{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:37:38Z","timestamp":1783489058147,"version":"3.55.0"},"reference-count":0,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[1997,6,1]],"date-time":"1997-06-01T00:00:00Z","timestamp":865123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1997,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Over a period of 20 years 84 papillary and 82 follicular carcinomas operated on by one surgeon and examined by\none pathologist were documented prospectively, treated selectively, and\nfollowed for 1 to 20 years (median 7 years). Tumors with a low risk of\nrecurrence or incurable disease\u2014i.e., papillary carcinoma pT1\u20133\u00a0N0\u00a0M0\n(<jats:italic>n<\/jats:italic>= 56) and minimally invasive follicular carcinoma (<jats:italic>n<\/jats:italic>= 37)\u2014were treated by a limited\u2010radicality\nhemithyroidectomy or total thyroidectomy without radioiodine in 79 of\nthe 93 cases (85%). No unfavorable course was observed, and only one\ncurable recurrence (1.3%) developed contralaterally after\nhemithyroidectomy for papillary cancer. Of the remaining 73 patients, including 100% of those with nodal involvement, 65 (89%) underwent\ntotal thyroidectomy with radioiodine. Total thyroidectomy was achieved\nin 34% of the cases by completion thyroidectomy, based on definitive\nhistologic examination. No instance of a serious, potentially incurable\nrecurrence and no tumor\u2010related death was observed in patients with a\npapillary TNM stage I + II or with a minimally invasive follicular\ncarcinoma. Five of the patients (6%) with papillary carcinoma, all\nwith TNM stage III or IV, and seven of the patients (8.5%) with\nfollicular carcinoma, all grossly invasive and pT3 or pT4, had\ntumor\u2010related deaths following total thyroidectomy in all and with\nremnant ablation in 10 cases. A potentially curable node recurrence\noccurred in two patients 1 and 10 years, respectively, after primary\ntreatment. Permanent hypoparathyroidism (<jats:italic>n<\/jats:italic>= 4)\n(2.4%) and permanent recurrent laryngeal nerve palsy\n(<jats:italic>n<\/jats:italic>= 2) (1.2%) were observed only in patients with a\ngrossly invasive follicular carcinoma and concomitant benign recurrent\ngoiter. We conclude that (1) hemithyroidectomy or total thyroidectomy\nwithout radioiodine is adequate for papillary carcinoma pT1\u20133\u00a0N0 and\nminimally invasive follicular carcinoma; (2) there were no nodal\nrecurrences in tumors recognized as node\u2010negative; and (3)\nextracapsular excision of one or both lobes can be carried out\ntechnically with low morbidity. The study confirms the prognostic value\nof age\u2010related TNM classification for papillary carcinoma;\nclassification of follicular thyroid carcinoma as minimally invasive or\ngrossly invasive proved to be useful.<\/jats:p>","DOI":"10.1007\/pl00012284","type":"journal-article","created":{"date-parts":[[2006,2,17]],"date-time":"2006-02-17T17:43:08Z","timestamp":1140198188000},"page":"546-552","source":"Crossref","is-referenced-by-count":35,"title":["Selective Treatment of Differentiated Thyroid Carcinoma"],"prefix":"10.1002","volume":"21","author":[{"given":"Ernst","family":"Gemsenj\u00e4ger","sequence":"first","affiliation":[{"name":"Surgical Clinic Neumunster Hospital Trichtenhauserstrasse 20, 8125 Zollikerberg Zurich Switzerland<!--<country1>CH<\/country1>-->"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp U.","family":"Heitz","sequence":"additional","affiliation":[{"name":"University Department of Pathology University Hospital Schmelzbergstrasse 12 8091 Zurich Switzerland<!--<country1>CH<\/country1>-->"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedict","family":"Martina","sequence":"additional","affiliation":[{"name":"Medical Outpatient Department Cantonal Hospital Petersgraben 4 4031 Basel Switzerland<!--<country1>CH<\/country1>-->"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1997,6]]},"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/PL00012284.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/PL00012284\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/PL00012284","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T16:01:30Z","timestamp":1704988890000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/PL00012284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,6]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1997,6]]}},"alternative-id":["10.1007\/PL00012284"],"URL":"https:\/\/doi.org\/10.1007\/pl00012284","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,6]]}}}