{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T10:22:37Z","timestamp":1758709357081,"version":"3.37.3"},"reference-count":39,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T00:00:00Z","timestamp":1627430400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T00:00:00Z","timestamp":1627430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003336","name":"Bulgarian National Science Fund","doi-asserted-by":"publisher","award":["DDVU 02\/34"],"award-info":[{"award-number":["DDVU 02\/34"]}],"id":[{"id":"10.13039\/501100003336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch. Immunol. Ther. Exp."],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s00005-021-00624-7","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T16:03:04Z","timestamp":1627488184000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Anti-ANX A1 Antibody Therapy in MRL\/lpr Murine Model of Systemic Lupus Erythematosus"],"prefix":"10.2478","volume":"69","author":[{"given":"Silvya","family":"Bradyanova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolina","family":"Mihaylova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petroslav","family":"Chipinski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yordan","family":"Manassiev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melinda","family":"Herb\u00e1th","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dobroslav","family":"Kyurkchiev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f3zsef","family":"Prechl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrey I.","family":"Tchorbanov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,7,28]]},"reference":[{"key":"624_CR1","doi-asserted-by":"publisher","first-page":"3351","DOI":"10.4049\/jimmunol.179.5.3351","volume":"179","author":"A Ahuja","year":"2007","unstructured":"Ahuja A, Shupe J, Dunn R, Kashgarian M, Kehry MR, Shlomchik MJ (2007) Depletion of B cells in murine lupus: efficacy and resistance. J Immunol 179:3351\u20133361","journal-title":"J Immunol"},{"key":"624_CR2","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.3390\/ijms19051348","volume":"19","author":"M Bruschi","year":"2018","unstructured":"Bruschi M, Petretto A, Vaglio A, Santucci L, Candiano G, Ghiggeri GM (2018) Annexin A1 and autoimmunity: from basic science to clinical applications. Int J Mol Sci 19:1348","journal-title":"Int J Mol Sci"},{"key":"624_CR3","first-page":"317","volume":"6","author":"JC Crisp\u00edn","year":"2010","unstructured":"Crisp\u00edn JC, Kyttaris VC, Terhorst C, Tsokos GC (2010) T cells as therapeutic targets in SLE Nature Reviews. Rheumatology 6:317\u2013325","journal-title":"Rheumatology"},{"key":"624_CR4","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.coph.2009.04.007","volume":"9","author":"F D\u2019Acquisto","year":"2009","unstructured":"D\u2019Acquisto F (2009) On the adaptive nature of Annexin-A1. Curr Opin Pharmacol 9:521\u2013528","journal-title":"Curr Opin Pharmacol"},{"key":"624_CR5","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1182\/blood-2006-05-022798","volume":"109","author":"F D'Acquisto","year":"2007","unstructured":"D\u2019Acquisto F et al (2007) Annexin-1 modulates T-cell activation and differentiation. Blood 109:1095\u20131102","journal-title":"Blood"},{"key":"624_CR6","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1186\/ar3433","volume":"13","author":"T D\u00f6rner","year":"2011","unstructured":"D\u00f6rner T, Giesecke C, Lipsky PE (2011) Mechanisms of B Cell Autoimmunity in SLE. Arthrit Res Therapy 13:243","journal-title":"Arthrit Res Therapy"},{"issue":"10","key":"624_CR7","doi-asserted-by":"publisher","first-page":"308","DOI":"10.3390\/biology9100308","volume":"9","author":"K Dossybayeva","year":"2020","unstructured":"Dossybayeva K, Abdukhakimova D, Poddighe D (2020) Basophils and systemic lupus erythematosus in murine models and human patients. Biology (basel). 9(10):308. https:\/\/doi.org\/10.3390\/biology9100308","journal-title":"Biology (basel)."},{"doi-asserted-by":"crossref","unstructured":"Foster MH (2007) T cells and B cells in lupus nephritis. In: Seminars in nephrology, vol 1. Elsevier, pp 47\u201358","key":"624_CR8","DOI":"10.1016\/j.semnephrol.2006.09.007"},{"key":"624_CR9","first-page":"1233","volume":"10","author":"C He","year":"2017","unstructured":"He C, Feng P, Su H, Gu A, Yan Z, Zhu X (2017) Disrupted Th1\/Th2 balance in patients with rheumatoid arthritis (RA). Int J Clin Exp Pathol 10:1233\u20131242","journal-title":"Int J Clin Exp Pathol"},{"key":"624_CR10","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1093\/jmcb\/mjr043","volume":"4","author":"SC Juvet","year":"2012","unstructured":"Juvet SC, Zhang L (2012) Double Negative Regulatory T Cells in Transplantation and Autoimmunity: Recent Progress and Future Directions. J Mol Cell Biol 4:48\u201358","journal-title":"J Mol Cell Biol"},{"key":"624_CR11","doi-asserted-by":"publisher","first-page":"1648","DOI":"10.1126\/scitranslmed.aav1648","volume":"11","author":"R Kansal","year":"2019","unstructured":"Kansal R et al (2019) Sustained B cell depletion by CD19-targeted CAR T cells is a highly effective treatment for murine lupus. Sci Transl Med 11:1648","journal-title":"Sci Transl Med"},{"key":"624_CR12","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1111\/j.1600-0625.2010.01145.x","volume":"19","author":"CC Kretz","year":"2010","unstructured":"Kretz CC et al (2010) Anti-annexin 1 antibodies: A new diagnostic marker in the serum of patients with discoid lupus erythematosus. Experim Dermatol 19:919\u2013921","journal-title":"Experim Dermatol"},{"doi-asserted-by":"crossref","unstructured":"Mei HE, Schmidt S, D\u00f6rner T (2012) Rationale of anti-CD19 immunotherapy: an option to target autoreactive plasma cells in autoimmunity. Arthritis Res therapy 14:S1","key":"624_CR13","DOI":"10.1186\/ar3909"},{"key":"624_CR14","doi-asserted-by":"publisher","first-page":"3077","DOI":"10.1002\/art.27601","volume":"62","author":"J Merrill","year":"2010","unstructured":"Merrill J et al (2010) The efficacy and safety of abatacept in patients with non\u2013life-threatening manifestations of systemic lupus erythematosus: results of a twelve-month, multicenter, exploratory, phase IIb, randomized, double-blind, placebo-controlled trial. Arthritis Rheumatism 62:3077\u20133087","journal-title":"Arthritis Rheumatism"},{"key":"624_CR15","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12915","volume":"92","author":"N Mihaylova","year":"2020","unstructured":"Mihaylova N, Bradyanova S, Chipinski P, Chausheva S, Kyurkchiev D, Tchorbanov AI (2020) Monoclonal antibody therapy that targets phospholipid-binding protein delays lupus activity in MRL\/lpr mice. Scandinavian J Immunol 92:e12915","journal-title":"Scandinavian J Immunol"},{"key":"624_CR16","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1080\/08916934.2017.1300884","volume":"50","author":"N Mihaylova","year":"2017","unstructured":"Mihaylova N et al (2017) Annexin A1 as a target for managing murine pristane-induced systemic lupus erythematosus. Autoimmunity 50:257\u2013268","journal-title":"Autoimmunity"},{"key":"624_CR17","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1111\/cei.13399","volume":"199","author":"N Mihaylova","year":"2020","unstructured":"Mihaylova N et al (2020) Suppression of autoreactive T and B lymphocytes by anti-annexin A1 antibody in a humanized NSG murine model of systemic lupus erythematosus. Clin Experim Immunol 199:278\u2013293","journal-title":"Clin Experim Immunol"},{"key":"624_CR18","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1089\/jir.2011.0065","volume":"31","author":"KD Moudgil","year":"2011","unstructured":"Moudgil KD, Choubey D (2011) Cytokines in autoimmunity: role in induction, regulation, and treatment. J Interf Cytokine Res 31:695\u2013703","journal-title":"J Interf Cytokine Res"},{"key":"624_CR19","doi-asserted-by":"publisher","first-page":"2273","DOI":"10.1093\/rheumatology\/keq278","volume":"49","author":"K Papp","year":"2010","unstructured":"Papp K, V\u00e9gh P, Tchorbanov A, Vassilev T, Erdei A, Prechl J (2010) Progression of lupus-like disease drives the appearance of complement-activating IgG antibodies in MRL\/lpr mice. Rheumatology 49:2273\u20132280","journal-title":"Rheumatology"},{"key":"624_CR20","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/1742-2094-6-33","volume":"6","author":"N Paschalidis","year":"2009","unstructured":"Paschalidis N, Iqbal AJ, Maione F, Wood EG, Perretti M, Flower RJ, D\u2019Acquisto F (2009) Modulation of experimental autoimmune encephalomyelitis by endogenous annexin A1. J Neuroinflamm 6:33","journal-title":"J Neuroinflamm"},{"key":"624_CR21","doi-asserted-by":"publisher","first-page":"785","DOI":"10.4161\/cc.9.4.10673","volume":"9","author":"N Paschalidis","year":"2010","unstructured":"Paschalidis N et al (2010) Role of endogenous annexin-A1 in the regulation of thymocyte positive and negative selection. Cell Cycle 9:785\u2013794","journal-title":"Cell Cycle"},{"key":"624_CR22","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/nri2470","volume":"9","author":"M Perretti","year":"2009","unstructured":"Perretti M, D\u2019acquisto F (2009) Annexin A1 and glucocorticoids as effectors of the resolution of inflammation. Nature Rev Immunol 9:62\u201370","journal-title":"Nature Rev Immunol"},{"key":"624_CR23","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1111\/j.1476-5381.2009.00483.x","volume":"158","author":"M Perretti","year":"2009","unstructured":"Perretti M, Dalli J (2009) Exploiting the Annexin A1 pathway for the development of novel anti-inflammatory therapeutics. British J Pharmacol 158:936\u2013946","journal-title":"British J Pharmacol"},{"key":"624_CR24","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.immuni.2007.11.017","volume":"28","author":"TH Pham","year":"2008","unstructured":"Pham TH, Okada T, Matloubian M, Lo CG, Cyster JG (2008) S1P1 receptor signaling overrides retention mediated by G\u03b1i-coupled receptors to promote T cell egress. Immunity 28:122\u2013133","journal-title":"Immunity"},{"unstructured":"Piras G (2014) From the bench to the pipeline: testing the immunosuppressive potential of novel therapy targeting Annexin A1. Queen Mary University of London","key":"624_CR25"},{"key":"624_CR26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012771","volume":"5","author":"D Renshaw","year":"2010","unstructured":"Renshaw D et al (2010) Downstream gene activation of the receptor ALX by the agonist annexin A1. PLoS ONE 5:e12771","journal-title":"PLoS ONE"},{"doi-asserted-by":"crossref","unstructured":"Richard ML, Gilkeson G (2018) Mouse models of lupus: what they tell us and what they don\u2019t. Lupus Sci Med 5(1):e000199","key":"624_CR27","DOI":"10.1136\/lupus-2016-000199"},{"doi-asserted-by":"crossref","unstructured":"Rojas M et al (2018) Cytokines and inflammatory mediators in systemic lupus erythematosus. EMJ Rheumatol 5(1):83\u201392","key":"624_CR28","DOI":"10.33590\/emjrheumatol\/10311457"},{"key":"624_CR29","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1177\/0300985810370005","volume":"47","author":"J Rottman","year":"2010","unstructured":"Rottman J, Willis C (2010) Mouse models of systemic lupus erythematosus reveal a complex pathogenesis. Vet Pathol 47:664\u2013676","journal-title":"Vet Pathol"},{"key":"624_CR30","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1002\/art.34359","volume":"64","author":"BH Rovin","year":"2012","unstructured":"Rovin BH et al (2012) Efficacy and safety of rituximab in patients with active proliferative lupus nephritis: the Lupus Nephritis Assessment with Rituximab study. Arthritis Rheum 64:1215\u20131226","journal-title":"Arthritis Rheum"},{"key":"624_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biologicals.2020.11.002","volume":"69","author":"K Shah","year":"2021","unstructured":"Shah K, Cragg M, Leandro M, Reddy V (2021) Anti-CD20 monoclonal antibodies in Systemic Lupus Erythematosus. Biol J Int Assoc Biol Standard. 69:1\u201314. https:\/\/doi.org\/10.1016\/j.biologicals.2020.11.002","journal-title":"Biol J Int Assoc Biol Standard."},{"key":"624_CR32","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.3390\/ijms19041045","volume":"19","author":"MH Sheikh","year":"2018","unstructured":"Sheikh MH, Solito E (2018) Annexin A1: uncovering the many talents of an old protein. Int J Mol Sci 19:1045","journal-title":"Int J Mol Sci"},{"key":"624_CR33","doi-asserted-by":"publisher","first-page":"642","DOI":"10.3389\/fphar.2018.00642","volume":"9","author":"Y Tai","year":"2018","unstructured":"Tai Y, Wang Q, Korner H, Zhang L, Wei W (2018) Molecular mechanisms of T cells activation by dendritic cells in autoimmune diseases. Front Pharmacol 9:642","journal-title":"Front Pharmacol"},{"key":"624_CR34","first-page":"678","volume":"188","author":"LL Teichmann","year":"2012","unstructured":"Teichmann LL, Kashgarian M, Weaver CT, Roers A, M\u00fcller W, Shlomchik MJ (2012) B cell-derived IL-10 does not regulate spontaneous systemic autoimmunity in MRL. Faslpr Mice J Immunol 188:678\u2013685","journal-title":"Faslpr Mice J Immunol"},{"key":"624_CR35","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1136\/annrheumdis-2012-202760","volume":"73","author":"DJ Wallace","year":"2014","unstructured":"Wallace DJ et al (2014) Efficacy and safety of epratuzumab in patients with moderate\/severe active systemic lupus erythematosus: results from EMBLEM, a phase IIb, randomised, double-blind, placebo-controlled, multicentre study. Annals Rheum Dis 73:183\u2013190","journal-title":"Annals Rheum Dis"},{"key":"624_CR36","doi-asserted-by":"publisher","first-page":"214","DOI":"10.3389\/fimmu.2019.00214","volume":"10","author":"MGL Wilkinson","year":"2019","unstructured":"Wilkinson MGL, Rosser EC (2019) B cells as a therapeutic target in paediatric rheumatic disease. Front Immunol 10:214","journal-title":"Front Immunol"},{"key":"624_CR37","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1038\/nrrheum.2013.126","volume":"9","author":"YH Yang","year":"2013","unstructured":"Yang YH, Morand E, Leech M (2013) Annexin A1: potential for glucocorticoid sparing in RA. Nature Rev Rheumatol 9:595\u2013603","journal-title":"Nature Rev Rheumatol"},{"key":"624_CR38","doi-asserted-by":"publisher","first-page":"997","DOI":"10.4049\/jimmunol.1202236","volume":"190","author":"YH Yang","year":"2013","unstructured":"Yang YH et al (2013) Deficiency of annexin A1 in CD4+ T cells exacerbates T cell\u2013dependent inflammation. J Immunol 190:997\u20131007","journal-title":"J Immunol"},{"key":"624_CR39","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1016\/j.immuni.2016.04.017","volume":"44","author":"Q Zhang","year":"2016","unstructured":"Zhang Q, Vignali DA (2016) Co-stimulatory and co-inhibitory pathways in autoimmunity. Immunity 44:1034\u20131051","journal-title":"Immunity"}],"container-title":["Archivum Immunologiae et Therapiae Experimentalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00005-021-00624-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00005-021-00624-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00005-021-00624-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T20:49:34Z","timestamp":1704228574000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00005-021-00624-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,28]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["624"],"URL":"https:\/\/doi.org\/10.1007\/s00005-021-00624-7","relation":{},"ISSN":["0004-069X","1661-4917"],"issn-type":[{"type":"print","value":"0004-069X"},{"type":"electronic","value":"1661-4917"}],"subject":[],"published":{"date-parts":[[2021,7,28]]},"assertion":[{"value":"1 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None of the authors has any potential financial conflict of interest related to this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}],"article-number":"19"}}