{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:03:03Z","timestamp":1705017783122},"reference-count":0,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[1997,6,1]],"date-time":"1997-06-01T00:00:00Z","timestamp":865123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1997,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Serum levels of parathyroid hormone (PTH), alkaline phosphatase (ALP), calcium, creatinine, and vitamin D\nand the glomerular filtration rate were compared with the histologic\nproperties and expression of PTH and chromogranin A in excised\nparathyroid adenomas from patients with primary hyperparathyroidism\n(pHPT). PTH and chromogranin A were detected immunohistochemically, and\ntheir mRNA was demonstrated by in situ hybridization with\nquantification of their mRNA levels by image analysis. There was a\npositive correlation between the cellular levels of PTH mRNA and the\ncellular levels of chromogranin A mRNA (<jats:italic>r<\/jats:italic>= 0.4;<jats:italic>p<\/jats:italic> &lt; 0.05). However, within certain parts of the adenomas, mostly consisting of chief cells, the expression of PTH mRNA\nand chromogranin A mRNA was heterogeneous and the levels did not\ncorrespond to each other. A reduced suppressibility of PTH in patients\nwith pHPT was confirmed. Although cellular levels of PTH and\nchromogranin A and their mRNAs were low in the oxyphilic parts of the\nadenomas, there was no correlation between the amount of oxyphilic\ncells in the adenomas and the suppressibility of PTH by calcium. There\nwas also no association between the cellular levels of PTH mRNA or\nchromogranin A mRNA as studied by image analysis and \u201ccalcium\nsensitivity.\u201d Our results thus demonstrate that although PTH and\nchromogranin A mRNA levels are in general correlated to each other\nthere are differences in their expression within and between individual\nparathyroid adenomas. It therefore seems likely that the expression of\nPTH and chromogranin A are differentially regulated, and that PTH and\nchromogranin A may not always be co\u2010secreted. This point could be of\nimportance, as chromogranin A and its cleavage products are known to\ninfluence PTH secretion.<\/jats:p>","DOI":"10.1007\/pl00012285","type":"journal-article","created":{"date-parts":[[2006,2,17]],"date-time":"2006-02-17T17:43:08Z","timestamp":1140198188000},"page":"553-563","source":"Crossref","is-referenced-by-count":3,"title":["Parathyroid Function and Histology in Patients with Parathyroid Adenoma: Correlation of Clinical and Morphologic Findings"],"prefix":"10.1002","volume":"21","author":[{"given":"Lena","family":"Luts","sequence":"first","affiliation":[{"name":"Department of Physiology and Neuroscience Neuroendocrine Cell Biology University Hospital of Lund Experimental Research Center E\u2010Blocket S\u2010221 85 Lund Sweden<!--<country1>SE<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Bergenfelz","sequence":"additional","affiliation":[{"name":"Department of Surgery University Hospital of Lund S\u201022185 Lund Sweden<!--<country1>SE<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Alumets","sequence":"additional","affiliation":[{"name":"Department of Pathology University Hospital of Lund S\u2010221 85 Lund Sweden<!--<country1>SE<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Sundler","sequence":"additional","affiliation":[{"name":"Department of Physiology and Neuroscience Neuroendocrine Cell Biology University Hospital of Lund Experimental Research Center E\u2010Blocket S\u2010221 85 Lund Sweden<!--<country1>SE<\/country1>-->"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1997,6]]},"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/PL00012285.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/PL00012285\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/PL00012285","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T16:01:46Z","timestamp":1704988906000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/PL00012285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,6]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1997,6]]}},"alternative-id":["10.1007\/PL00012285"],"URL":"https:\/\/doi.org\/10.1007\/pl00012285","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,6]]}}}