{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T14:18:24Z","timestamp":1758637104126},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1979,4,1]],"date-time":"1979-04-01T00:00:00Z","timestamp":291772800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"published-print":{"date-parts":[[1979,4]]},"DOI":"10.1007\/bf03349302","type":"journal-article","created":{"date-parts":[[2014,4,9]],"date-time":"2014-04-09T03:37:47Z","timestamp":1397014667000},"page":"117-124","source":"Crossref","is-referenced-by-count":1,"title":["Effect of vitamin B6 on the serum concentration of pituitary hormones in normal humans and under pathologic conditions"],"prefix":"10.1007","volume":"2","author":[{"given":"M.","family":"Bigazzi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ferraro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Ronga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Scarselli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Bruni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. L.","family":"Olivotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,4,4]]},"reference":[{"key":"BF03349302_CR1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1749-6632.1969.tb46369.x","volume":"166","author":"DB Coursin","year":"1969","unstructured":"Coursin D.B. Vitamin B6 and brain functions in animals and man. Ann. N.Y. Acad. Sci., 166: 7, 1969.","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"BF03349302_CR2","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1093\/jn\/104.12.1657","volume":"104","author":"JA Driskell","year":"1974","unstructured":"Driskell J.A., Lee Chuang S.L. Relationship between glutamnic decarboxylase activities in brains, and the vitamin B6 requirement of male rats. J. Nutr. 104: 1657, 1974.","journal-title":"J. Nutr."},{"key":"BF03349302_CR3","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1093\/jn\/103.5.670","volume":"103","author":"JP Driskell","year":"1973","unstructured":"Driskell J.P., Strickland L.A., Poon L.H., Foshee D.P. The vitamin B6 requirement of the male rat as determined by behavioral patterns, brain pyridoxal phosphate and nucleic acid composition and erythrocyte alanine amino transferase activity. J. Nutr. 103: 670, 1973.","journal-title":"J. Nutr."},{"key":"BF03349302_CR4","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1093\/jn\/104.7.810","volume":"704","author":"JA Driskell","year":"1974","unstructured":"Driskell J.A., Foshee D.P. Behavioral patterns and brain nucleic acid and pyridoxal phosphate contents of male rat progeny from vitamin B6 repleted dams. J. Nutr. 704:810, 1974.","journal-title":"J. Nutr."},{"key":"BF03349302_CR5","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0083-6729(08)60350-7","volume":"22","author":"O Wiss","year":"1964","unstructured":"Wiss O., Weber F. Biochemical pathology of vitamin B6 deficiency. Vitam. Horm. 22: 495, 1964.","journal-title":"Vitam. Horm."},{"key":"BF03349302_CR6","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1007\/BF02112730","volume":"26","author":"IA Kamberi","year":"1970","unstructured":"Kamberi I.A., Mical R.S., Porter J.C. Prolactin inhibiting activity in hypophyseal stalk blood and elevation by dopamine. Experentia 26: 1150, 1970.","journal-title":"Experentia"},{"key":"BF03349302_CR7","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/B978-0-12-475560-4.50009-7","volume-title":"Neurochemical aspects of hypothalamic function","author":"C Kordon","year":"1970","unstructured":"Kordon C, Glowinsky J. Role of brain cathecolamines in the control of anterior pituitary function. In: Martini L, Meites J. (Eds.), Neurochemical aspects of hypothalamic function. Academic Press, New York, 1970, p. 85."},{"key":"BF03349302_CR8","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1210\/endo-88-6-1288","volume":"88","author":"IA Kamberi","year":"1971","unstructured":"Kamberi I.A., Mical R.S., Porter J.C. Effects of melatonin and serotonin on the release of FSH and prolactin. Endocrinology 88: 1288, 1971.","journal-title":"Endocrinology"},{"key":"BF03349302_CR9","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1210\/jcem-36-1-204","volume":"36","author":"H Imura","year":"1973","unstructured":"Imura H., Nakai Y., Yoshimi T. Effect of 5-hydroxytryptophan (5 HPT) on growth hormone and ACTH release in man. J. Clin. Endocrinol. Metab. 36: 204, 1973.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03349302_CR10","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1055\/s-0028-1093907","volume":"5","author":"A Makris","year":"1973","unstructured":"Makris A., Gershoff S.N. Growth hormone levels in vitamin B6 deficient rats. Horm. Metab. Res. 5: 457, 1973.","journal-title":"Horm. Metab. Res."},{"key":"BF03349302_CR11","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/jn\/87.4.407","volume":"87","author":"AM Huber","year":"1965","unstructured":"Huber A.M., Gershoff S.N. Some effects of vitamin B6 deficiency on rat pituitary glands. J. Nutr. 87: 407, 1965.","journal-title":"J. Nutr."},{"key":"BF03349302_CR12","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/path.1711170302","volume":"117","author":"RA Rodda","year":"1975","unstructured":"Rodda R.A. Bone growth change in pyridoxine deficient rats. J. Pathol. 117: 131, 1975.","journal-title":"J. Pathol."},{"key":"BF03349302_CR13","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1111\/j.1471-0528.1973.tb16057.x","volume":"30","author":"MD Foukas","year":"1973","unstructured":"Foukas M.D. An antilactogenic effect of pyridoxine. J. Obstet. Gynaecol. Br. Commonw. 30: 718, 1973.","journal-title":"J. Obstet. Gynaecol. Br. Commonw."},{"key":"BF03349302_CR14","first-page":"291","volume-title":"Patologia espansiva ipofisaria","author":"M Bigazzi","year":"1977","unstructured":"Bigazzi M., Ferraro S., Ronga R., Zurli A. The use of pyridoxine as a test of diencephalous-pituitary function In: Butturini U., Valenti G. (Eds.) Patologia espansiva ipofisaria. Pacini, Pisa, 1977, p. 291."},{"key":"BF03349302_CR15","first-page":"2155","volume":"49","author":"RG Marcus","year":"1975","unstructured":"Marcus R.G. Suppression of lactation with high doses of pyridoxine. S. Afr. Med. J. 49:2155, 1975.","journal-title":"S. Afr. Med. J."},{"key":"BF03349302_CR16","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1471-0528.1976.tb00730.x","volume":"83","author":"HN Mac Donald","year":"1976","unstructured":"Mac Donald H.N. The failure of pyridoxine in suppression of puerperal lactation. Br. J. Obstet. Gynaecol. 83: 54, 1976.","journal-title":"Br. J. Obstet. Gynaecol."},{"key":"BF03349302_CR17","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.1471-0528.1976.tb00848.x","volume":"83","author":"ES Canales","year":"1976","unstructured":"Canales E.S., Soria J., Zarate A., Mason M., Molina M. The influence of pyridoxine on prolactin secretion and milk production in women. Br. J. Obstet. Gynaecol. 83: 387, 1976.","journal-title":"Br. J. Obstet. Gynaecol."},{"key":"BF03349302_CR18","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1210\/jcem-42-6-1192","volume":"42","author":"EN Mcintosh","year":"1976","unstructured":"Mcintosh E.N. Treatment of women with the galactorrhea-amenorrhea syndrome with pyridoxine (vit. B6). J. Clin. Endocrinol. Metab. 42: 1192, 1976.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03349302_CR19","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1210\/jcem-42-3-603","volume":"42","author":"G Delitala","year":"1976","unstructured":"Delitala G., Masala A., Alagna S., Devilla L. Effect of pyridoxine on human hypophyseal thropic hormone release: a possible stimulation of hypothalamic dopaminergic pathway. J. Clin. Endocrinol. Metab. 42: 603, 1976.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03349302_CR20","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1210\/jcem-45-5-1019","volume":"45","author":"G Delitala","year":"1977","unstructured":"Delitala G., Rovasio P., Lotti G. Suppression of thyrotropin (TSH) and prolactin (PRL) release by pyridoxine in chronic primary hypothyroidism. J. Clin. Endocrinol. Metab. 45: 1019, 1977.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03349302_CR21","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1210\/jcem-44-6-1197","volume":"44","author":"G Tolis","year":"1977","unstructured":"Tolis G., Laliberte\u2019 R., Guyda H., Naftolin F. Ineffectiveness of Pyridoxine (Be) to after secretion of growth hormone and prolactin and absence of therapeu tic effects on galactorrhea-amenorrhea syndromes. J. Clin. Endocrinol. Metab. 44: 1197, 1977.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03349302_CR22","first-page":"525","volume":"3","author":"G Delitala","year":"1975","unstructured":"Delitala G., Masala A., Alagna S., Devilla L. Plasma prolactin response to pyridoxine in the galactorrhea-amenorrhea syndrome. IRCS Med. Sci. 3: 525, 1975.","journal-title":"IRCS Med. Sci."},{"key":"BF03349302_CR23","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1530\/acta.0.0870682","volume":"87","author":"P Lehtovirta","year":"1978","unstructured":"Lehtovirta P., Rauta T., Sepp\u00e4l\u00e4 M. Pyridoxine treatment of galactorrhea-amenorrhea syndromes. Acta Endocrinol. (Kbh.) 87: 682, 1978.","journal-title":"Acta Endocrinol. (Kbh.)"},{"key":"BF03349302_CR24","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1210\/jcem-46-4-686","volume":"46","author":"AM Spiegel","year":"1978","unstructured":"Spiegel A.M., Rosen S.W., Weintraub B.D., Marynick S.M. Effect of intravenous pyridoxine on plasma prolactin in hyperprolactinemic subjects. J. Clin. Endocrinol. Metab. 46: 686, 1978.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03349302_CR25","first-page":"240","volume":"1","author":"E Robins","year":"1976","unstructured":"Robins E., Robins M.J., Croninger A.B., Moses S.G., Spencer S.J., Mudgens R.W. Brain amines and their synthesis in man. Biochemistry 1: 240, 1976.","journal-title":"Biochemistry"},{"key":"BF03349302_CR26","doi-asserted-by":"crossref","first-page":"578","DOI":"10.3181\/00379727-143-37370","volume":"143","author":"TH Hsu","year":"1973","unstructured":"Hsu T.H., Bianchine J.R., Preziosi J., Messina F.S., Effect of pyridoxine on levodopa metabolism in normal and parkinsonian subjects. Proc. Soc. Exp. Biol. Med. 143: 578, 1973.","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"BF03349302_CR27","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1136\/bmj.4.5886.236-b","volume":"1","author":"AB Carter","year":"1973","unstructured":"Carter A.B. Pyridoxine and parkinsonism. Br. Med. J. 1:236, 1973.","journal-title":"Br. Med. J."},{"key":"BF03349302_CR28","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1210\/jcem-40-2-256","volume":"40","author":"RB Mims","year":"1975","unstructured":"Mims R.B., Scott C.L. Modebe O., Bethune J.E. Inhibition of L-dopa induced growth hormone stimulation by pyridoxine and chlorpromazine. J. Clin. Endocrinol. Metab. 40: 256, 1975.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03349302_CR29","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1210\/endo-102-2-362","volume":"102","author":"AC Harris","year":"1978","unstructured":"Harris A.C., Smith M.S., Alex S., Salhanick H.A., Vagenakis A.G., Braverman L.E. Pyridoxine (Bo) \u2014 induced inhibition of prolactin release in the female rat. Endocrinology 102: 362, 1978.","journal-title":"Endocrinology"},{"key":"BF03349302_CR30","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1056\/NEJM197111182852102","volume":"285","author":"WB Malarkey","year":"1971","unstructured":"Malarkey W.B., Jacobs L.S., Daughaday W.H. L-dopa suppression of prolactin in non puerperal galactorrhea. N. Engl. J. Med. 285: 1160, 1971.","journal-title":"N. Engl. J. Med."},{"key":"BF03349302_CR31","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1210\/jcem-34-2-306","volume":"34","author":"RW Turkington","year":"1972","unstructured":"Turkington R.W. Inhibition of prolactin secretion and successful! therapy of the Forbes-Albright syndrome with L-dopa. J. Clin. Endocrinol. Metab. 34: 306, 1972.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03349302_CR32","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1210\/jcem-35-6-941","volume":"35","author":"A Liuzzi","year":"1972","unstructured":"Liuzzi A., Chiodini P.G., Botalla L, Cremascioli G., Silvestrini F. Inhibitory effect of L-dopa on GH release in acromegalic patients. J. Clin. Endocrinol. Metab. 35: 941, 1972.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03349302_CR33","first-page":"179","volume-title":"Prolactin and human reproduction","author":"A Caufriez","year":"1977","unstructured":"Caufriez A., Robyn C. Pathophysiology of human prolactin secretion with special reference to prolactin secreting pituitary adenomas and isolated galactorrhea. In: Crosignani P.G., Robyn C. (Eds.), Prolactin and human reproduction. Academic Press, London 1977, p. 179."},{"key":"BF03349302_CR34","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1210\/jcem-38-5-910","volume":"38","author":"A Liuzzi","year":"1974","unstructured":"Liuzzi A., Chiodini P.G., Botalla L., Cremascioli G., M\u00fcller E.E., Silvestrini F. Decreased plasma growth hormone (GH) levels in acromegalics following CB-154 administration. J. Clin. Endocrinol. Metab. 38: 910, 1974.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03349302_CR35","first-page":"343","volume":"14","author":"K Azuma","year":"1976","unstructured":"Azuma K. Apparent deficiency of vitamin B6 in typical individuals who commonly serve as normals controls. Res. Commun. Chem. Pathol. Pharmacol. 14: 343, 1976.","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"BF03349302_CR36","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1093\/ajcn\/29.8.847","volume":"29","author":"CS Rose","year":"1976","unstructured":"Rose CS. Age differences in Vit. B6 status of 617 men. Ann. J. Clin. Nutr. 29: 847, 1976.","journal-title":"Ann. J. Clin. Nutr."},{"key":"BF03349302_CR37","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S0140-6736(73)91359-7","volume":"1","author":"PV Adams","year":"1973","unstructured":"Adams P.V., Wynn V., Rose D.P., Seed M., Folkard J., Strong R. Effect of pyridoxine hydrochloride (vitamin B6) upon depression associated with oral contraception. Lancet 1:897, 1973.","journal-title":"Lancet"},{"key":"BF03349302_CR38","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1136\/bmj.2.6042.979-a","volume":"2","author":"D Tant","year":"1976","unstructured":"Tant D. Megaloblastic anaemia due to pyridoxine deficiency associated with prolonged ingestion of an oestrogen-containing oral contraceptive. Br. Med. J. 2:979, 1976.","journal-title":"Br. Med. J."},{"key":"BF03349302_CR39","first-page":"813","volume":"87","author":"JA Driskell","year":"1976","unstructured":"Driskell J.A. Vitamin B6 status of young men, women, and women using oral contraceptive. J. Lab. Clin. Med. 87:813, 1976.","journal-title":"J. Lab. Clin. Med."},{"key":"BF03349302_CR40","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/0002-9378(76)90809-7","volume":"125","author":"AS Prasad","year":"1976","unstructured":"Prasad A.S., Lei K.Y., Mochissi K.S., Stryken J.G., Oberleas D. Effect of oral contraceptive on nutrients: III vitamin B6, B12, and folic acid. Am. J. Obstet. Gynaecol. 125: 1603, 1976.","journal-title":"Am. J. Obstet. Gynaecol."},{"key":"BF03349302_CR41","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1159\/000398276","volume":"3","author":"AA Hasples","year":"1975","unstructured":"Hasples A.A. Estrogens and vit. B6 Front. Horm. Res. 3: 199, 1975.","journal-title":"Front. Horm. Res."},{"key":"BF03349302_CR42","first-page":"733","volume":"295","author":"L Howard","year":"1976","unstructured":"Howard L, Oldemorf M., Chu R. Pyridoxine deficiency: another potential signalof the jejunal ileal \u2014 bypass procedure. N. Engl. J. Med. 295: 733, 1976.","journal-title":"N. Engl. J. Med."},{"key":"BF03349302_CR43","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S0016-5085(76)80056-X","volume":"71","author":"D Mitchell","year":"1976","unstructured":"Mitchell D., Wagner C, Stone W.J., Wilinson G.R., Schenfer S. Abnormal regulation of plasma pyridoxal 5-phosphate in patients with liver diseases. Gastroenterology 71: 1043, 1976.","journal-title":"Gastroenterology"},{"key":"BF03349302_CR44","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1136\/bmj.3.5974.13","volume":"3","author":"HJ Ooelingh Benmuik","year":"1975","unstructured":"Ooelingh Benmuik H.J., Schreurs W.H. Improvement of oral tolerance in gestational diabetes by pyridoxine. Br. Med. J. 3: 13, 1975.","journal-title":"Br. Med. J."},{"key":"BF03349302_CR45","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S0140-6736(74)93168-7","volume":"1","author":"BT Nobbs","year":"1974","unstructured":"Nobbs B.T. Pyridoxal phosphate status in clinical depression. Lancet 1: 405, 1974.","journal-title":"Lancet"},{"key":"BF03349302_CR46","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1136\/bmj.1.5850.389","volume":"1","author":"DY Mason","year":"1973","unstructured":"Mason D.Y., Emerson P.M. Primary acquired sideroblastic anaemia: response to treatment with pyridoxal 5-phosphate. Br. Med. J. 1:389, 1973.","journal-title":"Br. Med. J."},{"key":"BF03349302_CR47","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1056\/NEJM197008272830901","volume":"283","author":"JD Hines","year":"1970","unstructured":"Hines J.D., Cowan D.H. Studies on the pathogenesis of alcohol-induced sideroblastic bone-marrow abnormalities. N. Engl. J. Med. 283:441, 1970.","journal-title":"N. Engl. J. Med."},{"key":"BF03349302_CR48","doi-asserted-by":"crossref","first-page":"3708","DOI":"10.1016\/S0021-9258(19)75329-0","volume":"238","author":"O Greengard","year":"1964","unstructured":"Greengard O., Gordon M. The cofactor mediated regulation of apoenzyme levels in animal tissues. J. Biol. Chem. 238: 3708, 1964.","journal-title":"J. Biol. Chem."},{"key":"BF03349302_CR49","first-page":"48","volume":"26","author":"DP Rose","year":"1973","unstructured":"Rose D.P., Strong R., Folkard J., Adams P.W. Erythrocyte aminotransferase activities in women using oral contraceptives, and the effect of vit. B6 supplementation. Am. J. Clin. Nutr. 26: 48, 1973.","journal-title":"Am. J. Clin. Nutr."},{"key":"BF03349302_CR50","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1210\/endo-72-1-33","volume":"72","author":"VE Davis","year":"1963","unstructured":"Davis V.E. Effect of cortisone and tyroxine on aromatic aminoacid decarboxylation. Endocrinology 72: 33, 1963.","journal-title":"Endocrinology"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03349302.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF03349302\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03349302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T04:12:20Z","timestamp":1648786340000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF03349302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,4]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1979,4]]}},"alternative-id":["BF03349302"],"URL":"https:\/\/doi.org\/10.1007\/bf03349302","relation":{},"ISSN":["0391-4097","1720-8386"],"issn-type":[{"value":"0391-4097","type":"print"},{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,4]]}}}