{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T13:42:36Z","timestamp":1772026956469,"version":"3.50.1"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,5]]},"DOI":"10.1007\/dcr.0b013e3182092bde","type":"journal-article","created":{"date-parts":[[2011,4,12]],"date-time":"2011-04-12T14:40:23Z","timestamp":1302619223000},"page":"570-578","source":"Crossref","is-referenced-by-count":50,"title":["Safety and Efficacy of Methylnaltrexone in Shortening the Duration of Postoperative Ileus Following Segmental Colectomy: Results of Two Randomized, Placebo-Controlled Phase 3 Trials"],"prefix":"10.1097","volume":"54","author":[{"given":"Chang Sik","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ho-Kyung","family":"Chun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Stambler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Carpenito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seth","family":"Schulman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evan","family":"Tzanis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Randazzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-9-20210119","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1053\/cgh.2003.50012","article-title":"Postoperative ileus: etiologies and interventions.","volume":"1","author":"Behm","year":"2003","journal-title":"Clin Gastroenterol Hepatol"},{"key":"R2-9-20210119","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/BF01537233","article-title":"Postoperative ileus.","volume":"35","author":"Livingston","year":"1990","journal-title":"Dig Dis Sci"},{"key":"R3-9-20210119","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1001\/archsurg.138.2.206","article-title":"Mechanisms and treatment of postoperative ileus.","volume":"138","author":"Luckey","year":"2003","journal-title":"Arch Surg"},{"key":"R4-9-20210119","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.amjsurg.2005.10.026","article-title":"Postoperative upper and lower gastrointestinal recovery and gastrointestinal morbidity in patients undergoing bowel resection: pooled analysis of placebo data from 3 randomized controlled trials.","volume":"191","author":"Delaney","year":"2006","journal-title":"Am J Surg"},{"key":"R5-9-20210119","doi-asserted-by":"crossref","first-page":"485","DOI":"10.18553\/jmcp.2009.15.6.485","article-title":"Economic burden of postoperative ileus associated with colectomy in the United States","volume":"15","author":"Iyer","year":"2009","journal-title":"J Manag Care Pharm"},{"key":"R6-9-20210119","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/S0022-3565(25)24947-3","article-title":"Inhibition of gastrointestinal transit by morphine in rats results primarily from direct drug action on gut opioid sites.","volume":"237","author":"Manara","year":"1986","journal-title":"J Pharmacol Exp Ther"},{"key":"R7-9-20210119","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1191\/026921698674125048","article-title":"The relationship between opioid use and laxative use in terminally ill cancer patients.","volume":"12","author":"Sykes","year":"1998","journal-title":"Palliat Med"},{"key":"R8-9-20210119","article-title":"NCCN Clinical Practice Guidelines in Oncology: Palliative Care V.","year":"2009"},{"key":"R9-9-20210119","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00210-007-0146-x","article-title":"The in vitro pharmacology of the peripherally restricted opioid receptor antagonists, alvimopan, ADL 08-0011 and methylnaltrexone.","volume":"375","author":"Beattie","year":"2007","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"R10-9-20210119","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0009-9236(96)90117-4","article-title":"Methylnaltrexone prevents morphine-induced delay in oral-cecal transit time without affecting analgesia: a double-blind randomized placebo-controlled trial.","volume":"59","author":"Yuan","year":"1996","journal-title":"Clin Pharmacol Ther"},{"key":"R11-9-20210119","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1097\/00000542-199710000-00008","article-title":"Opioid-induced delay in gastric emptying: a peripheral mechanism in humans.","volume":"87","author":"Murphy","year":"1997","journal-title":"Anesthesiology"},{"key":"R12-9-20210119","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1124\/jpet.300.1.118","article-title":"Effects of subcutaneous methylnaltrexone on morphine-induced peripherally mediated side effects: a double-blind randomized placebo-controlled trial.","volume":"300","author":"Yuan","year":"2002","journal-title":"J Pharmacol Exp Ther"},{"key":"R13-9-20210119","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1177\/0091270004273491","article-title":"Tolerability, gut effects, and pharmacokinetics of methylnaltrexone following repeated intravenous administration in humans.","volume":"45","author":"Yuan","year":"2005","journal-title":"J Clin Pharmacol"},{"key":"R15-9-20210119","article-title":"Relistor [package insert].","year":"2009"},{"key":"R16-9-20210119","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1056\/NEJMoa0707377","article-title":"Methylnaltrexone for opioid-induced constipation in advanced illness.","volume":"328","author":"Thomas","year":"2008","journal-title":"N Engl J Med"},{"key":"R17-9-20210119","first-page":"39","article-title":"Methylnaltrexone for treatment of opioid-induced constipation in advanced illness patients.","volume":"7","author":"Slatkin","year":"2009","journal-title":"J Support Oncol"},{"key":"R19-9-20210119","article-title":"Entereg [package insert].","year":"2008"},{"key":"R20-9-20210119","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1007\/s10350-005-0035-7","article-title":"Phase III trial of alvimopan, a novel, peripherally acting, mu opioid antagonist, for postoperative ileus after major abdominal surgery.","volume":"48","author":"Delaney","year":"2005","journal-title":"Dis Colon Rectum"},{"key":"R21-9-20210119","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s00464-005-0104-y","article-title":"Alvimopan, a peripherally acting mu-opioid receptor antagonist, compared with placebo in postoperative ileus after major abdominal surgery: results of a randomized, double-blind, controlled study.","volume":"20","author":"Viscusi","year":"2006","journal-title":"Surg Endosc"},{"key":"R22-9-20210119","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1097\/01.sla.0000141158.27977.66","article-title":"Alvimopan, a novel, peripherally acting mu opioid antagonist: results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial of major abdominal surgery and postoperative ileus.","volume":"240","author":"Wolff","year":"2004","journal-title":"Ann Surg"},{"key":"R23-9-20210119","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1592\/phco.19.6.416.31040","article-title":"Prokinetic agents for the treatment of postoperative ileus in adults: a review of the literature.","volume":"19","author":"Bungard","year":"1999","journal-title":"Pharmacotherapy"}],"container-title":["Diseases of the Colon &amp; Rectum"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.lww.com\/00003453-201105000-00009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T01:16:06Z","timestamp":1741137366000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00003453-201105000-00009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1007\/dcr.0b013e3182092bde","relation":{},"ISSN":["0012-3706"],"issn-type":[{"value":"0012-3706","type":"print"}],"subject":[],"published":{"date-parts":[[2011,5]]}}}