{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:19:10Z","timestamp":1783477150124,"version":"3.55.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[1994,4,1]],"date-time":"1994-04-01T00:00:00Z","timestamp":765158400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"published-print":{"date-parts":[[1994,4]]},"DOI":"10.1007\/bf03348974","type":"journal-article","created":{"date-parts":[[2014,4,10]],"date-time":"2014-04-10T22:56:57Z","timestamp":1397170617000},"page":"269-274","source":"Crossref","is-referenced-by-count":62,"title":["Relationship of the increased serum interleukin-6 concentration to changes of thyroid function in nonthyroidal illness"],"prefix":"10.1007","volume":"17","author":[{"given":"L.","family":"Bartalena","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Brogioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Grasso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Velluzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Martino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,4,4]]},"reference":[{"key":"BF03348974_CR1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/1043-2760(92)90085-F","volume":"3","author":"TK Wong","year":"1992","unstructured":"Wong T.K., Hershman J.M. Changes in thyroid function in nonthyroid illness. Trends Endocrinol. Metab. 3: 8, 1992.","journal-title":"Trends Endocrinol. Metab."},{"key":"BF03348974_CR2","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1210\/edrv-3-2-164","volume":"3","author":"L Wartofsky","year":"1982","unstructured":"Wartofsky L., Burman K.D. Alterations in thyroid function in patients with systemic illness: the \u201ceuthyroid sick syndrome\u201d. Endocr. Rev. 3: 164, 1982.","journal-title":"Endocr. Rev."},{"key":"BF03348974_CR3","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1210\/jcem-70-1-293","volume":"70","author":"L Bartalena","year":"1990","unstructured":"Bartalena L., Martino E., Brandi L.S., Falcone M., Pacchiarotti A., Ricci C., Bogazzi F., Grasso L., Mammoli C., Pinchera A. Lack of nocturnal serum thyrotropin surge after surgery. J. Clin. Endocrinol. Metab. 70: 293, 1990.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03348974_CR4","first-page":"30","volume":"34","author":"L Bartalena","year":"1990","unstructured":"Bartalena L., Pacchiarotti A., Palla R., Antonangeli L., Mammoli C., Monzani F., De Negri F., Panichi V., Martino E., Baschieri L., Pinchera A. Lack of nocturnal serum thyrotropin (TSH) surge in patients with chronic renal failure undergoing regular maintenance hemofiltration: a case of central hypothyroidism. Clin. Nephrol. 34: 30, 1990.","journal-title":"Clin. Nephrol."},{"key":"BF03348974_CR5","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1210\/jcem-71-3-650","volume":"71","author":"L Bartalena","year":"1990","unstructured":"Bartalena L., Placidi G.F., Martino E., Falcone M., Pellegrini L., Dell\u2019Osso L., Pacchiarotti A., Pinchera A. Nocturnal serum thyrotropin (TSH) surge and the TSH response to TSH-releasing hormone: dissociated behavior in untreated depressives. J. Clin. Endocrinol. Metab. 71: 650, 1990.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03348974_CR6","first-page":"983","volume":"76","author":"L Bartalena","year":"1993","unstructured":"Bartalena L., Cossu E., Grasso L., Velluzzi F., Loviselli A., Cirillo R., Martino E. Relationship between nocturnal serum thyrotropin peak and metabolic control in diabetic patients. J. Clin. Endocrinol. Metab. 76: 983, 1993.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03348974_CR7","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1210\/jcem-70-6-1735","volume":"70","author":"K Sato","year":"1990","unstructured":"Sato K., Satoh T., Shizume K., Ozawa M., Han D.C., Imamura H., Tsushima T., Demura H., Kanaji Y., Ito Y., Obara T., Fujimoto Y., Konaji Y. Inhibition of 125-1 organification and thyroid hormone release by interleukin-1, tumor necrosis factor-\u03b1 and interferon-\u03b3 in human thyrocytes in suspension culture. J. Clin. Endocrinol. Metab. 70: 1735, 1990.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03348974_CR8","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1530\/acta.0.1230203","volume":"123","author":"XP Pang","year":"1990","unstructured":"Pang X.P., Hershman J.M., Smith V., Pekary E.A., Sugawara M. The mechanism of action of tumor necrosis factor-alpha and interleukin-1. Acta Endocrinol. (Copenh.) 123: 203, 1990.","journal-title":"Acta Endocrinol. (Copenh.)"},{"key":"BF03348974_CR9","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1089\/thy.1991.1.235","volume":"1","author":"M Poth","year":"1991","unstructured":"Poth M., Tseng Y-C.L., Wartofsky L. Inihibition of TSH activation of human cultured thyroid cells by tumor necrosis factor: an explanation for decreased thyroid function in systemic illness? Thyroid 1: 235, 1991.","journal-title":"Thyroid"},{"key":"BF03348974_CR10","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1210\/endo-123-3-1461","volume":"123","author":"M Ozawa","year":"1988","unstructured":"Ozawa M., Sato K., Han D.C., Kawakami M., Tsushima T., Shizume K. Effects of tumor necrosis factor-alpha\/cachectin on thyroid hormone metabolism in mice. Endocrinology 123: 1461, 1988.","journal-title":"Endocrinology"},{"key":"BF03348974_CR11","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1210\/jcem-71-5-1239","volume":"71","author":"AD Mooradian","year":"1990","unstructured":"Mooradian A.D., Reed D.L., Osterweil D., Schiffman R., Scuderi P. Decreased serum triiodothyronine is associated with increased concentration of tumor necrosis factor. J. Clin. Endocrinol. Metab. 71: 1239, 1990.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03348974_CR12","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1210\/jcem-71-6-1567","volume":"71","author":"T Poll Van der","year":"1990","unstructured":"Van der Poll T., Romijn J.A., Wiersinga W.M., Sauerwein H.P. Tumor necrosis factor: a putative mediator of the sick euthyroid syndrome in man. J. Clin. Endocrinol. Metab. 71: 1567, 1990.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03348974_CR13","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1210\/jcem-72-5-1113","volume":"72","author":"IJ Chopra","year":"1991","unstructured":"Chopra I.J., Sakane S., Chua Teco G.N. A study of the serum concentration of tumor necrosis factor-alpha in thyroidal and nonthyroidal illnesses. J. Clin. Endocrinol. Metab. 72: 1113, 1991.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03348974_CR14","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1042\/bj2650621","volume":"265","author":"PC Heinrich","year":"1990","unstructured":"Heinrich P.C., Castell J.V., Andus T. Interleukin-6 and the acute phase response. Biochem. J. 265: 621, 1990.","journal-title":"Biochem. J."},{"key":"BF03348974_CR15","first-page":"935","volume":"6","author":"L Bartalena","year":"1992","unstructured":"Bartalena L., Farsetti A., Flink I.L., Robbins J. Effects of interleukin-6 on the expression of thyroid hormone-binding protein genes in cultured human hepatoblastoma-derived (Hep G2) cells. Mol. Endocrinol. 6: 935, 1992.","journal-title":"Mol. Endocrinol."},{"key":"BF03348974_CR16","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1210\/endo.133.1.8391424","volume":"133","author":"L Bartalena","year":"1993","unstructured":"Bartalena L., Hammond G.L., Farsetti A., Flink I.L., Robbins J. Interleukin-6 inhibits corticosteroid-binding globulin synthesis by human hepatoblastoma-derived (Hep G2) cells. Endocrinology 133: 291, 1993.","journal-title":"Endocrinology"},{"key":"BF03348974_CR17","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1530\/acta.0.1240290","volume":"124","author":"T Tominaga","year":"1991","unstructured":"Tominaga T., Yamashita S., Nagayama Y., Morita S., Yokoyama N., Izumi M., Nagataki S. Interleukin 6 inhibits human thyroid peroxidase gene expression. Acta Endocrinol. (Copenh.) 124: 290, 1991.","journal-title":"Acta Endocrinol. (Copenh.)"},{"key":"BF03348974_CR18","first-page":"355","volume-title":"80 years of Hashimoto\u2019s Disease","author":"N Onoda","year":"1993","unstructured":"Onoda N., Tsushima T., Isozaki O., Emoto N., Demura H., Arai M., Shizume K., Sato Y., Miyakawa M., Murakami H., Ohmura E. Effect of interleukin-6 on hypothalamic-pituitary-thyroid axis in rat. In: Nagataki S., Mori T., Torizuka K., (Eds.), 80 years of Hashimoto\u2019s Disease. Elsevier Science Publ., Amsterdam, 1993, p. 355."},{"key":"BF03348974_CR19","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/BF03344951","volume":"16","author":"L Bartalena","year":"1993","unstructured":"Bartalena L., Brogioni S., Grasso L., Martino E. Increased serum interleukin-6 concentration in patients with subacute thyroiditis: relationship with concomitant changes in serum T4-binding globulin concentration. J. Endocrinol. Invest. 16: 213, 1993.","journal-title":"J. Endocrinol. Invest."},{"key":"BF03348974_CR20","first-page":"324","volume":"77","author":"B Grubeck-Loebenstein","year":"1989","unstructured":"Grubeck-Loebenstein B., Buchan G., Chantry D., Kassal H., Londei M., Pirich K., Barrett K., Turner M., Waldhausl W., Feldmann M. Analysis of intrathyroidal cytokine production in thyroid autoimmune disease: thyroid follicular cells produce interleukin-1\u03b1 and interleukin-6. Clin. Exp. Immunol. 77: 324, 1989.","journal-title":"Clin. Exp. Immunol."},{"key":"BF03348974_CR21","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1677\/joe.0.1270357","volume":"127","author":"AP Weetman","year":"1990","unstructured":"Weetman A.P., Bright-Thomas R., Freeman M. Regulation of interleukin-6 release by human thyrocytes. J. Endocrinol. 127: 351, 1990.","journal-title":"J. Endocrinol."},{"key":"BF03348974_CR22","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/1043-4666(91)90504-7","volume":"3","author":"M Iwamoto","year":"1991","unstructured":"Iwamoto M., Sakihama T., Kimura N., Tasaka K., Onaya T. Augmented interleukin 6 production by rat thyrocytes (FRTL5): effect of interleukin-1\u00df and thyroid-stimulating hormone. Cytokine 3: 345, 1991.","journal-title":"Cytokine"},{"key":"BF03348974_CR23","first-page":"423","volume":"78","author":"L Bartalena","year":"1994","unstructured":"Bartalena L., Grasso L., Brogioni S., Aghini-Lombardi F., Braverman L.E., Martino E. Serum interleukin-6 in amiodarone-induced thyrotoxicosis. J. Clin. Endocrinol. Metab. 78: 423, 1994.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03348974_CR24","first-page":"T","volume":"3","author":"L Bartalena","year":"1993","unstructured":"Bartalena L., Pinchera A., Brogioni S., Grasso L., Rago T., Vitti P., Martino E. Serum interleukin-6 (IL-6) levels in thyroidal destructive processes. Thyroid 3 (Suppl.): T\u201337, 1993 (Abstract).","journal-title":"Thyroid"},{"key":"BF03348974_CR25","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1002\/art.1780310614","volume":"31","author":"FA Houssiau","year":"1988","unstructured":"Houssiau F.A., Devogelaer J.-P., Van Damme J., Nagant de Deuxchaisnes C., Van Snick J. Interleukin-6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides. Arthritis Rheum. 31: 784, 1988.","journal-title":"Arthritis Rheum."},{"key":"BF03348974_CR26","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/00000658-199101000-00005","volume":"213","author":"KCH Fearon","year":"1991","unstructured":"Fearon K.C.H., McMillan D.C., Preston T., Winstanley P., Cruickshank A.M., Shenkin A. Elevated circulating interleukin-6 is associated with an acute-phase response but reduced fixed hepatic protein synthesis in patients with cancer. Ann. Surg. 213: 26, 1991.","journal-title":"Ann. Surg."},{"key":"BF03348974_CR27","first-page":"320","volume":"71","author":"FA Houssiau","year":"1988","unstructured":"Houssiau F.A., Bukasa K., Sindic C.J.M., Van Damme J., Van Snick J. Elevated levels of the 26 K human hybridoma growth factor (interleukin 6) in the cerebrospinal fluid of patients with acute infections of the central nervous system. Clin. Exp. Immunol. 71: 320, 1988.","journal-title":"Clin. Exp. Immunol."},{"key":"BF03348974_CR28","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1182\/blood.V74.5.1704.1704","volume":"74","author":"CE Hack","year":"1989","unstructured":"Hack C.E., De Groot E.R., Felt-Bersma R.J.F., Nuijens J.H., Strack Van Schijndel R.J.M., Eerenberg-Belmer A.J.M., Thijs L.G., Arden L.A. Increased plasma levels of interleukin-6 in sepsis. Blood 74: 1704, 1989.","journal-title":"Blood"},{"key":"BF03348974_CR29","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.1365-2265.1993.tb02393.x","volume":"39","author":"M Reincke","year":"1993","unstructured":"Reincke M., Allolio B., Petzke F., Heppner C., Mbulamberi D., Vollmer D., Winkelmann W., Chrousos G.P. Thyroid dysfunction in African trypanosomiasis: a possible role for inflammatory cytokines. Clin. Endocrinol. (Oxf.) 39: 455, 1993.","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"BF03348974_CR30","doi-asserted-by":"crossref","first-page":"771","DOI":"10.7326\/0003-4819-119-8-199310150-00001","volume":"119","author":"LC Casey","year":"1993","unstructured":"Casey L.C., Balk R.A., Bone R.C. Plasma cytokine and endotoxin levels correlate with survival in patients with the sepsis syndrome. Ann. Intern. Med. 119: 771, 1993.","journal-title":"Ann. Intern. Med."},{"key":"BF03348974_CR31","doi-asserted-by":"crossref","first-page":"4966","DOI":"10.1073\/pnas.87.13.4966","volume":"87","author":"JE Gershenwald","year":"1990","unstructured":"Gershenwald J.E., Fong Y.M., Fahey T.J. III, Calvano S.E., Chizzonite R., Kilian P.L. Interleukin 1 receptor blockade attenuates the host inflammatory response. Proc. Natl. Acad. Sci. USA 87: 4966, 1990.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BF03348974_CR32","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1084\/jem.170.5.1627","volume":"170","author":"Y Fong","year":"1989","unstructured":"Fong Y., Tracey K.J., Moldawer L.L., Hesse D.G., Manogue K.B., Kenney J.S. Antibodies to cachectin\/tumor necrosis factor reduce interleukin 1 and interleukin 6 appearance during lethal bacteremia. J. Exp. Med. 170: 1627, 1989.","journal-title":"J. Exp. Med."},{"key":"BF03348974_CR33","first-page":"1695","volume":"77","author":"A Boelen","year":"1993","unstructured":"Boelen A., Platvoet-ter Schriphorst M.C., Wiersinga W.M. Association between serum interleukin-6 and serum 3, 5, 3\u2032-triiodothyronine in nonthyroidal illeness. J. Clin. Endocrinol. Metab. 77: 1695, 1993.","journal-title":"J. Clin. Endocrinol. Metab."}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03348974.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF03348974\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03348974","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T16:15:45Z","timestamp":1597680945000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF03348974"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,4]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1994,4]]}},"alternative-id":["BF03348974"],"URL":"https:\/\/doi.org\/10.1007\/bf03348974","relation":{},"ISSN":["0391-4097","1720-8386"],"issn-type":[{"value":"0391-4097","type":"print"},{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,4]]}}}