{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T17:46:52Z","timestamp":1774547212531,"version":"3.50.1"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1995,1,1]],"date-time":"1995-01-01T00:00:00Z","timestamp":788918400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"published-print":{"date-parts":[[1995,1]]},"DOI":"10.1007\/bf03349694","type":"journal-article","created":{"date-parts":[[2014,4,10]],"date-time":"2014-04-10T15:05:01Z","timestamp":1397142301000},"page":"35-40","source":"Crossref","is-referenced-by-count":55,"title":["Natural course of subclinical hypothyroidism in Down\u2019s syndrome: Prospective study results and therapeutic considerations"],"prefix":"10.1007","volume":"18","author":[{"given":"D.","family":"Rubello","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. B.","family":"Pozzan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Casara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. E.","family":"Girelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Boccato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Rigon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Baccichetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Piccolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Betterle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedetto","family":"Busnardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,4,9]]},"reference":[{"key":"BF03349694_CR1","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1016\/S0140-6736(75)90645-5","volume":"2","author":"RH Davis","year":"1975","unstructured":"Davis R.H., Pitkow H.S., Hill H.G. Down syndrome and thyroid function. Lancet 2: 1308, 1975.","journal-title":"Lancet"},{"key":"BF03349694_CR2","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.1399-0004.1978.tb02121.x","volume":"14","author":"Z Sare","year":"1978","unstructured":"Sare Z., Ruvalcaba R.H.A., Kelley V.C. Prevalence of thyroid disorder in Down syndrome. Clin. Genet. 14: 154, 1978.","journal-title":"Clin. Genet."},{"key":"BF03349694_CR3","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1136\/bmj.280.6226.1253","volume":"1280","author":"ED Lobo","year":"1980","unstructured":"Lobo E.D., Knan M., Tews J. Community study of hypothyroidism in Down\u2019s syndrome. Br. Med. J. 1280: 1253, 1980.","journal-title":"Br. Med. J."},{"key":"BF03349694_CR4","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1136\/bmj.302.6777.628","volume":"302","author":"JG Thorpe-Beeson","year":"1991","unstructured":"Thorpe-Beeson J.G., Nicolaides K.M., Ewins D.L., Gosden C.M., McGregor A.M. Thyroid function in fetuses with chromosomal abnormalities. Br. Med. J. 302: 628, 1991.","journal-title":"Br. Med. J."},{"key":"BF03349694_CR5","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1365-2265.1992.tb01475.x","volume":"37","author":"RL Kennedy","year":"1992","unstructured":"Kennedy R.L., Jones T.H., Cuckle H.S. Down\u2019s syndrome and the thyroid. Clin. Endocrinol. (Oxf.) 37: 471, 1992.","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"BF03349694_CR6","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/ajmg.1320360205","volume":"36","author":"ME Percy","year":"1990","unstructured":"Percy M.E., Dalton A.J., Mercovic V.D., McLachlan D.R.C., Gera E., Hummel J.T., Rusk A.C.M., Somerville M.J., Andrews D.F., Walfish P.G. Autoimmune thyroiditis associated with mild \u201csubclinical\u201d hypothyroidism in adults with Down syndrome: a comparison of patients with and without manifestations of Alzheimer disease. Am. J. Med. Genet. 36: 148, 1990.","journal-title":"Am. J. Med. Genet."},{"key":"BF03349694_CR7","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/BF00493546","volume":"127","author":"GR Burgio","year":"1978","unstructured":"Burgio G.R., Ugazio A.G. Immunity in Down\u2019s syndrome. Eur. J. Pediatrics 127: 293, 1978.","journal-title":"Eur. J. Pediatrics"},{"key":"BF03349694_CR8","first-page":"636","volume":"139","author":"SM Pueschel","year":"1985","unstructured":"Pueschel S.M. Pezzullo J.C. Thyroid dysfunction in Down\u2019s syndrome. AJDC 139: 636, 1985.","journal-title":"Thyroid dysfunction in Down\u2019s syndrome. AJDC"},{"key":"BF03349694_CR9","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1365-2265.1992.tb01453.x","volume":"36","author":"AP Weetman","year":"1992","unstructured":"Weetman A.P. Autoimmune thyroiditis: predisposition and pathogenesis. Clin. Endocrinol. (Oxf.) 36: 307, 1992.","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"BF03349694_CR10","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1530\/acta.0.1140321","volume":"114","author":"C Betterle","year":"1987","unstructured":"Betterle C., Callegari G., Presotto F., Zanette F., Pedini B., Rampazzo T., Slack R.S., Girelli M.E., Busnardo B. Thyroid autoantibodies: a good marker for the study of symptomless autoimmune thyroiditis. Acta Endocrinol. (Copenh.) 114: 321, 1987","journal-title":"Acta Endocrinol. (Copenh.)"},{"key":"BF03349694_CR11","first-page":"172","volume":"145","author":"T Sharav","year":"1991","unstructured":"Sharav T., Landau H., Zadik Z., Einerson T.R. Age-related patterns of thyroid-stimulating hormone response to thyrotropin-releasing hormone stimulation in Down syndrome. AJDC 145: 172, 1991.","journal-title":"AJDC"},{"key":"BF03349694_CR12","first-page":"451","volume":"118","author":"RHA Ruvalcaba","year":"1969","unstructured":"Ruvalcaba R.H.A., Ferrier P.E., Thuline H.C. Incidence of goitre in patients with Down\u2019s syndrome. AJDC 118: 451, 1969.","journal-title":"AJDC"},{"key":"BF03349694_CR13","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0009-8981(88)90326-9","volume":"172","author":"JJ Series","year":"1988","unstructured":"Series J.J., Biggart E.M., O\u2019Reilly D.S.tJ., Packard C.J., Shepherd J. Thyroid dysfunction and hypercholesterolemia in the general population in Glasgow, Scotland. Clin. Chim. Acta 172: 217, 1988.","journal-title":"Clin. Chim. Acta"},{"key":"BF03349694_CR14","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1001\/archinte.1990.00390210077017","volume":"150","author":"R Arem","year":"1990","unstructured":"Arem R., Patsch W. Lipoprotein and apolipoprotein levels in subclinical hypothyroidism. Arch. Intern. Med. 150: 2097, 1990.","journal-title":"Arch. Intern. Med."},{"key":"BF03349694_CR15","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/j.1365-2265.1990.tb03889.x","volume":"33","author":"P Caron","year":"1990","unstructured":"Caron P., Calazel C., Parra H.J., Hoff M., Louvet J.P. Decreased HDL cholesterol in subclinical hypothyroidism: the effect of L-thyroxine therapy. Clin. Endocrinol. (Oxf.) 33: 519, 1990.","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"BF03349694_CR16","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2190\/ADLY-1UU0-1A8L-HPXY","volume":"20","author":"JJ Haggerty","year":"1990","unstructured":"Haggerty J.J., Garbutt J.C., Evans D.L., Golden R.N., Pedersen C., Simon J.S., Nemeroff C.B. Subclinical hypothyroidism: a review of neuropsy-chiatric aspects. Int. J. Psychiatry Med. 20: 193, 1990.","journal-title":"Int. J. Psychiatry Med."}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03349694.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF03349694\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03349694","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T07:48:00Z","timestamp":1565336880000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF03349694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1995,1]]}},"alternative-id":["BF03349694"],"URL":"https:\/\/doi.org\/10.1007\/bf03349694","relation":{},"ISSN":["0391-4097","1720-8386"],"issn-type":[{"value":"0391-4097","type":"print"},{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,1]]}}}