{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:17:49Z","timestamp":1760955469322},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[1988,11,1]],"date-time":"1988-11-01T00:00:00Z","timestamp":594345600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"published-print":{"date-parts":[[1988,11]]},"DOI":"10.1007\/bf03350940","type":"journal-article","created":{"date-parts":[[2014,4,12]],"date-time":"2014-04-12T14:28:20Z","timestamp":1397312900000},"page":"755-762","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Anti-estrogens and aromatase inhibitors: Tamoxifen and testolactone"],"prefix":"10.1007","volume":"11","author":[{"given":"F.","family":"Sciarra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,4,13]]},"reference":[{"key":"BF03350940_CR1","first-page":"1870","volume":"46","author":"VC Jordan","year":"1987","unstructured":"Jordan V.C., Robinsons S.P. Species-specific pharmacology of anti-estrogens: role of metabolism. Fed. Proc. 46: 1870, 1987.","journal-title":"Fed. Proc."},{"key":"BF03350940_CR2","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/0022-4731(87)90164-6","volume":"27","author":"JR Pasqualini","year":"1987","unstructured":"Pasqualini J.R., Sumida C., Giambiagi N.A., Nguyen B.-L. The complexity of anti-estrogen responses. J. Steroid Biochem. 27: 883, 1987.","journal-title":"J. Steroid Biochem."},{"key":"BF03350940_CR3","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/0022-4731(87)90165-8","volume":"27","author":"RL Sutherland","year":"1987","unstructured":"Sutherland R.L., Watts C.K.W., Hall R.E., Ruenitz P.C. Mechanisms of growth inhibition by nonsteroidal antiestrogens in human breast cancer cells. J. Steroid Biochem. 27: 891, 1987.","journal-title":"J. Steroid Biochem."},{"key":"BF03350940_CR4","first-page":"126","volume":"8","author":"H Rochefort","year":"1987","unstructured":"Rochefort H. Do antiestrogens and antiprogestins act as hormone antagonists or receptor-targeted drugs in breast cancer? T.I.P.S. 8: 126, 1987.","journal-title":"T.I.P.S."},{"key":"BF03350940_CR5","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S0015-0282(16)43160-2","volume":"29","author":"A Vermeulen","year":"1978","unstructured":"Vermeulen A., Comhaire F. Hormonal effects of an antiestrogen, Tamoxifen, in normal and Oligospermic men. Fertil. and Steril., 29: 320, 1978.","journal-title":"Fertil. and Steril."},{"key":"BF03350940_CR6","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0163-7258(84)90043-3","volume":"25","author":"BJA Furr","year":"1984","unstructured":"Furr B.J.A., Jordan V.C. The pharmacology and clinical uses of Tamoxifen. Pharmacol. Ther. 25: 127, 1984.","journal-title":"Pharmacol. Ther."},{"key":"BF03350940_CR7","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3109\/10799898109038795","volume":"2","author":"JC Allegra","year":"1981","unstructured":"Allegra J.C., Korat O., Do H.M.T., Lippman M. The regulation of progesterone receptor by,1 7\u03b2 estradiol and Tamoxifen in the ZR-75-1 human breast cancer cell line in defined medium. J. Receptor Res. 2: 17, 1981.","journal-title":"J. Receptor Res."},{"key":"BF03350940_CR8","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/j.1439-0272.1985.tb01024.x","volume":"17","author":"JMJ Dony","year":"1985","unstructured":"Dony J.M.J., Smals A.G.H., Rolland R., Fauser B.C.J.M., Thomas C.M.G. Effect of lower versus higher doses of Tamoxifen on pituitary-gonadal function and sperm indices in Oligozoospermic men. Andrologia 17: 369, 1985.","journal-title":"Andrologia"},{"key":"BF03350940_CR9","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1439-0272.1985.tb01004.x","volume":"17","author":"W Krause","year":"1985","unstructured":"Krause W., Hubner H.M., Wichmann U. Treatment of oligozoospermia by Tamoxifen: no evidence for direct testicular action. Andrologia 17: 285, 1985.","journal-title":"Andrologia"},{"key":"BF03350940_CR10","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1111\/j.1439-0272.1983.tb00221.x","volume":"15","author":"Ch Danner","year":"1983","unstructured":"Danner Ch., Frick J., Maier F. Results of treatment with Tamoxifen in Oligozoospermie men. Andrologia 15: 584, 1983.","journal-title":"Andrologia"},{"key":"BF03350940_CR11","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1111\/j.1439-0272.1981.tb00087.x","volume":"13","author":"AI Traub","year":"1981","unstructured":"Traub A.I., Thompson W. The effect of Tamoxifen on Spermatogenesis in subfertile men. Andrologia 13: 486, 1981.","journal-title":"Andrologia"},{"key":"BF03350940_CR12","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1439-0272.1987.tb01865.x","volume":"19","author":"DI Lewis-Jones","year":"1987","unstructured":"Lewis-Jones D.I., Lynch R.V., Machin D.C., Desmond A.D. Improvement in semen quality in infertile males after treatment with Tamoxifen. Andrologia 19: 86, 1987.","journal-title":"Andrologia"},{"key":"BF03350940_CR13","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0015-0282(16)59734-9","volume":"49","author":"AR Glass","year":"1988","unstructured":"Glass A.R. Paradoxical suppression of spermatogenesis during Tamoxifen treatment of oligospermia. Fertil. Steril. 49: 376, 1988.","journal-title":"Fertil. Steril."},{"key":"BF03350940_CR14","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/S0015-0282(16)47069-X","volume":"39","author":"J Buvat","year":"1983","unstructured":"Buvat J., Ardaens K., Lemaire A., Gauthier A., Gasnault J.P., Buvat-Herbaut M. Increased sperm count in 25 cases of idiopathic normogonadotropic oligospermia following treatment with Tamoxifen. Fertil. Steril. 39: 700, 1983.","journal-title":"Fertil. Steril."},{"key":"BF03350940_CR15","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0015-0282(16)59299-1","volume":"48","author":"Y AinMelk","year":"1987","unstructured":"AinMelk Y., Belisle S., Carmel M., Tetreault J.-P. Tamoxifen citrate therapy in male infertility. Fertil. Steril. 48: 113, 1987.","journal-title":"Fertil. Steril."},{"key":"BF03350940_CR16","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/0022-4731(88)90130-6","volume":"30","author":"E Petrangeli","year":"1988","unstructured":"Petrangeli E., Sciarra F., Di Silverio F., Toscano V., Concolino C. Effects of two different medical treatment on dihydrotestosterone content and androgen receptors in human benign prostatic hyperplasia. J. Steroid. Biochem. 30: 395, 1988.","journal-title":"J. Steroid. Biochem."},{"key":"BF03350940_CR17","unstructured":"Di Silverio F., Tenaglia R. Anti-oestrogens in oncological urology. In: F. Pannuti (Ed.), Proceedings of the International Symposium, of Hormonotherapy, \u201cAnti Oestrogens in Oncology\u201d, Bologna 1985. Excerpta Medica, Amsterdam, 1985, p. 233."},{"key":"BF03350940_CR18","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/0022-4731(87)90166-X","volume":"27","author":"AMH Brodie","year":"1987","unstructured":"Brodie A.M.H., Coombes R.C., Dowsett M. Aromatase inhibitors: basic and clinical studies. J. Steroid Biochem. 27: 899, 1987.","journal-title":"J. Steroid Biochem."},{"key":"BF03350940_CR19","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/0022-4731(87)90167-1","volume":"27","author":"D Henderson","year":"1987","unstructured":"Henderson D. Aromatase inhibitors: their biochemistry and clinical potential. J. Steroid Biochem. 27: 905, 1987.","journal-title":"J. Steroid Biochem."},{"key":"BF03350940_CR20","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1210\/jcem-60-6-1127","volume":"60","author":"AGH Smals","year":"1985","unstructured":"Smals A.G.H., Dony J.M.J., Smals A.E.M., Pieters G.F.F.M., Hermus A.R.M.M., Boers G.H.J., Benraad Th.J., Kloppenborg P.W.C. Aromatase inhibition by \u03941 -Testolactone does not relieve the gonadotropin-induced late steroidogenic block in normal men. J. Clin. Endocrinol. Metab. 60: 1127, 1985.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03350940_CR21","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1111\/j.1439-0272.1984.tb00414.x","volume":"16","author":"LJG Gooren","year":"1984","unstructured":"Gooren L.J.G., Van der Veen E.A., Van Kessel H., Harmsen-Louman W. Estrogens in the feedback regulation of gonadotropin secretion in men: Effects of administration of estrogen to agonadal subjects and the antiestrogen Tamoxifen and the aromatase inhibitor Testolacton to eugonadal subjects. Andrologia 16: 568, 1984.","journal-title":"Andrologia"},{"key":"BF03350940_CR22","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1530\/acta.0.0970145","volume":"97","author":"R D\u2019Agata","year":"1981","unstructured":"D\u2019Agata R., Vicari E., Aliffi A., Gulizia S., Palumbo G. Direct evidence in men for a role of endogenous oestrogens on gonadotropin release. Acta Endocrinol. (Kbh.) 97: 145, 1981.","journal-title":"Acta Endocrinol. (Kbh.)"},{"key":"BF03350940_CR23","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1210\/jcem-49-5-672","volume":"49","author":"RM Barone","year":"1979","unstructured":"Barone R.M., Shamonki I.M., Siiteri P.K., Judd H.L. Inhibition of peripheral aromatization of androstenedione to estrone in postmenopausal women with breast cancer using Testolactone. J. Clin. Endocrinol. Metab. 49: 672, 1979.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03350940_CR24","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1001\/jama.1973.03220110045012","volume":"223","author":"LS Goldenberg","year":"1973","unstructured":"Goldenberg L.S., Waters M.N., Ravdin R.S., Ansfield F.I., Segaloff A. Androgenic therapy for advanced breast cancer in women. JAMA 223: 1267, 1973.","journal-title":"JAMA"},{"key":"BF03350940_CR25","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/1097-0142(197401)33:1<9::AID-CNCR2820330104>3.0.CO;2-#","volume":"33","author":"H Volk","year":"1974","unstructured":"Volk H., Deupree R.H., Goldenberg L.S., Wilde R.C., Carabasi R.A., Escher G.C. A dose response evaluation of delta-1 -testololactone in advanced breast cancer. Cancer 33: 9, 1974.","journal-title":"Cancer"},{"key":"BF03350940_CR26","first-page":"3387","volume":"42","author":"A Segaloff","year":"1982","unstructured":"Segaloff A. Testololactone: clinical trials. Cancer Res. 42: 3387, 1982.","journal-title":"Cancer Res."},{"key":"BF03350940_CR27","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1439-0272.1986.tb01741.x","volume":"18","author":"JMJ Dony","year":"1986","unstructured":"Dony J.M.J., Smals A.G.H., Rolland R., Fauser B.C.J.M., Thomas CM. Effect of chronic aromatase inhibition by Testolactone in pituitary gonadal function in Oligozoospermie men. Andrologia 18: 69, 1986.","journal-title":"Andrologia"},{"key":"BF03350940_CR28","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1210\/jcem-52-5-897","volume":"52","author":"RA Vigersky","year":"1981","unstructured":"Vigersky R.A., Glass A.R. Effects of testolactone on the pituitary-testicular axis in Oligospermic men. J. Clin. Endocrinol. Metab. 52: 897, 1981.","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF03350940_CR29","first-page":"395","volume":"38","author":"W-B Schill","year":"1987","unstructured":"Schill W.-B., Reiter F., Korting H.C., Schweikert H.-U. Langzeittherapie der Oligozoospermie mit dem aroma-tasehemmer testolakton. Der Hautarzt 38: 395, 1987.","journal-title":"Der Hautarzt"},{"key":"BF03350940_CR30","first-page":"33","volume":"4","author":"RV Clark","year":"1983","unstructured":"Clark R.V., Sherins R.J. Clinical trial of testolactone for treatment of idiopathic male infertility. J. Androl. 4: 33, 1983.","journal-title":"J. Androl."},{"key":"BF03350940_CR31","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1056\/NEJM198610303151802","volume":"315","author":"PP Feuillan","year":"1986","unstructured":"Feuillan P.P., Foster C.M., Pescovitz O.H., Hench K.D., Shawker T., Dwyer A., Malley J.D., Barnes K., Loriaux D.L., Cutler G.B. Treatment of precocious puberty in the McCune-AIbright syndrome with the aromatase inhibitor testolactone. N. Engl. J. Med. 315: 1115, 1986.","journal-title":"N. Engl. J. Med."},{"key":"BF03350940_CR32","first-page":"443","volume":"42","author":"GB Cutler","year":"1986","unstructured":"Cutler G.B., Cassorla F.G., Ross J.D., Pescovitz O.H., Barnes K.M., Comite F., Feuillan P.P., Laue L., Foster C.M., Kenigsberg D., Caruso-Nicoletti M., Garcia H.B., Uriarte M., Hench K.D., Skerda M.C., Long L.M., Loriaux D.L. Pubertal growth: physiology and pathophysiology. Recent Prog. in Horm. Res. 42: 443, 1986.","journal-title":"Recent Prog. in Horm. Res."},{"key":"BF03350940_CR33","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1530\/acta.0.112S218","volume":"279","author":"M Zachmann","year":"1986","unstructured":"Zachmann M., Eiholzer U., Muritano M., Werder E.A., Manella B. Treatment of pubertal gynaecomastia with Testolactone. Acta Endocrinol. 279: 218, 1986.","journal-title":"Acta Endocrinol."},{"key":"BF03350940_CR34","first-page":"87","volume-title":"Regulation of androgen action","author":"UW Tunn","year":"1984","unstructured":"Tunn U.W., Kaivers P., Schweikert H.U. Conservative treatment of human benign prostatic hyperplasia. In: N. Bruchovsky, A. Chapdelaine, F. Neumann (Eds.), Regulation of androgen action. Congressdruck R. Br\u00fcckner, Berlin (West), 1984, p. 87."}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03350940.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF03350940\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF03350940","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T09:09:51Z","timestamp":1565341791000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF03350940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,11]]},"references-count":34,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1988,11]]}},"alternative-id":["BF03350940"],"URL":"https:\/\/doi.org\/10.1007\/bf03350940","relation":{},"ISSN":["0391-4097","1720-8386"],"issn-type":[{"value":"0391-4097","type":"print"},{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,11]]}}}