{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T02:31:19Z","timestamp":1769049079798,"version":"3.49.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2010,6,4]],"date-time":"2010-06-04T00:00:00Z","timestamp":1275609600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1007\/bf03347083","type":"journal-article","created":{"date-parts":[[2014,4,10]],"date-time":"2014-04-10T22:42:46Z","timestamp":1397169766000},"page":"265-270","source":"Crossref","is-referenced-by-count":17,"title":["Is there an association between non-functioning adrenal adenoma and endothelial dysfunction?"],"prefix":"10.1007","volume":"34","author":[{"given":"S.","family":"Yener","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Baris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Secil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Akinci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Comlekci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Yesil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,6,4]]},"reference":[{"key":"BF03347083_CR1","first-page":"1440","volume":"85","author":"R Rossi","year":"2000","unstructured":"Rossi R, Tauchmanova L, Luciano A, et al. Subclinical Cushing\u2019s syndrome in patients with adrenal incidentaloma: clinical and biochemical features. J Clin Endocrinol Metab 2000, 85: 1440\u20138.","journal-title":"J Clin Endocrinol Metab"},{"key":"BF03347083_CR2","doi-asserted-by":"crossref","first-page":"4872","DOI":"10.1210\/jc.2001-011766","volume":"87","author":"L Tauchmanov\u00e0","year":"2002","unstructured":"Tauchmanov\u00e0 L, Rossi R, Biondi B, et al. Patients with subclinical Cushing\u2019s syndrome due to adrenal adenoma have increased cardiovascular risk. J Clin Endocrinol Metab 2002, 87: 4872\u20138.","journal-title":"J Clin Endocrinol Metab"},{"key":"BF03347083_CR3","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.ecl.2005.01.008","volume":"34","author":"M Terzolo","year":"2005","unstructured":"Terzolo M, Bovio S, Reimondo G, et al., Subclinical Cushing\u2019s syndrome in adrenal incidentalomas. Endocrinol Metab Clin North Am 2005, 34: 423\u201339, x.","journal-title":"Endocrinol Metab Clin North Am"},{"key":"BF03347083_CR4","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1210\/jcem.87.3.8277","volume":"87","author":"M Terzolo","year":"2002","unstructured":"Terzolo M, Pia A, Al\u00ec A, Osella G, et al. Adrenal incidentaloma: a new cause of the metabolic syndrome? J Clin Endocrinol Metab 2002, 87: 998\u20131003.","journal-title":"J Clin Endocrinol Metab"},{"key":"BF03347083_CR5","first-page":"637","volume":"85","author":"F Mantero","year":"2000","unstructured":"Mantero F, Terzolo M, Arnaldi G, et al. A survey on adrenal incidentaloma in Italy. Study Group on Adrenal Tumors of the Italian Society of Endocrinology. J Clin Endocrinol Metab 2000, 85: 637\u201344.","journal-title":"J Clin Endocrinol Metab"},{"key":"BF03347083_CR6","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.metabol.2006.12.018","volume":"56","author":"F Ermetici","year":"2007","unstructured":"Ermetici F, Malavazos AE, Corbetta S, et al. Adipokine levels and cardiovascular risk in patients with adrenal incidentaloma. Metabolism 2007, 56: 686\u201392.","journal-title":"Metabolism"},{"key":"BF03347083_CR7","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s12020-009-9160-8","volume":"35","author":"S Yener","year":"2009","unstructured":"Yener S, Genc S, Akinci B, et al. Carotid intima media thickness is increased and associated with morning cortisol in subjects with non-functioning adrenal incidentaloma. Endocrine 2009, 35: 365\u201370.","journal-title":"Endocrine"},{"key":"BF03347083_CR8","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1530\/eje.0.1380146","volume":"138","author":"A Sartorio","year":"1998","unstructured":"Sartorio A, Conti A, Ferrero S, et al. Evaluation of markers of bone and collagen turnover in patients with active and preclinical Cushing\u2019s syndrome and in patients with adrenal incidentaloma. Eur J Endocrinol 1998, 138: 146\u201352.","journal-title":"Eur J Endocrinol"},{"key":"BF03347083_CR9","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1530\/EJE-07-0455","volume":"157","author":"BR Walker","year":"2007","unstructured":"Walker BR. Glucocorticoids and cardiovascular disease. Eur J Endocrinol 2007, 157: 545\u201359.","journal-title":"Eur J Endocrinol"},{"key":"BF03347083_CR10","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1530\/eje.1.01959","volume":"153","author":"M Terzolo","year":"2005","unstructured":"Terzolo M, Bovio S, Pia A, et al. Midnight serum cortisol as a marker of increased cardiovascular risk in patients with a clinically inapparent adrenal adenoma. Eur J Endocrinol 2005, 153: 307\u201315.","journal-title":"Eur J Endocrinol"},{"key":"BF03347083_CR11","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2147\/vhrm.2006.2.1.19","volume":"2","author":"HA Lane","year":"2006","unstructured":"Lane HA, Smith JC, Davies JS. Noninvasive assessment of preclinical atherosclerosis. Vasc Health Risk Manag 2006, 2: 19\u201330.","journal-title":"Vasc Health Risk Manag"},{"key":"BF03347083_CR12","doi-asserted-by":"crossref","first-page":"3591","DOI":"10.2174\/1381612043382765","volume":"10","author":"S Nadar","year":"2004","unstructured":"Nadar S, Blann AD, Lip GY. Endothelial dysfunction: methods of assessment and application to hypertension. Curr Pharm Des 2004, 10: 3591\u2013605.","journal-title":"Curr Pharm Des"},{"key":"BF03347083_CR13","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s11102-005-4024-6","volume":"7","author":"M Terzolo","year":"2004","unstructured":"Terzolo M, Reimondo G, Bovio S, Angeli A. Subclinical Cushing\u2019s syndrome. Pituitary 2004, 7: 217\u201323.","journal-title":"Pituitary"},{"key":"BF03347083_CR14","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1210\/me.2005-0266","volume":"20","author":"G Formoso","year":"2006","unstructured":"Formoso G, Chen H, Kim JA, Montagnani M, Consoli A, Quon MJ. Dehydroepiandrosterone mimics acute actions of insulin to stimulate production of both nitric oxide and endothelin 1 via distinct phosphatidylinositol 3-kinase- and mitogen-activated protein kinase-dependent pathways in vascular endothelium. Mol Endocrinol 2006, 20: 1153\u201363.","journal-title":"Mol Endocrinol"},{"key":"BF03347083_CR15","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.1210\/en.2006-1378","volume":"148","author":"D Liu","year":"2007","unstructured":"Liu D, Si H, Reynolds KA, Zhen W, Jia Z, Dillon JS. Dehydroepiandrosterone protects vascular endothelial cells against apoptosis through a Galphai protein-dependent activation of phosphatidylinositol 3-kinase\/Akt and regulation of antiapoptotic Bcl-2 expression. Endocrinology 2007, 148: 3068\u201376.","journal-title":"Endocrinology"},{"key":"BF03347083_CR16","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.1210\/en.2003-0044","volume":"144","author":"T Simoncini","year":"2003","unstructured":"Simoncini T, Mannella P, Fornari L, Varone G, Caruso A, Genazzani AR. Dehydroepiandrosterone modulates endothelial nitric oxide synthesis via direct genomic and nongenomic mechanisms. Endocrinology 2003, 144: 3449\u201355.","journal-title":"Endocrinology"},{"key":"BF03347083_CR17","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.1210\/jc.2002-021603","volume":"88","author":"H Kawano","year":"2003","unstructured":"Kawano H, Yasue H, Kitagawa A, et al. Dehydroepiandrosterone supplementation improves endothelial function and insulin sensitivity in men. J Clin Endocrinol Metab 2003, 88: 3190\u20135.","journal-title":"J Clin Endocrinol Metab"},{"key":"BF03347083_CR18","doi-asserted-by":"crossref","first-page":"4708","DOI":"10.1210\/jc.2003-031560","volume":"89","author":"MR Williams","year":"2004","unstructured":"Williams MR, Dawood T, Ling S, et al. Dehydroepiandrosterone increases endothelial cell proliferation in vitro and improves endothelial function in vivo by mechanisms independent of androgen and estrogen receptors. J Clin Endocrinol Metab 2004, 89: 4708\u201315.","journal-title":"J Clin Endocrinol Metab"},{"key":"BF03347083_CR19","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1210\/en.2007-1125","volume":"149","author":"D Liu","year":"2008","unstructured":"Liu D, Iruthayanathan M, Homan LL, et al. Dehydroepiandrosterone stimulates endothelial proliferation and angiogenesis through extracellular signal-regulated kinase 1\/2-mediated mechanisms. Endocrinology 2008, 149: 889\u201398.","journal-title":"Endocrinology"},{"key":"BF03347083_CR20","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0895-7061(00)01201-2","volume":"13","author":"GJ Mangos","year":"2000","unstructured":"Mangos GJ, Walker BR, Kelly JJ, Lawson JA, Webb DJ, Whitworth JA. Cortisol inhibits cholinergic vasodilation in the human forearm. Am J Hypertens 2000, 13: 1155\u201360.","journal-title":"Am J Hypertens"},{"key":"BF03347083_CR21","doi-asserted-by":"crossref","first-page":"169","DOI":"10.2174\/157016109787455680","volume":"7","author":"MK Ohman","year":"2009","unstructured":"Ohman MK, Wright AP, Wickenheiser KJ, Luo W, Eitzman DT. Visceral adipose tissue and atherosclerosis. Curr Vasc Pharmacol 2009, 7: 169\u201379.","journal-title":"Curr Vasc Pharmacol"},{"key":"BF03347083_CR22","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.diabet.2008.04.002","volume":"34","author":"J Girard","year":"2008","unstructured":"Girard J, Lafontan M. Impact of visceral adipose tissue on liver metabolism and insulin resistance. Part II: Visceral adipose tissue production and liver metabolism. Diabetes Metab 2008, 34: 439\u201345.","journal-title":"Diabetes Metab"},{"key":"BF03347083_CR23","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1210\/jcem-54-1-131","volume":"54","author":"RA Rizza","year":"1982","unstructured":"Rizza RA, Mandarino LJ, Gerich JE. Cortisol-induced insulin resistance in man: impaired suppression of glucose production and stimulation of glucose utilization due to a postreceptor detect of insulin action. J Clin Endocrinol Metab 1982, 54: 131\u20138.","journal-title":"J Clin Endocrinol Metab"},{"key":"BF03347083_CR24","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.2337\/diabetes.51.4.1066","volume":"51","author":"CB Whorwood","year":"2002","unstructured":"Whorwood CB, Donovan SJ, Flanagan D, Phillips DI, Byrne CD. Increased glucocorticoid receptor expression in human skeletal muscle cells may contribute to the pathogenesis of the metabolic syndrome. Diabetes 2002, 51: 1066\u201375.","journal-title":"Diabetes"},{"key":"BF03347083_CR25","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1373\/clinchem.2007.097360","volume":"54","author":"RR Packard","year":"2008","unstructured":"Packard RR, Libby P. Inflammation in atherosclerosis: from vascular biology to biomarker discovery and risk prediction. Clin Chem 2008, 54: 24\u201338.","journal-title":"Clin Chem"},{"key":"BF03347083_CR26","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1161\/01.CIR.0000099509.76044.A2","volume":"108","author":"S Blankenberg","year":"2003","unstructured":"Blankenberg S, Luc G, Ducimeti\u00e8re P, et al. Interleukin-18 and the risk of coronary heart disease in European men: the Prospective Epidemiological Study of Myocardial Infarction (PRIME). Circulation 2003, 108: 2453\u20139.","journal-title":"Circulation"},{"key":"BF03347083_CR27","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1161\/01.CIR.0000020546.30940.92","volume":"106","author":"S Blankenberg","year":"2002","unstructured":"Blankenberg S, Tiret L, Bickel C, et al. Interleukin-18 is a strong predictor of cardiovascular death in stable and unstable angina. Circulation 2002, 106: 24\u201330.","journal-title":"Circulation"},{"key":"BF03347083_CR28","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/ncpcardio1453","volume":"6","author":"SW Rabkin","year":"2009","unstructured":"Rabkin SW. The role of interleukin 18 in the pathogenesis of hypertension-induced vascular disease. Nat Clin Pract Cardiovasc Med 2009, 6: 192\u20139.","journal-title":"Nat Clin Pract Cardiovasc Med"},{"key":"BF03347083_CR29","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1210\/jc.2006-2283","volume":"92","author":"A Dovio","year":"2007","unstructured":"Dovio A, Allasino B, Palmas E, et al. Increased osteoprotegerin levels in Cushing\u2019s syndrome are associated with an adverse cardiovascular risk profile. J Clin Endocrinol Metab 2007, 92: 1803\u20138.","journal-title":"J Clin Endocrinol Metab"},{"key":"BF03347083_CR30","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1161\/01.CIR.0000127957.43874.BB","volume":"109","author":"S Kiechl","year":"2004","unstructured":"Kiechl S, Schett G, Wenning G, et al. Osteoprotegerin is a risk factor for progressive atherosclerosis and cardiovascular disease. Circulation 2004, 109: 2175\u201380.","journal-title":"Circulation"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03347083.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF03347083\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03347083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T10:43:23Z","timestamp":1558521803000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF03347083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,4]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["BF03347083"],"URL":"https:\/\/doi.org\/10.1007\/bf03347083","relation":{},"ISSN":["0391-4097","1720-8386"],"issn-type":[{"value":"0391-4097","type":"print"},{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,4]]}}}