{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T05:41:43Z","timestamp":1778910103752,"version":"3.51.4"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2012,2,11]],"date-time":"2012-02-11T00:00:00Z","timestamp":1328918400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Inflamm. Res."],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1007\/s00011-012-0447-5","type":"journal-article","created":{"date-parts":[[2012,2,10]],"date-time":"2012-02-10T12:56:32Z","timestamp":1328878592000},"page":"411-415","source":"Crossref","is-referenced-by-count":24,"title":["The association between the functional PTPN22 1858 C\/T and MIF \u2212173 C\/G polymorphisms and juvenile idiopathic arthritis: a meta-analysis"],"prefix":"10.1007","volume":"61","author":[{"given":"Young Ho","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang-Cheol","family":"Bae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gwan Gyu","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,2,11]]},"reference":[{"key":"447_CR1","first-page":"1991","volume":"25","author":"RE Petty","year":"1998","unstructured":"Petty RE, Southwood TR, Baum J, et al. Revision of the proposed classification criteria for juvenile idiopathic arthritis: Durban, 1997. J Rheumatol. 1998;25:1991\u20134.","journal-title":"J Rheumatol"},{"key":"447_CR2","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1182\/blood.V93.6.2013.406k25_2013_2024","volume":"93","author":"S Cohen","year":"1999","unstructured":"Cohen S, Dadi H, Shaoul E, Sharfe N, Roifman CM. Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase. Lyp Blood. 1999;93:2013\u201324.","journal-title":"Lyp Blood"},{"key":"447_CR3","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1084\/jem.189.1.111","volume":"189","author":"JF Cloutier","year":"1999","unstructured":"Cloutier JF, Veillette A. Cooperative inhibition of T-cell antigen receptor signaling by a complex between a kinase and a phosphatase. J Exp Med. 1999;189:111\u201321.","journal-title":"J Exp Med"},{"key":"447_CR4","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/ng1323","volume":"36","author":"N Bottini","year":"2004","unstructured":"Bottini N, Musumeci L, Alonso A, et al. A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. Nat Genet. 2004;36:337\u20138.","journal-title":"Nat Genet"},{"key":"447_CR5","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/S1357-4310(97)01133-7","volume":"3","author":"SC Donnelly","year":"1997","unstructured":"Donnelly SC, Bucala R. Macrophage migration inhibitory factor: a regulator of glucocorticoid activity with a critical role in inflammatory disease. Mol Med Today. 1997;3:502\u20137.","journal-title":"Mol Med Today"},{"key":"447_CR6","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1002\/1529-0131(200108)44:8<1782::AID-ART314>3.0.CO;2-#","volume":"44","author":"RP Donn","year":"2001","unstructured":"Donn RP, Shelley E, Ollier WE, Thomson W. A novel 5\u2032-flanking region polymorphism of macrophage migration inhibitory factor is associated with systemic-onset juvenile idiopathic arthritis. Arthritis Rheum. 2001;44:1782\u20135.","journal-title":"Arthritis Rheum"},{"key":"447_CR7","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1002\/art.10492","volume":"46","author":"R Donn","year":"2002","unstructured":"Donn R, Alourfi Z, De Benedetti F, et al. Mutation screening of the macrophage migration inhibitory factor gene: positive association of a functional polymorphism of macrophage migration inhibitory factor with juvenile idiopathic arthritis. Arthritis Rheum. 2002;46:2402\u20139.","journal-title":"Arthritis Rheum"},{"key":"447_CR8","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.1002\/art.27688","volume":"62","author":"SD Thompson","year":"2010","unstructured":"Thompson SD, Sudman M, Ramos PS, et al. The susceptibility loci juvenile idiopathic arthritis shares with other autoimmune diseases extend to PTPN2, COG6, and ANGPT1. Arthritis Rheum. 2010;62:3265\u201376.","journal-title":"Arthritis Rheum"},{"key":"447_CR9","first-page":"1146","volume":"26","author":"B Pazar","year":"2008","unstructured":"Pazar B, Gergely P Jr, Nagy ZB, et al. Role of HLA-DRB1 and PTPN22 genes in susceptibility to juvenile idiopathic arthritis in Hungarian patients. Clin Exp Rheumatol. 2008;26:1146\u201352.","journal-title":"Clin Exp Rheumatol"},{"key":"447_CR10","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.diabres.2006.09.009","volume":"76","author":"O Cinek","year":"2007","unstructured":"Cinek O, Hradsky O, Ahmedov G, et al. No independent role of the \u22121123 G\u00a0>\u00a0C and\u00a0+\u00a02740 A\u00a0>\u00a0G variants in the association of PTPN22 with type 1 diabetes and juvenile idiopathic arthritis in two Caucasian populations. Diabetes Res Clin Pract. 2007;76:297\u2013303.","journal-title":"Diabetes Res Clin Pract"},{"key":"447_CR11","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/sj.gene.6364255","volume":"6","author":"MF Seldin","year":"2005","unstructured":"Seldin MF, Shigeta R, Laiho K, et al. Finnish case-control and family studies support PTPN22 R620\u00a0W polymorphism as a risk factor in rheumatoid arthritis, but suggest only minimal or no effect in juvenile idiopathic arthritis. Genes Immun. 2005;6:720\u20132.","journal-title":"Genes Immun"},{"key":"447_CR12","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1002\/art.21049","volume":"52","author":"A Hinks","year":"2005","unstructured":"Hinks A, Barton A, John S, et al. Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population: further support that PTPN22 is an autoimmunity gene. Arthritis Rheum. 2005;52:1694\u20139.","journal-title":"Arthritis Rheum"},{"key":"447_CR13","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/sj.gene.6364178","volume":"6","author":"MK Viken","year":"2005","unstructured":"Viken MK, Amundsen SS, Kvien TK, et al. Association analysis of the 1858C\u00a0>\u00a0T polymorphism in the PTPN22 gene in juvenile idiopathic arthritis and other autoimmune diseases. Genes Immun. 2005;6:271\u20133.","journal-title":"Genes Immun"},{"key":"447_CR14","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1007\/s00296-005-0062-7","volume":"26","author":"A Berdeli","year":"2006","unstructured":"Berdeli A, Ozyurek AR, Ulger Z, et al. Association of macrophage migration inhibitory factor gene -173 G\/C polymorphism with prognosis in Turkish children with juvenile rheumatoid arthritis. Rheumatol Int. 2006;26:726\u201331.","journal-title":"Rheumatol Int"},{"key":"447_CR15","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-2156-5-2","volume":"5","author":"B Miterski","year":"2004","unstructured":"Miterski B, Drynda S, Boschow G, et al. Complex genetic predisposition in adult and juvenile rheumatoid arthritis. BMC Genet. 2004;5:2.","journal-title":"BMC Genet"},{"key":"447_CR16","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","volume":"315","author":"M Egger","year":"1997","unstructured":"Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315:629\u201334.","journal-title":"BMJ"},{"key":"447_CR17","doi-asserted-by":"crossref","unstructured":"Davey Smith G, Egger M. Meta-analyses of randomised controlled trials. Lancet. 1997; 350:1182.","DOI":"10.1016\/S0140-6736(05)63833-0"},{"key":"447_CR18","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","volume":"7","author":"R DerSimonian","year":"1986","unstructured":"DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177\u201388.","journal-title":"Control Clin Trials"},{"key":"447_CR19","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1136\/bmj.315.7121.1533","volume":"315","author":"M Egger","year":"1997","unstructured":"Egger M, Smith GD, Phillips AN. Meta-analysis: principles and procedures. BMJ. 1997;315:1533\u20137.","journal-title":"BMJ"},{"key":"447_CR20","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","volume":"21","author":"JP Higgins","year":"2002","unstructured":"Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21:1539\u201358.","journal-title":"Stat Med"},{"key":"447_CR21","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/rheumatology\/kel170","volume":"46","author":"YH Lee","year":"2007","unstructured":"Lee YH, Rho YH, Choi SJ, et al. The PTPN22 C1858T functional polymorphism and autoimmune diseases\u2013a meta-analysis. Rheumatology (Oxford). 2007;46:49\u201356.","journal-title":"Rheumatology (Oxford)"},{"key":"447_CR22","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/1529-0131(200201)46:1<232::AID-ART10059>3.0.CO;2-B","volume":"46","author":"C Meazza","year":"2002","unstructured":"Meazza C, Travaglino P, Pignatti P, et al. Macrophage migration inhibitory factor in patients with juvenile idiopathic arthritis. Arthritis Rheum. 2002;46:232\u20137.","journal-title":"Arthritis Rheum"}],"container-title":["Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-012-0447-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00011-012-0447-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-012-0447-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T04:59:18Z","timestamp":1593665958000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00011-012-0447-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,11]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["447"],"URL":"https:\/\/doi.org\/10.1007\/s00011-012-0447-5","relation":{},"ISSN":["1023-3830","1420-908X"],"issn-type":[{"value":"1023-3830","type":"print"},{"value":"1420-908X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,11]]}}}