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Among them, endocrine disruptors are particularly harmful to human health. Bisphenol A (BPA) is a xenoestrogen that has been shown to disrupt the endocrine system and cause reproductive toxicity. In this study, we aimed to verify the potential relationship between BPA and miscarriage involving the formation of neutrophil extracellular traps (NETs). Blood samples were collected from healthy women and women who had miscarriage in the first trimester of pregnancy. The serum levels of cytoplasmic anti-PR3 antibody and perinuclear anti-MPO antibody were determined using an immunoenzymatic method. The concentrations of key proinflammatory proteins TNF-\u03b1 and MCP-1, as well as NADPH oxidase subunits NOX1 and NCF2, were also measured in the serum samples. The serum concentration of BPA was determined using gas chromatography. The results showed that the concentrations of BPA were significantly elevated in the serum of women who had miscarriage compared to the control group, with the highest concentration found in the \u201cNETs-positive\u201d group. The levels of MCP-1 and TNF-\u03b1 were significantly higher in the \u201cNETs-positive\u201d group compared to the \u201cNETs-negative\u201d and control group. The levels of NOX1 and NCF2 were also higher in the \u201cNETs-positive\u201d group compared to the \u201cNETs-negative\u201d group. The study showed that BPA could play a role in the course of miscarriage through the formation of NETs. The results indicate the need to limit the exposure of women planning pregnancy to xenoestrogens, including BPA.<\/jats:p>","DOI":"10.1007\/s00005-022-00661-w","type":"journal-article","created":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T06:02:23Z","timestamp":1664604143000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Bisphenol A: Potential Factor of Miscarriage in Women in the Context of the Phenomenon of Neutrophil Extracellular Traps"],"prefix":"10.2478","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8412-3937","authenticated-orcid":false,"given":"Wioleta Justyna","family":"Omeljaniuk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelika Edyta","family":"Charkiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzena","family":"Garley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wioletta","family":"Ratajczak-Wrona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Czerniecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Jab\u0142o\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzanna","family":"Cechowska-Pasko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Miltyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2022,10,1]]},"reference":[{"key":"661_CR1","doi-asserted-by":"publisher","first-page":"e197","DOI":"10.1097\/AOG.0000000000002899","volume":"132","author":"A College of Obstetricians and Gynecologists\u2019 Committee on Practice Bulletins\u2014Gynecology","year":"2018","unstructured":"A College of Obstetricians and Gynecologists\u2019 Committee on Practice Bulletins\u2014Gynecology (2018) ACOG practice bulletin No. 200: early pregnancy loss. 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