{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:29:23Z","timestamp":1791995363484,"version":"4.4.0"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1999,2,1]],"date-time":"1999-02-01T00:00:00Z","timestamp":917827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1999,2]]},"abstract":"<jats:p>n = 5), esophageal adenocarcinoma (<jats:italic>n<\/jats:italic>= 1), pulmonary squamous cell carcinoma (<jats:italic>n<\/jats:italic>= 1), gastric leiomyosarcoma (<jats:italic>n<\/jats:italic>= 1), lingual squamous cell carcinoma (<jats:italic>n<\/jats:italic>= 1), and parotid gland carcinoma (<jats:italic>n<\/jats:italic>= 1). Three patients underwent preoperative fine\u2010needle aspiration (FNA), all of which were suggestive of metastatic disease. The mean time from resection of the primary tumor to thyroid metastases was 3.5 \u00b1 6.0 years (range 0\u201319.5 years). Total thyroidectomy (<jats:italic>n<\/jats:italic>= 5) or lobectomy (<jats:italic>n<\/jats:italic>= 5) was performed without morbidity or mortality. After a median follow\u2010up of 5.2 years six patients are alive and two are free of disease. Moreover, no patients have had recurrent disease in the neck. Thus carcinomas metastatic to the thyroid represent a rare cause of clinically significant thyroid disease, with RCCs comprising 50%. Most thyroid metastases (80%) present within 3 years of primary tumor resection, but with RCC they can occur as late as 19 years. The diagnosis of metastatic disease should be suspected in patients with even a remote history of cancer, especially RCC, and an FNA revealing clear cell or spindle cell carcinoma. Contrary to previous reports, long\u2010term survival can be achieved after resection of the metastatic tumor. Furthermore, thyroidectomy may also palliate\/prevent the potential morbidity of tumor recurrence in the neck.<\/jats:p>","DOI":"10.1007\/pl00013162","type":"journal-article","created":{"date-parts":[[2006,2,17]],"date-time":"2006-02-17T14:44:31Z","timestamp":1140187471000},"page":"177-181","source":"Crossref","is-referenced-by-count":156,"title":["Clinically Significant, Isolated Metastatic Disease to the Thyroid Gland"],"prefix":"10.1002","volume":"23","author":[{"given":"Herbert","family":"Chen","sequence":"first","affiliation":[{"name":"Division of Endocrine and Oncologic Surgery Department of Surgery, Blalock 688 The Johns Hopkins Hospital 600\u00a0North Wolfe Street Baltimore Maryland 21287 USA<!--<country1>US<\/country1>-->"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa L.","family":"Nicol","sequence":"additional","affiliation":[{"name":"Department of Pathology The Johns Hopkins Medical Institutions, 600\u00a0North Wolfe Street, Baltimore, Maryland 21287, USA and The Johns Hopkins Thyroid Tumor Center 600\u00a0North Wolfe Street Baltimore Maryland 21287 USA<!--<country1>US<\/country1>-->"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Udelsman","sequence":"additional","affiliation":[{"name":"Division of Endocrine and Oncologic Surgery Department of Surgery, Blalock 688 The Johns Hopkins Hospital 600\u00a0North Wolfe Street Baltimore Maryland 21287 USA<!--<country1>US<\/country1>-->"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1999,2]]},"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/PL00013162.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/PL00013162\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/PL00013162","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T16:53:23Z","timestamp":1704992003000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/PL00013162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1999,2]]}},"alternative-id":["10.1007\/PL00013162"],"URL":"https:\/\/doi.org\/10.1007\/pl00013162","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,2]]}}}