{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T06:08:23Z","timestamp":1776146903101,"version":"3.50.1"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[1981,7,1]],"date-time":"1981-07-01T00:00:00Z","timestamp":362793600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"published-print":{"date-parts":[[1981,7]]},"DOI":"10.1007\/bf03349456","type":"journal-article","created":{"date-parts":[[2014,4,9]],"date-time":"2014-04-09T03:34:24Z","timestamp":1397014464000},"page":"349-358","source":"Crossref","is-referenced-by-count":33,"title":["The biochemical properties of urinary human chorionic gonadotropin from the patients with trophoblastic diseases"],"prefix":"10.1007","volume":"4","author":[{"given":"R.","family":"Nishimura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Endo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Tanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Ashitaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Tojo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,4,4]]},"reference":[{"key":"BF03349456_CR1","doi-asserted-by":"crossref","first-page":"6810","DOI":"10.1016\/S0021-9258(19)43425-X","volume":"248","author":"RB Carlsen","year":"1973","unstructured":"Carlsen R.B., Bahl O.P., Swaminathan N. Human chorionic gonadotropin: Linear amino acid sequence of the subunit. J. Biol. Chem. 248: 6810, 1973.","journal-title":"J. Biol. Chem."},{"key":"BF03349456_CR2","doi-asserted-by":"crossref","first-page":"5247","DOI":"10.1016\/S0021-9258(19)41303-3","volume":"250","author":"FJ Morgan","year":"1975","unstructured":"Morgan F.J., Birken S., Canfield R.E. The amino acid sequence of human chorionic gonadotropin: the \u03b1 subunit and \u03b2 subunit. J. Biol. Chem. 250: 5247, 1975.","journal-title":"J. Biol. Chem."},{"key":"BF03349456_CR3","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0021-9258(18)94395-4","volume":"244","author":"OP Bahl","year":"1969","unstructured":"Bahl O.P. Human chorionic gonadotropin. II. Nature of the carbohydrate units. J. Biol. Chem. 244: 575, 1969.","journal-title":"J. Biol. Chem."},{"key":"BF03349456_CR4","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1042\/bj1550303","volume":"155","author":"JF Kennedy","year":"1976","unstructured":"Kennedy J.F., Chaplin M.F. The structures of the carbohydrate moieties of the \u03b1 subunits of human chorionic gonadotropin. J. Biochem. (Tokyo) 155: 303, 1976.","journal-title":"J. Biochem. (Tokyo)"},{"key":"BF03349456_CR5","first-page":"669","volume":"85","author":"Y Endo","year":"1979","unstructured":"Endo Y., Yamashita K., Tachibana Y., Tojo S., Kobata A. Structures of the asparagine-linked sugar chains of human chorionic gonadotropin. J. Biochem. (Tokyo) 85: 669, 1979.","journal-title":"J. Biochem. (Tokyo)"},{"key":"BF03349456_CR6","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1677\/joe.0.0560441","volume":"56","author":"A Pala","year":"1973","unstructured":"Pala A., Meirinho M., Benagiano G. Purification and properties of chorionic gonadotropin from trophoblastic tissue, urine and plasma of a patient with hydatidiform mole. J. Endocrinol. 56: 441, 1973.","journal-title":"J. Endocrinol."},{"key":"BF03349456_CR7","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/S0021-9258(17)34182-0","volume":"254","author":"YM Choy","year":"1979","unstructured":"Choy Y.M., Lau K.M., Lee C.Y. Purification and characterization of urinary choriogonadotropin from patients with hydatidiform mole. J. Biol. Chem. 254: 1159, 1979.","journal-title":"J. Biol. Chem."},{"key":"BF03349456_CR8","doi-asserted-by":"crossref","first-page":"39","DOI":"10.7326\/0003-4819-78-1-39","volume":"78","author":"GD Braunstein","year":"1973","unstructured":"Braunstein G.D., Vaitukaitis J.L., Carbone P.P., Ross G.T. Ectopic production of human chorionic gonadotropin by neoplasms. Ann. Intern. Med. 78: 39, 1973.","journal-title":"Ann. Intern. Med."},{"key":"BF03349456_CR9","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1210\/jcem-37-4-505","volume":"37","author":"JL Vaitukaitis","year":"1973","unstructured":"Vaitukaitis J.L. Immunologic and physical characterisation of hCG secreted by tumor. J. Clin. Endocrinol. Metab. 37: 505, 1973.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03349456_CR10","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/0014-2964(78)90255-4","volume":"14","author":"M Dosogne-Gu\u00e9rin","year":"1978","unstructured":"Dosogne-Gu\u00e9rin M., Stolarczyk A., Borkowski A. Prospective study of the \u03b1 and \u03b2 subunits of human chorionic gonadotropin in the blood of patients with various benign and malignant conditions. Eur. J. Cancer 14: 525, 1978.","journal-title":"Eur. J. Cancer"},{"key":"BF03349456_CR11","unstructured":"Borth R., Lunnenfeld B., Menzi A. Comparison of Kaolin-acetone methods. In: Albert A. (Ed.), Human pituitary gonadotropins. Charles C. Thomas, Springfield, p. 13."},{"key":"BF03349456_CR12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/jcem-21-1-1","volume":"21","author":"A Albert","year":"1961","unstructured":"Albert A., Kobi J., Leiferman J., Derner I. Purification of pituitary gonadotropin from urine of normal men. J. Clin. Endocrinol. Metab. 21: 1, 1961.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03349456_CR13","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the folin phenol reagents. J. Biol. Chem. 193: 265, 1951.","journal-title":"J. Biol. Chem."},{"key":"BF03349456_CR14","first-page":"65","volume":"2","author":"ML Wolfrom","year":"1962","unstructured":"Wolfrom M.L., Thompson A. In: Wistler R.L., Wolfrom M.L., BeMiller J.N. (Eds.), Methods in carbohydrate chemistry. Academic Press, New York, 1962, Vol. 2, p. 65.","journal-title":"Methods in carbohydrate chemistry"},{"key":"BF03349456_CR15","unstructured":"Crimmin W.R.C. 2-acetamide-2-deoxy-D-galactitol(N-acetyl-D-galactosaninol). J. Chem. Soc. (Perkin I) 2838, 1957."},{"key":"BF03349456_CR16","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1016\/S0021-9258(18)69851-5","volume":"234","author":"L Warren","year":"1959","unstructured":"Warren L. The thiobarbituric acid assay of sialic acids. J. Biol. Chem. 234: 1971, 1959.","journal-title":"J. Biol. Chem."},{"key":"BF03349456_CR17","doi-asserted-by":"crossref","first-page":"4406","DOI":"10.1016\/S0021-9258(18)94333-4","volume":"244","author":"K Weber","year":"1969","unstructured":"Weber K., Osbom M. The reliability of molecular weight determinations by dodecyl sulfate-Polyacrylamide gel electrophoresis. J. Biol. Chem. 244: 4406, 1969.","journal-title":"J. Biol. Chem."},{"key":"BF03349456_CR18","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1210\/jcem-34-1-23","volume":"34","author":"Y Miyachi","year":"1972","unstructured":"Miyachi Y., Vaitukaitis J.L., Nieschlag E., Lipsett M.B. Enzymatic radioiodination of gonadotropins. J. Clin. Endocrinol. Metab. 34: 23, 1972.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03349456_CR19","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1507\/endocrj1954.21.429","volume":"21","author":"Y Ashitaka","year":"1974","unstructured":"Ashitaka Y., Nishimura R., Endo Y., Tojo S. Subunits of human chorionic gonadotropin and their radioimmunoassays. Endocrinol. Jpn. 21: 429, 1974.","journal-title":"Endocrinol. Jpn."},{"key":"BF03349456_CR20","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/0006-291X(70)91026-0","volume":"40","author":"N Swaminathan","year":"1970","unstructured":"Swaminathan N., Bahl O.P. Dissociation and recombination of the subunits of human chorionic gonadotropin. Biochem. Biophys. Res. Commun. 40: 422, 1970.","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BF03349456_CR21","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1210\/jcem-34-1-123","volume":"34","author":"KJ Catt","year":"1972","unstructured":"Catt K.J., Dufau M.L., Tsuruhara T. Radioligand-receptor assay of lutenizing hormone and chorionic gonadotropin. J. Clin. Endocrinol. Metab. 34: 123, 1972.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03349456_CR22","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1210\/endo-87-2-233","volume":"87","author":"Y Ashitaka","year":"1970","unstructured":"Ashitaka Y., Tokura Y., Tane M., Mochizuki M., Tojo S. Studies on the biological properties of highly purified hCG. Endocrinology 87: 233, 1970.","journal-title":"Endocrinology"},{"key":"BF03349456_CR23","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1210\/jcem-24-2-197","volume":"24","author":"J Lewis Jr.","year":"1964","unstructured":"Lewis J. Jr., Dray S., Genuth S., Schwartz H.S. Determination of immunological similarities of human pregnancy gonadotropin and choriocarcinoma gonadotropin with antisera prepared in rabbits and monkeys. J. Clin. Endocrinol. Metab. 24: 197, 1964.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03349456_CR24","first-page":"121","volume":"27","author":"RE Canfield","year":"1971","unstructured":"Canfield R.E., Morgan F.J., Kammerman S., Bell J.J., Agosto G.M. Studies of human chorionic gonadotropin. Recent Prog. Horm. Res. 27: 121, 1971.","journal-title":"Recent Prog. Horm. Res."},{"key":"BF03349456_CR25","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1210\/endo-88-4-1045","volume":"88","author":"FJ Morgan","year":"1971","unstructured":"Morgan F.J., Canfield R.E. Nature of the subunits of human chorionic gonadotropin. Endocrinology 88: 1045, 1971.","journal-title":"Endocrinology"},{"key":"BF03349456_CR26","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1210\/endo-92-4-1034","volume":"92","author":"LE Reichert Jr.","year":"1973","unstructured":"Reichert L.E. Jr., Lawson G.M. Jr. Molecular weight relationships among the subunits of human glycoprotein hormones. Endocrinology 92: 1034, 1973.","journal-title":"Endocrinology"},{"key":"BF03349456_CR27","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/B978-0-12-508850-3.50015-1","volume-title":"Gonadotropins and gonadal function","author":"PK Chan","year":"1974","unstructured":"Chan P.K., Lee C.Y., Ma L. Purification and characterization of human chorionic gonadotropin in hydatidiform mole. In: Moudgal N.R. (Ed.), Gonadotropins and gonadal function. Academic Press New York, 1974, p. 93."},{"key":"BF03349456_CR28","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1515\/bchm2.1974.355.2.1035","volume":"355","author":"WE Merz","year":"1974","unstructured":"Merz W.E., Hilgenfeld U., Dorner M., Brossmer K. Biological, immunological and physical investigations on human chorionic gonadotropin. Hoppe Seylers Z. Physiol. Chem. 355: 1035, 1974.","journal-title":"Hoppe Seylers Z. Physiol. Chem."},{"key":"BF03349456_CR29","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1210\/endo-98-5-1220","volume":"98","author":"TD Landefeld","year":"1976","unstructured":"Landefeld T.D., Boguslawski S., Corash L., Boime I. The cell-free synthesis of the \u03b1 subunit of human chorionic gonadotropin. Endocrinology 98: 1220, 1976.","journal-title":"Endocrinology"},{"key":"BF03349456_CR30","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/0006-3002(60)90477-7","volume":"43","author":"RA Reisfeld","year":"1960","unstructured":"Reisfeld R.A., Hertz R. Purification of chorionic gonadotropin from the urine of patients with trophoblastic tumors. Biochim. Biophys. Acta 43: 540, 1960.","journal-title":"Biochim. Biophys. Acta"},{"key":"BF03349456_CR31","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1210\/jcem-33-1-145","volume":"33","author":"WE Bridson","year":"1971","unstructured":"Bridson W.E., Ross G.T., Kohier P.O. Immunologic and biologic activity of chorionic gonadotropin synthesized by cloned choriocarcinoma cells in culture. J. Clin. Endocrinol. Metab. 33: 145, 1971.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03349456_CR32","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1210\/endo-89-3-801","volume":"89","author":"JM Hammond","year":"1971","unstructured":"Hammond J.M., Bridson W.E., Kohier P.O., Chrambach A. Physical characteristics of immunoreactive chorionic gonadotropin produced in culture. Endocrinology 89: 801, 1971.","journal-title":"Endocrinology"},{"key":"BF03349456_CR33","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/S0006-291X(71)80188-2","volume":"44","author":"ML Dufau","year":"1971","unstructured":"Dufau M.L., Catt K.J., Tsuruhara T. Retention of in vitro biological activities by desialylated human lutenizing hormone and chorionic gonadotropin. Biochem. Biophys. Res. Commun. 44: 1022, 1971.","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BF03349456_CR34","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1210\/endo-91-2-463","volume":"91","author":"T Tsuruhara","year":"1972","unstructured":"Tsuruhara T., Van Hall E.V., Dufau M.L., Catt K.J. Ovarian binding of intact and desialylated hCG in vivo and in vitro. Endocrinology 91: 463, 1972.","journal-title":"Endocrinology"},{"key":"BF03349456_CR35","volume-title":"Human chorionic gonadotropin. Its physiochemical, immunological and biological properties","author":"S Tojo","year":"1968","unstructured":"Tojo S. Human chorionic gonadotropin. Its physiochemical, immunological and biological properties. Report on the theme commissioned by Japanese Obstetrical and Gynecological Society. Tokyo, March, 1968."},{"key":"BF03349456_CR36","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1210\/endo-89-1-11","volume":"89","author":"EV Hall Van","year":"1971","unstructured":"Van Hall E.V., Vaitukaitis J.L., Ross G.T. Disappearance of immunoreactive hCG from plasma in rats. Endocrinology 89: 11, 1971.","journal-title":"Endocrinology"},{"key":"BF03349456_CR37","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1530\/acta.0.0900349","volume":"90","author":"J Odink","year":"1979","unstructured":"Odink J., Brand E.C., Van Hall E.V. Ovarian binding and intrinsic biological activity of desialylated human chorionic gonadotropin (asialo-hCG) in immature superovulated rats. Acta Endocrinol. (Kbh.) 90: 349, 1979.","journal-title":"Acta Endocrinol. (Kbh.)"},{"key":"BF03349456_CR38","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/S0021-9258(19)76994-4","volume":"246","author":"AG Moreli","year":"1971","unstructured":"Moreli A.G., Gregoriadis G., Schneinberg H., Hickman J., Ashwell G. The role of sialic acid in determining the survival of glycoprotein in the circulation. J. Biol. Chem. 246: 1461, 1971.","journal-title":"J. Biol. Chem."},{"key":"BF03349456_CR39","doi-asserted-by":"crossref","first-page":"9163","DOI":"10.1016\/S0021-9258(19)40704-7","volume":"250","author":"WR Moyle","year":"1975","unstructured":"Moyle W.R., Bahl O.P., M\u00e4rz L. Role of carbohydrate of human chorionic gonadotropin in the mechanism of hormone action. J. Biol. Chem. 250: 9163, 1975.","journal-title":"J. Biol. Chem."},{"key":"BF03349456_CR40","first-page":"2119","volume":"36","author":"OP Bahl","year":"1977","unstructured":"Bahl O.P. Human chorionic gonadotropin, its receptor and mechanism of action. Fed. Proc. 36: 2119, 1977.","journal-title":"Fed. Proc."},{"key":"BF03349456_CR41","first-page":"27","volume-title":"Choriocarcinoma and related gestational trophoblastic tumors in women","author":"R Hertz","year":"1978","unstructured":"Hertz R. Choriocarcinoma and related gestational trophoblastic tumors in women. Raven Press, New York, 1978, p. 27."},{"key":"BF03349456_CR42","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0065-3233(08)60451-9","volume":"27","author":"RG Spiro","year":"1973","unstructured":"Spiro R.G. Glycoproteins. Adv. Protein Chem. 27: 349, 1973.","journal-title":"Adv. Protein Chem."},{"key":"BF03349456_CR43","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1146\/annurev.bi.45.070176.000523","volume":"45","author":"CJ Waechter","year":"1976","unstructured":"Waechter C.J., Lennarz W.J. The role of polyprenol-linked sugars in glycoprotein synthesis. Annu. Rev. Biochem. 45: 95, 1976.","journal-title":"Annu. Rev. Biochem."},{"key":"BF03349456_CR44","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/236147a0","volume":"236","author":"PJ Winterburn","year":"1972","unstructured":"Winterburn P.J., Phelps G.F. The significance of glycosylated proteins. Nature 236: 147, 1972.","journal-title":"Nature"},{"key":"BF03349456_CR45","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1073\/pnas.59.1.254","volume":"59","author":"S Hakomori","year":"1968","unstructured":"Hakomori S., Murakami W.T. Glycolipids of hamster fibroblast and derived malignant-transformed cell-lines. Proc. Natl. Acad. Sci. USA 59: 254, 1968.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BF03349456_CR46","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1021\/bi00834a038","volume":"8","author":"HC Wu","year":"1969","unstructured":"Wu H.C., Meezan E., Black P.H., Robbins P.W. Comparative studies on the carbohydrate-containing membrane component of normal and virus-transformed mouse fibroblasts. Glucosamine-labeling patterns in 3T3, spontaneously transformed 3T3, and SV-40-transformed 3T3 cells. Biochemistry 8: 2509, 1969.","journal-title":"Biochemistry"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03349456.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF03349456\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03349456","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T04:12:22Z","timestamp":1648786342000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF03349456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,7]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1981,7]]}},"alternative-id":["BF03349456"],"URL":"https:\/\/doi.org\/10.1007\/bf03349456","relation":{},"ISSN":["0391-4097","1720-8386"],"issn-type":[{"value":"0391-4097","type":"print"},{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,7]]}}}