{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:02:57Z","timestamp":1790226177115,"version":"4.1.0"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2016,2,13]],"date-time":"2016-02-13T00:00:00Z","timestamp":1455321600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflamm. Res."],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1007\/s00011-016-0922-5","type":"journal-article","created":{"date-parts":[[2016,2,13]],"date-time":"2016-02-13T14:57:06Z","timestamp":1455375426000},"page":"367-387","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Contribution of PPAR\u03b1\/\u03b2\/\u03b3, AP-1, importin-\u03b13, and RXR\u03b1 to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against hypotension, tachycardia, and inflammation in a rat model of septic shock"],"prefix":"10.1007","volume":"65","author":[{"given":"Sefika Pinar","family":"Senol","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meryem","family":"Temiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demet Sinem","family":"Guden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pelin","family":"Cecen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayse Nihal","family":"Sari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyhan","family":"Sahan-Firat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Falck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rambabu","family":"Dakarapu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kafait U.","family":"Malik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahar","family":"Tunctan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,2,13]]},"reference":[{"key":"922_CR1","doi-asserted-by":"crossref","first-page":"706","DOI":"10.2174\/1389200211314060007","volume":"14","author":"OH Elshenawy","year":"2013","unstructured":"Elshenawy OH, Anwar-Mohamed A, El-Kadi AO. 20-Hydroxyeicosatetraenoic acid is a potential therapeutic target in cardiovascular diseases. Curr Drug Metab. 2013;14:706\u201319.","journal-title":"Curr Drug Metab"},{"key":"922_CR2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1097\/MNH.0000000000000088","volume":"24","author":"F Fan","year":"2015","unstructured":"Fan F, Muroya Y, Roman RJ. Cytochrome P450 eicosanoids in hypertension and renal disease. Curr Opin Nephrol Hypertens. 2015;24:37\u201346.","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"922_CR3","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1152\/physrev.00021.2001","volume":"82","author":"RJ Roman","year":"2002","unstructured":"Roman RJ. P-450 metabolites of arachidonic acid in the control of cardiovascular function. Physiol Rev. 2002;82:131\u201385.","journal-title":"Physiol Rev"},{"key":"922_CR4","doi-asserted-by":"crossref","first-page":"121","DOI":"10.2174\/187152312803305759","volume":"11","author":"B Tunctan","year":"2012","unstructured":"Tunctan B, Korkmaz B, Sari AN, Kacan M, Unsal D, Serin MS, Buharalioglu CK, Sahan-Firat S, Schunck WH, Falck JR, Malik KU. A novel treatment strategy for sepsis and septic shock based on the interactions between prostanoids, nitric oxide, and 20-hydroxyeicosatetraenoic acid. Antiinflamm Antiallergy Agents Med Chem. 2012;11:121\u201350.","journal-title":"Antiinflamm Antiallergy Agents Med Chem."},{"key":"922_CR5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/CRD.0b013e3182961659","volume":"22","author":"CC Wu","year":"2014","unstructured":"Wu CC, Gupta T, Garcia V, Ding Y, Schwartzman ML. 20-HETE and blood pressure regulation: clinical implications. Cardiol Rev. 2014;22:1\u201312.","journal-title":"Cardiol Rev."},{"key":"922_CR6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-2999(93)90812-V","volume":"235","author":"B Escalante","year":"1993","unstructured":"Escalante B, Omata K, Sessa W, Lee SG, Falck JR, Schwartzman ML. 20-hydroxyeicosatetraenoic acid is an endothelium-dependent vasoconstrictor in rabbit arteries. Eur J Pharmacol. 1993;235:1\u20137.","journal-title":"Eur J Pharmacol"},{"key":"922_CR7","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1161\/01.HYP.0000047240.33861.6B","volume":"41","author":"V Randriamboavonjy","year":"2003","unstructured":"Randriamboavonjy V, Busse R, Fleming I. 20-HETE-induced contraction of small coronary arteries depends on the activation of Rho-kinase. Hypertension. 2003;41:801\u20136.","journal-title":"Hypertension"},{"key":"922_CR8","first-page":"R228","volume":"270","author":"AP Zou","year":"1996","unstructured":"Zou AP, Fleming JT, Falck JR, Jacobs ER, Gebremedhin D, Harder DR, Roman RJ. 20-HETE is an endogenous inhibitor of the large-conductance Ca(2+)-activated K+ channel in renal arterioles. Am J Physiol. 1996;270:R228\u201337.","journal-title":"Am J Physiol"},{"key":"922_CR9","doi-asserted-by":"crossref","first-page":"159A","DOI":"10.1016\/S0895-7061(01)02034-9","volume":"14","author":"MA Carroll","year":"2001","unstructured":"Carroll MA, Capparelli MF, Doumand AB, Cheng MK, Jiang H, McGiff JC. Renal vasoactive eicosanoids: interactions between cytochrome P450 and cyclooxygenase metabolites during salt depletion. Am J Hypertens. 2001;14:159A.","journal-title":"Am J Hypertens"},{"key":"922_CR10","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1161\/01.HYP.31.1.237","volume":"31","author":"PF Pratt","year":"1998","unstructured":"Pratt PF, Falck JR, Reddy KM, Kurian JB, Campbell WB. 20-HETE relaxes bovine coronary arteries through the release of prostacyclin. Hypertension. 1998;31:237\u201341.","journal-title":"Hypertension"},{"key":"922_CR11","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1124\/jpet.109.159863","volume":"332","author":"J Cheng","year":"2010","unstructured":"Cheng J, Wu CC, Gotlinger KH, Zhang F, Falck JR, Narsimhaswamy D, Schwartzman ML. 20-hydroxy-5,8,11,14-eicosatetraenoic acid mediates endothelial dysfunction via IkappaB kinase-dependent endothelial nitric-oxide synthase uncoupling. J Pharmacol Exp Ther. 2010;332:57\u201365.","journal-title":"J Pharmacol Exp Ther"},{"key":"922_CR12","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1124\/jpet.107.130336","volume":"324","author":"T Ishizuka","year":"2008","unstructured":"Ishizuka T, Cheng J, Singh H, Vitto MD, Manthati VL, Falck JR, Laniado-Schwartzman M. 20-Hydroxyeicosatetraenoic acid stimulates nuclear factor-\u03baB activation and the production of inflammatory cytokines in human endothelial cells. J Pharmacol Exp Ther. 2008;324:103\u201310.","journal-title":"J Pharmacol Exp Ther"},{"key":"922_CR13","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1111\/bph.12079","volume":"168","author":"P Toth","year":"2013","unstructured":"Toth P, Csiszar A, Sosnowska D, Tucsek Z, Cseplo P, Springo Z, Tarantini S, Sonntag WE, Ungvari Z, Koller A. Treatment with the cytochrome P450 \u03c9-hydroxylase inhibitor HET0016 attenuates cerebrovascular inflammation, oxidative stress and improves vasomotor function in spontaneously hypertensive rats. Br J Pharmacol. 2013;168:1878\u201388.","journal-title":"Br J Pharmacol"},{"key":"922_CR14","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.phrs.2009.12.015","volume":"61","author":"A Anwar-mohamed","year":"2010","unstructured":"Anwar-mohamed A, Zordoky BN, Aboutabl ME, El-Kadi AO. Alteration of cardiac cytochrome P450-mediated arachidonic acid metabolism in response to lipopolysaccharide-induced acute systemic inflammation. Pharmacol Res. 2010;61:410\u20138.","journal-title":"Pharmacol Res"},{"key":"922_CR15","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1124\/dmd.110.035287","volume":"39","author":"KN Theken","year":"2011","unstructured":"Theken KN, Deng Y, Kannon MA, Miller TM, Poloyac SM, Lee CR. Activation of the acute inflammatory response alters cytochrome P450 expression and eicosanoid metabolism. Drug Metab Dispos. 2011;39:22\u20139.","journal-title":"Drug Metab Dispos"},{"key":"922_CR16","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1002\/iub.1201","volume":"65","author":"NJ Bernard","year":"2013","unstructured":"Bernard NJ, O\u2019Neill LA. Mal, more than a bridge to MyD88. IUBMB Life. 2013;65:777\u201386.","journal-title":"IUBMB Life"},{"key":"922_CR17","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.bbagrm.2010.05.004","volume":"1799","author":"SC Gupta","year":"2010","unstructured":"Gupta SC, Sundaram C, Reuter S, Aggarwal BB. Inhibiting NF-\u03baB activation by small molecules as a therapeutic strategy. Biochim Biophys Acta. 2010;1799:775\u201387.","journal-title":"Biochim Biophys Acta"},{"key":"922_CR18","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.biocel.2009.12.023","volume":"42","author":"M Landstr\u00f6m","year":"2010","unstructured":"Landstr\u00f6m M. The TAK1-TRAF6 signalling pathway. Int J Biochem Cell Biol. 2010;42:585\u20139.","journal-title":"Int J Biochem Cell Biol"},{"key":"922_CR19","first-page":"L622","volume":"290","author":"SF Liu","year":"2006","unstructured":"Liu SF, Malik AB. NF-kappa B activation as a pathological mechanism of septic shock and inflammation. Am J Physiol. 2006;290:L622\u201345.","journal-title":"Am J Physiol"},{"key":"922_CR20","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.cyto.2008.01.006","volume":"42","author":"YC Lu","year":"2008","unstructured":"Lu YC, Yeh WC, Ohashi PS. LPS\/TLR4 signal transduction pathway. Cytokine. 2008;42:145\u201351.","journal-title":"Cytokine"},{"key":"922_CR21","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.cellimm.2011.06.021","volume":"271","author":"JJ Haddad","year":"2011","unstructured":"Haddad JJ, Abdel-Karim NE. NF-\u03baB cellular and molecular regulatory mechanisms and pathways: therapeutic pattern or pseudoregulation? Cell Immunol. 2011;271:5\u201314.","journal-title":"Cell Immunol"},{"key":"922_CR22","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1016\/j.freeradbiomed.2012.08.572","volume":"53","author":"AM Ferreira","year":"2012","unstructured":"Ferreira AM, Minarrieta L, Lamas Bervejillo M, Rubbo H. Nitro-fatty acids as novel electrophilic ligands for peroxisome proliferator-activated receptors. Free Radic Biol Med. 2012;53:1654\u201363.","journal-title":"Free Radic Biol Med"},{"issue":"17","key":"922_CR23","first-page":"23","volume":"13","author":"B Grygiel-Gorniak","year":"2014","unstructured":"Grygiel-Gorniak B. Peroxisome proliferator-activated receptors and their ligands: nutritional and clinical implications-a review. Nutr J. 2014;13(17):23.","journal-title":"Nutr J"},{"key":"922_CR24","unstructured":"Neher MD1, Weckbach S, Huber-Lang MS, Stahel PF. New insights into the role of peroxisome proliferator-activated receptors in regulating the inflammatory response after tissue injury. PPAR Res. 2012;2012:728461."},{"key":"922_CR25","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1210\/me.2013-1427","volume":"28","author":"MB Wright","year":"2014","unstructured":"Wright MB, Bortolini M, Tadayyon M, Bopst M. Minireview: challenges and opportunities in development of PPAR agonists. Mol Endocrinol. 2014;28:1756\u201368.","journal-title":"Mol Endocrinol"},{"key":"922_CR26","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00005-007-0005-y","volume":"55","author":"A Knethen von","year":"2007","unstructured":"von Knethen A, Soller M, Brune B. Peroxisome proliferator-activated receptor gamma (PPAR gamma) and sepsis. Arch Immunol Ther Exp. 2007;55:19\u201325.","journal-title":"Arch Immunol Ther Exp."},{"key":"922_CR27","doi-asserted-by":"crossref","first-page":"476357","DOI":"10.1155\/2014\/476357","volume":"2014","author":"A Aggarwal","year":"2014","unstructured":"Aggarwal A, Agrawal DK. Importins and exportins regulating allergic immune responses. Mediators Inflamm. 2014;2014:476357.","journal-title":"Mediators Inflamm"},{"key":"922_CR28","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/febs.13163","volume":"282","author":"B Cautain","year":"2015","unstructured":"Cautain B, Hill R, de Pedro N, Link W. Components and regulation of nuclear transport processes. FEBS J. 2015;282:445\u201362.","journal-title":"FEBS J."},{"key":"922_CR29","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1016\/j.bbamcr.2014.08.003","volume":"1843","author":"EJ Tran","year":"2014","unstructured":"Tran EJ, King MC, Corbett AH. Macromolecular transport between the nucleus and the cytoplasm: advances in mechanism and emerging links to disease. Biochim Biophys Acta. 2014;1843:2784\u201395.","journal-title":"Biochim Biophys Acta"},{"key":"922_CR30","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1742-7843.2009.00501.x","volume":"106","author":"T Cuez","year":"2010","unstructured":"Cuez T, Korkmaz B, Buharalioglu CK, Sahan-Firat S, Falck J, Malik KU, Tunctan B. A synthetic analogue of 20-HETE, 5,14-HEDGE, reverses endotoxin-induced hypotension via increased 20-HETE levels associated with decreased iNOS protein expression and vasodilator prostanoid production in rats. Basic Clin Pharmacol. 2010;106:378\u201388.","journal-title":"Basic Clin Pharmacol."},{"key":"922_CR31","doi-asserted-by":"crossref","unstructured":"Sari AN, Korkmaz B, Serin MS, Kacan M, Unsal D, Buharalioglu CK, Sahan Firat S, Manthati VL, Falck JR, Malik KU, Tunctan B. Effects of 5,14-HEDGE, a 20-HETE mimetic, on lipopolysaccharide-induced changes in MyD88\/TAK1\/IKK\u03b2\/I\u03baB-\u03b1\/NF-\u03baB pathway and circulating miR-150, miR-223, and miR-297 levels in a rat model of septic shock. Inflam Res. 2014;63:741\u201356.","DOI":"10.1007\/s00011-014-0747-z"},{"key":"922_CR32","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1097\/SHK.0b013e31816471c6","volume":"30","author":"B Tunctan","year":"2008","unstructured":"Tunctan B, Korkmaz B, Buharalioglu CK. Sahan Firat S, Anjaiah S, Falck J, Roman RJ, Malik KU. A 20-HETE agonist, N-[20-hydroxyeicosa-5(Z),14(Z)-dienoyl]glycine, opposes the fall in blood pressure and vascular reactivity in endotoxin-treated rats. Shock. 2008;30:329\u201335.","journal-title":"Shock."},{"key":"922_CR33","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.niox.2013.05.001","volume":"33","author":"B Tunctan","year":"2013","unstructured":"Tunctan B, Korkmaz B, Sari AN, Kacan M, Unsal D, Serin MS, Buharalioglu CK, Sahan-Firat S, Cuez T, Schunck WH, Manthati VL, Falck JR, Malik KU. Contribution of iNOS\/sGC\/PKG pathway, COX-2, CYP4A1, and gp91phox to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against vasodilation, hypotension, tachycardia, and inflammation in a rat model of septic shock. Nitric Oxide. 2013;33:18\u201341.","journal-title":"Nitric Oxide"},{"key":"922_CR34","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.prostaglandins.2013.01.005","volume":"102\u2013103","author":"B Tunctan","year":"2013","unstructured":"Tunctan B, Korkmaz B, Sari AN, Kacan M, Unsal D, Serin MS, Buharalioglu CK, Sahan-Firat S, Cuez T, Schunck WH, Falck JR, Malik KU. 5,14-HEDGE, a 20-HETE mimetic, reverses hypotension and improves survival in a rodent model of septic shock: contribution of soluble epoxide hydrolase, CYP2C23, MEK1\/ERK1\/2\/IKK\u03b2\/I\u03baB-\u03b1\/NF-\u03baB pathway, and proinflammatory cytokine formation. Prostaglandins Other Lipid Mediat. 2013;102\u2013103:31\u201341.","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"922_CR35","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3844\/ajidsp.2005.111.115","volume":"1","author":"B Tunctan","year":"2005","unstructured":"Tunctan B, Korkmaz B, Yildirim H, Tamer L, Atik U, Buharalioglu C. Increased production of nitric oxide contributes to renal oxidative stress in endotoxemic rat. Am J Infect Dis. 2005;1:111\u20135.","journal-title":"Am J Infect Dis."},{"key":"922_CR36","doi-asserted-by":"crossref","first-page":"5786","DOI":"10.4049\/jimmunol.173.9.5786","volume":"173","author":"M Gadjeva","year":"2004","unstructured":"Gadjeva M, Tomczak MF, Zhang M, Wang YY, Dull K, Rogers AB, Erdman SE, Fox JG, Carroll M, Horwitz BH. A role for NF-kappa B subunits p50 and p65 in the inhibition of lipopolysaccharide-induced shock. J Immunol. 2004;173:5786\u201393.","journal-title":"J Immunol."},{"key":"922_CR37","doi-asserted-by":"crossref","first-page":"S81","DOI":"10.1016\/S0092-8674(02)00703-1","volume":"109","author":"S Ghosh","year":"2002","unstructured":"Ghosh S, Karin M. Missing pieces in the NF-kappaB puzzle. Cell. 2002;109:S81\u201396.","journal-title":"Cell"},{"key":"922_CR38","doi-asserted-by":"crossref","first-page":"10842","DOI":"10.1074\/jbc.M112475200","volume":"277","author":"A Birbach","year":"2002","unstructured":"Birbach A, Gold P, Binder BR, Hofer E, de Martin R, Schmid JA. Signaling molecules of the NF-kappa B pathway shuttle constitutively between cytoplasm and nucleus. J Biol Chem. 2002;277:10842\u201351.","journal-title":"J Biol Chem"},{"key":"922_CR39","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1073\/pnas.97.3.1014","volume":"97","author":"TT Huang","year":"2000","unstructured":"Huang TT, Kudo N, Yoshida M, Miyamoto S. A nuclear export signal in the N-terminal regulatory domain of IkappaBalpha controls cytoplasmic localization of inactive NF-kappaB\/IkappaBalpha complexes. Proc Natl Acad Sci USA. 2000;97:1014\u20139.","journal-title":"Proc Natl Acad Sci USA"},{"key":"922_CR40","doi-asserted-by":"crossref","first-page":"6682","DOI":"10.1093\/emboj\/18.23.6682","volume":"18","author":"C Johnson","year":"1999","unstructured":"Johnson C, Van Antwerp D, Hope TJ. An N-terminal nuclear export signal is required for the nucleocytoplasmic shuttling of IkappaBalpha. EMBO J. 1999;18:6682\u201393.","journal-title":"EMBO J"},{"key":"922_CR41","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1128\/MCB.9.6.2424","volume":"9","author":"F Shirakawa","year":"1989","unstructured":"Shirakawa F, Mizel SB. In vitro activation and nuclear translocation of NF-kappa B catalyzed by cyclic AMP-dependent protein kinase and protein kinase C. Mol Cell Biol. 1989;9:2424\u201330.","journal-title":"Mol Cell Biol"},{"key":"922_CR42","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/j.cellsig.2008.03.012","volume":"20","author":"R Fagerlund","year":"2008","unstructured":"Fagerlund R, Mel\u00e9n K, Cao X, Julkunen I. NF-kappaB p52, RelB and c-Rel are transported into the nucleus via a subset of importin alpha molecules. Cell Signal. 2008;20:1442\u201351.","journal-title":"Cell Signal"},{"key":"922_CR43","doi-asserted-by":"crossref","first-page":"15942","DOI":"10.1074\/jbc.M500814200","volume":"280","author":"R Fagerlund","year":"2005","unstructured":"Fagerlund R, Kinnunen L, K\u00f6hler M, Julkunen I, Melen K. NF-{kappa}B is transported into the nucleus by importin {alpha}3 and importin {alpha}4. J Biol Chem. 2005;280:15942\u201351.","journal-title":"J Biol Chem"},{"key":"922_CR44","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.4049\/jimmunol.1000646","volume":"185","author":"M Zerfaoui","year":"2010","unstructured":"Zerfaoui M, Errami Y, Naura AS, Suzuki Y, Kim H, Ju J, Liu T, Hans CP, Kim JG, Abd Elmageed ZY, Koochekpour S, Catling A, Boulares AH. Poly(ADP-ribose) polymerase-1 is a determining factor in Crm1-mediated nuclear export and retention of p65 NF-kappa B upon TLR4 stimulation. J Immunol. 2010;185:1894\u2013902.","journal-title":"J Immunol."},{"key":"922_CR45","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.surg.2010.01.014","volume":"148","author":"A Iida","year":"2010","unstructured":"Iida A, Yoshidome H, Shida T, Takano S, Takeuchi D, Kimura F, Shimizu H, Ohtsuka M, Miyazaki M. Hepatocyte nuclear factor-kappa beta (NF-kappaB) activation is protective but is decreased in the cholestatic liver with endotoxemia. Surgery. 2010;148:477\u201389.","journal-title":"Surgery."},{"key":"922_CR46","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.mce.2010.07.023","volume":"331","author":"Q Jiang","year":"2011","unstructured":"Jiang Q, Liu P, Wu X, Liu W, Shen X, Lan T, Xu S, Peng J, Xie X, Huang H. Berberine attenuates lipopolysaccharide-induced extracellular matrix accumulation and inflammation in rat mesangial cells: involvement of NF-\u03baB signaling pathway. Mol Cell Endocrinol. 2011;331:34\u201340.","journal-title":"Mol Cell Endocrinol"},{"key":"922_CR47","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1097\/CCM.0b013e3181feeae4","volume":"39","author":"WY Kwon","year":"2011","unstructured":"Kwon WY, Suh GJ, Kim KS, Kwak YH. Niacin attenuates lung inflammation and improves survival during sepsis by downregulating the nuclear factor-\u03baB pathway. Crit Care Med. 2011;39:328\u201334.","journal-title":"Crit Care Med"},{"key":"922_CR48","first-page":"F1088","volume":"296","author":"C Meyer-Schwesinger","year":"2009","unstructured":"Meyer-Schwesinger C, Dehde S, von Ruffer C, Gatzemeier S, Klug P, Wenzel UO, Stahl RA, Thaiss F, Meyer TN. Rho kinase inhibition attenuates LPS-induced renal failure in mice in part by attenuation of NF-kappaB p65 signaling. Am J Physiol. 2009;296:F1088\u201399.","journal-title":"Am J Physiol"},{"key":"922_CR49","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1007\/s00011-008-8007-8","volume":"57","author":"X Zhang","year":"2008","unstructured":"Zhang X, Song Y, Ci X, An N, Ju Y, Li H, Wang X, Han C, Cui J, Deng X. Ivermectin inhibits LPS-induced production of inflammatory cytokines and improves LPS-induced survival in mice. Inflamm Res. 2008;57:524\u20139.","journal-title":"Inflamm Res"},{"key":"922_CR50","doi-asserted-by":"crossref","first-page":"613864","DOI":"10.1155\/2013\/613864","volume":"2013","author":"S Mandard","year":"2013","unstructured":"Mandard S, Patsouris D. Nuclear control of the inflammatory response in mammals by peroxisome proliferator-activated receptors. PPAR Res. 2013;2013:613864.","journal-title":"PPAR Res."},{"key":"922_CR51","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1291\/hypres.26.929","volume":"26","author":"T Ishizuka","year":"2003","unstructured":"Ishizuka T, Ito O, Tan L, Ogawa S, Kohzuki M, Omata K, Takeuchi K, Ito S. Regulation of cytochrome P-450 4A activity by peroxisome proliferator-activated receptors in the rat kidney. Hypertens Res. 2003;26:929\u201336.","journal-title":"Hypertens Res"},{"key":"922_CR52","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s11010-005-9038-x","volume":"284","author":"O Ito","year":"2006","unstructured":"Ito O, Nakamura Y, Tan L, Ishizuka T, Sasaki Y, Minami N, Kanazawa M, Ito S, Sasano H, Kohzuki M. Expression of cytochrome P-450 4 enzymes in the kidney and liver: regulation by PPAR and species-difference between rat and human. Mol Cell Biochem. 2006;284:141\u20138.","journal-title":"Mol Cell Biochem"},{"key":"922_CR53","first-page":"502631","volume":"2011","author":"DL Lee","year":"2011","unstructured":"Lee DL, Wilson JL, Duan R, Hudson T, El-Marakby A. Peroxisome proliferator-activated receptor-\u03b1 activation decreases mean arterial pressure, plasma interleukin-6, and COX-2 while increasing renal CYP4A expression in an acute model of DOCA-salt hypertension. PPAR Res. 2011;2011:502631.","journal-title":"PPAR Res."},{"key":"922_CR54","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1124\/dmd.106.013839","volume":"35","author":"VY Ng","year":"2007","unstructured":"Ng VY, Huang Y, Reddy LM, Falck JR, Lin ET, Kroetz DL. Cytochrome P450 eicosanoids are activators of peroxisome proliferator-activated receptor alpha. Drug Metab Dispos. 2007;35:1126\u201334.","journal-title":"Drug Metab Dispos"},{"key":"922_CR55","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1038\/ki.2008.300","volume":"74","author":"Y Zhou","year":"2008","unstructured":"Zhou Y, Luo P, Chang HH, Huang H, Yang T, Dong Z, Wang CY, Wang MH. Clofibrate attenuates blood pressure and sodium retention in DOCA-salt hypertension. Kidney Int. 2008;74:1040\u20138.","journal-title":"Kidney Int"},{"key":"922_CR56","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/j.1476-5381.2011.01263.x","volume":"163","author":"CJ Liang","year":"2011","unstructured":"Liang CJ, Tseng CP, Yang CM, Ma YH. 20-Hydroxyeicosatetraenoic acid inhibits ATP-induced COX-2 expression via peroxisome proliferator activator receptor-\u03b1 in vascular smooth muscle cells. Br J Pharmacol. 2011;163:815\u201325.","journal-title":"Br J Pharmacol"},{"key":"922_CR57","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/S0022-3565(24)35029-3","volume":"290","author":"TB Barclay","year":"1999","unstructured":"Barclay TB, Peters JM, Sewer MB, Ferrari L, Gonzalez FJ, Morgan ET. Modulation of cytochrome P-450 gene expression in endotoxemic mice is tissue specific and peroxisome proliferator-activated receptor-alpha dependent. J Pharmacol Exp Ther. 1999;290:1250\u20137.","journal-title":"J Pharmacol Exp Ther"},{"key":"922_CR58","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/jb\/mvq144","volume":"149","author":"F Iwamoto","year":"2011","unstructured":"Iwamoto F, Umemoto T, Motojima K, Fujiki Y. Nuclear transport of peroxisome-proliferator activated receptor & alpha. J Biochem. 2011;149:311\u20139.","journal-title":"J Biochem"},{"key":"922_CR59","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1111\/j.1365-2443.2012.01607.x","volume":"17","author":"T Umemoto","year":"2012","unstructured":"Umemoto T, Fujiki Y. Ligand-dependent nucleo-cytoplasmic shuttling of peroxisome proliferator-activated receptors. PPAR\u03b1 and PPAR\u03b3. Genes Cells. 2012;17:576\u201396.","journal-title":"PPAR\u03b1 and PPAR\u03b3. Genes Cells."},{"key":"922_CR60","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1242\/jcs.055475","volume":"123","author":"A Knethen von","year":"2010","unstructured":"von Knethen A, Tzieply N, Jennewein C, Br\u00fcne B. Casein-kinase-II-dependent phosphorylation of PPARgamma provokes CRM1-mediated shuttling of PPARgamma from the nucleus to the cytosol. J Cell Sci. 2010;123:192\u2013201.","journal-title":"J Cell Sci"},{"key":"922_CR61","doi-asserted-by":"crossref","first-page":"5208","DOI":"10.1021\/bi002732+","volume":"40","author":"JK Forwood","year":"2001","unstructured":"Forwood JK, Lam MH, Jans DA. Nuclear import of Creb and AP-1 transcription factors requires importin-beta 1 and Ran but is independent of importin-alpha. Biochemistry. 2001;40:5208\u201317.","journal-title":"Biochemistry"},{"key":"922_CR62","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.bbrc.2011.03.092","volume":"407","author":"I Schreck","year":"2011","unstructured":"Schreck I, Al-Rawi M, Mingot JM, Scholl C, Diefenbacher ME, O\u2019Donnell P, Bohmann D, Weiss C. c-Jun localizes to the nucleus independent of its phosphorylation by and interaction with JNK and vice versa promotes nuclear accumulation of JNK. Biochem Biophys Res Commun. 2011;407:735\u201340.","journal-title":"Biochem Biophys Res Commun."},{"key":"922_CR63","doi-asserted-by":"crossref","first-page":"27685","DOI":"10.1074\/jbc.M703301200","volume":"282","author":"I Waldmann","year":"2007","unstructured":"Waldmann I, W\u00e4lde S, Kehlenbach RH. Nuclear import of c-Jun is mediated by multiple transport receptors. J Biol Chem. 2007;282:27685\u2013892.","journal-title":"J Biol Chem"},{"key":"922_CR64","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.4161\/cc.6.13.4453","volume":"6","author":"E Burgermeister","year":"2007","unstructured":"Burgermeister E, Seger R. MAPK kinases as nucleo-cytoplasmic shuttles for PPARgamma. Cell Cycle. 2007;6:1539\u201348.","journal-title":"Cell Cycle"},{"key":"922_CR65","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.1194\/jlr.M042283","volume":"54","author":"R Ramer","year":"2013","unstructured":"Ramer R, Walther U, Borchert P, Laufer S, Linnebacher M, Hinz B. Induction but not inhibition of COX-2 confers human lung cancer cell apoptosis by celecoxib. J Lipid Res. 2013;54:3116\u201329.","journal-title":"J Lipid Res"},{"key":"922_CR66","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1124\/mol.109.061101","volume":"78","author":"HH Chen","year":"2010","unstructured":"Chen HH, Chen TW, Lin H. Pravastatin attenuates carboplatin-induced nephrotoxicity in rodents via peroxisome proliferator-activated receptor alpha-regulated heme oxygenase-1. Mol Pharmacol. 2010;78:36\u201345.","journal-title":"Mol Pharmacol"},{"key":"922_CR67","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0014-5793(02)03059-4","volume":"525","author":"A Shibuya","year":"2002","unstructured":"Shibuya A, Wada K, Nakajima A, Saeki M, Katayama K, Mayumi T, Kadowaki T, Niwa H, Kamisaki Y. Nitration of PPARgamma inhibits ligand-dependent translocation into the nucleus in a macrophage-like cell line, RAW 264. FEBS Lett. 2002;525:43\u20137.","journal-title":"FEBS Lett"},{"key":"922_CR68","doi-asserted-by":"crossref","first-page":"931","DOI":"10.3109\/00365521.2011.568516","volume":"46","author":"H Xue","year":"2011","unstructured":"Xue H, Chen B, Fan Y, Palikhe M, Li Y. The inhibitory effect of polypeptide cSN50 on alcoholic hepatic injuries through blocking the binding of NF-\u03baB to importin \u03b1. Scand J Gastroenterol. 2011;46:931\u201340.","journal-title":"Scand J Gastroenterol"}],"container-title":["Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-016-0922-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00011-016-0922-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-016-0922-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T11:08:19Z","timestamp":1748776099000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00011-016-0922-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,13]]},"references-count":68,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["922"],"URL":"https:\/\/doi.org\/10.1007\/s00011-016-0922-5","relation":{},"ISSN":["1023-3830","1420-908X"],"issn-type":[{"value":"1023-3830","type":"print"},{"value":"1420-908X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,13]]}}}