{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T05:15:12Z","timestamp":1761110112640},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[1998,10,1]],"date-time":"1998-10-01T00:00:00Z","timestamp":907200000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"published-print":{"date-parts":[[1998,10]]},"DOI":"10.1007\/bf03350786","type":"journal-article","created":{"date-parts":[[2014,4,10]],"date-time":"2014-04-10T23:04:42Z","timestamp":1397171082000},"page":"613-617","source":"Crossref","is-referenced-by-count":19,"title":["How possible is the prevention of polycystic ovary syndrome development in adolescent patients with early onset of hyperandrogenism"],"prefix":"10.1007","volume":"21","author":[{"given":"Dan","family":"Apter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,4,11]]},"reference":[{"key":"BF03350786_CR1","unstructured":"Huffman J.W. Polycystic ovaries in young girls. Proceedings of the III International Symposium on Pediatric and Adolescent Gynecology, 1976, p. 193."},{"key":"BF03350786_CR2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1365-2265.1980.tb02132.x","volume":"12","author":"SSC Yen","year":"1980","unstructured":"Yen S.S.C. The polycystic ovary syndrome. Clin. Endocrinol. 12: 177, 1980.","journal-title":"Clin. Endocrinol."},{"key":"BF03350786_CR3","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0015-0282(16)59294-2","volume":"48","author":"S Venturoli","year":"1987","unstructured":"Venturoli S., Porcu E., Fabbri R., Magrini O., Paradisi R., Pallotti G., Gammi L., Flamigni C. Postmenarcheal evolution of endocrine pattern and ovarian aspects in adolescents with menstrual irregularities. Fertil. Steril. 48: 78, 1987.","journal-title":"Fertil. Steril."},{"key":"BF03350786_CR4","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/S0015-0282(16)49824-9","volume":"46","author":"R Siegberg","year":"1986","unstructured":"Siegberg R., Nilsson C.G., Stenman U.-H., Widholm O. Endocrinologic features of oligomenorrheic adolescent girls. Fertil. Steril. 46: 852, 1986.","journal-title":"Fertil. Steril."},{"key":"BF03350786_CR5","first-page":"119","volume":"79","author":"D Apter","year":"1994","unstructured":"Apter D., B\u00fctzow T.L., Laughlin G.A., Yen S.S.C. Accelerated 24-hour luteinizing hormone pulsatile activity in adolescent girls with ovarian hyperandrogenism: Relevance to the developmental phase of polycystic ovarian syndrome. J. Clin. Endocrinol. Metab. 79: 119, 1994.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03350786_CR6","first-page":"2966","volume":"80","author":"D Apter","year":"1995","unstructured":"Apter D., B\u00fctzow T., Laughlin G.A., Yen S.S.C. Metabolic features of polycystic ovary syndrome are found in adolescent girls with hyperandrogenism. J. Clin. Endocrinol. Metab. 80: 2966, 1995.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03350786_CR7","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3109\/09513599309152512","volume":"7","author":"B G\u00fclekli","year":"1993","unstructured":"G\u00fclekli B., Turhan N.\u00d6., Sen\u00f6z S., K\u00fckner S., Oral H., G\u00f6kmen O. Endocrinological, ultrasonographic and clinical findings in adolescent and adult polycystic ovary patients: a comparative study. Gynecol. Endocrinol. 7: 273, 1993.","journal-title":"Gynecol. Endocrinol."},{"key":"BF03350786_CR8","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S1083-3188(97)70072-X","volume":"10","author":"V Dramusic","year":"1997","unstructured":"Dramusic V., Goh V.H., Rajan U., Wong Y.C., Ratnam S.S. Clinical, endocrinologie, and ultrasonographic features of polycystic ovary syndrome in Singaporean adolescents. J. Pediatr. Adolesc. Gynecol. 10: 125, 1997.","journal-title":"J. Pediatr. Adolesc. Gynecol."},{"key":"BF03350786_CR9","doi-asserted-by":"crossref","first-page":"599","DOI":"10.3109\/00016349209006227","volume":"71","author":"E Dahlgren","year":"1992","unstructured":"Dahlgren E., Janson P., Johansson S., Lapidus L., Oden A. Polycystic ovary syndrome and risk for myocardial infarction. Evaluated from a risk factor model based on a prospective population study of women. Acta Obstet. Gynecol. Scand. 71: 599, 1992.","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"BF03350786_CR10","first-page":"1599","volume":"76","author":"L Ib\u00e1\u00f1ez","year":"1993","unstructured":"Ib\u00e1\u00f1ez L., Potau N., Virdis R., Zampolli M., Terzi C., Gussinye M., Carrascosa A., Vicens C.E. Postpubertal outcome in girls diagnosed of premature pubarche during childhood: increased frequency of functional ovarian hyperandrogenism. J. Clin. Endocrinol. Metab. 76: 1599, 1993.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03350786_CR11","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0015-0282(97)81396-9","volume":"67","author":"L Ib\u00e1\u00f1ez","year":"1997","unstructured":"Ib\u00e1\u00f1ez L., Potau N., Zampolli M., Street M.E., Carrascosa A. Girls diagnosed with premature pubarche show an exaggerated ovarian androgen synthesis from the early stages of puberty: evidence from gonadotropin-releasing hormone agonist testing. Fertil. Steril. 67: 849, 1997.","journal-title":"Fertil. Steril."},{"key":"BF03350786_CR12","first-page":"2283","volume":"82","author":"L Ib\u00e1\u00f1ez","year":"1997","unstructured":"Ib\u00e1\u00f1ez L., Potau N., Zampolli M., Rique S., Saenger P., Carrascosa A. Hyperinsulinemia and decreased insulin-like growth factor-binding protein-1 are common features in prepubertal and pubertal girls with a history of premature pubarche. J. Clin. Endocrinol. Metab. 82: 2283, 1997.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03350786_CR13","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1007\/BF02072100","volume":"154","author":"A Pere","year":"1995","unstructured":"Pere A., Perheentupa J., Peter M., Voutilainen R. Follow-up of growth and steroids in premature adrenarche. Eur. J. Pediatr. 154: 346, 1995.","journal-title":"Eur. J. Pediatr."},{"key":"BF03350786_CR14","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0022-3476(87)80522-X","volume":"110","author":"CA Bloch","year":"1987","unstructured":"Bloch C.A., Clemons P., Sperling M.A. Puberty decreases insulin sensitivity. J. Pediatr. 110: 481, 1987.","journal-title":"J. Pediatr."},{"key":"BF03350786_CR15","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1651-2227.1990.tb11489.x","volume":"79","author":"F Lindgren","year":"1990","unstructured":"Lindgren F., Dahlquist G., Efendic S., Persson B., Skottner A. Insulin sensitivity and glucose-induced insulin response changes during adolescence. Acta Paediatr. Scand. 79: 431, 1990.","journal-title":"Acta Paediatr. Scand."},{"key":"BF03350786_CR16","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0022-3476(85)80182-7","volume":"107","author":"GE Richards","year":"1985","unstructured":"Richards G.E., Cavallo A., Meyer III W.J., Prince M.J., Peters E.J., Stuart C.A., Smith E.R. Obesity, acanthosis nigricans, insulin resistance, and hyperandrogenemia: Pediatric perspective and natural history. J. Pediatr. 107: 893, 1985.","journal-title":"J. Pediatr."},{"key":"BF03350786_CR17","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1210\/jcem-72-6-1308","volume":"72","author":"TJ DeClue","year":"1991","unstructured":"DeClue T.J., Shah S.C., Marchese M., Malone J.I. Insulin resistance and hyperinsulinemia induce hyperandrogenism in a young type B insulin-resistant female. J. Clin. Endocrinol. Metab. 72: 1308, 1991.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03350786_CR18","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1365-2265.1992.tb02909.x","volume":"36","author":"DS Kiddy","year":"1992","unstructured":"Kiddy D.S., Hamilton-Fairley D., Bush A., Short F., Anyaoku V., Reed M.J., Franks S. Improvement in endocrine and ovarian function during dietary treatment of obese women with polycystic ovary syndrome. Clin. Endocrinol. 36: 105, 1992.","journal-title":"Clin. Endocrinol."},{"key":"BF03350786_CR19","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1210\/jcem-68-1-173","volume":"68","author":"R Pasquali","year":"1989","unstructured":"Pasquali R., Antenucci D., Casimirri F., Venturoli S., Paradisi R., Fabbri R., Balestra V. Clinical and hormonal characteristics of obese ame-norrheic hyperandrogenic women before and after weight loss. J. Clin. Endocrinol. Metab. 68: 173, 1989.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03350786_CR20","first-page":"940","volume":"76","author":"D Apter","year":"1993","unstructured":"Apter D., B\u00fctzow T.L., Laughlin G.A., Yen S.S.C. GnRH pulse generator activity during pubertal transition in girls: Pulsatile and diurnal patterns of circulating gonadotropins. J. Clin. Endocrinol. Metab. 76: 940, 1993.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03350786_CR21","first-page":"3728","volume":"82","author":"A Arroyo","year":"1997","unstructured":"Arroyo A., Laughlin G.A., Morales A.J., Yen S.S. Inappropriate gonadotropin secretion in polycystic ovary syndrome: influence of adiposity. J. Clin. Endocrinol. Metab. 82: 3728, 1997.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03350786_CR22","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0010-7824(87)90048-5","volume":"35","author":"R Siegberg","year":"1987","unstructured":"Siegberg R., Nilsson C.G., Stenman U.-H., Widholm O. The effect of oral contraceptives on hormonal profiles of oligomenorrheic adolescent cycles. Contraception 35: 29, 1987.","journal-title":"Contraception"},{"key":"BF03350786_CR23","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1210\/jcem-71-4-970","volume":"71","author":"D Apter","year":"1990","unstructured":"Apter D., Vihko R. Endocrine determinants of fertility: Serum androgen concentrations during follow-up of adolescents into the third decade of life. J. Clin. Endocrinol. Metab. 71: 970, 1990.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03350786_CR24","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0932-8610(12)80084-3","volume":"4","author":"B Cacciatore","year":"1991","unstructured":"Cacciatore B., Apter D., Alfthan H., Stenman U.-H. Ultrasonic characteristics of the uterus and ovaries in relation to pubertal development and serum LH, FSH and estradiol concentrations. Adolesc. Pediatr. Gynecol. 4: 15, 1991.","journal-title":"Adolesc. Pediatr. Gynecol."},{"key":"BF03350786_CR25","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/S0015-0282(16)59184-5","volume":"47","author":"R Stanhope","year":"1987","unstructured":"Stanhope R., Adams J., Pringle J.P., Jacobs H.S., Brook C.G. The evolution of polycystic ovaries in a girl with hypogonadotropic hypogonadism before puberty and during puberty induced with pulsatile gonadotropin-releasing hormone. Fertil. Steril. 47: 872, 1987.","journal-title":"Fertil. Steril."},{"key":"BF03350786_CR26","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1365-2265.1995.tb01853.x","volume":"42","author":"NA Bridges","year":"1995","unstructured":"Bridges N.A., Cooke A., Healy M.J., Hindmarsh P.C., Brook C.G. Ovaries in sexual precocity. Clin. Endocrinol. 42: 135, 1995.","journal-title":"Clin. Endocrinol."},{"key":"BF03350786_CR27","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0022-3476(98)70493-7","volume":"132","author":"AM Jensen","year":"1998","unstructured":"Jensen A.M., Brocks V., Holm K., Laursen E.M., Muller J. Central precocious puberty in girls: internal genitalia before, during, and after treatment with long-acting gonadotropin-releasing hormone analogues. J. Pediatr. 132: 105, 1998.","journal-title":"J. Pediatr."},{"key":"BF03350786_CR28","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1097\/00008480-199408000-00006","volume":"6","author":"S Venturoli","year":"1994","unstructured":"Venturoli S., Porcu E., Flamigni C. Polycystic ovary syndrome. Curr. Opin. Pediatr. 6: 388, 1994.","journal-title":"Curr. Opin. Pediatr."},{"key":"BF03350786_CR29","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1210\/jcem-47-5-944","volume":"47","author":"D Apter","year":"1978","unstructured":"Apter D., Viinikka L., Vihko R. Hormonal pattern of adolescent menstrual cycles. J. Clin. Endocrinol. Metab. 47: 944, 1978.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03350786_CR30","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/0002-9378(66)90398-X","volume":"94","author":"AL Southam","year":"1966","unstructured":"Southam A.L., Richart R.M. The prognosis for adolescents with menstrual abnormalities. Am. J. Obstet. Gynecol. 94: 637, 1966.","journal-title":"Am. J. Obstet. Gynecol."}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03350786.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF03350786\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03350786","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T10:52:18Z","timestamp":1558522338000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF03350786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,10]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1998,10]]}},"alternative-id":["BF03350786"],"URL":"https:\/\/doi.org\/10.1007\/bf03350786","relation":{},"ISSN":["0391-4097","1720-8386"],"issn-type":[{"value":"0391-4097","type":"print"},{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,10]]}}}