{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T20:27:05Z","timestamp":1783542425749,"version":"3.55.0"},"reference-count":168,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T00:00:00Z","timestamp":1437696000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflamm. Res."],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1007\/s00011-015-0855-4","type":"journal-article","created":{"date-parts":[[2015,7,23]],"date-time":"2015-07-23T09:25:09Z","timestamp":1437643509000},"page":"753-765","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Usefulness of targeting lymphocyte Kv1.3-channels in the treatment of respiratory diseases"],"prefix":"10.1007","volume":"64","author":[{"given":"Itsuro","family":"Kazama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Tamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Tachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,7,24]]},"reference":[{"key":"855_CR1","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/nri3739","volume":"14","author":"MJ Holtzman","year":"2014","unstructured":"Holtzman MJ, Byers DE, Alexander-Brett J, Wang X. The role of airway epithelial cells and innate immune cells in chronic respiratory disease. Nat Rev Immunol. 2014;14:686\u201398.","journal-title":"Nat Rev Immunol"},{"key":"855_CR2","first-page":"1184","volume":"47","author":"DM Mannino","year":"2002","unstructured":"Mannino DM, Homa DM, Akinbami LJ, Ford ES, Redd SC. Chronic obstructive pulmonary disease surveillance\u2014United States, 1971\u20132000. Respir Care. 2002;47:1184\u201399.","journal-title":"Respir Care"},{"key":"855_CR3","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.rmed.2013.02.009","volume":"107","author":"K Suresh Babu","year":"2013","unstructured":"Suresh Babu K, Kastelik J, Morjaria JB. Role of long term antibiotics in chronic respiratory diseases. Respir Med. 2013;107:800\u201315.","journal-title":"Respir Med"},{"issue":"Suppl C","key":"855_CR4","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/S0954-6111(03)80020-3","volume":"97","author":"EF Wouters","year":"2003","unstructured":"Wouters EF. Economic analysis of the Confronting COPD survey: an overview of results. Respir Med. 2003;97(Suppl C):S3\u201314.","journal-title":"Respir Med"},{"key":"855_CR5","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0091-6749(03)02011-6","volume":"112","author":"ER Sutherland","year":"2003","unstructured":"Sutherland ER, Martin RJ. Airway inflammation in chronic obstructive pulmonary disease: comparisons with asthma. J Allergy Clin Immunol. 2003;112:819\u201327 (quiz 828).","journal-title":"J Allergy Clin Immunol"},{"key":"855_CR6","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1124\/pr.56.4.2","volume":"56","author":"PJ Barnes","year":"2004","unstructured":"Barnes PJ. Mediators of chronic obstructive pulmonary disease. Pharmacol Rev. 2004;56:515\u201348.","journal-title":"Pharmacol Rev"},{"key":"855_CR7","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1111\/j.1365-2222.2008.02971.x","volume":"38","author":"ST Holgate","year":"2008","unstructured":"Holgate ST. Pathogenesis of asthma. Clin Exp Allergy. 2008;38:872\u201397.","journal-title":"Clin Exp Allergy"},{"key":"855_CR8","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1164\/ajrccm\/144.1.51","volume":"144","author":"MC Liu","year":"1991","unstructured":"Liu MC, Hubbard WC, Proud D, Stealey BA, Galli SJ, Kagey-Sobotka A, Bleecker ER, Lichtenstein LM. Immediate and late inflammatory responses to ragweed antigen challenge of the peripheral airways in allergic asthmatics. Cellular, mediator, and permeability changes. Am Rev Respir Dis. 1991;144:51\u20138.","journal-title":"Am Rev Respir Dis"},{"key":"855_CR9","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1164\/ajrccm.152.2.7633715","volume":"152","author":"H Mukae","year":"1995","unstructured":"Mukae H, Kadota J, Kohno S, Kusano S, Morikawa T, Matsukura S, Hara K. Increase in activated CD8+ cells in bronchoalveolar lavage fluid in patients with diffuse panbronchiolitis. Am J Respir Crit Care Med. 1995;152:613\u20138.","journal-title":"Am J Respir Crit Care Med"},{"issue":"Suppl 1","key":"855_CR10","doi-asserted-by":"crossref","first-page":"S83","DOI":"10.1016\/S0924-8579(01)00403-4","volume":"18","author":"K Yanagihara","year":"2001","unstructured":"Yanagihara K, Kadoto J, Kohno S. Diffuse panbronchiolitis\u2013pathophysiology and treatment mechanisms. Int J Antimicrob Agents. 2001;18(Suppl 1):S83\u20137.","journal-title":"Int J Antimicrob Agents"},{"key":"855_CR11","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1164\/rccm.200404-543OC","volume":"170","author":"DD Sin","year":"2004","unstructured":"Sin DD, Lacy P, York E, Man SF. Effects of fluticasone on systemic markers of inflammation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2004;170:760\u20135.","journal-title":"Am J Respir Crit Care Med"},{"key":"855_CR12","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1136\/thx.2005.045385","volume":"60","author":"DD Sin","year":"2005","unstructured":"Sin DD, Wu L, Anderson JA, Anthonisen NR, Buist AS, Burge PS, Calverley PM, Connett JE, Lindmark B, Pauwels RA, Postma DS, Soriano JB, Szafranski W, Vestbo J. Inhaled corticosteroids and mortality in chronic obstructive pulmonary disease. Thorax. 2005;60:992\u20137.","journal-title":"Thorax"},{"key":"855_CR13","author":"JA Walters","year":"2005","unstructured":"Walters JA, Walters EH, Wood-Baker R. Oral corticosteroids for stable chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2005;. doi: 10.1002\/14651858.CD005374CD005374 .","journal-title":"Cochrane Database Syst Rev"},{"key":"855_CR14","first-page":"632","volume":"25","author":"S Kudoh","year":"1987","unstructured":"Kudoh S, Uetake T, Hagiwara K, Hirayama M, Hus LH, Kimura H, Sugiyama Y. Clinical effects of low-dose long-term erythromycin chemotherapy on diffuse panbronchiolitis. Nihon Kyobu Shikkan Gakkai Zasshi. 1987;25:632\u201342.","journal-title":"Nihon Kyobu Shikkan Gakkai Zasshi"},{"key":"855_CR15","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1097\/00063198-199803000-00010","volume":"4","author":"S Kudoh","year":"1998","unstructured":"Kudoh S. Erythromycin treatment in diffuse panbronchiolitis. Curr Opin Pulm Med. 1998;4:116\u201321.","journal-title":"Curr Opin Pulm Med"},{"key":"855_CR16","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1164\/ajrccm.157.6.9710075","volume":"157","author":"S Kudoh","year":"1998","unstructured":"Kudoh S, Azuma A, Yamamoto M, Izumi T, Ando M. Improvement of survival in patients with diffuse panbronchiolitis treated with low-dose erythromycin. Am J Respir Crit Care Med. 1998;157:1829\u201332.","journal-title":"Am J Respir Crit Care Med"},{"key":"855_CR17","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1183\/09031936.00136712","volume":"42","author":"P Spagnolo","year":"2013","unstructured":"Spagnolo P, Fabbri LM, Bush A. Long-term macrolide treatment for chronic respiratory disease. Eur Respir J. 2013;42:239\u201351.","journal-title":"Eur Respir J"},{"key":"855_CR18","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1183\/09031936.00208011","volume":"40","author":"M Yamaya","year":"2012","unstructured":"Yamaya M, Azuma A, Takizawa H, Kadota J, Tamaoki J, Kudoh S. Macrolide effects on the prevention of COPD exacerbations. Eur Respir J. 2012;40:485\u201394.","journal-title":"Eur Respir J"},{"key":"855_CR19","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S2213-2600(14)70107-9","volume":"2","author":"EH Wong","year":"2014","unstructured":"Wong EH, Porter JD, Edwards MR, Johnston SL. The role of macrolides in asthma: current evidence and future directions. Lancet Respir Med. 2014;2:657\u201370.","journal-title":"Lancet Respir Med"},{"key":"855_CR20","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1476-7961-2-4","volume":"2","author":"U Hatipoglu","year":"2004","unstructured":"Hatipoglu U, Rubinstein I. Low-dose, long-term macrolide therapy in asthma: an overview. Clin Mol Allergy. 2004;2:4.","journal-title":"Clin Mol Allergy"},{"key":"855_CR21","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1128\/CMR.00078-09","volume":"23","author":"S Kanoh","year":"2010","unstructured":"Kanoh S, Rubin BK. Mechanisms of action and clinical application of macrolides as immunomodulatory medications. Clin Microbiol Rev. 2010;23:590\u2013615.","journal-title":"Clin Microbiol Rev"},{"key":"855_CR22","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/j.1365-2249.2007.03299.x","volume":"147","author":"K Sugiyama","year":"2007","unstructured":"Sugiyama K, Shirai R, Mukae H, Ishimoto H, Nagata T, Sakamoto N, Ishii H, Nakayama S, Yanagihara K, Mizuta Y, Kohno S. Differing effects of clarithromycin and azithromycin on cytokine production by murine dendritic cells. Clin Exp Immunol. 2007;147:540\u20136.","journal-title":"Clin Exp Immunol"},{"key":"855_CR23","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0924-8579(01)00457-5","volume":"19","author":"K Morikawa","year":"2002","unstructured":"Morikawa K, Zhang J, Nonaka M, Morikawa S. Modulatory effect of macrolide antibiotics on the Th1- and Th2-type cytokine production. Int J Antimicrob Agents. 2002;19:53\u20139.","journal-title":"Int J Antimicrob Agents"},{"key":"855_CR24","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0924-8579(98)00091-0","volume":"11","author":"AA Khan","year":"1999","unstructured":"Khan AA, Slifer TR, Araujo FG, Remington JS. Effect of clarithromycin and azithromycin on production of cytokines by human monocytes. Int J Antimicrob Agents. 1999;11:121\u201332.","journal-title":"Int J Antimicrob Agents"},{"key":"855_CR25","first-page":"74","volume":"23","author":"I Kazama","year":"2015","unstructured":"Kazama I, Tamada T, Nakajima T. Macroscopic haemoglobinuria associated with Mycoplasma pneumoniae infection successfully treated by clarithromycin. Infez Med. 2015;23:74\u20138.","journal-title":"Infez Med"},{"key":"855_CR26","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1590\/S1413-86702009000100018","volume":"13","author":"FY Khan","year":"2009","unstructured":"Khan FY, Ay M. Mycoplasma pneumoniae associated with severe autoimmune hemolytic anemia: case report and literature review. Braz J Infect Dis. 2009;13:77\u20139.","journal-title":"Braz J Infect Dis"},{"key":"855_CR27","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1146\/annurev.iy.13.040195.003203","volume":"13","author":"RS Lewis","year":"1995","unstructured":"Lewis RS, Cahalan MD. Potassium and calcium channels in lymphocytes. Annu Rev Immunol. 1995;13:623\u201353.","journal-title":"Annu Rev Immunol"},{"key":"855_CR28","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.bcp.2010.05.012","volume":"80","author":"N Villalonga","year":"2010","unstructured":"Villalonga N, David M, Bielanska J, Gonzalez T, Parra D, Soler C, Comes N, Valenzuela C, Felipe A. Immunomodulatory effects of diclofenac in leukocytes through the targeting of Kv1.3 voltage-dependent potassium channels. Biochem Pharmacol. 2010;80:858\u201366.","journal-title":"Biochem Pharmacol"},{"key":"855_CR29","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0165-6147(03)00198-6","volume":"24","author":"J Matko","year":"2003","unstructured":"Matko J. K+ channels and T-cell synapses: the molecular background for efficient immunomodulation is shaping up. Trends Pharmacol Sci. 2003;24:385\u20139.","journal-title":"Trends Pharmacol Sci"},{"key":"855_CR30","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.tips.2004.03.010","volume":"25","author":"KG Chandy","year":"2004","unstructured":"Chandy KG, Wulff H, Beeton C, Pennington M, Gutman GA, Cahalan MD. K+ channels as targets for specific immunomodulation. Trends Pharmacol Sci. 2004;25:280\u20139.","journal-title":"Trends Pharmacol Sci"},{"key":"855_CR31","doi-asserted-by":"crossref","first-page":"760","DOI":"10.3109\/13880209.2013.764539","volume":"51","author":"I Kazama","year":"2013","unstructured":"Kazama I, Maruyama Y. Differential effects of clarithromycin and azithromycin on delayed rectifier K(+)-channel currents in murine thymocytes. Pharm Biol. 2013;51:760\u20135.","journal-title":"Pharm Biol"},{"key":"855_CR32","first-page":"1075","volume":"151","author":"TZ Khan","year":"1995","unstructured":"Khan TZ, Wagener JS, Bost T, Martinez J, Accurso FJ, Riches DW. Early pulmonary inflammation in infants with cystic fibrosis. Am J Respir Crit Care Med. 1995;151:1075\u201382.","journal-title":"Am J Respir Crit Care Med"},{"key":"855_CR33","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1164\/ajrccm.157.3.9709027","volume":"157","author":"M Saetta","year":"1998","unstructured":"Saetta M, Di Stefano A, Turato G, Facchini FM, Corbino L, Mapp CE, Maestrelli P, Ciaccia A, Fabbri LM. CD8+ T-lymphocytes in peripheral airways of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1998;157:822\u20136.","journal-title":"Am J Respir Crit Care Med"},{"key":"855_CR34","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1164\/ajrccm.155.3.9117016","volume":"155","author":"TC O\u2019Shaughnessy","year":"1997","unstructured":"O\u2019Shaughnessy TC, Ansari TW, Barnes NC, Jeffery PK. Inflammation in bronchial biopsies of subjects with chronic bronchitis: inverse relationship of CD8+ T lymphocytes with FEV1. Am J Respir Crit Care Med. 1997;155:852\u20137.","journal-title":"Am J Respir Crit Care Med"},{"key":"855_CR35","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1146\/annurev.immunol.26.021607.090312","volume":"26","author":"BD Medoff","year":"2008","unstructured":"Medoff BD, Thomas SY, Luster AD. T cell trafficking in allergic asthma: the ins and outs. Annu Rev Immunol. 2008;26:205\u201332.","journal-title":"Annu Rev Immunol"},{"key":"855_CR36","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.coph.2013.03.013","volume":"13","author":"MJ Schuijs","year":"2013","unstructured":"Schuijs MJ, Willart MA, Hammad H, Lambrecht BN. Cytokine targets in airway inflammation. Curr Opin Pharmacol. 2013;13:351\u201361.","journal-title":"Curr Opin Pharmacol"},{"key":"855_CR37","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.jaci.2010.06.025","volume":"126","author":"DS Robinson","year":"2010","unstructured":"Robinson DS. The role of the T cell in asthma. J Allergy Clin Immunol. 2010;126:1081\u201391 (quiz 1092-1083).","journal-title":"J Allergy Clin Immunol"},{"key":"855_CR38","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/j.1365-2567.2006.02440.x","volume":"119","author":"SL Gyles","year":"2006","unstructured":"Gyles SL, Xue L, Townsend ER, Wettey F, Pettipher R. A dominant role for chemoattractant receptor-homologous molecule expressed on T helper type 2 (Th2) cells (CRTH2) in mediating chemotaxis of CRTH2\u00a0+\u00a0CD4\u00a0+\u00a0Th2 lymphocytes in response to mast cell supernatants. Immunology. 2006;119:362\u20138.","journal-title":"Immunology"},{"key":"855_CR39","first-page":"133","volume":"162","author":"ED Chan","year":"1995","unstructured":"Chan ED, Welsh CH. Fulminant Mycoplasma pneumoniae pneumonia. West J Med. 1995;162:133\u201342.","journal-title":"West J Med"},{"key":"855_CR40","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0171-2985(97)80073-3","volume":"196","author":"O Opitz","year":"1996","unstructured":"Opitz O, Pietsch K, Ehlers S, Jacobs E. Cytokine gene expression in immune mice reinfected with Mycoplasma pneumoniae: the role of T cell subsets in aggravating the inflammatory response. Immunobiology. 1996;196:575\u201387.","journal-title":"Immunobiology"},{"key":"855_CR41","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1586\/14760584.3.6.693","volume":"3","author":"MF Delgado","year":"2004","unstructured":"Delgado MF, Polack FP. Involvement of antibody, complement and cellular immunity in the pathogenesis of enhanced respiratory syncytial virus disease. Expert Rev Vaccines. 2004;3:693\u2013700.","journal-title":"Expert Rev Vaccines"},{"key":"855_CR42","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1128\/CMR.17.4.697-728.2004","volume":"17","author":"KB Waites","year":"2004","unstructured":"Waites KB, Talkington DF. Mycoplasma pneumoniae and its role as a human pathogen. Clin Microbiol Rev. 2004;17:697\u2013728 (table of contents).","journal-title":"Clin Microbiol Rev"},{"issue":"Suppl 1","key":"855_CR43","doi-asserted-by":"crossref","first-page":"S187","DOI":"10.1093\/clinids\/17.Supplement_1.S187","volume":"17","author":"PM Stuart","year":"1993","unstructured":"Stuart PM. Mycoplasmal induction of cytokine production and major histocompatibility complex expression. Clin Infect Dis. 1993;17(Suppl 1):S187\u201391.","journal-title":"Clin Infect Dis"},{"key":"855_CR44","doi-asserted-by":"crossref","first-page":"S137","DOI":"10.1164\/ajrccm\/154.4_Pt_2.S137","volume":"154","author":"JB Baseman","year":"1996","unstructured":"Baseman JB, Reddy SP, Dallo SF. Interplay between mycoplasma surface proteins, airway cells, and the protean manifestations of mycoplasma-mediated human infections. Am J Respir Crit Care Med. 1996;154:S137\u201344.","journal-title":"Am J Respir Crit Care Med"},{"key":"855_CR45","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1006\/mpat.1993.1079","volume":"15","author":"SS Kaukoranta-Tolvanen","year":"1993","unstructured":"Kaukoranta-Tolvanen SS, Laurila AL, Saikku P, Leinonen M, Liesirova L, Laitinen K. Experimental infection of Chlamydia pneumoniae in mice. Microb Pathog. 1993;15:293\u2013302.","journal-title":"Microb Pathog"},{"key":"855_CR46","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1469-0691.2008.02130.x","volume":"15","author":"F Blasi","year":"2009","unstructured":"Blasi F, Tarsia P, Aliberti S. Chlamydophila pneumoniae. Clin Microbiol Infect. 2009;15:29\u201335.","journal-title":"Clin Microbiol Infect"},{"key":"855_CR47","first-page":"41","volume":"22","author":"I Kazama","year":"2014","unstructured":"Kazama I, Nakajima T. Dual infection of Mycoplasma pneumoniae and Chlamydophila pneumoniae in patients with atopic predispositions successfully treated by moxifloxacin. Infez Med. 2014;22:41\u20137.","journal-title":"Infez Med"},{"key":"855_CR48","first-page":"288","volume":"20","author":"I Kazama","year":"2012","unstructured":"Kazama I, Tamada T, Nakajima T. Resolution of migratory pulmonary infiltrates by moxifloxacin in a patient with dual infection of Mycoplasma pneumoniae and Bordetella pertussis. Infez Med. 2012;20:288\u201392.","journal-title":"Infez Med"},{"key":"855_CR49","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1177\/000992289103000107","volume":"30","author":"M Levy","year":"1991","unstructured":"Levy M, Shear NH. Mycoplasma pneumoniae infections and Stevens-Johnson syndrome. Report of eight cases and review of the literature. Clin Pediatr (Phila). 1991;30:42\u20139.","journal-title":"Clin Pediatr (Phila)"},{"key":"855_CR50","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s12288-011-0054-6","volume":"27","author":"S Aviner","year":"2011","unstructured":"Aviner S, Miskin H, London D, Horowitz S, Schlesinger M. Mycoplasma pneumonia infection: a possible trigger for immune thrombocytopenia. Indian J Hematol Blood Transfus. 2011;27:46\u201350.","journal-title":"Indian J Hematol Blood Transfus"},{"key":"855_CR51","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1007\/s11604-010-0473-6","volume":"28","author":"H Natori","year":"2010","unstructured":"Natori H, Koga T, Fujimoto K, Taguchi J, Kamimura T, Nishimura M. Organizing pneumonia associated with Mycoplasma pneumoniae infection. Jpn J Radiol. 2010;28:688\u201391.","journal-title":"Jpn J Radiol"},{"key":"855_CR52","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1600-065X.2009.00816.x","volume":"231","author":"MD Cahalan","year":"2009","unstructured":"Cahalan MD, Chandy KG. The functional network of ion channels in T lymphocytes. Immunol Rev. 2009;231:59\u201387.","journal-title":"Immunol Rev"},{"key":"855_CR53","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1113\/jphysiol.1985.sp015548","volume":"358","author":"MD Cahalan","year":"1985","unstructured":"Cahalan MD, Chandy KG, DeCoursey TE, Gupta S. A voltage-gated potassium channel in human T lymphocytes. J Physiol. 1985;358:197\u2013237.","journal-title":"J Physiol"},{"key":"855_CR54","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/307465a0","volume":"307","author":"TE DeCoursey","year":"1984","unstructured":"DeCoursey TE, Chandy KG, Gupta S, Cahalan MD. Voltage-gated K+ channels in human T lymphocytes: a role in mitogenesis? Nature. 1984;307:465\u20138.","journal-title":"Nature"},{"key":"855_CR55","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s12576-012-0195-x","volume":"62","author":"I Kazama","year":"2012","unstructured":"Kazama I, Maruyama Y, Murata Y, Sano M. Voltage-dependent biphasic effects of chloroquine on delayed rectifier K(+)-channel currents in murine thymocytes. J Physiol Sci. 2012;62:267\u201374.","journal-title":"J Physiol Sci"},{"key":"855_CR56","doi-asserted-by":"crossref","first-page":"874","DOI":"10.3109\/08923973.2012.666249","volume":"34","author":"I Kazama","year":"2012","unstructured":"Kazama I, Maruyama Y, Murata Y. Suppressive effects of nonsteroidal anti-inflammatory drugs diclofenac sodium, salicylate and indomethacin on delayed rectifier K+ -channel currents in murine thymocytes. Immunopharmacol Immunotoxicol. 2012;34:874\u20138.","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"855_CR57","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3109\/08923973.2012.723011","volume":"35","author":"I Kazama","year":"2013","unstructured":"Kazama I, Maruyama Y, Matsubara M. Benidipine persistently inhibits delayed rectifier K(+)-channel currents in murine thymocytes. Immunopharmacol Immunotoxicol. 2013;35:28\u201333.","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"855_CR58","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.pharep.2014.03.002","volume":"66","author":"I Kazama","year":"2014","unstructured":"Kazama I, Baba A, Maruyama Y. HMG-CoA reductase inhibitors pravastatin, lovastatin and simvastatin suppress delayed rectifier K(+)-channel currents in murine thymocytes. Pharmacol Rep. 2014;66:712\u20137.","journal-title":"Pharmacol Rep"},{"key":"855_CR59","doi-asserted-by":"crossref","unstructured":"Baba A, Tachi M, Maruyama Y, Kazama I, Suppressive effects of diltiazem and verapamil on delayed rectifier K+-channel currents in murine thymocytes. Pharmacol Rep. 2015 in press.","DOI":"10.1016\/j.pharep.2015.01.009"},{"key":"855_CR60","doi-asserted-by":"crossref","first-page":"12790","DOI":"10.1074\/jbc.M413548200","volume":"280","author":"I Szabo","year":"2005","unstructured":"Szabo I, Bock J, Jekle A, Soddemann M, Adams C, Lang F, Zoratti M, Gulbins E. A novel potassium channel in lymphocyte mitochondria. J Biol Chem. 2005;280:12790\u20138.","journal-title":"J Biol Chem"},{"key":"855_CR61","doi-asserted-by":"crossref","first-page":"581581","DOI":"10.1155\/2012\/581581","volume":"2012","author":"I Kazama","year":"2012","unstructured":"Kazama I, Maruyama Y, Endo Y, Toyama H, Ejima Y, Matsubara M, Kurosawa S. Overexpression of delayed rectifier K(+) channels promotes in situ proliferation of leukocytes in rat kidneys with advanced chronic renal failure. Int J Nephrol. 2012;2012:581581.","journal-title":"Int J Nephrol"},{"key":"855_CR62","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.1002\/cne.22393","volume":"518","author":"VR Gazula","year":"2010","unstructured":"Gazula VR, Strumbos JG, Mei X, Chen H, Rahner C, Kaczmarek LK. Localization of Kv1.3 channels in presynaptic terminals of brainstem auditory neurons. J Comp Neurol. 2010;518:3205\u201320.","journal-title":"J Comp Neurol"},{"key":"855_CR63","doi-asserted-by":"crossref","first-page":"17414","DOI":"10.1073\/pnas.0605136103","volume":"103","author":"C Beeton","year":"2006","unstructured":"Beeton C, Wulff H, Standifer NE, Azam P, Mullen KM, Pennington MW, Kolski-Andreaco A, Wei E, Grino A, Counts DR, Wang PH, LeeHealey CJ, Andrews BS, Sankaranarayanan A, Homerick D, Roeck WW, Tehranzadeh J, Stanhope KL, Zimin P, Havel PJ, Griffey S, Knaus HG, Nepom GT, Gutman GA, Calabresi PA, Chandy KG. Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases. Proc Natl Acad Sci USA. 2006;103:17414\u20139.","journal-title":"Proc Natl Acad Sci USA"},{"key":"855_CR64","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1177\/1076029612461845","volume":"20","author":"I Kazama","year":"2014","unstructured":"Kazama I, Maruyama Y, Nakamichi S. Aspirin-induced microscopic surface changes stimulate thrombopoiesis in rat megakaryocytes. Clin Appl Thromb Hemost. 2014;20:318\u201325.","journal-title":"Clin Appl Thromb Hemost"},{"key":"855_CR65","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1159\/000374039","volume":"35","author":"I Kazama","year":"2015","unstructured":"Kazama I, Baba A, Endo Y, Toyama H, Ejima Y, Matsubara M, Tachi M. Salicylate inhibits thrombopoiesis in rat megakaryocytes by changing the membrane micro-architecture. Cell Physiol Biochem. 2015;35:2371\u201382.","journal-title":"Cell Physiol Biochem"},{"key":"855_CR66","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1159\/000333018","volume":"1","author":"I Kazama","year":"2011","unstructured":"Kazama I, Endo Y, Toyama H, Ejima Y, Kurosawa S, Murata Y, Matsubara M, Maruyama M. Compensatory thrombopoietin production from liver and bone marrow stimulates thrombopoiesis of living rat megakaryocytes in chronic renal failure. Nephron Extra. 2011;1:147\u201356.","journal-title":"Nephron Extra"},{"key":"855_CR67","doi-asserted-by":"crossref","first-page":"C965","DOI":"10.1152\/ajpcell.00074.2003","volume":"286","author":"LI Escobar","year":"2004","unstructured":"Escobar LI, Martinez-Tellez JC, Salas M, Castilla SA, Carrisoza R, Tapia D, Vazquez M, Bargas J, Bolivar JJ. A voltage-gated K(+) current in renal inner medullary collecting duct cells. Am J Physiol Cell Physiol. 2004;286:C965\u201374.","journal-title":"Am J Physiol Cell Physiol"},{"key":"855_CR68","doi-asserted-by":"crossref","first-page":"F255","DOI":"10.1152\/ajprenal.00697.2009","volume":"299","author":"R Carrisoza-Gaytan","year":"2010","unstructured":"Carrisoza-Gaytan R, Salvador C, Satlin LM, Liu W, Zavilowitz B, Bobadilla NA, Trujillo J, Escobar LI. Potassium secretion by voltage-gated potassium channel Kv1.3 in the rat kidney. Am J Physiol Renal Physiol. 2010;299:F255\u201364.","journal-title":"Am J Physiol Renal Physiol."},{"key":"855_CR69","doi-asserted-by":"crossref","first-page":"610","DOI":"10.4049\/jimmunol.151.2.610","volume":"151","author":"Y Ishida","year":"1993","unstructured":"Ishida Y, Chused TM. Lack of voltage sensitive potassium channels and generation of membrane potential by sodium potassium ATPase in murine T lymphocytes. J Immunol. 1993;151:610\u201320.","journal-title":"J Immunol"},{"key":"855_CR70","doi-asserted-by":"crossref","first-page":"10036","DOI":"10.1073\/pnas.90.21.10036","volume":"90","author":"C Deutsch","year":"1993","unstructured":"Deutsch C, Chen LQ. Heterologous expression of specific K+ channels in T lymphocytes: functional consequences for volume regulation. Proc Natl Acad Sci USA. 1993;90:10036\u201340.","journal-title":"Proc Natl Acad Sci USA"},{"key":"855_CR71","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1023\/A:1010958907271","volume":"21","author":"MD Cahalan","year":"2001","unstructured":"Cahalan MD, Wulff H, Chandy KG. Molecular properties and physiological roles of ion channels in the immune system. J Clin Immunol. 2001;21:235\u201352.","journal-title":"J Clin Immunol"},{"key":"855_CR72","doi-asserted-by":"crossref","first-page":"4563","DOI":"10.4049\/jimmunol.179.7.4563","volume":"179","author":"L Hu","year":"2007","unstructured":"Hu L, Pennington M, Jiang Q, Whartenby KA, Calabresi PA. Characterization of the functional properties of the voltage-gated potassium channel Kv1.3 in human CD4+ T lymphocytes. J Immunol. 2007;179:4563\u201370.","journal-title":"J Immunol"},{"key":"855_CR73","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s12576-014-0331-x","volume":"65","author":"I Kazama","year":"2015","unstructured":"Kazama I. Physiological significance of delayed rectifier K(+) channels (Kv1.3) expressed in T lymphocytes and their pathological significance in chronic kidney disease. J Physiol Sci. 2015;65:25\u201335.","journal-title":"J Physiol Sci"},{"key":"855_CR74","doi-asserted-by":"crossref","first-page":"145","DOI":"10.5414\/CPP49145","volume":"49","author":"K Sugiyama","year":"2011","unstructured":"Sugiyama K, Isogai K, Toyama A, Satoh H, Saito K, Nakagawa Y, Tasaki M, Takahashi K, Hirano T. Correlation between the pharmacological efficacy of cyclosporine and tacrolimus as evaluated by the lymphocyte immunosuppressant sensitivity test (LIST) and the MTT assay procedure in patients before and after renal transplantation. Int J Clin Pharmacol Ther. 2011;49:145\u201352.","journal-title":"Int J Clin Pharmacol Ther"},{"key":"855_CR75","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1517\/14728220903018957","volume":"13","author":"S Rangaraju","year":"2009","unstructured":"Rangaraju S, Chi V, Pennington MW, Chandy KG. Kv1.3 potassium channels as a therapeutic target in multiple sclerosis. Expert Opin Ther Targets. 2009;13:909\u201324.","journal-title":"Expert Opin Ther Targets"},{"key":"855_CR76","doi-asserted-by":"crossref","first-page":"R101","DOI":"10.1093\/hmg\/ddp001","volume":"18","author":"GA Heap","year":"2009","unstructured":"Heap GA, van Heel DA. The genetics of chronic inflammatory diseases. Hum Mol Genet. 2009;18:R101\u20136.","journal-title":"Hum Mol Genet"},{"key":"855_CR77","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.mehy.2013.11.037","volume":"82","author":"I Kazama","year":"2014","unstructured":"Kazama I, Maruyama Y, Baba A. Amphipath-induced plasma membrane curvature controls microparticle formation from adipocytes: novel therapeutic implications for metabolic disorders. Med Hypotheses. 2014;82:196\u20138.","journal-title":"Med Hypotheses"},{"key":"855_CR78","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0304-3835(02)00348-8","volume":"186","author":"M Abdul","year":"2002","unstructured":"Abdul M, Hoosein N. Expression and activity of potassium ion channels in human prostate cancer. Cancer Lett. 2002;186:99\u2013105.","journal-title":"Cancer Lett"},{"key":"855_CR79","doi-asserted-by":"crossref","first-page":"535","DOI":"10.5483\/BMBRep.2009.42.8.535","volume":"42","author":"SH Jang","year":"2009","unstructured":"Jang SH, Kang KS, Ryu PD, Lee SY. Kv1.3 voltage-gated K(+) channel subunit as a potential diagnostic marker and therapeutic target for breast cancer. BMB Rep. 2009;42:535\u20139.","journal-title":"BMB Rep"},{"key":"855_CR80","first-page":"40","volume":"7","author":"S Huang","year":"2010","unstructured":"Huang S, Tang CT, Tang J-R, Tang J, Cai L, Zhang Z, Zhou M-G. Upregulated voltage-gated potassium channel Kv1.3 on CD4+ CD28 null T lymphocytes from patients with acute coronary syndrome. J Geriatr Cardiol. 2010;7:40\u20136.","journal-title":"J Geriatr Cardiol"},{"key":"855_CR81","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.imbio.2012.05.013","volume":"218","author":"G Toldi","year":"2013","unstructured":"Toldi G, Bajnok A, Dobi D, Kaposi A, Kovacs L, Vasarhelyi B, Balog A. The effects of Kv1.3 and IKCa1 potassium channel inhibition on calcium influx of human peripheral T lymphocytes in rheumatoid arthritis. Immunobiology. 2013;218:311\u20136.","journal-title":"Immunobiology"},{"key":"855_CR82","doi-asserted-by":"crossref","first-page":"11094","DOI":"10.1073\/pnas.0501770102","volume":"102","author":"H Rus","year":"2005","unstructured":"Rus H, Pardo CA, Hu L, Darrah E, Cudrici C, Niculescu T, Niculescu F, Mullen KM, Allie R, Guo L, Wulff H, Beeton C, Judge SI, Kerr DA, Knaus HG, Chandy KG, Calabresi PA. The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain. Proc Natl Acad Sci USA. 2005;102:11094\u20139.","journal-title":"Proc Natl Acad Sci USA"},{"key":"855_CR83","doi-asserted-by":"crossref","first-page":"936","DOI":"10.4049\/jimmunol.166.2.936","volume":"166","author":"C Beeton","year":"2001","unstructured":"Beeton C, Barbaria J, Giraud P, Devaux J, Benoliel AM, Gola M, Sabatier JM, Bernard D, Crest M, Beraud E. Selective blocking of voltage-gated K\u00a0+\u00a0channels improves experimental autoimmune encephalomyelitis and inhibits T cell activation. J Immunol. 2001;166:936\u201344.","journal-title":"J Immunol"},{"key":"855_CR84","doi-asserted-by":"crossref","first-page":"13942","DOI":"10.1073\/pnas.241497298","volume":"98","author":"C Beeton","year":"2001","unstructured":"Beeton C, Wulff H, Barbaria J, Clot-Faybesse O, Pennington M, Bernard D, Cahalan MD, Chandy KG, Beraud E. Selective blockade of T lymphocyte K(+) channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis. Proc Natl Acad Sci USA. 2001;98:13942\u20137.","journal-title":"Proc Natl Acad Sci USA"},{"key":"855_CR85","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1124\/mol.104.008193","volume":"67","author":"C Beeton","year":"2005","unstructured":"Beeton C, Pennington MW, Wulff H, Singh S, Nugent D, Crossley G, Khaytin I, Calabresi PA, Chen CY, Gutman GA, Chandy KG. Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases. Mol Pharmacol. 2005;67:1369\u201381.","journal-title":"Mol Pharmacol"},{"key":"855_CR86","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/jid.2010.245","volume":"131","author":"A Gilhar","year":"2011","unstructured":"Gilhar A, Bergman R, Assay B, Ullmann Y, Etzioni A. The beneficial effect of blocking Kv1.3 in the psoriasiform SCID mouse model. J Invest Dermatol. 2011;131:118\u201324.","journal-title":"J Invest Dermatol"},{"key":"855_CR87","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jaut.2014.07.003","volume":"55","author":"S Kundu-Raychaudhuri","year":"2014","unstructured":"Kundu-Raychaudhuri S, Chen YJ, Wulff H, Raychaudhuri SP. Kv1.3 in psoriatic disease: PAP-1, a small molecule inhibitor of Kv1.3 is effective in the SCID mouse psoriasis\u2013xenograft model. J Autoimmun. 2014;55:63\u201372.","journal-title":"J Autoimmun"},{"key":"855_CR88","author":"I Kazama","year":"2015","unstructured":"Kazama I. Roles of lymphocyte Kv1.3-channels in gut mucosal immune system: novel therapeutic implications for inflammatory bowel disease. Med Hypotheses. 2015. doi: 10.1016\/j.mehy.2015.03.023 .","journal-title":"Med Hypotheses"},{"key":"855_CR89","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.crohns.2014.04.003","volume":"8","author":"L Koch Hansen","year":"2014","unstructured":"Koch Hansen L, Sevelsted-Moller L, Rabjerg M, Larsen D, Hansen TP, Klinge L, Wulff H, Knudsen T, Kjeldsen J, Kohler R. Expression of T-cell KV1.3 potassium channel correlates with pro-inflammatory cytokines and disease activity in ulcerative colitis. J Crohns Colitis. 2014;8:1378\u201391.","journal-title":"J Crohns Colitis"},{"key":"855_CR90","first-page":"B4946","volume":"61","author":"LK Hansen","year":"2014","unstructured":"Hansen LK. The role of T cell potassium channels, KV1.3 and KCa3.1, in the inflammatory cascade in ulcerative colitis. Dan Med J. 2014;61:B4946.","journal-title":"Dan Med J"},{"key":"855_CR91","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1016\/j.transproceed.2009.06.025","volume":"41","author":"I Grgic","year":"2009","unstructured":"Grgic I, Wulff H, Eichler I, Flothmann C, Kohler R, Hoyer J. Blockade of T-lymphocyte KCa3.1 and Kv1.3 channels as novel immunosuppression strategy to prevent kidney allograft rejection. Transplant Proc. 2009;41:2601\u20136.","journal-title":"Transplant Proc"},{"key":"855_CR92","doi-asserted-by":"crossref","first-page":"F1258","DOI":"10.1152\/ajprenal.00374.2010","volume":"299","author":"T Hyodo","year":"2010","unstructured":"Hyodo T, Oda T, Kikuchi Y, Higashi K, Kushiyama T, Yamamoto K, Yamada M, Suzuki S, Hokari R, Kinoshita M, Seki S, Fujinaka H, Yamamoto T, Miura S, Kumagai H. Voltage-gated potassium channel Kv1.3 blocker as a potential treatment for rat anti-glomerular basement membrane glomerulonephritis. Am J Physiol Renal Physiol. 2010;299:F1258\u201369.","journal-title":"Am J Physiol Renal Physiol"},{"key":"855_CR93","doi-asserted-by":"crossref","first-page":"12623","DOI":"10.1074\/jbc.M113.517037","volume":"289","author":"S Koshy","year":"2014","unstructured":"Koshy S, Huq R, Tanner MR, Atik MA, Porter PC, Khan FS, Pennington MW, Hanania NA, Corry DB, Beeton C. Blocking KV1.3 channels inhibits Th2 lymphocyte function and treats a rat model of asthma. J Biol Chem. 2014;289:12623\u201332.","journal-title":"J Biol Chem"},{"key":"855_CR94","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00232-007-9080-6","volume":"221","author":"H Ouadid-Ahidouch","year":"2008","unstructured":"Ouadid-Ahidouch H, Ahidouch A. K\u00a0+\u00a0channel expression in human breast cancer cells: involvement in cell cycle regulation and carcinogenesis. J Membr Biol. 2008;221:1\u20136.","journal-title":"J Membr Biol"},{"key":"855_CR95","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3389\/fphys.2013.00283","volume":"4","author":"N Comes","year":"2013","unstructured":"Comes N, Bielanska J, Vallejo-Gracia A, Serrano-Albarras A, Marruecos L, Gomez D, Soler C, Condom E, Ramon YCS, Hernandez-Losa J, Ferreres JC, Felipe A. The voltage-dependent K(+) channels Kv1.3 and Kv1.5 in human cancer. Front Physiol. 2013;4:283.","journal-title":"Front Physiol"},{"key":"855_CR96","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ejphar.2010.10.066","volume":"651","author":"SH Jang","year":"2011","unstructured":"Jang SH, Choi SY, Ryu PD, Lee SY. Anti-proliferative effect of Kv1.3 blockers in A549 human lung adenocarcinoma in vitro and in vivo. Eur J Pharmacol. 2011;651:26\u201332.","journal-title":"Eur J Pharmacol"},{"key":"855_CR97","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1183\/09031936.06.00131805","volume":"28","author":"V Poletti","year":"2006","unstructured":"Poletti V, Casoni G, Chilosi M, Zompatori M. Diffuse panbronchiolitis. Eur Respir J. 2006;28:862\u201371.","journal-title":"Eur Respir J"},{"key":"855_CR98","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1159\/000368080","volume":"128","author":"I Kazama","year":"2014","unstructured":"Kazama I, Baba A, Matsubara M, Endo Y, Toyama H, Ejima Y. Benidipine suppresses in situ proliferation of leukocytes and slows the progression of renal fibrosis in rat kidneys with advanced chronic renal failure. Nephron Exp Nephrol. 2014;128:67\u201379.","journal-title":"Nephron Exp Nephrol"},{"issue":"Suppl C","key":"855_CR99","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jac\/31.suppl_C.1","volume":"31","author":"T Mazzei","year":"1993","unstructured":"Mazzei T, Mini E, Novelli A, Periti P. Chemistry and mode of action of macrolides. J Antimicrob Chemother. 1993;31(Suppl C):1\u20139.","journal-title":"J Antimicrob Chemother"},{"key":"855_CR100","doi-asserted-by":"crossref","first-page":"331","DOI":"10.2147\/COPD.S681","volume":"3","author":"FJ Martinez","year":"2008","unstructured":"Martinez FJ, Curtis JL, Albert R. Role of macrolide therapy in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2008;3:331\u201350.","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"855_CR101","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1136\/thorax.57.3.212","volume":"57","author":"J Wolter","year":"2002","unstructured":"Wolter J, Seeney S, Bell S, Bowler S, Masel P, McCormack J. Effect of long term treatment with azithromycin on disease parameters in cystic fibrosis: a randomised trial. Thorax. 2002;57:212\u20136.","journal-title":"Thorax"},{"key":"855_CR102","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/S0140-6736(02)11081-6","volume":"360","author":"A Equi","year":"2002","unstructured":"Equi A, Balfour-Lynn IM, Bush A, Rosenthal M. Long term azithromycin in children with cystic fibrosis: a randomised, placebo-controlled crossover trial. Lancet. 2002;360:978\u201384.","journal-title":"Lancet"},{"key":"855_CR103","doi-asserted-by":"crossref","first-page":"10171","DOI":"10.1073\/pnas.86.24.10171","volume":"86","author":"M Price","year":"1989","unstructured":"Price M, Lee SC, Deutsch C. Charybdotoxin inhibits proliferation and interleukin 2 production in human peripheral blood lymphocytes. Proc Natl Acad Sci USA. 1989;86:10171\u20135.","journal-title":"Proc Natl Acad Sci USA"},{"key":"855_CR104","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1046\/j.1472-8206.2003.00186.x","volume":"17","author":"P Gluais","year":"2003","unstructured":"Gluais P, Bastide M, Grandmougin D, Fayad G, Adamantidis M. Clarithromycin reduces Isus and Ito currents in human atrial myocytes with minor repercussions on action potential duration. Fundam Clin Pharmacol. 2003;17:691\u2013701.","journal-title":"Fundam Clin Pharmacol"},{"key":"855_CR105","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1124\/jpet.302.1.320","volume":"302","author":"WA Volberg","year":"2002","unstructured":"Volberg WA, Koci BJ, Su W, Lin J, Zhou J. Blockade of human cardiac potassium channel human ether-a-go-go-related gene (HERG) by macrolide antibiotics. J Pharmacol Exp Ther. 2002;302:320\u20137.","journal-title":"J Pharmacol Exp Ther"},{"key":"855_CR106","doi-asserted-by":"crossref","first-page":"32697","DOI":"10.1074\/jbc.273.49.32697","volume":"273","author":"K Kalman","year":"1998","unstructured":"Kalman K, Pennington MW, Lanigan MD, Nguyen A, Rauer H, Mahnir V, Paschetto K, Kem WR, Grissmer S, Gutman GA, Christian EP, Cahalan MD, Norton RS, Chandy KG. ShK-Dap22, a potent Kv1.3-specific immunosuppressive polypeptide. J Biol Chem. 1998;273:32697\u2013707.","journal-title":"J Biol Chem"},{"key":"855_CR107","doi-asserted-by":"crossref","first-page":"3185","DOI":"10.1128\/AAC.00532-07","volume":"51","author":"F Traunmuller","year":"2007","unstructured":"Traunmuller F, Zeitlinger M, Zeleny P, Muller M, Joukhadar C. Pharmacokinetics of single- and multiple-dose oral clarithromycin in soft tissues determined by microdialysis. Antimicrob Agents Chemother. 2007;51:3185\u20139.","journal-title":"Antimicrob Agents Chemother"},{"key":"855_CR108","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1007\/BF01975842","volume":"10","author":"DL Morris","year":"1991","unstructured":"Morris DL, De Souza A, Jones JA, Morgan WE. High and prolonged pulmonary tissue concentrations of azithromycin following a single oral dose. Eur J Clin Microbiol Infect Dis. 1991;10:859\u201361.","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"855_CR109","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0149-2918(00)80033-8","volume":"22","author":"JM McCarty","year":"2000","unstructured":"McCarty JM. Clarithromycin in the management of community-acquired pneumonia. Clin Ther. 2000;22:281\u201394 discussion 265.","journal-title":"Clin Ther"},{"key":"855_CR110","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1165\/rcmb.2003-0224OC","volume":"31","author":"JL Fisher","year":"2004","unstructured":"Fisher JL, Levitan I, Margulies SS. Plasma membrane surface increases with tonic stretch of alveolar epithelial cells. Am J Respir Cell Mol Biol. 2004;31:200\u20138.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"855_CR111","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/BF01870073","volume":"113","author":"A Rich","year":"1990","unstructured":"Rich A, Dixon TE, Clausen C. Changes in membrane conductances and areas associated with bicarbonate secretion in turtle bladder. J Membr Biol. 1990;113:211\u20139.","journal-title":"J Membr Biol"},{"key":"855_CR112","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1113\/jphysiol.1988.sp016914","volume":"395","author":"E Neher","year":"1988","unstructured":"Neher E. The influence of intracellular calcium concentration on degranulation of dialysed mast cells from rat peritoneum. J Physiol. 1988;395:193\u2013214.","journal-title":"J Physiol"},{"key":"855_CR113","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1159\/000350079","volume":"31","author":"I Kazama","year":"2013","unstructured":"Kazama I, Maruyama Y, Takahashi S, Kokumai T. Amphipaths differentially modulate membrane surface deformation in rat peritoneal mast cells during exocytosis. Cell Physiol Biochem. 2013;31:592\u2013600.","journal-title":"Cell Physiol Biochem"},{"key":"855_CR114","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1159\/000369704","volume":"35","author":"A Baba","year":"2015","unstructured":"Baba A, Tachi M, Maruyama Y, Kazama I. Olopatadine inhibits exocytosis in rat peritoneal mast cells by counteracting membrane surface deformation. Cell Physiol Biochem. 2015;35:386\u201396.","journal-title":"Cell Physiol Biochem"},{"key":"855_CR115","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1182\/blood-2008-06-163832","volume":"113","author":"R Flaumenhaft","year":"2009","unstructured":"Flaumenhaft R, Dilks JR, Richardson J, Alden E, Patel-Hett SR, Battinelli E, Klement GL, Sola-Visner M, Italiano JE Jr. Megakaryocyte-derived microparticles: direct visualization and distinction from platelet-derived microparticles. Blood. 2009;113:1112\u201321.","journal-title":"Blood"},{"key":"855_CR116","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s002320010040","volume":"179","author":"CE Morris","year":"2001","unstructured":"Morris CE, Homann U. Cell surface area regulation and membrane tension. J Membr Biol. 2001;179:79\u2013102.","journal-title":"J Membr Biol"},{"key":"855_CR117","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1128\/AAC.33.3.277","volume":"33","author":"RP Gladue","year":"1989","unstructured":"Gladue RP, Bright GM, Isaacson RE, Newborg MF. In vitro and in vivo uptake of azithromycin (CP-62,993) by phagocytic cells: possible mechanism of delivery and release at sites of infection. Antimicrob Agents Chemother. 1989;33:277\u201382.","journal-title":"Antimicrob Agents Chemother"},{"key":"855_CR118","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.idc.2004.04.010","volume":"18","author":"JM Zuckerman","year":"2004","unstructured":"Zuckerman JM. Macrolides and ketolides: azithromycin, clarithromycin, telithromycin. Infect Dis Clin North Am. 2004;18:621\u201349 xi-.","journal-title":"Infect Dis Clin North Am"},{"key":"855_CR119","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.2174\/1381612043383322","volume":"10","author":"R Jain","year":"2004","unstructured":"Jain R, Danziger LH. The macrolide antibiotics: a pharmacokinetic and pharmacodynamic overview. Curr Pharm Des. 2004;10:3045\u201353.","journal-title":"Curr Pharm Des"},{"key":"855_CR120","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0165-2478(03)00002-6","volume":"86","author":"P Conti","year":"2003","unstructured":"Conti P, Kempuraj D, Kandere K, Di Gioacchino M, Barbacane RC, Castellani ML, Felaco M, Boucher W, Letourneau R, Theoharides TC. IL-10, an inflammatory\/inhibitory cytokine, but not always. Immunol Lett. 2003;86:123\u20139.","journal-title":"Immunol Lett"},{"key":"855_CR121","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/nri2711","volume":"10","author":"M Saraiva","year":"2010","unstructured":"Saraiva M, O\u2019Garra A. The regulation of IL-10 production by immune cells. Nat Rev Immunol. 2010;10:170\u201381.","journal-title":"Nat Rev Immunol"},{"key":"855_CR122","first-page":"169","volume":"7","author":"K Yamauchi","year":"2008","unstructured":"Yamauchi K, Ishikawa T, Shibata Y, Abe S, Inoue S, Takabatake N, Kubota I. Enhanced interleukin-10 signaling with 14-member macrolides in lipopolysaccharide-stimulated macrophages. Excli J. 2008;7:169\u201376.","journal-title":"Excli J"},{"key":"855_CR123","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1111\/j.1476-5381.2009.00362.x","volume":"157","author":"P Bradding","year":"2009","unstructured":"Bradding P, Wulff H. The K\u00a0+\u00a0channels K(Ca)3.1 and K(v)1.3 as novel targets for asthma therapy. Br J Pharmacol. 2009;157:1330\u20139.","journal-title":"Br J Pharmacol"},{"key":"855_CR124","doi-asserted-by":"crossref","first-page":"2904","DOI":"10.4049\/jimmunol.133.6.2904","volume":"133","author":"DL Birx","year":"1984","unstructured":"Birx DL, Berger M, Fleisher TA. The interference of T cell activation by calcium channel blocking agents. J Immunol. 1984;133:2904\u20139.","journal-title":"J Immunol"},{"key":"855_CR125","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0006-291X(89)91076-0","volume":"165","author":"KB Bacon","year":"1989","unstructured":"Bacon KB, Westwick J, Camp RD. Potent and specific inhibition of IL-8-, IL-1 alpha- and IL-1 beta-induced in vitro human lymphocyte migration by calcium channel antagonists. Biochem Biophys Res Commun. 1989;165:349\u201354.","journal-title":"Biochem Biophys Res Commun"},{"key":"855_CR126","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1253\/circj.CJ-09-0467","volume":"74","author":"A Matsumori","year":"2010","unstructured":"Matsumori A, Nishio R, Nose Y. Calcium channel blockers differentially modulate cytokine production by peripheral blood mononuclear cells. Circ J. 2010;74:567\u201371.","journal-title":"Circ J"},{"key":"855_CR127","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1097\/QCO.0b013e3283463e5b","volume":"24","author":"W Liu","year":"2011","unstructured":"Liu W, Matsumori A. Calcium channel blockers and modulation of innate immunity. Curr Opin Infect Dis. 2011;24:254\u20138.","journal-title":"Curr Opin Infect Dis"},{"key":"855_CR128","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1097\/00007890-199307000-00033","volume":"56","author":"L Dumont","year":"1993","unstructured":"Dumont L, Chen H, Daloze P, Xu D, Garceau D. Immunosuppressive properties of the benzothiazepine calcium antagonists diltiazem and clentiazem, with and without cyclosporine, in heterotopic rat heart transplantation. Transplantation. 1993;56:181\u20134.","journal-title":"Transplantation"},{"key":"855_CR129","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/0192-0561(94)90102-3","volume":"16","author":"B Zanker","year":"1994","unstructured":"Zanker B, Marx S, Strom TB, Kohler H. The immunosuppressive effects of verapamil upon mitogen activated and allo-antigen inducible human cytotoxic T-lymphocytes. Int J Immunopharmacol. 1994;16:507\u201317.","journal-title":"Int J Immunopharmacol"},{"key":"855_CR130","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1097\/00007890-200002270-00021","volume":"69","author":"RA Blaheta","year":"2000","unstructured":"Blaheta RA, Hailer NP, Brude N, Wittig B, Leckel K, Oppermann E, Bachmann M, Harder S, Cinatl J, Scholz M, Bereiter-Hahn J, Weber S, Encke A, Markus BH. In vitro analysis of verapamil-induced immunosuppression: potent inhibition of T cell motility and lymphocytic transmigration through allogeneic endothelial cells. Transplantation. 2000;69:588\u201397.","journal-title":"Transplantation"},{"key":"855_CR131","first-page":"404","volume":"1","author":"M Horvath","year":"1991","unstructured":"Horvath M, Mezey Z, Josfay A, Nanay I, Varsanyi M, Gero S. The effect of some drugs on in vitro cellular immune reactions and on circulating immune complexes in patients with myocardial infarction. J Investig Allergol Clin Immunol. 1991;1:404\u201310.","journal-title":"J Investig Allergol Clin Immunol"},{"key":"855_CR132","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.clim.2005.06.014","volume":"117","author":"H Bessler","year":"2005","unstructured":"Bessler H, Salman H, Bergman M, Straussberg R, Djaldetti M. In vitro effect of statins on cytokine production and mitogen response of human peripheral blood mononuclear cells. Clin Immunol. 2005;117:73\u20137.","journal-title":"Clin Immunol"},{"key":"855_CR133","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0140-6736(98)05917-0","volume":"353","author":"RS Rosenson","year":"1999","unstructured":"Rosenson RS, Tangney CC, Casey LC. Inhibition of proinflammatory cytokine production by pravastatin. Lancet. 1999;353:983\u20134.","journal-title":"Lancet"},{"key":"855_CR134","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/BF02977780","volume":"30","author":"JY Cho","year":"2007","unstructured":"Cho JY. Immunomodulatory effect of nonsteroidal anti-inflammatory drugs (NSAIDs) at the clinically available doses. Arch Pharm Res. 2007;30:64\u201374.","journal-title":"Arch Pharm Res"},{"key":"855_CR135","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1038\/82219","volume":"6","author":"B Kwak","year":"2000","unstructured":"Kwak B, Mulhaupt F, Myit S, Mach F. Statins as a newly recognized type of immunomodulator. Nat Med. 2000;6:1399\u2013402.","journal-title":"Nat Med"},{"key":"855_CR136","doi-asserted-by":"crossref","first-page":"111","DOI":"10.4049\/jimmunol.163.1.111","volume":"163","author":"MA Iniguez","year":"1999","unstructured":"Iniguez MA, Punzon C, Fresno M. Induction of cyclooxygenase-2 on activated T lymphocytes: regulation of T cell activation by cyclooxygenase-2 inhibitors. J Immunol. 1999;163:111\u20139.","journal-title":"J Immunol"},{"key":"855_CR137","doi-asserted-by":"crossref","first-page":"7053","DOI":"10.4049\/jimmunol.166.12.7053","volume":"166","author":"H Hackstein","year":"2001","unstructured":"Hackstein H, Morelli AE, Larregina AT, Ganster RW, Papworth GD, Logar AJ, Watkins SC, Falo LD, Thomson AW. Aspirin inhibits in vitro maturation and in vivo immunostimulatory function of murine myeloid dendritic cells. J Immunol. 2001;166:7053\u201362.","journal-title":"J Immunol"},{"key":"855_CR138","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/0192-0561(93)90016-R","volume":"15","author":"JX Gao","year":"1993","unstructured":"Gao JX, Issekutz AC. The effect of ebselen on polymorphonuclear leukocyte migration to joints in rats with adjuvant arthritis. Int J Immunopharmacol. 1993;15:793\u2013802.","journal-title":"Int J Immunopharmacol"},{"key":"855_CR139","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1124\/mol.105.015669","volume":"68","author":"A Schmitz","year":"2005","unstructured":"Schmitz A, Sankaranarayanan A, Azam P, Schmidt-Lassen K, Homerick D, Hansel W, Wulff H. Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases. Mol Pharmacol. 2005;68:1254\u201370.","journal-title":"Mol Pharmacol"},{"key":"855_CR140","first-page":"283","volume":"24","author":"GR Brown","year":"1986","unstructured":"Brown GR, Fraser DG, Castile JA, Gaudreault P, Platt DR, Friedman PA. Nifedipine serum concentrations following sublingual and oral doses. Int J Clin Pharmacol Ther Toxicol. 1986;24:283\u20136.","journal-title":"Int J Clin Pharmacol Ther Toxicol"},{"key":"855_CR141","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1742-7843.2010.00666.x","volume":"108","author":"B Megarbane","year":"2011","unstructured":"Megarbane B, Karyo S, Abidi K, Delhotal-Landes B, Aout M, Sauder P, Baud FJ. Predictors of mortality in verapamil overdose: usefulness of serum verapamil concentrations. Basic Clin Pharmacol Toxicol. 2011;108:385\u20139.","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"855_CR142","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/j.1365-2125.2011.03907.x","volume":"72","author":"L Bjorkhem-Bergman","year":"2011","unstructured":"Bjorkhem-Bergman L, Lindh JD, Bergman P. What is a relevant statin concentration in cell experiments claiming pleiotropic effects? Br J Clin Pharmacol. 2011;72:164\u20135.","journal-title":"Br J Clin Pharmacol"},{"key":"855_CR143","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.yjmcc.2007.03.807","volume":"42","author":"M Vaquero","year":"2007","unstructured":"Vaquero M, Caballero R, Gomez R, Nunez L, Tamargo J, Delpon E. Effects of atorvastatin and simvastatin on atrial plateau currents. J Mol Cell Cardiol. 2007;42:931\u201345.","journal-title":"J Mol Cell Cardiol"},{"key":"855_CR144","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/S0026-895X(25)10594-4","volume":"45","author":"S Grissmer","year":"1994","unstructured":"Grissmer S, Nguyen AN, Aiyar J, Hanson DC, Mather RJ, Gutman GA, Karmilowicz MJ, Auperin DD, Chandy KG. Pharmacological characterization of five cloned voltage-gated K\u00a0+\u00a0channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines. Mol Pharmacol. 1994;45:1227\u201334.","journal-title":"Mol Pharmacol"},{"key":"855_CR145","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/sj.bjp.0706113","volume":"144","author":"Z Gao","year":"2005","unstructured":"Gao Z, Sun H, Chiu SW, Lau CP, Li GR. Effects of diltiazem and nifedipine on transient outward and ultra-rapid delayed rectifier potassium currents in human atrial myocytes. Br J Pharmacol. 2005;144:595\u2013604.","journal-title":"Br J Pharmacol"},{"key":"855_CR146","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1038\/sj.bjp.0702599","volume":"127","author":"H Rauer","year":"1999","unstructured":"Rauer H, Grissmer S. The effect of deep pore mutations on the action of phenylalkylamines on the Kv1.3 potassium channel. Br J Pharmacol. 1999;127:1065\u201374.","journal-title":"Br J Pharmacol"},{"key":"855_CR147","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/S0006-3495(87)83295-2","volume":"52","author":"DW Chester","year":"1987","unstructured":"Chester DW, Herbette LG, Mason RP, Joslyn AF, Triggle DJ, Koppel DE. Diffusion of dihydropyridine calcium channel antagonists in cardiac sarcolemmal lipid multibilayers. Biophys J. 1987;52:1021\u201330.","journal-title":"Biophys J"},{"key":"855_CR148","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1080\/080370598438410-2","volume":"2","author":"PA Zwieten van","year":"1998","unstructured":"van Zwieten PA. The pharmacological properties of lipophilic calcium antagonists. Blood Press Suppl. 1998;2:5\u20139.","journal-title":"Blood Press Suppl"},{"key":"855_CR149","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1211\/146080899128734820","volume":"5","author":"HNFM Joshi","year":"1999","unstructured":"Joshi HNFM, Serajuddin AT. Differentiation of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors by their relative lipophilicity. Pharm Pharmacol Commun. 1999;5:269\u201371.","journal-title":"Pharm Pharmacol Commun"},{"key":"855_CR150","doi-asserted-by":"crossref","first-page":"35188","DOI":"10.1074\/jbc.M110.141200","volume":"285","author":"Y Zhou","year":"2010","unstructured":"Zhou Y, Plowman SJ, Lichtenberger LM, Hancock JF. The anti-inflammatory drug indomethacin alters nanoclustering in synthetic and cell plasma membranes. J Biol Chem. 2010;285:35188\u201395.","journal-title":"J Biol Chem"},{"key":"855_CR151","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/S0022-3565(25)25020-0","volume":"238","author":"EL Todd","year":"1986","unstructured":"Todd EL, Abernethy DR. Pharmacokinetics and dynamics of (\u00b1)-verapamil in lean and obese Zucker rats. J Pharmacol Exp Ther. 1986;238:642\u20137.","journal-title":"J Pharmacol Exp Ther"},{"key":"855_CR152","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/S0735-1097(98)00556-7","volume":"33","author":"M Kitakaze","year":"1999","unstructured":"Kitakaze M, Node K, Minamino T, Asanuma H, Kuzuya T, Hori M. A Ca channel blocker, benidipine, increases coronary blood flow and attenuates the severity of myocardial ischemia via NO-dependent mechanisms in dogs. J Am Coll Cardiol. 1999;33:242\u20139.","journal-title":"J Am Coll Cardiol"},{"key":"855_CR153","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/j.1476-5381.1990.tb14074.x","volume":"100","author":"M Yamamoto","year":"1990","unstructured":"Yamamoto M, Gotoh Y, Imaizumi Y, Watanabe M. Mechanisms of long-lasting effects of benidipine on Ca current in guinea-pig ventricular cells. Br J Pharmacol. 1990;100:669\u201376.","journal-title":"Br J Pharmacol"},{"key":"855_CR154","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1254\/jjp.47.35","volume":"47","author":"A Karasawa","year":"1988","unstructured":"Karasawa A, Kubo K. Calcium antagonistic effects and the in vitro duration of actions of KW-3049, a new 1,4-dihydropyridine derivative, in isolated canine coronary arteries. Jpn J Pharmacol. 1988;47:35\u201344.","journal-title":"Jpn J Pharmacol"},{"key":"855_CR155","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/BF00314959","volume":"41","author":"E Imhof","year":"1991","unstructured":"Imhof E, Elsasser S, Rosmus B, Ha HR, Follath F, Perruchoud AP. Verapamil in the prophylaxis of bronchial asthma. Is the bronchoprotective effect related to the plasma level? Eur J Clin Pharmacol. 1991;41:317\u20139.","journal-title":"Eur J Clin Pharmacol"},{"key":"855_CR156","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3109\/02770909009073291","volume":"27","author":"SK Sharma","year":"1990","unstructured":"Sharma SK, Pande JN. Effect of verapamil inhalation on bronchial asthma. J Asthma. 1990;27:31\u20136.","journal-title":"J Asthma"},{"key":"855_CR157","first-page":"27","volume":"29","author":"C Zhang","year":"2009","unstructured":"Zhang C, Lv F, Zhou L, Li X, Wu XX, Hoffman RM. Effect of verapamil on the expression of EGFR and NM23 in A549 human lung cancer cells. Anticancer Res. 2009;29:27\u201332.","journal-title":"Anticancer Res"},{"key":"855_CR158","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1038\/bjc.1993.189","volume":"67","author":"MJ Millward","year":"1993","unstructured":"Millward MJ, Cantwell BM, Munro NC, Robinson A, Corris PA, Harris AL. Oral verapamil with chemotherapy for advanced non-small cell lung cancer: a randomised study. Br J Cancer. 1993;67:1031\u20135.","journal-title":"Br J Cancer"},{"key":"855_CR159","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s12576-013-0285-4","volume":"64","author":"DL Hamilton","year":"2014","unstructured":"Hamilton DL, Beall C, Jeromson S, Chevtzoff C, Cuthbertson DJ, Ashford ML. Kv1.3 inhibitors have differential effects on glucose uptake and AMPK activity in skeletal muscle cell lines and mouse ex vivo skeletal muscle. J Physiol Sci. 2014;64:13\u201320.","journal-title":"J Physiol Sci"},{"key":"855_CR160","doi-asserted-by":"crossref","first-page":"19058","DOI":"10.1074\/jbc.M802054200","volume":"283","author":"S Han","year":"2008","unstructured":"Han S, Yi H, Yin SJ, Chen ZY, Liu H, Cao ZJ, Wu YL, Li WX. Structural basis of a potent peptide inhibitor designed for Kv1.3 channel, a therapeutic target of autoimmune disease. J Biol Chem. 2008;283:19058\u201365.","journal-title":"J Biol Chem"},{"key":"855_CR161","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/S0041-0101(01)00120-9","volume":"39","author":"KG Chandy","year":"2001","unstructured":"Chandy KG, Cahalan M, Pennington M, Norton RS, Wulff H, Gutman GA. Potassium channels in T lymphocytes: toxins to therapeutic immunosuppressants. Toxicon. 2001;39:1269\u201376.","journal-title":"Toxicon"},{"key":"855_CR162","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1124\/mol.105.017210","volume":"69","author":"S Mouhat","year":"2006","unstructured":"Mouhat S, Teodorescu G, Homerick D, Visan V, Wulff H, Wu Y, Grissmer S, Darbon H, De Waard M, Sabatier JM. Pharmacological profiling of Orthochirus scrobiculosus toxin 1 analogs with a trimmed N-terminal domain. Mol Pharmacol. 2006;69:354\u201362.","journal-title":"Mol Pharmacol"},{"key":"855_CR163","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/nrd1197","volume":"2","author":"RJ Lewis","year":"2003","unstructured":"Lewis RJ, Garcia ML. Therapeutic potential of venom peptides. Nat Rev Drug Discov. 2003;2:790\u2013802.","journal-title":"Nat Rev Drug Discov"},{"key":"855_CR164","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1682\/JRRD.2004.09.0116","volume":"43","author":"SI Judge","year":"2006","unstructured":"Judge SI, Lee JM, Bever CT Jr, Hoffman PM. Voltage-gated potassium channels in multiple sclerosis: overview and new implications for treatment of central nervous system inflammation and degeneration. J Rehabil Res Dev. 2006;43:111\u201322.","journal-title":"J Rehabil Res Dev"},{"key":"855_CR165","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1172\/JCI114464","volume":"85","author":"KH Krause","year":"1990","unstructured":"Krause KH, Welsh MJ. Voltage-dependent and Ca2(+)-activated ion channels in human neutrophils. J Clin Invest. 1990;85:491\u20138.","journal-title":"J Clin Invest"},{"key":"855_CR166","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1067\/mai.2000.107752","volume":"106","author":"A Schwingshackl","year":"2000","unstructured":"Schwingshackl A, Moqbel R, Duszyk M. Involvement of ion channels in human eosinophil respiratory burst. J Allergy Clin Immunol. 2000;106:272\u20139.","journal-title":"J Allergy Clin Immunol"},{"key":"855_CR167","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1083\/jcb.105.2.761","volume":"105","author":"C Randriamampita","year":"1987","unstructured":"Randriamampita C, Trautmann A. Ionic channels in murine macrophages. J Cell Biol. 1987;105:761\u20139.","journal-title":"J Cell Biol"},{"key":"855_CR168","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/cea.12043","volume":"43","author":"I Ashmole","year":"2013","unstructured":"Ashmole I, Bradding P. Ion channels regulating mast cell biology. Clin Exp Allergy. 2013;43:491\u2013502.","journal-title":"Clin Exp Allergy"}],"container-title":["Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-015-0855-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00011-015-0855-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-015-0855-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T16:10:12Z","timestamp":1748535012000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00011-015-0855-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,24]]},"references-count":168,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["855"],"URL":"https:\/\/doi.org\/10.1007\/s00011-015-0855-4","relation":{},"ISSN":["1023-3830","1420-908X"],"issn-type":[{"value":"1023-3830","type":"print"},{"value":"1420-908X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,24]]}}}