{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:20:58Z","timestamp":1761128458469},"reference-count":0,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[1999,5,1]],"date-time":"1999-05-01T00:00:00Z","timestamp":925516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1999,5]]},"abstract":"Abstract.<\/jats:title>The object of this study was to determine the muscle force and bone mineral density (BMD) of patients with secondary hyperparathyroidism before and 3\u00a0months after operation. Thirty\u2010nine patients with secondary hyperparathyroidism and regular dialysis were operated. Their ages were 47 \u00b1 12 (mean \u00b1 SD) years and duration of dialysis was 70.5 \u00b1 35.8\u00a0months. The clinical symptoms included bone pain in 23 patients (59%), skin itching in 21 (53.8%), general weakness in 13 (33.3%), conscious disturbance in 2, chest tightness in 1, and failure to thrive in 1. Total parathyroidectomy and autotransplantation of 60\u00a0mg of parathyroid gland into subcutaneous tissue was done routinely. BMD was measured in the lumbar spine (L2\u2013L4) and left proximal femur, expressed as grams per square centimeter and as fracture risk. The extension force of the quadriceps muscle was measured at 60 degrees of right knee flexion, expressed as newtons (N) in a peak force and an average force. Three months after operation the BMD of the study group increased (in g\/cm2<\/jats:sup>) from 1.063 \u00b1 0.181 to 1.148 \u00b1 0.149 (p<\/jats:italic> < 0.001) in L2\u20134 (n<\/jats:italic>= 25), from 0.792 \u00b1 0.14 to 0.875 \u00b1 0.161 (p<\/jats:italic> < 0.001), in femoral neck (n<\/jats:italic>= 25), from 0.672 \u00b1 0.171 to 0.754 \u00b1 0.21 (p<\/jats:italic> < 0.001) in Ward's triangle (n<\/jats:italic>= 25), and from 0.69 \u00b1 0.149 to 0.738 \u00b1 0.143 (p<\/jats:italic> < 0.001) in trochanter (n<\/jats:italic>= 25). Fracture risk also was reduced significantly 3\u00a0months after operation at L2\u20134 (p<\/jats:italic>= 0.003), femoral neck (p<\/jats:italic>= 0.001), Ward's triangle (p<\/jats:italic>= 0.003), and trochanter (p<\/jats:italic>= 0.005). Muscle force (in newtons) increased from 264.8 \u00b1 110.5 to 326 \u00b1 110.9 (p<\/jats:italic>= 0.023) in peak force (n<\/jats:italic>= 18) and from 195.3 \u00b1 90.4 to 258 \u00b1 99 (p<\/jats:italic>= 0.012) in average force (n<\/jats:italic>= 18). The patients with general weakness had improved muscle force more prominently than those without general weakness. In addition to skin itching, bone pain, and soft tissue calcification, general weakness that causes disability is an indication for surgery in secondary hyperparathyroidism. After parathyroidectomy and autotransplantation, the muscle force tends to increase, especially in those with general weakness. An increment of BMD and reduction of fracture risk are also found after surgery.<\/jats:p>","DOI":"10.1007\/pl00012328","type":"journal-article","created":{"date-parts":[[2006,2,17]],"date-time":"2006-02-17T17:15:56Z","timestamp":1140196556000},"page":"452-457","source":"Crossref","is-referenced-by-count":18,"title":["Muscle Force and Bone Mineral Density after Parathyroidectomy and Subcutaneous Autotransplantation for Secondary Hyperparathyroidism"],"prefix":"10.1002","volume":"23","author":[{"given":"Fong\u2010Fu","family":"Chou","sequence":"first","affiliation":[{"name":"Department of Surgery Chang Gung Memorial Hospital at Kaohsiung Chang Gung University 123 Ta\u2010Pei Road, Naio\u2010Sung Hsiang Kaohsiung Hsien Taiwan Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiang Hsuan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Chang Gung Memorial Hospital at Kaohsiung Chang Gung University 123 Ta\u2010Pei Road, Naio\u2010Sung Hsiang Kaohsiung Hsien Taiwan Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien Te","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chang Gung Memorial Hospital at Kaohsiung Chang Gung University 123 Ta\u2010Pei Road, Naio\u2010Sung Hsiang Kaohsiung Hsien Taiwan Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1999,5]]},"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/PL00012328.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/PL00012328\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/PL00012328","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T08:20:23Z","timestamp":1704874823000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/PL00012328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,5]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1999,5]]}},"alternative-id":["10.1007\/PL00012328"],"URL":"https:\/\/doi.org\/10.1007\/pl00012328","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,5]]}}}