{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T14:41:42Z","timestamp":1759588902145},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[1993,7,1]],"date-time":"1993-07-01T00:00:00Z","timestamp":741484800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"published-print":{"date-parts":[[1993,7]]},"DOI":"10.1007\/bf03348887","type":"journal-article","created":{"date-parts":[[2014,4,4]],"date-time":"2014-04-04T11:52:05Z","timestamp":1396612325000},"page":"485-493","source":"Crossref","is-referenced-by-count":7,"title":["Immunogenicity of a unique region of the human thyrotropin receptor"],"prefix":"10.1007","volume":"16","author":[{"given":"E. V.","family":"Nagy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. B.","family":"Burch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. G.","family":"Lukes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. E.","family":"Carr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Kosugi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. D.","family":"Kohn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth D.","family":"Burman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,4,4]]},"reference":[{"key":"BF03348887_CR1","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1152\/physrev.1968.48.1.252","volume":"43","author":"JM McKenzie","year":"1968","unstructured":"McKenzie J.M. Humoral factors in the pathogenesis of Graves\u2019 disease. Physiol. Rev. 43: 252, 1968.","journal-title":"Physiol. Rev."},{"key":"BF03348887_CR2","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1210\/edrv-6-2-183","volume":"6","author":"KD Burman","year":"1985","unstructured":"Burman, K.D., Baker J.R.Jr. Immune Mechanisms in Graves\u2019 Disease. Endocr. Rev. 6: 183, 1985.","journal-title":"Endocr. Rev."},{"key":"BF03348887_CR3","doi-asserted-by":"crossref","first-page":"3180","DOI":"10.1073\/pnas.78.5.3180","volume":"78","author":"E Yavin","year":"1981","unstructured":"Yavin E., Schneider M.D., Kohn L.D. Monoclonal antibodies to the thyrotropin receptor: implications for receptor structure and the action of autoantibodies in Graves\u2019 disease. Proc. Natl. Acad. Sci. USA 78: 3180, 1981.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BF03348887_CR4","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0022-2836(82)90515-0","volume":"157","author":"J Kyle","year":"1982","unstructured":"Kyle J., Doolittle R.F. A simple method for displaying the hydropathic nature of a protein. J. Molec. Biol. 157: 105, 1982.","journal-title":"J. Molec. Biol."},{"key":"BF03348887_CR5","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1126\/science.2502842","volume":"245","author":"KC McFarland","year":"1989","unstructured":"McFarland K.C., Sprengel R., Phillips H.S., Kohler M., Rosemblit N., Nikolics K., Segaloff D.L., Seeburg P.H. Lutropin-choriogonadotropin receptor: an unusual member of the G protein-coupled receptor family. Science 245: 494, 1989.","journal-title":"Science"},{"key":"BF03348887_CR6","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1126\/science.2502844","volume":"245","author":"H Loosfelt","year":"1989","unstructured":"Loosfelt H., Misrahi M., Atger M., Salesse R., Thi M.T.V.H.L., Jolivet A., Guiochon-Mantel A., Sar S., Jallal B., Gamier J., Milgrom E. Cloning and sequencing of porcine LH-hCG receptor cDNA: variants lacking transmembrane domain. Science 245: 525, 1989.","journal-title":"Science"},{"key":"BF03348887_CR7","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1126\/science.2169649","volume":"249","author":"HL Wadsworth","year":"1990","unstructured":"Wadsworth H.L., Chazenbalk G.D., Nagayama Y., Russo D., Rapoport B. An insertion in the human thyrotropin receptor critical for high affinity hormone binding. Science 249: 1423, 1990.","journal-title":"Science"},{"key":"BF03348887_CR8","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/0006-291X(90)91958-U","volume":"166","author":"M Misrahi","year":"1990","unstructured":"Misrahi M., Loosfelt H., Atger M., Sar S., Guiochon-Mantel A., Milgrom E. Cloning, sequencing and expression of human TSH receptor. Biochem. Biophys. Res. Commun. 166: 394, 1990.","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BF03348887_CR9","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/0006-291X(89)92727-7","volume":"165","author":"Y Nagayama","year":"1989","unstructured":"Nagayama Y., Kaufman K.D., Seto P., Rapoport B. Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor. Biochem. Biophys. Res. Commun. 165: 1184, 1989.","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BF03348887_CR10","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/0006-291X(89)92736-8","volume":"165","author":"F Libert","year":"1989","unstructured":"Libert F., Lefort A., Gerard C., Paramentier M., Perret J., Ludgate M., Dumont J.E., Vassart G. Cloning, sequencing and expression of the human thyrotropin (TSH) receptor: evidence for binding of autoantibodies. Biochem. Biophys. Res. Commun. 165: 1250, 1989.","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BF03348887_CR11","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1126\/science.2556796","volume":"246","author":"M Parmentier","year":"1989","unstructured":"Parmentier M., Libert F., Maenhaut C., Lefort A., Gerard C., Perret J., Van S.J., Dumont J.E., Vassart G. Molecular cloning of the thyrotropin receptor. Science 246: 1620, 1989.","journal-title":"Science"},{"key":"BF03348887_CR12","doi-asserted-by":"crossref","first-page":"5677","DOI":"10.1073\/pnas.87.15.5677","volume":"87","author":"T Akamizu","year":"1990","unstructured":"Akamizu, T., Ikuyama S., Saji M., Kosugi S., Kozak C., McBride O.W., Kohn L.D. Cloning, chromosomal assignment, and regulation of the rat thyrotropin receptor: expression of the gene is regulated by thyrotropin, agents that increase cAMP levels, and thyroid autoantibodies. Proc. Natl. Acad. Sci. USA 87: 5677, 1990.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BF03348887_CR13","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/S0006-291X(05)81447-0","volume":"181","author":"HB Burch","year":"1991","unstructured":"Burch H.B., Nagy E.V., Lukes Y.G., Cai W.Y., Wartofsky L., Burman K.D. Nucleotide and amino acid homology between the human thyrotropin receptor and the HIV-1 Nef protein: Identification and functional analysis. Biochem. Biophys. Res. Commun. 181: 498, 1991.","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BF03348887_CR14","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1021\/ja00897a025","volume":"85","author":"RB Merrifield","year":"1963","unstructured":"Merrifield R.B. Solid phase peptide synthesis I. The synthesis of a tetrapeptide. J. Am. Chem. Soc. 85: 2149, 1963.","journal-title":"J. Am. Chem. Soc."},{"key":"BF03348887_CR15","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/j.1399-3011.1986.tb01064.x","volume":"27","author":"RA Houghten","year":"1985","unstructured":"Houghten R.A., Bray M.K., DeGraw ST., Kirby C.J. Simplified procedure for carrying out simultaneous multiple hydrogen fluoride cleavage of protected peptide resins. Int. J. Pept. Protein. Res. 27: 673, 1985.","journal-title":"Int. J. Pept. Protein. Res."},{"key":"BF03348887_CR16","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1172\/JCI111105","volume":"72","author":"JR Baker Jr.","year":"1983","unstructured":"Baker J.R.Jr., Lukes Y.G., Smallridge R.C., Berger M., Burman K.D. Partial characterization and clinical correlation of circulating human immunoglobulins directed against thyrotropin binding sites in guinea pig fat cell membranes (Development of a direct immunoassay). J. Clin. Invest. 72: 1487, 1983.","journal-title":"J. Clin. Invest."},{"key":"BF03348887_CR17","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.4049\/jimmunol.140.8.2593","volume":"140","author":"JR Baker Jr.","year":"1988","unstructured":"Baker J.R.Jr., Saunders N.B., Kaulfersch W., Burman K.D. The development of human monoclonal antibodies from Graves\u2019 disease patients which demonstrate the ability to inhibit TSH-mediated production of cyclic-adenosine monophosphate in thyrocytes. J. Immunol. 140: 2593, 1988.","journal-title":"J. Immunol."},{"key":"BF03348887_CR18","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1084\/jem.177.2.567","volume":"177","author":"MJ Mamula","year":"1993","unstructured":"Mamula M.J. The inability to process a self-peptide allows autoreactive T cells to escape tolerance. J. Exp. Med. 177: 567, 1993.","journal-title":"J. Exp. Med."},{"key":"BF03348887_CR19","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1172\/JCI111476","volume":"74","author":"P Heyma","year":"1984","unstructured":"Heyma P., Harrison L.C. Immunoprecipitation of the thyrotropin receptor and identification of thyroid autoantigens using Graves\u2019 disease immunoglobulins. J. Clin. Invest. 74: 1090, 1984.","journal-title":"J. Clin. Invest."},{"key":"BF03348887_CR20","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1210\/endo-115-6-2137","volume":"115","author":"B Rapoport","year":"1984","unstructured":"Rapoport B., Seto P., Magnusson R.P. Immunoprecipitation of radiolabelled human thyroid cell proteins by serum from patients with autoimmune thyroid disease. Endocrinology 115: 2137, 1984.","journal-title":"Endocrinology"},{"key":"BF03348887_CR21","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1210\/endo-116-1-124","volume":"116","author":"PA Ealey","year":"1985","unstructured":"Ealey P.A., Valentine W.A., Ekins R.P., Kohn L.D., Marshal N.J. Characterization of monoclonal antibodies raised against solubilized thyrotropin receptors in a cyto-chemical bioassay for thyroid stimulators. Endocrinology 116: 124, 1985.","journal-title":"Endocrinology"},{"key":"BF03348887_CR22","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0006-291X(86)91175-7","volume":"137","author":"R McQuade","year":"1986","unstructured":"McQuade R., Thomas C.G., Nayfeh S.N. Further characterization of the low and high affinity binding components of the thyrotropin receptor. Biochem. Biophys. Res. Commun. 137: 61, 1986.","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BF03348887_CR23","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/0006-291X(87)90660-7","volume":"143","author":"L Bartalena","year":"1987","unstructured":"Bartalena L., Fenzi G., Vitti P., Tombaccini D., Antonelli A., Macchia E., Chiovato L., Kohn L.D., Pinchera A. Interaction of the thyrotropin receptor on rat FRTL-5 thyroid cells with thyrotropin and thyrotropin-stimulating autoantibody from Graves\u2019 patients. Biochem. Biophys. Res. Commun. 143: 266, 1987.","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BF03348887_CR24","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1210\/endo-121-6-2119","volume":"121","author":"SE Gennick","year":"1987","unstructured":"Gennick S.E., Thomas C.G.Jr., Nayfeh S.N. Characterization of the subunit structure of the thyrotropin receptor in the FRTL-5 rat thyroid cell line. Endocrinology 121: 2119, 1987.","journal-title":"Endocrinology"},{"key":"BF03348887_CR25","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1210\/jcem-69-1-134","volume":"69","author":"JP Leedman","year":"1989","unstructured":"Leedman J.P., Newman J.D., Harrison L.C. Human thyrotropin receptor subunits characterized by thyrotropin affinity purification and Western blotting. J. Clin. Endocrinol. Metab. 69: 134, 1989.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03348887_CR26","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1089\/thy.1991.1.207","volume":"1","author":"M Salvi","year":"1991","unstructured":"Salvi M., Bernard N., Miller A., Zhang Z., Gardini E., Wall J.R. Prevalence of antibodies reactive with a 64 kDa eye muscle membrane antigen in thyroid-associated ophthalmopathy. Thyroid 1: 207, 1991.","journal-title":"Thyroid"},{"key":"BF03348887_CR27","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0090-1229(87)90143-7","volume":"43","author":"AP Weetman","year":"1987","unstructured":"Weetman A.P., Nutman T.B., Burman K.D., Baker J.R.Jr., Volkman D.J. Heterogeneity of thyroid autoantigens identified by immunoblotting. Clin. Immunol. Immunopathol. 43: 333, 1987.","journal-title":"Clin. Immunol. Immunopathol."},{"key":"BF03348887_CR28","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1210\/jcem-72-6-1375","volume":"72","author":"Q Dong","year":"1991","unstructured":"Dong Q., Ludgate M.,. Vassart G. Cloning and sequencing of a novel 64 kDa autoantigen recognized by patients with autoimmune thyroid disease. J. Clin. Endocrinol. Metab. 72: 1375, 1991.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03348887_CR29","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1016\/0006-291X(91)91749-3","volume":"179","author":"T Endo","year":"1991","unstructured":"Endo T., Ohmori M., Ikeda M., Kotani S., Onaya T. Rabbit antibodies against two different extracellular domains of human thyrotropin receptor possess thyroid stimulating antibodies. Biochem. Biophys. Res. Commun. 179: 1548, 1991.","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BF03348887_CR30","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0006-291X(91)91794-D","volume":"178","author":"T Mori","year":"1991","unstructured":"Mori T., Sugawa H., Piraphatdist T., Inoue D., Enomoto T., Imura H. A synthetic oligopeptide derived from human thyrotropin receptor sequence binds to Graves\u2019 immunoglobulin and inhibits thyroid stimulating antibody activity but lacks interactions with TSH. Biochem. Biophys. Res. Commun. 178: 165, 1991.","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BF03348887_CR31","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/0006-291X(92)91884-S","volume":"182","author":"S Sakata","year":"1992","unstructured":"Sakata S., Ogawa T., Matsui I., Manshouri T., Atassi M.Z. Biological activities of rabbit antibodies against synthetic human thyrotropin receptor peptides representing thyrotropin binding regions. Biochem. Biophys. Res. Commun. 182: 1369, 1992.","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BF03348887_CR32","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1210\/endo-121-5-1627","volume":"121","author":"Y lida","year":"1987","unstructured":"lida, Y., Amir S.M., Ingbar S.H. Stabilization, partial purification and characterization of thyrotropin receptor in solubilized guinea pig fat cell membranes. Endocrinology 121: 1627, 1987.","journal-title":"Endocrinology"},{"key":"BF03348887_CR33","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/0006-291X(92)92345-X","volume":"188","author":"EV Nagy","year":"1992","unstructured":"Nagy E.V., Burch H.B., Mahoney K., Lukes Y.G., Morris J.C., Burman K.D. Graves\u2019 IgG recognizes linear epitopes in the human thyrotropin receptor. Biochem. Biophys. Res. Commun. 188: 28, 1992.","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BF03348887_CR34","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0006-291X(91)91372-J","volume":"179","author":"O Takai","year":"1991","unstructured":"Takai O., Desai R.K., Seetharamaiah G.S., Jones CA., Allaway G.P., Akamizu T., Kohn L.D., Prabhakar B.S. Prokaryotic expression of the thyrotropin receptor and identification of an immunogenic region of the protein using synthetic peptides. Biochem. Biophys. Res. Commun. 179: 319, 1991.","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03348887.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF03348887\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03348887","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T20:09:44Z","timestamp":1689106184000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF03348887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,7]]},"references-count":34,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1993,7]]}},"alternative-id":["BF03348887"],"URL":"https:\/\/doi.org\/10.1007\/bf03348887","relation":{},"ISSN":["0391-4097","1720-8386"],"issn-type":[{"value":"0391-4097","type":"print"},{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,7]]}}}