{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T14:23:40Z","timestamp":1778768620551,"version":"3.51.4"},"reference-count":40,"publisher":"Walter de Gruyter GmbH","issue":"S1","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch. Immunol. Ther. Exp."],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1007\/s00005-016-0435-5","type":"journal-article","created":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T13:48:00Z","timestamp":1484228880000},"page":"89-98","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Distribution of HLA-DQB1 in Czech Patients with Central Hypersomnias"],"prefix":"10.2478","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6905-6227","authenticated-orcid":false,"given":"Milena","family":"Vrana","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera","family":"Siffnerova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavla","family":"Pecherkova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Ratajova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karel","family":"Sonka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2017,1,12]]},"reference":[{"key":"435_CR1","unstructured":"American Academy of Sleep Medicine (2014) The international classification of sleep disorders, 3rd edn (ICSD-3). ISBN 978-0991543410. http:\/\/www.esst.org\/adds\/ICSD.pdf . Accessed 29 Aug 2014"},{"key":"435_CR2","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1093\/sleep\/30.10.1274","volume":"30","author":"KN Anderson","year":"2007","unstructured":"Anderson KN, Pilsworth S, Sharples LD et al (2007) Idiopathic hypersomnia: a study of 77 cases. Sleep 30:1274\u20131281","journal-title":"Sleep"},{"key":"435_CR3","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.5665\/sleep.2080","volume":"35","author":"O Andlauer","year":"2012","unstructured":"Andlauer O, Moore H 4th, Hong SC et al (2012) Predictors of hypocretin (orexin) deficiency in narcolepsy without cataplexy. Sleep 35:1247\u20131255","journal-title":"Sleep"},{"key":"435_CR4","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1093\/sleep\/32.8.979","volume":"32","author":"A Aran","year":"2009","unstructured":"Aran A, Lin L, Nevsimalova S et al (2009) Elevated anti-streptococcal antibodies in patients with recent narcolepsy onset. Sleep 32:979\u2013983","journal-title":"Sleep"},{"key":"435_CR5","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.jsmc.2016.04.005","volume":"11","author":"JA Berkowski","year":"2016","unstructured":"Berkowski JA, Shelgikar AV (2016) Disorders of excessive daytime sleepiness including narcolepsy and idiopathic hypersomnia. Sleep Med Clin 11:365\u2013378","journal-title":"Sleep Med Clin"},{"key":"435_CR6","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.jclinepi.2005.01.016","volume":"58","author":"JJ Deeks","year":"2005","unstructured":"Deeks JJ, Macaskill P, Irwig L (2005) The performance of tests of publication bias and other sample size effects in systematic reviews of diagnostic test accuracy was assessed. J Clin Epidemiol 58:882\u2013893","journal-title":"J Clin Epidemiol"},{"key":"435_CR7","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","volume":"7","author":"R DerSimonian","year":"1986","unstructured":"DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177\u2013188","journal-title":"Control Clin Trials"},{"key":"435_CR8","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1399-0039.2007.00836.x","volume":"69","author":"M Dobrovolna","year":"2007","unstructured":"Dobrovolna M, Jiraskova K, Sonka K et al (2007) HLA association with narcolepsy in Czech patients. Abstracts for the 21st European Immunogenetics and Histocompatibility Conference, Barcelona, Spain, May 5\u20138, 2007. Tissue Antigens 69:373\u2013532","journal-title":"Tissue Antigens"},{"key":"435_CR9","volume-title":"Statistical methods for rates and proportions","author":"JL Fleiss","year":"1981","unstructured":"Fleiss JL (1981) Statistical methods for rates and proportions, 2nd edn. Wiley, New York","edition":"2"},{"key":"435_CR10","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1212\/WNL.0b013e3181f9615d","volume":"75","author":"N Goel","year":"2010","unstructured":"Goel N, Banks S, Mignot E et al (2010) DQB1*0602 predicts interindividual differences in physiologic sleep, sleepiness and fatigue. Neurology 75:1509\u20131519","journal-title":"Neurology"},{"key":"435_CR11","doi-asserted-by":"crossref","first-page":"D784","DOI":"10.1093\/nar\/gku1166","volume":"43","author":"FF Gonzalez-Galarza","year":"2015","unstructured":"Gonzalez-Galarza FF, Takeshita LY et al (2015) Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations. Nucleic Acid Res 43:D784\u2013D788","journal-title":"Nucleic Acid Res"},{"key":"435_CR12","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/j.1399-0039.2012.01948.x","volume":"80","author":"F Han","year":"2012","unstructured":"Han F, Lin L, Li J et al (2012) HLA-DQ association and allele competition in Chinese narcolepsy. Tissue Antigens 80:328\u2013335","journal-title":"Tissue Antigens"},{"key":"435_CR13","doi-asserted-by":"crossref","first-page":"565","DOI":"10.5664\/jcsm.5692","volume":"12","author":"A Heidbreder","year":"2016","unstructured":"Heidbreder A, Frauscher B et al (2016) Not only sleepwalking but NREM parasomnia irrespective of the type is associated with HLA DQB1*05:01. J Clin Sleep Med 12:565\u2013570","journal-title":"J Clin Sleep Med"},{"key":"435_CR14","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s002510000269","volume":"52","author":"H Hohjoh","year":"2001","unstructured":"Hohjoh H, Terada N, Honda Y et al (2001) Negative association of the HLA-DRB1*1502-DQB1*0601 haplotype with human narcolepsy. Immunogenetics 52:299\u2013301","journal-title":"Immunogenetics"},{"key":"435_CR15","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.humimm.2006.10.006","volume":"68","author":"SC Hong","year":"2007","unstructured":"Hong SC, Lin L et al (2007) DQB1*0301 and DQB1*0601 modulate narcolepsy susceptibility in Koreans. Hum Immunol 68:59\u201368","journal-title":"Hum Immunol"},{"key":"435_CR16","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/ng.647","volume":"42","author":"H Hor","year":"2010","unstructured":"Hor H, Kutalik Z et al (2010) Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy. Nat Genet 42:786\u2013789","journal-title":"Nat Genet"},{"key":"435_CR17","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/sj.mp.4001203","volume":"8","author":"M Lecendreux","year":"2003","unstructured":"Lecendreux M, Bassetti C et al (2003) HLA and genetic susceptibility to sleepwalking. Mol Psychiatry 8:114\u2013117","journal-title":"Mol Psychiatry"},{"key":"435_CR18","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S1474-4422(14)70218-2","volume":"14","author":"RS Liblau","year":"2015","unstructured":"Liblau RS, Vassalli A, Seifinejad A et al (2015) Hypocretin (orexin) biology and the pathology of narcolepsy with cataplexy. Lancet Neurol 14:318\u2013328","journal-title":"Lancet Neurol"},{"key":"435_CR19","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0165-5728(01)00333-2","volume":"117","author":"L Lin","year":"2001","unstructured":"Lin L, Hungs M, Mignot E (2001) Narcolepsy and the HLA region. J Neuroimmunol 117:9\u201320","journal-title":"J Neuroimmunol"},{"key":"435_CR20","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/sleep\/28.1.113","volume":"28","author":"MR Littner","year":"2005","unstructured":"Littner MR, Kushida C et al (2005) Practice parameters for clinical use of the multiple sleep latency test and the maintenance of wakefulness test. Sleep 28:113\u2013121","journal-title":"Sleep"},{"key":"435_CR21","doi-asserted-by":"crossref","first-page":"49","DOI":"10.33588\/rn.5802.2013361","volume":"58","author":"A Martins-da-Silva","year":"2014","unstructured":"Martins-da-Silva A, Lopes J et al (2014) Usefulness of genetic characterization of narcolepsy and hypersomnia on phenotype definition: a study in Portuguese patients. Rev Neurol 58:49\u201354","journal-title":"Rev Neurol"},{"key":"435_CR22","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/S1474-4422(16)30204-6","volume":"15","author":"K Maski","year":"2016","unstructured":"Maski K, Owens JA (2016) Insomnia, parasomnias, and narcolepsy in children: clinical features, diagnosis, and management. Lancet Neurol 15:1170\u20131181","journal-title":"Lancet Neurol"},{"key":"435_CR23","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1093\/sleep\/17.suppl_8.S60","volume":"17","author":"E Mignot","year":"1994","unstructured":"Mignot E, Lin X, Arrigoni J et al (1994) DQB1*0602 and DQA1*0102 (DQ1) are better markers than DR2 for narcolepsy in Caucasian and black Americans. Sleep 17:60\u201367","journal-title":"Sleep"},{"key":"435_CR24","first-page":"1012","volume":"20","author":"E Mignot","year":"1997","unstructured":"Mignot E, Hayduk R, Grumet FC et al (1997) HLA DQB1*0602 is associated with cataplexy in 509 narcoleptic patients. Sleep 20:1012\u20131020","journal-title":"Sleep"},{"key":"435_CR25","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0140-6736(05)78496-8","volume":"351","author":"E Mignot","year":"1998","unstructured":"Mignot E, Young T, Lin L et al (1998) Reduction of REM sleep latency associated with HLA-DQB1*0602 in normal adults. Lancet 351:727","journal-title":"Lancet"},{"key":"435_CR26","first-page":"347","volume":"22","author":"E Mignot","year":"1999","unstructured":"Mignot E, Young T et al (1999) Nocturnal sleep and daytime sleepiness in normal subjects with HLA-DQB1*0602. Sleep 22:347\u2013352","journal-title":"Sleep"},{"key":"435_CR27","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1086\/318799","volume":"68","author":"E Mignot","year":"2001","unstructured":"Mignot E, Lin L et al (2001) Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups. Am J Hum Genet 68:686\u2013699","journal-title":"Am J Hum Genet"},{"key":"435_CR28","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1001\/archneur.59.10.1553","volume":"59","author":"E Mignot","year":"2002","unstructured":"Mignot E, Lammers GJ et al (2002) The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias. Arch Neurol 59:1553\u20131562","journal-title":"Arch Neurol"},{"key":"435_CR29","doi-asserted-by":"crossref","first-page":"15031","DOI":"10.1038\/hgv.2015.31","volume":"2","author":"T Miyagawa","year":"2015","unstructured":"Miyagawa T, Toyoda H et al (2015) An association analysis of HLA-DQB1 with narcolepsy without cataplexy and idiopathic hypersomnia with\/without long sleep time in a Japanese population. Hum Genome Var 2:15031","journal-title":"Hum Genome Var"},{"key":"435_CR30","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1053\/smrv.1999.0069","volume":"4","author":"S Nishino","year":"2000","unstructured":"Nishino S, Okura M, Mignot E (2000) Narcolepsy: genetic predisposition and neuropharmacological mechanisms. Review article. Sleep Med Rev 4:57\u201399","journal-title":"Sleep Med Rev"},{"key":"435_CR31","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1038\/nbt1209-1135","volume":"27","author":"WS Noble","year":"2009","unstructured":"Noble WS (2009) How does multiple testing correction work? Nat Biotechnol 27:1135\u20131137","journal-title":"Nat Biotechnol"},{"key":"435_CR32","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/S1474-4422(14)70075-4","volume":"13","author":"M Partinen","year":"2014","unstructured":"Partinen M, Kornum BR et al (2014) Narcolepsy as an autoimmune disease: the role of H1N1 infection and vaccination. Lancet Neurol 13:600\u2013613","journal-title":"Lancet Neurol"},{"key":"435_CR33","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1399-0039.1998.tb02952.x","volume":"51","author":"Z Pelin","year":"1998","unstructured":"Pelin Z, Guilleminault C, Risch N et al (1998) HLA-DQB1*0602 homozygosity increases relative risk for narcolepsy but not disease severity in two ethnic groups: US Modafinil in Narcolepsy Multicenter Study Group. Tissue Antigens 51:96\u2013100","journal-title":"Tissue Antigens"},{"key":"435_CR34","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/79690","volume":"6","author":"C Peyron","year":"2000","unstructured":"Peyron C, Faraco J et al (2000) A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat Med 6:991\u2013997","journal-title":"Nat Med"},{"key":"435_CR35","doi-asserted-by":"crossref","first-page":"D423","DOI":"10.1093\/nar\/gku1161","volume":"43","author":"J Robinson","year":"2015","unstructured":"Robinson J, Halliwell JA et al (2015) The IPD and IPD-IMGT\/HLA Database: allele variant databases. Nucleic Acids Res 43:D423\u2013D431","journal-title":"Nucleic Acids Res"},{"key":"435_CR36","first-page":"41","volume":"139","author":"B Roth","year":"1985","unstructured":"Roth B, Nevsimalova S et al (1985) A study of the occurrence of HLA DR2 in 124 narcoleptics: clinical aspects. Schweizer Arch Neurol Psychiatr 139:41\u201351","journal-title":"Schweizer Arch Neurol Psychiatr"},{"issue":"110","key":"435_CR37","first-page":"444","volume":"77","author":"K Sonka","year":"2014","unstructured":"Sonka K, Pazderova L et al (2014) The value of repeated non-confirmatory multiple sleep latency test (MSLT) for the diagnosis of narcolepsy. Cesk Slov Neurol 77(110):444\u2013448","journal-title":"Cesk Slov Neurol"},{"key":"435_CR38","doi-asserted-by":"crossref","first-page":"19","DOI":"10.5665\/sleep.3300","volume":"37","author":"M Tafti","year":"2014","unstructured":"Tafti M, Hor H et al (2014) DQB1 locus alone explains most of the risk and protection in narcolepsy with cataplexy in Europe. Sleep 37:19\u201325","journal-title":"Sleep"},{"key":"435_CR39","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1080\/01621459.1970.10481069","volume":"329","author":"MW Tate","year":"1970","unstructured":"Tate MW, Brown SM (1970) Note on the Cochran Q test. J Am Statistical Assoc 329:155\u2013160","journal-title":"J Am Statistical Assoc"},{"key":"435_CR40","doi-asserted-by":"crossref","first-page":"789","DOI":"10.5664\/jcsm.2922","volume":"9","author":"LM Trotti","year":"2013","unstructured":"Trotti LM, Staab BA, Rye DB (2013) Test-retest reliability of the multiple sleep latency test in narcolepsy without cataplexy and idiopathic hypersomnia. J Clin Sleep Med 9:789\u2013795","journal-title":"J Clin Sleep Med"}],"container-title":["Archivum Immunologiae et Therapiae Experimentalis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00005-016-0435-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00005-016-0435-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00005-016-0435-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T10:38:00Z","timestamp":1749897480000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00005-016-0435-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":40,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["435"],"URL":"https:\/\/doi.org\/10.1007\/s00005-016-0435-5","relation":{},"ISSN":["0004-069X","1661-4917"],"issn-type":[{"value":"0004-069X","type":"print"},{"value":"1661-4917","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12]]}}}