{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T21:28:48Z","timestamp":1783632528056,"version":"3.55.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[1998,11,1]],"date-time":"1998-11-01T00:00:00Z","timestamp":909878400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"published-print":{"date-parts":[[1998,11]]},"DOI":"10.1007\/bf03350799","type":"journal-article","created":{"date-parts":[[2014,4,12]],"date-time":"2014-04-12T16:54:52Z","timestamp":1397321692000},"page":"688-693","source":"Crossref","is-referenced-by-count":28,"title":["Bone mineral density and circulating cytokines in patients with acromegaly"],"prefix":"10.1007","volume":"21","author":[{"given":"S.","family":"Longobardi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Di Somma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Di Relia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Angelillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Ferone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Colao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Merola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Lombardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,4,11]]},"reference":[{"key":"BF03350799_CR1","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1210\/jcem-27-2-178","volume":"27","author":"NH Bell","year":"1967","unstructured":"Bell N.H., Bartter F.C. Studies of 47Ca metabolism in acromegaly. J. Clin. Endocrinol. Metab. 27: 178, 1967.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03350799_CR2","first-page":"1452","volume":"76","author":"S Ezzat","year":"1993","unstructured":"Ezzat S., Melmed S., Endres D., Eyre D.R., Singer F.R. Biochemical assessment of bone formation and resorption in acromegaly. J. Clin. Endocrinol. Metab. 76: 1452, 1993.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03350799_CR3","doi-asserted-by":"crossref","first-page":"567","DOI":"10.7326\/0003-4819-111-7-567","volume":"111","author":"T Diamond","year":"1989","unstructured":"Diamond T., Neri L., Posen S. Spinal and peripheral bone mineral densities in acromegaly: the effects of excess growth hormone and hypogonadism. Ann. Intern. Med. 111: 567, 1989.","journal-title":"Ann. Intern. Med."},{"key":"BF03350799_CR4","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/jbmr.5650080410","volume":"8","author":"H Kotzmann","year":"1993","unstructured":"Kotzmann H., Bernecker P., Hubsch P., Pietschmann P., Woloszczuk P., Svoboda T., Geyer G., Luger A. Bone mineral density and parameters of bone metabolism in patients with acromegaly. J. Bone Miner. Res. 8: 459, 1993.","journal-title":"J. Bone Miner. Res."},{"key":"BF03350799_CR5","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1007\/BF01622293","volume":"7","author":"MJ Kayath","year":"1997","unstructured":"Kayath M.J., Vieira J.G. Osteopenia occurs in a minority of patients with acromegaly and is predominant in the spine. Osteoporos. Int. 7: 226, 1997.","journal-title":"Osteoporos. Int."},{"key":"BF03350799_CR6","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1002\/jbmr.5650070607","volume":"7","author":"DM Black","year":"1992","unstructured":"Black D.M., Cummings S.R., Genant H.K., Nevitt M.C., Palermo L., Browner W. Axial and appendicular bone density predict fractures in older women. J. Bone Miner. Res. 7: 633, 1992.","journal-title":"J. Bone Miner. Res."},{"key":"BF03350799_CR7","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1126\/science.8480174","volume":"260","author":"MC Horowitz","year":"1993","unstructured":"Horowitz M.C. Cytokines and estrogen in bone: anti-osteoporotic effects. Science 260: 626, 1993.","journal-title":"Science"},{"key":"BF03350799_CR8","first-page":"3450","volume":"81","author":"A Grey","year":"1996","unstructured":"Grey A., Mitnick M.A., Shapses S., Ellison A., Gundberg C., Insogna K. Circulating levels of interleukin-6 and tumor necrosis factor-\u03b1 are elevated in primary hyperparathyroidism and correlate with markers of bone resorption. A clinical research center study. J. Clin. Endocrinol. Metab. 81: 3450, 1996.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03350799_CR9","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1159\/000181504","volume":"33","author":"RM Schimpff","year":"1990","unstructured":"Schimpff R.M., Repellin A.M. Production of interleukin-1-alpha and interleukin-2 by mononuclear cells in healthy adults in relation to different experimental conditions and to presence of growth hormone. Horm. Res. 33: 171, 1990.","journal-title":"Horm. Res."},{"key":"BF03350799_CR10","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1210\/endo-128-2-989","volume":"128","author":"CK Edwards","year":"1991","unstructured":"Edwards C.K., Lorence R.M., Dunham D.M., Arkins S., Yunger L.M., Greager J.A., Walter R.J., Dantzer R., Kelley K.W. Hypophysectomy inhibits the synthesis of Tumor necrosis factor-alpha by rat macrophages: Partial restoration by exogenous growth hormone or interferon gamma. Endocrinology 128: 989, 1991.","journal-title":"Endocrinology"},{"key":"BF03350799_CR11","first-page":"2356","volume":"81","author":"A Colao","year":"1996","unstructured":"Colao A., Ferone D., Lastoria S., Marzullo P., Cerbone G., Di Sarno A., Longobardi S., Merola B., Salvatore M., Lombardi G. Prediction of efficacy of Octreotide therapy in patients with acromegaly. J. Clin. Endocrinol. Metab. 81: 2356, 1996.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03350799_CR12","first-page":"1131","volume":"60","author":"FH Doyle","year":"1967","unstructured":"Doyle F.H. Radiology of the skeleton in endocrine disease. Proc. R. Soc. Med. 60: 1131, 1967.","journal-title":"Proc. R. Soc. Med."},{"key":"BF03350799_CR13","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1172\/JCI110570","volume":"69","author":"E Seeman","year":"1982","unstructured":"Seeman E., Wahner H.W., Offord K.P., Kumar R., Johnson W.J., Riggs B.L. Differential effects of endocrine dysfunction on the axial and the appendicular skeleton. J. Clin. Invest. 69: 1302, 1982.","journal-title":"J. Clin. Invest."},{"key":"BF03350799_CR14","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1159\/000179855","volume":"19","author":"C Foresta","year":"1984","unstructured":"Foresta C., Ruzza G., Mioni R., Guarneri G., Gribaldo R., Meneghello A., Mastrogiacomo I. Osteoporosis and decline of gonadal function in the elderly male. Horm. Res. 19: 18, 1984.","journal-title":"Horm. Res."},{"key":"BF03350799_CR15","doi-asserted-by":"crossref","first-page":"605","DOI":"10.7326\/0003-4819-101-5-605","volume":"101","author":"DE Meir","year":"1984","unstructured":"Meir D.E., Orwoll E.S., Jones J.M. Marked disparity between trabecular and cortical bone loss with age in healthy men. Measurement by vertebral computed tomography and radial photon absorptiometry. Ann. Intern. Med. 101: 605, 1984.","journal-title":"Ann. Intern. Med."},{"key":"BF03350799_CR16","first-page":"737","volume":"60","author":"J Auwerx","year":"1986","unstructured":"Auwerx J., Bouillon R. Mineral and bone metabolism in thyroid disease: a review. Q. J. Med. 60: 737, 1986.","journal-title":"Q. J. Med."},{"key":"BF03350799_CR17","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/BF00350200","volume":"15","author":"ML Richardson","year":"1986","unstructured":"Richardson M.L., Pozzi-Mucelli R.S., Kanter A.S., Kolb F.O., Ettinger B., Genant H.K. Bone mineral changes in primary hyperparathyroidism. Skeletal Radiol. 15: 85, 1986.","journal-title":"Skeletal Radiol."},{"key":"BF03350799_CR18","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1365-2265.1991.tb00929.x","volume":"35","author":"AM Parfitt","year":"1991","unstructured":"Parfitt A.M. Growth hormone and adult bone remodelling. Clin. Endocrinol. (Oxf.) 35: 467, 1991.","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"BF03350799_CR19","first-page":"669","volume":"78","author":"SJ Holmes","year":"1994","unstructured":"Holmes S.J., Economou G., Whitehouse R.W., Adams J.E., Shalet S.M. Reduced bone mineral density in patients with adult onset growth hormone deficiency. J. Clin. Endocrinol. Metab. 78: 669, 1994.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03350799_CR20","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1172\/JCI104405","volume":"48","author":"E Eisenberg","year":"1961","unstructured":"Eisenberg E., Gordan G.S. Skeletal dynamics in men measured by nonradioactive stronzium. J. Clin. Invest. 48: 1809, 1961.","journal-title":"J. Clin. Invest."},{"key":"BF03350799_CR21","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1210\/jcem-34-6-911","volume":"34","author":"BL Riggs","year":"1972","unstructured":"Riggs B.L., Randall R.V., Whaner H.W., Jowsey J., Kelly P.J., Singh M. The nature of the metabolic bone disorders in acromegaly. J. Clin. Endocrinol. Metab. 34: 911, 1972.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03350799_CR22","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1530\/acta.0.0970018","volume":"97","author":"J Halse","year":"1981","unstructured":"Halse J., Meisen F., Mosekilde L. Iliac crest bone mass and remodelling in acromegaly. Acta Endocrinol. (Copenh.) 97: 18, 1981.","journal-title":"Acta Endocrinol. (Copenh.)"},{"key":"BF03350799_CR23","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/0006-291X(88)90570-0","volume":"151","author":"M Ernst","year":"1988","unstructured":"Ernst M., Froesch E.R. Growth hormone dependent stimulation of osteoblast-like cells in serum-free cultures via local synthesis of insulin-like growth factor I. Biochem. Biophys. Res. Commun. 151: 142, 1988.","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BF03350799_CR24","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/0006-291X(91)91466-P","volume":"174","author":"BA Scheven","year":"1991","unstructured":"Scheven B.A., Halmiton N.J. Stimulation of macrophage growth and multinucleated cell formation in rat bone marrow cultures by insulin-like growth factor I. Biochem. Biophys. Res. Commun. 174: 647, 1991.","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BF03350799_CR25","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/jbmr.5650070410","volume":"7","author":"KJ Ibbotson","year":"1992","unstructured":"Ibbotson K.J., Orcutt C.M., D\u2019Souza S.M., Paddock C.L., Arthur J.A., Jankowsky M.L., Boyce R.W. Contrasting effect of parathyroid hormone and insulin-like growth factor I in an aged ovariectomized rat model of postmenopausal osteoporosis. J. Bone Miner. Res. 7: 425, 1992.","journal-title":"J. Bone Miner. Res."},{"key":"BF03350799_CR26","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0300-595X(72)80057-4","volume":"1","author":"PJ Bordler","year":"1972","unstructured":"Bordler P.J., Tun Chot S. Quantitative histology of metabolic bone disease. Clin. Endocrinol. Metab. 1: 197, 1972.","journal-title":"Clin. Endocrinol. Metab."},{"key":"BF03350799_CR27","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1210\/endo.130.5.1572280","volume":"130","author":"LR Chaudhary","year":"1992","unstructured":"Chaudhary L.R., Spelsberg T.C., Riggs B.L. Production of various cytokines by normal human osteoblast-like cells in response to interleukin-1beta and tumor necrosis factor-alpha: lack of regulation by 17 beta-estradiol. Endocrinology 130: 2528, 1992.","journal-title":"Endocrinology"},{"key":"BF03350799_CR28","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1126\/science.1621100","volume":"257","author":"RL Jika","year":"1992","unstructured":"Jika R.L., Hangoc G., Girasole G., Passeri G., Williams D.C., Abrams J.S., Boyce B., Broxmeyer H., Manolagas S.C. Increased osteoclast development after estrogen loss: mediation by interleukin-6. Science 257: 88, 1992.","journal-title":"Science"},{"key":"BF03350799_CR29","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/BF01623843","volume":"2","author":"D Rickard","year":"1992","unstructured":"Rickard D., Russell G., Gowen M. Oestradiol inhibits the release of tumor necrosis factor but not interleukin 6 from adult human osteoblasts in vitro. Osteoporos. Int. 2: 94, 1992.","journal-title":"Osteoporos. Int."},{"issue":"Suppl 1","key":"BF03350799_CR30","first-page":"S361","volume":"8","author":"L Rifas","year":"1993","unstructured":"Rifas L., Marcelli M., Kenney J.S., Dawson L., Avioli L.V. IL-6 is not regulated by ovarian steroids in human bone marrow stromal cells and osteoblasts with functional estrogen receptors. J. Bone Miner. Res. 8(Suppl 1): S361, 1993.","journal-title":"J. Bone Miner. Res."}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03350799.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF03350799\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03350799","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T13:07:16Z","timestamp":1565356036000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF03350799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,11]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1998,11]]}},"alternative-id":["BF03350799"],"URL":"https:\/\/doi.org\/10.1007\/bf03350799","relation":{},"ISSN":["0391-4097","1720-8386"],"issn-type":[{"value":"0391-4097","type":"print"},{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,11]]}}}