pergamon Press, 1981."},{"key":"BF03347068_CR26","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/BF01907955","volume":"76","author":"D Baller","year":"1981","unstructured":"Baller D, Bretschneider HJ, Hellige G. A critical look at currently used indirect indices of myocardial oxygen consumption. Bas Res Cardiol 1981, 76: 163\u201370.","journal-title":"Bas Res Cardiol"},{"key":"BF03347068_CR27","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/S0140-6736(73)91089-1","volume":"302","author":"MS Manku","year":"1973","unstructured":"Manku MS, Nassar BA, Horrobin DF. Effects of prolactin on theresponses of rat aortic and arteriolar smooth-muscle preparations to noradrenaline and angiotensin. Lancet 1973, 302: 991\u20134.","journal-title":"Lancet"},{"key":"BF03347068_CR28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/acta.0.0900001","volume":"90","author":"JR Sowers","year":"1979","unstructured":"Sowers JR, Resch G, Tempel G, Herzog J, Colantino M. Hyperprolactinaemia in the spontaneously hypertensive rat. Acta Endocrinol 1979, 90: 1\u20137.","journal-title":"Acta Endocrinol"},{"key":"BF03347068_CR29","first-page":"19","volume":"29","author":"I Maciejewska","year":"1995","unstructured":"Maciejewska I, Wieczorek M, Ryszka F. Wp\u0142yw prolaktyny na zmiany czynno\u015bci i struktury serca po adrenalinie. Ann Acad Med Siles 1995, 29: 19\u201325.","journal-title":"Ann Acad Med Siles"},{"key":"BF03347068_CR30","first-page":"886","volume":"53","author":"F Ryszka","year":"1998","unstructured":"Ryszka F, Dol\u0144ska B, Suszka-\u015awitek A. The effect of multiple doses of \u201cBiolactin\u201d (prolactin) on the systolic blood pressure in rats with spontaneous arterial hypertension. Pharmazie 1998, 53: 886.","journal-title":"Pharmazie"},{"key":"BF03347068_CR31","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1161\/01.HYP.2.4.390","volume":"2","author":"R Kolloch","year":"1980","unstructured":"Kolloch R, Kobayashi K, DeQuattro V. Dopaminergic control of sympathetic tone and blood pressure: evidence in primary hypertension. Hypertension 1980, 2: 390\u20134.","journal-title":"Hypertension"},{"key":"BF03347068_CR32","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/S0022-3565(25)21708-6","volume":"228","author":"S Nagahama","year":"1984","unstructured":"Nagahama S, Chen YF, Oparil S. Mechanism of the depressor effect of bromocriptine in the spontaneously hypertensive rats. J Pharmacol Exp Ther 1984, 228: 370\u20135.","journal-title":"J Pharmacol Exp Ther"},{"key":"BF03347068_CR33","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1210\/endo-117-6-2483","volume":"117","author":"O Khorram","year":"1985","unstructured":"Khorram O, Bedran de Castro JC, McCann SM. Stress-induced secretion of alpha-melanocyte-stimulating hormone and its physiological role in modulating the secretion of prolactin and luteinizing hormone in the female rat. Endocrinology 1985, 117: 2483\u20139.","journal-title":"Endocrinology"},{"key":"BF03347068_CR34","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.1210\/endo.133.6.8243327","volume":"133","author":"JB Hill","year":"1993","unstructured":"Hill JB, Lacy ER, Nagy GM, G\u00f6rcs TJ, Frawley LS. Does alphamelanocyte-stimulating hormone from the pars intermedia regulate suckling-induced prolactin release? Supportive evidence from morphological and functional studies. Endocrinology 1993, 133: 2991\u20137.","journal-title":"Endocrinology"},{"key":"BF03347068_CR35","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1210\/endo-119-3-1071","volume":"119","author":"O Khorram","year":"1986","unstructured":"Khorram O, McCann SM. Interaction of alpha-melanocyte-stimulating hormone with beta-endorphin to influence anterior pituitary secretion in the female rat. Endocrinology 1986, 119: 1071\u20135.","journal-title":"Endocrinology"},{"key":"BF03347068_CR36","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1749-6632.1987.tb35763.x","volume":"496","author":"SM McCann","year":"1987","unstructured":"McCann SM, Ono N, Khorram O, Kentroti S, Aguila C. The role of brain peptides in neuroimmunomodulation. Ann N Y Acad Sci 1987, 496: 172\u20138.","journal-title":"Ann N Y Acad Sci"},{"key":"BF03347068_CR37","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0006-8993(86)91496-4","volume":"398","author":"O Khorram","year":"1986","unstructured":"Khorram O, Bedran de Castro JC, McCann SM. The influence of suckling on the hypothalamic and pituitary secretion of immunoreactive alpha-melanocyte-stimulating hormone. Brain Res 1986, 398: 361\u20135.","journal-title":"Brain Res"},{"key":"BF03347068_CR38","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0014-2999(03)01780-1","volume":"470","author":"M Vecsernyes","year":"2003","unstructured":"Vecsernyes M, Juhasz B, Der P, et al. The administration of alphamelanocyte-stimulating hormone protects the ischemic\/reperfused myocardium. Eur J Pharmacol 2003, 470: 177\u201383.","journal-title":"Eur J Pharmacol"},{"key":"BF03347068_CR39","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1089\/ars.2006.1535","volume":"9","author":"B Juhasz","year":"2007","unstructured":"Juhasz B, Der P, Szondoray P, Gesztelei R, Lekli I, Bak I, et al. Adrenocorticotrope hormone fragment(4\u201310) attenuates the ischemia\/reperfusion-induced cardiac injury in isolated rat hearts. Antioxid Redox Signal 2007, 9: 1851\u201361.","journal-title":"Antioxid Redox Signal"},{"key":"BF03347068_CR40","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1210\/endo-111-4-1045","volume":"111","author":"G Aguilera","year":"1982","unstructured":"Aguilera G, Hyde CL, Catt KJ. Angiotensin II receptors and prolactin release in pituitary lactotrophs. Endocrinology 1982, 111: 1045\u201350.","journal-title":"Endocrinology"},{"key":"BF03347068_CR41","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1210\/endo-118-1-233","volume":"118","author":"PL Canonico","year":"1986","unstructured":"Canonico PL, MacLeod RM. Angiotensin peptides stimulate phosphoinositide breakdown and prolactin release in anterior pituitary cells in culture. Endocrinology 1986, 118: 233\u20138.","journal-title":"Endocrinology"},{"issue":"Suppl1","key":"BF03347068_CR42","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1159\/000181923","volume":"35","author":"T Kubota","year":"1991","unstructured":"Kubota T, Aso T. Role of angiotensin on paracrine prolactin release in the pituitary gland and its possible effects on ovarian function. Horm Res 1991, 35(Suppl 1): 13\u201320.","journal-title":"Horm Res"},{"key":"BF03347068_CR43","doi-asserted-by":"crossref","first-page":"4071","DOI":"10.1016\/S0021-9258(17)35623-5","volume":"261","author":"A Enjalbert","year":"1986","unstructured":"Enjalbert A, Sladeczek F, Guillon G, et al. Angiotensin II and dopamine modulate both cAMP and inositol phosphate productions in anterior pituitary cells. Involvement in prolactin secretion. J Biol Chem 1986, 261: 4071\u20135.","journal-title":"J Biol Chem"},{"key":"BF03347068_CR44","doi-asserted-by":"crossref","first-page":"7812","DOI":"10.1073\/pnas.81.24.7812","volume":"81","author":"JB Smith","year":"1984","unstructured":"Smith JB, Smith L, Brown ER, et al. Angiotensin II rapidly increases phosphatidate-phosphoinositide synthesis and phosphoinositide hydrolysis and mobilizes intracellular calcium in cultured arterial muscle cells. Proc Natl Acad Sci USA 1984, 81: 7812\u20136.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF03347068_CR45","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1210\/jcem-63-1-231","volume":"63","author":"JP Saint-Andre","year":"1986","unstructured":"Saint-Andre JP, Rohmer V, Alhenc-Gelas F, Menard J, Bigorgne JC, Corvol P. Presence of renin, angiotensinogen, and converting enzyme in human pituitary lactotroph cells and prolactin adenomas. J Clin Endocrinol Metab 1986, 63: 231\u20137.","journal-title":"J Clin Endocrinol Metab"},{"key":"BF03347068_CR46","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1055\/s-2007-1011781","volume":"19","author":"AG Dupont","year":"1987","unstructured":"Dupont AG, Van Der Niepen P, Van Steirteghem AC, Vanhaelst L. Enhanced response of plasma prolactin to metoclopramide during chronic converting enzyme inhibition. Horm Metab Res 1987, 19: 212\u20135.","journal-title":"Horm Metab Res"},{"key":"BF03347068_CR47","first-page":"125","volume":"89","author":"A Wi\u0119cek","year":"1993","unstructured":"Wi\u0119cek A, Kokot F, \u017bukowska-Szczechowska E. The effect of long-term prazosin treatment on plasma follitropin (FSH), lutropin (LH), prolactin, estradiol and testosterone concentration in male patients with essential hypertension. Pol Arch Med Wewn 1993, 89: 125\u201335.","journal-title":"Pol Arch Med Wewn"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03347068.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF03347068\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03347068","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T07:08:19Z","timestamp":1746169699000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF03347068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,4]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["BF03347068"],"URL":"https:\/\/doi.org\/10.1007\/bf03347068","relation":{},"ISSN":["0391-4097","1720-8386"],"issn-type":[{"type":"print","value":"0391-4097"},{"type":"electronic","value":"1720-8386"}],"subject":[],"published":{"date-parts":[[2010,10,4]]}}}