{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T02:46:16Z","timestamp":1774579576186,"version":"3.50.1"},"reference-count":16,"publisher":"Walter de Gruyter GmbH","issue":"S1","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch. Immunol. Ther. Exp."],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1007\/s00005-016-0433-7","type":"journal-article","created":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T13:50:01Z","timestamp":1484229001000},"page":"147-150","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The Expression of Toll-Like Receptors in Patients with B-Cell Chronic Lymphocytic Leukemia"],"prefix":"10.2478","volume":"64","author":[{"given":"Justyna","family":"Rybka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Butrym","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Wr\u00f3bel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo\u017cena","family":"Ja\u017awiec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Bogucka-Fedorczuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafa\u0142","family":"Por\u0119ba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazimierz","family":"Kuliczkowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2017,1,12]]},"reference":[{"key":"433_CR1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri1391","volume":"4","author":"S Akira","year":"2004","unstructured":"Akira S, Takeda K (2004) Toll-like receptors signaling. Nat Rev Immunol 4:499\u2013511","journal-title":"Nat Rev Immunol"},{"key":"433_CR2","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.3324\/haematol.2011.044792","volume":"96","author":"E Arvaniti","year":"2011","unstructured":"Arvaniti E, Ntoufa S, Papakonstantinou N et al (2011) Toll-like receptor signaling pathway in chronic lymphocytic leukemia: distinct gene expression profiles of potential pathogenic significance in specific subsets of patients. Haematologica 96:1644\u20131652","journal-title":"Haematologica"},{"key":"433_CR3","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/431405a","volume":"431","author":"F Balkwill","year":"2004","unstructured":"Balkwill F, Coussens LM (2004) Cancer: an inflammatory link. Nature 431:405\u2013406","journal-title":"Nature"},{"key":"433_CR4","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.3109\/10428194.2013.856426","volume":"55","author":"W Barcellini","year":"2014","unstructured":"Barcellini W, Imperiali FG, Zaninoni A et al (2014) Toll-like receptor 4 and 9 expression in B-chronic lymphocytic leukemia: relationship with infections, autoimmunity and disease progression. Leuk Lymphoma 55:1768\u201317773","journal-title":"Leuk Lymphoma"},{"key":"433_CR5","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1046\/j.1468-0734.2000.00001.x","volume":"4","author":"F Caligaris-Cappio","year":"2000","unstructured":"Caligaris-Cappio F (2000) Biology of chronic lymphocytic leukemia. Rev Clin Exp Hematol 4:5\u201321","journal-title":"Rev Clin Exp Hematol"},{"key":"433_CR6","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1056\/NEJMra041720","volume":"352","author":"N Chiorazzi","year":"2005","unstructured":"Chiorazzi N, Rai KR, Ferrarini M (2005) Chronic lymphocytic leukemia. N Engl J Med 352:804\u2013815","journal-title":"N Engl J Med"},{"key":"433_CR7","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","volume":"162","author":"P Chomczynski","year":"1987","unstructured":"Chomczynski P, Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156\u2013159","journal-title":"Anal Biochem"},{"key":"433_CR8","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.3324\/haematol.10975","volume":"92","author":"C Grandjenette","year":"2007","unstructured":"Grandjenette C, Kennel A, Faure GC et al (2007) Expression of functional toll-like receptors by B-chronic lymphocytic leukemia cells. Haematologica 92:1279\u20131281","journal-title":"Haematologica"},{"key":"433_CR9","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/cmi.2012.61","volume":"10","author":"Z Hua","year":"2013","unstructured":"Hua Z, Hou B (2013) TLR signaling B-cell development and activation. Cell Mol Immunol 10:103\u2013106","journal-title":"Cell Mol Immunol"},{"key":"433_CR10","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.smim.2006.12.004","volume":"19","author":"T Kawai","year":"2007","unstructured":"Kawai T, Akira S (2007) TLRs signaling. Semin Immunol 19:24\u201332","journal-title":"Semin Immunol"},{"key":"433_CR11","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.immuni.2011.05.006","volume":"34","author":"T Kawai","year":"2011","unstructured":"Kawai T, Akira S (2011) Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity 34:637\u2013650","journal-title":"Immunity"},{"key":"433_CR12","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/j.1365-2141.2008.07475.x","volume":"144","author":"M Muzio","year":"2009","unstructured":"Muzio M, Scielzo C, Bertilaccio MT et al (2009) Expression and function of toll like receptors in chronic lymphocytic leukemia cells. Br J Haematol 144:507\u2013516","journal-title":"Br J Haematol"},{"key":"433_CR13","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1002\/ijc.24832","volume":"126","author":"D Rozkov\u00e1","year":"2010","unstructured":"Rozkov\u00e1 D, Novotn\u00e1 L, Pytl\u00edk R et al (2010) Toll-like receptors on B-CLL cells: expression and functional consequences of their stimulation. Int J Cancer 126:1132\u20131143","journal-title":"Int J Cancer"},{"key":"433_CR14","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","volume":"3","author":"TD Schmittgen","year":"2008","unstructured":"Schmittgen TD, Livak KJ (2008) Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 3:1101\u20131108","journal-title":"Nat Protoc"},{"key":"433_CR15","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/sj.leu.2404061","volume":"20","author":"DE Spaner","year":"2006","unstructured":"Spaner DE, Shi Y, White D et al (2006) Immunomodulatory effects of Toll-like receptor-7 activation on chronic lymphocytic leukemia cells. Leukemia 20:286\u2013295","journal-title":"Leukemia"},{"key":"433_CR16","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nrc2764","volume":"10","author":"T Zenz","year":"2010","unstructured":"Zenz T, Mertens D, Kuppers R et al (2010) From pathogenesis totreatment of chronic lymphocytic leukemia. Nat Rev Cancer 10:37\u201350","journal-title":"Nat Rev Cancer"}],"container-title":["Archivum Immunologiae et Therapiae Experimentalis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00005-016-0433-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00005-016-0433-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00005-016-0433-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T20:48:44Z","timestamp":1704228524000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00005-016-0433-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":16,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["433"],"URL":"https:\/\/doi.org\/10.1007\/s00005-016-0433-7","relation":{},"ISSN":["0004-069X","1661-4917"],"issn-type":[{"value":"0004-069X","type":"print"},{"value":"1661-4917","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12]]}}}