{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T06:57:09Z","timestamp":1793084229541,"version":"4.5.0"},"reference-count":26,"publisher":"Walter de Gruyter GmbH","issue":"4","license":[{"start":{"date-parts":[[2015,3,13]],"date-time":"2015-03-13T00:00:00Z","timestamp":1426204800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch. Immunol. Ther. Exp."],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1007\/s00005-015-0335-0","type":"journal-article","created":{"date-parts":[[2015,3,12]],"date-time":"2015-03-12T17:37:15Z","timestamp":1426181835000},"page":"299-304","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Macrophage Phenotype in the Ocular Surface of Experimental Murine Dry Eye Disease"],"prefix":"10.2478","volume":"63","author":[{"given":"In-Cheon","family":"You","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry G.","family":"Coursey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia L.","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cintia S.","family":"de Paiva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen C.","family":"Pflugfelder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2015,3,13]]},"reference":[{"key":"335_CR1","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/ni.1937","volume":"11","author":"SK Biswas","year":"2010","unstructured":"Biswas SK, Mantovani A (2010) Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nat Immunol 11:889\u2013896","journal-title":"Nat Immunol"},{"key":"335_CR2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/intimm\/dxm137","volume":"20","author":"CS Chiang","year":"2008","unstructured":"Chiang CS, Chen FH, Hong JH et al (2008) Functional phenotype of macrophages depends on assay procedures. Int Immunol 20:215\u2013222","journal-title":"Int Immunol"},{"key":"335_CR3","doi-asserted-by":"crossref","first-page":"e70","DOI":"10.1038\/emm.2013.135","volume":"46","author":"DI Cho","year":"2014","unstructured":"Cho DI, Kim MR, Jeong HY et al (2014) Mesenchymal stem cells reciprocally regulate the M1\/M2 balance in mouse bone marrow-derived macrophages. Exp Mol Med 46:e70","journal-title":"Exp Mol Med"},{"key":"335_CR4","doi-asserted-by":"crossref","first-page":"e78508","DOI":"10.1371\/journal.pone.0078508","volume":"8","author":"TG Coursey","year":"2013","unstructured":"Coursey TG, Gandhi NB, Volpe EA et al (2013) Chemokine receptors CCR6 and CXCR3 are necessary for CD4(+) T cell mediated ocular surface disease in experimental dry eye disease. PLoS One 8:e78508","journal-title":"PLoS One"},{"key":"335_CR5","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1167\/iovs.07-0069","volume":"48","author":"CS Paiva De","year":"2007","unstructured":"De Paiva CS, Villarreal AL, Corrales RM et al (2007) Dry eye-induced conjunctival epithelial squamous metaplasia is modulated by interferon-gamma. Invest Ophthalmol Vis Sci 48:2553\u20132560","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"335_CR6","first-page":"632","volume":"43","author":"D Dursun","year":"2002","unstructured":"Dursun D, Wang M, Monroy D et al (2002) A mouse model of keratoconjunctivitis sicca. Invest Ophthalmol Vis Sci 43:632\u2013638","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"335_CR7","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/ni.2109","volume":"12","author":"SJ Galli","year":"2011","unstructured":"Galli SJ, Borregaard N, Wynn TA (2011) Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils. Nat Immunol 12:1035\u20131044","journal-title":"Nat Immunol"},{"key":"335_CR8","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/nri1733","volume":"5","author":"S Gordon","year":"2005","unstructured":"Gordon S, Taylor PR (2005) Monocyte and macrophage heterogeneity. Nat Rev Immunol 5:953\u2013964","journal-title":"Nat Rev Immunol"},{"key":"335_CR9","doi-asserted-by":"crossref","first-page":"4293","DOI":"10.1167\/iovs.03-1145","volume":"45","author":"L Luo","year":"2004","unstructured":"Luo L, Li DQ, Doshi A et al (2004) Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface. Invest Ophthalmol Vis Sci 45:4293\u20134301","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"335_CR10","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S1471-4906(02)02302-5","volume":"23","author":"A Mantovani","year":"2002","unstructured":"Mantovani A, Sozzani S, Locati M et al (2002) Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol 23:549\u2013555","journal-title":"Trends Immunol"},{"key":"335_CR11","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.it.2004.09.015","volume":"25","author":"A Mantovani","year":"2004","unstructured":"Mantovani A, Sica A, Sozzani S et al (2004) The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol 25:677\u2013686","journal-title":"Trends Immunol"},{"key":"335_CR12","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1189\/jlb.0602325","volume":"73","author":"DM Mosser","year":"2003","unstructured":"Mosser DM (2003) The many faces of macrophage activation. J Leukoc Biol 73:209\u2013212","journal-title":"J Leukoc Biol"},{"key":"335_CR13","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/nri2448","volume":"8","author":"DM Mosser","year":"2008","unstructured":"Mosser DM, Edwards JP (2008) Exploring the full spectrum of macrophage activation. Nat Rev Immunol 8:958\u2013969","journal-title":"Nat Rev Immunol"},{"key":"335_CR14","doi-asserted-by":"crossref","first-page":"7779","DOI":"10.1167\/iovs.13-12650","volume":"54","author":"JY Oh","year":"2013","unstructured":"Oh JY, Lee HJ, Ko AY et al (2013) Analysis of macrophage phenotype in rejected corneal allografts. Invest Ophthalmol Vis Sci 54:7779\u20137784","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"335_CR15","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1542-0124(12)70005-8","volume":"1","author":"SC Pflugfelder","year":"2003","unstructured":"Pflugfelder SC (2003) Anti-inflammatory therapy of dry eye. Ocul Surf 1:31\u201336","journal-title":"Ocul Surf"},{"key":"335_CR16","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1076\/ceyr.19.3.201.5309","volume":"19","author":"SC Pflugfelder","year":"1999","unstructured":"Pflugfelder SC, Jones D, Ji Z et al (1999) Altered cytokine balance in the tear fluid and conjunctiva of patients with Sj\u00f6gren\u2019s syndrome keratoconjunctivitis sicca. Curr Eye Res 19:201\u2013211","journal-title":"Curr Eye Res"},{"key":"335_CR17","doi-asserted-by":"crossref","first-page":"3653","DOI":"10.4049\/jimmunol.1101442","volume":"187","author":"CS Schaumburg","year":"2011","unstructured":"Schaumburg CS, Siemasko KF, de Paiva CS et al (2011) Ocular surface APCs are necessary for autoreactive T cell-mediated experimental autoimmune lacrimal keratoconjunctivitis. J Immunol 187:3653\u20133662","journal-title":"J Immunol"},{"key":"335_CR18","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.2337\/db09-1402","volume":"59","author":"ME Shaul","year":"2010","unstructured":"Shaul ME, Bennett G, Strissel KJ et al (2010) Dynamic, M2-like remodeling phenotypes of CD11c+ adipose tissue macrophages during high-fat diet-induced obesity in mice. Diabetes 59:1171\u20131181","journal-title":"Diabetes"},{"key":"335_CR19","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1002\/path.4106","volume":"229","author":"R Shechter","year":"2013","unstructured":"Shechter R, Schwartz M (2013) Harnessing monocyte-derived macrophages to control central nervous system pathologies: no longer \u2018if\u2019 but \u2018how\u2019. J Pathol 229:332\u2013346","journal-title":"J Pathol"},{"key":"335_CR20","first-page":"153","volume":"32","author":"A Sica","year":"2010","unstructured":"Sica A (2010) Role of tumour-associated macrophages in cancer-related inflammation. Exp Oncol 32:153\u2013158","journal-title":"Exp Oncol"},{"key":"335_CR21","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1172\/JCI59643","volume":"122","author":"A Sica","year":"2012","unstructured":"Sica A, Mantovani A (2012) Macrophage plasticity and polarization: in vivo veritas. J Clin Invest 122:787\u2013795","journal-title":"J Clin Invest"},{"key":"335_CR22","first-page":"2283","volume":"42","author":"A Solomon","year":"2001","unstructured":"Solomon A, Dursun D, Liu Z et al (2001) Pro- and anti-inflammatory forms of interleukin-1 in the tear fluid and conjunctiva of patients with dry-eye disease. Invest Ophthalmol Vis Sci 42:2283\u20132292","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"335_CR23","first-page":"2609","volume":"43","author":"ME Stern","year":"2002","unstructured":"Stern ME, Gao J, Schwalb TA et al (2002) Conjunctival T-cell subpopulations in Sj\u00f6gren\u2019s and non- Sj\u00f6gren\u2019s patients with dry eye. Invest Ophthalmol Vis Sci 43:2609\u20132614","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"335_CR24","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1001\/archophthalmol.2011.364","volume":"130","author":"W Stevenson","year":"2012","unstructured":"Stevenson W, Chauhan SK, Dana R (2012) Dry eye disease: an immune-mediated ocular surface disorder. Arch Ophthalmol 130:90\u2013100","journal-title":"Arch Ophthalmol"},{"key":"335_CR25","doi-asserted-by":"crossref","first-page":"342","DOI":"10.4049\/jimmunol.175.1.342","volume":"175","author":"RD Stout","year":"2005","unstructured":"Stout RD, Jiang C, Matta B et al (2005) Macrophages sequentially change their functional phenotype in response to changes in microenvironmental influences. J Immunol 175:342\u2013349","journal-title":"J Immunol"},{"key":"335_CR26","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.ajpath.2012.05.014","volume":"181","author":"D Zhou","year":"2012","unstructured":"Zhou D, Chen YT, Chen F et al (2012) Critical involvement of macrophage infiltration in the development of Sj\u00f6gren\u2019s syndrome-associated dry eye. Am J Pathol 181:753\u2013760","journal-title":"Am J Pathol"}],"container-title":["Archivum Immunologiae et Therapiae Experimentalis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00005-015-0335-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00005-015-0335-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00005-015-0335-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T20:48:26Z","timestamp":1704228506000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00005-015-0335-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,13]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["335"],"URL":"https:\/\/doi.org\/10.1007\/s00005-015-0335-0","relation":{},"ISSN":["0004-069X","1661-4917"],"issn-type":[{"value":"0004-069X","type":"print"},{"value":"1661-4917","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,13]]}}}