{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:33:09Z","timestamp":1790807589339,"version":"4.1.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2011,1,29]],"date-time":"2011-01-29T00:00:00Z","timestamp":1296259200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Inflamm. Res."],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1007\/s00011-011-0307-8","type":"journal-article","created":{"date-parts":[[2011,1,28]],"date-time":"2011-01-28T20:16:31Z","timestamp":1296245791000},"page":"589-596","source":"Crossref","is-referenced-by-count":97,"title":["Anti-inflammatory effects of ivermectin in mouse model of allergic asthma"],"prefix":"10.1007","volume":"60","author":[{"given":"Shuhan","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Ci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangchao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuming","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,1,29]]},"reference":[{"key":"307_CR1","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1172\/JCI17748","volume":"111","author":"JA Elias","year":"2003","unstructured":"Elias JA, Lee CG, Zheng T, Ma B, Homer RJ, Zhu Z. New insights into the pathogenesis of asthma. J Clin Invest. 2003;111:291\u20137.","journal-title":"J Clin Invest"},{"key":"307_CR2","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1146\/annurev.immunol.17.1.255","volume":"17","author":"M Wills-Karp","year":"1999","unstructured":"Wills-Karp M. Immunologic basis of antigen-induced airway hyperresponsiveness. Annu Rev Immunol. 1999;17:255\u201381.","journal-title":"Annu Rev Immunol"},{"key":"307_CR3","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/0165-6147(94)90027-2","volume":"15","author":"GP Anderson","year":"1994","unstructured":"Anderson GP, Coyle AJ. Th2 and \u2018Th2-like\u2019 cells in allergy and asthma: pharmacological perspectives. Trends Pharmacol Sci. 1994;15:324\u201332.","journal-title":"Trends Pharmacol Sci"},{"key":"307_CR4","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1378\/chest.130.1_suppl.4S","volume":"130","author":"SS Braman","year":"2006","unstructured":"Braman SS. The global burden of asthma. Chest. 2006;130:4\u201312.","journal-title":"Chest"},{"key":"307_CR5","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1517\/13543784.3.4.405","volume":"3","author":"A Bryskier","year":"1994","unstructured":"Bryskier A, Agouridas C, Chantot JF. New medical targets for macrolides. Exp Opin Invest Drugs. 1994;3:405\u201310.","journal-title":"Exp Opin Invest Drugs"},{"key":"307_CR6","first-page":"77","volume":"4","author":"JP Tarayre","year":"1987","unstructured":"Tarayre JP, Aliaga M, Barbara M, Villanova G, Ballester R, Tisne-Versailles J, et al. Cutaneously applied erythromycin base reduces various types of inflammatory reactions in mouse ear. Int J Tiss Reac. 1987;4:77\u201385.","journal-title":"Int J Tiss Reac"},{"key":"307_CR7","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1093\/jac\/30.3.339","volume":"30","author":"K Mikasa","year":"1992","unstructured":"Mikasa K, Kita E, Sawaki M, Kunimatsu M, Hamada K, Konishi M, et al. The anti-inflammatory effect of erythromycin in zymosan-induced peritonitis of mice. J Antimicrob Chemother. 1992;30:339\u201348.","journal-title":"J Antimicrob Chemother"},{"key":"307_CR8","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/BF02027218","volume":"38","author":"C Agen","year":"1993","unstructured":"Agen C, Danesi R, Blandizzi C, Costa M, Stacchini B, Favini P, et al. Macrolide antibiotics as antiinflammatory agents: roxithromycin in an unexpected role. Agents Actions. 1993;38:85\u201390.","journal-title":"Agents Actions"},{"key":"307_CR9","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ijantimicag.2007.08.001","volume":"31","author":"EJ Giamarellos-Bourboulis","year":"2008","unstructured":"Giamarellos-Bourboulis EJ. Macrolides beyond the conventional antimicrobials: a class of potent immunomodulators. Int J Antimicrob Agents. 2008;31:12\u201320.","journal-title":"Int J Antimicrob Agents"},{"key":"307_CR10","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.ejphar.2009.06.032","volume":"15","author":"B Hrva\u010di\u0107","year":"2009","unstructured":"Hrva\u010di\u0107 B, Bo\u0161njak B, Bosnar M, Feren\u010di\u0107 \u017d, Glojnari\u0107 I, Erakovi\u0107 Haber V. Clarithromycin suppresses airway hyperresponsiveness and inflammation in mouse models of asthma. Eur J Pharmacol. 2009;15:236\u201343.","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"307_CR11","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1378\/chest.08-3056","volume":"136","author":"A Beigelman","year":"2009","unstructured":"Beigelman A, Gunsten S, Mikols CL, Vidavsky I, Cannon CL, Brody SL, et al. Azithromycin attenuates airway inflammation in a noninfectious mouse model of allergic asthma. Chest. 2009;136(2):498\u2013506.","journal-title":"Chest"},{"key":"307_CR12","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0248-8663(01)00350-2","volume":"22","author":"E Caumes","year":"2001","unstructured":"Caumes E, Danis M. New indications of ivermectin. Rev Med Interne. 2001;22:379\u201384.","journal-title":"Rev Med Interne"},{"key":"307_CR13","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0165-2427(94)05308-F","volume":"44","author":"M Stankiewicz","year":"1995","unstructured":"Stankiewicz M, Cabaj W, Jonas WE, Moore LG, Millar K, Ng Chie W. Influence of ivermectin on cellular and humoral immune responses of lambs. Vet Immunol Immunopathol. 1995;44:347\u201358.","journal-title":"Vet Immunol Immunopathol"},{"key":"307_CR14","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.intimp.2008.12.016","volume":"9","author":"X Zhang","year":"2009","unstructured":"Zhang X, Song Y, Xiong H, Ci X, Li H, Yu L, et al. Inhibitory effects of ivermectin on nitric oxide and prostaglandin E2 production in LPS-stimulated RAW 264.7 macrophages. Int J Immunopharmacol. 2009;9:354\u20139.","journal-title":"Int J Immunopharmacol"},{"key":"307_CR15","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1007\/s00011-008-8007-8","volume":"57","author":"X Zhang","year":"2008","unstructured":"Zhang X, Song Y, Ci X, An N, Ju Y, Li H, et al. Ivermectin inhibits LPS-induced production of inflammatory cytokines and improves LPS-induced survival in mice. Inflamm Res. 2008;57:524\u20139.","journal-title":"Inflamm Res"},{"key":"307_CR16","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jim.2004.03.004","volume":"288","author":"LS Rijt Van","year":"2004","unstructured":"Van Rijt LS, Kuipers H, Vos N, Hijdra D, Hoogsteden HC, Lambrecht BN. A rapid flow cytometric method for determining the cellular composition of bronchoalveolar lavage fluid cells in mouse models of asthma. J Immunol Methods. 2004;288:111\u201321.","journal-title":"J Immunol Methods"},{"key":"307_CR17","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1677\/joe.0.177R001","volume":"177","author":"J Zhou","year":"2003","unstructured":"Zhou J, Kang Z, Xie Q, Liu C, Lou S, Chen Y, et al. Rapid nongenomic effects of glucocorticoids on allergic asthma reaction in the guinea pig. J Endocrinol. 2003;177:R1\u20134.","journal-title":"J Endocrinol"},{"key":"307_CR18","doi-asserted-by":"crossref","first-page":"6880","DOI":"10.1073\/pnas.85.18.6880","volume":"85","author":"J Pene","year":"1988","unstructured":"Pene J, Rousset F, Briere F, Chretien I, Bonnefoy JY, Spits H, et al. IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons a, g and prostaglandin E2. Proc Nat Acad Sci USA. 1988;85:6880\u20134.","journal-title":"Proc Nat Acad Sci USA"},{"key":"307_CR19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0091-6749(97)70186-6","volume":"100","author":"DT Umetsu","year":"1997","unstructured":"Umetsu DT, DeKruyff RH. TH1 and TH2 CD4+ cells in human allergic diseases. J Allergy Clin Immunol. 1997;100:1\u20136.","journal-title":"J Allergy Clin Immunol"},{"key":"307_CR20","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/s008940050092","volume":"4","author":"DB Corry","year":"1998","unstructured":"Corry DB, Grunig G, Hadeiba H, Kurup VP, Warnock ML, Sheppard D, et al. Requirementsfor allergen-induced airway hyperreactivity in T and B cell-deficient mice. Mol Med. 1998;4:344\u201355.","journal-title":"Mol Med"},{"key":"307_CR21","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1172\/JCI115428","volume":"88","author":"JL Curtis","year":"1991","unstructured":"Curtis JL, Byrd PK, Warnock ML, Kaltreider HB. Requirement of CD4-positive T cells for cellular recruitment to the lungs of mice in response to a particulate intratracheal antigen. J Clin Invest. 1991;88:1244\u201354.","journal-title":"J Clin Invest"},{"key":"307_CR22","doi-asserted-by":"crossref","unstructured":"Kips JC. Cytokines in asthma. Eur Respir J. 2001;18:24\u201333.","DOI":"10.1183\/09031936.01.00229601"},{"key":"307_CR23","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.0105-2896.2004.00215.x","volume":"202","author":"M Wills-Karp","year":"2004","unstructured":"Wills-Karp M. Interleukin-13 in asthma pathogenesis. Immunol Rev. 2004;202:175\u201390.","journal-title":"Immunol Rev"},{"key":"307_CR24","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/01.all.0000162309.97480.45","volume":"5","author":"LP Ngoc","year":"2005","unstructured":"Ngoc LP, Gold DR, Tzianabos AO, Weiss ST, Celedon JC. Cytokines, allergy, and asthma. Curr Opin Allergy Clin Immunol. 2005;5:161\u20136.","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"307_CR25","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1126\/science.282.5397.2258","volume":"282","author":"M Wills-Karp","year":"1998","unstructured":"Wills-Karp M, Luyimbazi J, Xu X, Schofield B. Interleukin-13: central mediator of allergic asthma. Science. 1998;282:2258\u201361.","journal-title":"Science"},{"key":"307_CR26","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1096\/fasebj.6.14.1385241","volume":"6","author":"J Purkerson","year":"1992","unstructured":"Purkerson J, Isakson P. A two-signal model for regulation of immunoglobulin isotype switching. FASEB J. 1992;6:3245\u201352.","journal-title":"FASEB J"},{"key":"307_CR27","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1289\/ehp.5703","volume":"111","author":"I Kimber","year":"2003","unstructured":"Kimber I, Stone S, Dearman RJ. Assessment of the inherent allergenic potential of proteins in mice. Environ Health Perspect. 2003;111:227\u201331.","journal-title":"Environ Health Perspect"},{"key":"307_CR28","first-page":"137","volume":"57","author":"RI Abu-Ghazaleh","year":"1992","unstructured":"Abu-Ghazaleh RI, Kita H, Gleich GJ. Eosinophil activation and function in health and disease. Immunol Ser. 1992;57:137\u201367.","journal-title":"Immunol Ser"},{"key":"307_CR29","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1126\/science.2787531","volume":"245","author":"RL Coffman","year":"1898","unstructured":"Coffman RL, Seymour BW, Hudak S, Jackson J, Rennick D. Antibody to interleukin-5 inhibits helminth-induced eosinophilia in mice. Science. 1898;245:308\u201310.","journal-title":"Science"},{"key":"307_CR30","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S1074-7613(00)80294-0","volume":"4","author":"M Kopf","year":"1996","unstructured":"Kopf M, Brombacher F, Hodgkin PD, Ramsay AJ, Milbourne EA, Dai WJ, et al. IL-5-deficient mice have a developmental defect in CD5+ B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell responses. Immunity. 1996;4:15\u201324.","journal-title":"Immunity"},{"key":"307_CR31","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1084\/jem.185.12.2143","volume":"185","author":"JJ Lee","year":"1997","unstructured":"Lee JJ, McGarry MP, Farmer SC, Denzler KL, Larson KA, Carrigan PE, et al. Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma. J Exp Med. 1997;185:2143\u201356.","journal-title":"J Exp Med"},{"key":"307_CR32","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0163-7258(02)00220-6","volume":"94","author":"PS Fostera","year":"2002","unstructured":"Fostera PS, Martinez-Moczygembab M, Hustonb DP, Corry DB. Interleukins-4, -5, and -13: emerging therapeutic targets in allergic disease. Pharmacol Ther. 2002;94:253\u201364.","journal-title":"Pharmacol Ther"},{"key":"307_CR33","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1164\/ajrccm\/146.3.633","volume":"146","author":"BG Toelle","year":"1992","unstructured":"Toelle BG, Peat JK, Salome CM. Toward a definition of asthma for epidemiology. Am Rev Respir Dis. 1992;146:633\u20137.","journal-title":"Am Rev Respir Dis"},{"key":"307_CR34","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1183\/09031936.93.06050662","volume":"6","author":"J Peat","year":"1993","unstructured":"Peat J, Toelle B, Salome C. Predictive nature of bronchial responsiveness and respiratory symptoms in a one year cohort study of Sydney schoolchildren. Eur Respir J. 1993;6:662\u20139.","journal-title":"Eur Respir J"},{"key":"307_CR35","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1172\/JCI5909","volume":"103","author":"Z Zhu","year":"1999","unstructured":"Zhu Z, Homer RJ, Wang Z. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersesretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest. 1999;103:779\u201388.","journal-title":"J Clin Invest"},{"key":"307_CR36","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0891-5849(96)00501-1","volume":"22","author":"L Floh\u00e9","year":"1997","unstructured":"Floh\u00e9 L, Brigelius-Floh\u00e9 R, Saliou C, Traber MG, Packer L. Redox regulation of NF-kappa B activation. Free Radic Biol Med. 1997;22:1115\u201326.","journal-title":"Free Radic Biol Med"},{"key":"307_CR37","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.1074\/jbc.273.6.3285","volume":"273","author":"W Berghe Vanden","year":"1998","unstructured":"Vanden Berghe W, Plaisance S, Boone E, De Bosscher K, Schmitz ML, Fiers W. p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-kappaB p65 transactivation mediated by tumor necrosis factor. J Biol Chem. 1998;273:3285\u201390.","journal-title":"J Biol Chem"}],"container-title":["Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-011-0307-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00011-011-0307-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-011-0307-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T07:07:04Z","timestamp":1740899224000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00011-011-0307-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,29]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["307"],"URL":"https:\/\/doi.org\/10.1007\/s00011-011-0307-8","relation":{},"ISSN":["1023-3830","1420-908X"],"issn-type":[{"value":"1023-3830","type":"print"},{"value":"1420-908X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,29]]}}}