{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T12:07:50Z","timestamp":1777032470764,"version":"3.51.4"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2018,5,12]],"date-time":"2018-05-12T00:00:00Z","timestamp":1526083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflamm. Res."],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1007\/s00011-018-1158-3","type":"journal-article","created":{"date-parts":[[2018,5,11]],"date-time":"2018-05-11T23:13:15Z","timestamp":1526080395000},"page":"655-661","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Genes and their single nucleotide polymorphism involved in innate immune response in central nervous system in bacterial meningitis: review of literature data"],"prefix":"10.1007","volume":"67","author":[{"given":"Ewelina","family":"Gowin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danuta","family":"Januszkiewicz-Lewandowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,5,12]]},"reference":[{"key":"1158_CR1","unstructured":"World Health Organization. Surveillance for vaccine preventable diseases (VPDs). \n                    http:\/\/www.who.int\/immunization\/monitoring_surveillance\/ burden\/VPDs\/en\/\n                    \n                  . Accessed Aug 2017."},{"key":"1158_CR2","unstructured":"CDC. Active bacterial core surveillance report, emerging infections program network, Neisseria meningitidis. \n                    https:\/\/www.cdc.gov\/abcs\/reports-findings\/survreports\/mening14.pdf\n                    \n                  . Accessed Aug 2017."},{"key":"1158_CR3","doi-asserted-by":"crossref","unstructured":"Borrow R, Alarcon P, Carlos J, Caugant DA, Christensen H, Debbag R, et al. The Global meningococcal initiative: global epidemiology, the impact of vaccines on meningococcal disease and the importance of herd protection. Expert Rev Vaccines. 2016;1\u201316.","DOI":"10.1080\/14760584.2017.1258308"},{"key":"1158_CR4","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1128\/CMR.00070-09","volume":"23","author":"MC Brouwer","year":"2010","unstructured":"Brouwer MC, Tunkel AR, van de Beek D. Epidemiology, diagnosis, and antimicrobial treatment of acute bacterial meningitis. Clin Microbiol Rev. 2010;23:24.","journal-title":"Clin Microbiol Rev"},{"key":"1158_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/BJ20090272","volume":"420","author":"H Kumar","year":"2009","unstructured":"Kumar H, Kawai T, Akira S. Pathogen recognition in the innate immune response. Biochem J. 2009;420:1\u201316.","journal-title":"Biochem J"},{"key":"1158_CR6","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1093\/jnen\/62.6.593","volume":"62","author":"JS Pachter","year":"2003","unstructured":"Pachter JS, De Vries HE, Fabry Z. The blood\u2013brain barrier and its role in immune privilege in the central nervous system. J Neuropathol Exp Neurol. 2003;62:593\u2013604.","journal-title":"J Neuropathol Exp Neurol"},{"key":"1158_CR7","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1743-8454-1-2","volume":"1","author":"M Johnston","year":"2004","unstructured":"Johnston M, Zakharov A, Papaiconomou C, Salmasi G, Armstrong D. Evidence of connections between cerebrospinal fluid and nasal lymphatic vessels in humans, non-human primates and other mammalian species. Cerebrospinal Fluid Res. 2004;1:2.","journal-title":"Cerebrospinal Fluid Res"},{"key":"1158_CR8","first-page":"15","volume":"336","author":"U Koedel","year":"2009","unstructured":"Koedel U. Toll-like receptors in bacterial meningitis. Curr Top Microbiol Immunol. 2009;336:15\u201340.","journal-title":"Curr Top Microbiol Immunol"},{"key":"1158_CR9","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/nri1391","volume":"4","author":"S Akira","year":"2004","unstructured":"Akira S, Takeda K. Toll-like receptor signaling. Nat Rev Immunol. 2004;4:499\u2013511.","journal-title":"Nat Rev Immunol"},{"key":"1158_CR10","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1093\/jnen\/61.11.1013","volume":"61","author":"M Bsibsi","year":"2002","unstructured":"Bsibsi M, Ravid R, Gveric D, van Noort JM. Broad expression of Toll-like receptors in the human central nervous system. J Neuropathol Exp Neurol. 2002;61:1013\u201321.","journal-title":"J Neuropathol Exp Neurol"},{"key":"1158_CR11","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1038\/41131","volume":"388","author":"R Medzhitov","year":"1997","unstructured":"Medzhitov R, Preston-Hurlburt P, Janeway. CAJ.A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature. 1997;388:394\u20137.","journal-title":"Nature"},{"key":"1158_CR12","doi-asserted-by":"publisher","first-page":"438","DOI":"10.4049\/jimmunol.170.1.438","volume":"170","author":"U Koedel","year":"2003","unstructured":"Koedel U, Angele B, Rupprecht T, Wagner H, Roggenkamp A, Pfister HW, Kirschning CJ. Toll-Like receptor 2 participates in mediation of immune response in experimental pneumococcal meningitis. J Immunol. 2003;170:438\u201344.","journal-title":"J Immunol"},{"key":"1158_CR13","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1038\/nature02761","volume":"430","author":"B Beutler","year":"2004","unstructured":"Beutler B. Inferences, questions and possibilities in Toll-like receptor signalling. Nature. 2004;430:257\u201363.","journal-title":"Nature"},{"key":"1158_CR14","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/j.cell.2006.08.002","volume":"126","author":"Y Ogura","year":"2006","unstructured":"Ogura Y, Sutterwala FS, Flavell RA. The inflammasome: first line of the immune response to cell stress. Cell. 2006;126:659\u201362.","journal-title":"Cell"},{"key":"1158_CR15","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1146\/annurev.immunol.24.021605.090552","volume":"24","author":"B Beutler","year":"2006","unstructured":"Beutler B, Jiang Z, Georgel P, Crozat K, Croker B, Rutschmann S, Du X, Hoebe K. Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large. Annu Rev Immunol. 2006;24:353\u201389.","journal-title":"Annu Rev Immunol"},{"key":"1158_CR16","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1086\/342845","volume":"186","author":"H Echchannaoui","year":"2002","unstructured":"Echchannaoui H, Frei K, Schnell C, Leib SL, Zimmerli W, Landmann R. Toll-like receptor 2-deficient mice are highly susceptible to Streptococcus pneumoniae meningitis because of reduced bacterial clearing and enhanced inflammation. J Infect Dis. 2002;186:798\u2013806.","journal-title":"J Infect Dis"},{"key":"1158_CR17","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1086\/591626","volume":"198","author":"M Klein","year":"2008","unstructured":"Klein M, Angele B, Pfister HW, Wagner H, Koedel U, Kirschning CJ. Detection of pneumococcal infection of the central nervous system depends upon TLR2 and TLR4. J Infect Dis. 2008;198:1028\u201336.","journal-title":"J Infect Dis"},{"key":"1158_CR18","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1128\/IAI.72.1.371-380.2004","volume":"72","author":"SM Zughaier","year":"2004","unstructured":"Zughaier SM, Tzeng YL, Zimmer SM, Datta A, Carlson RW, Stephens DS. Neisseria meningitidis lipooligosaccharide structure-dependent activation of the macrophage CD14\/Toll-like receptor 4 pathway. Infect Immun. 2004;72:371\u201380.","journal-title":"Infect Immun"},{"key":"1158_CR19","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1189\/jlb.1105626","volume":"80","author":"TH Mogensen","year":"2006","unstructured":"Mogensen TH, Paludan SR, Kilian M, Ostergaard L. Live Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis activate the inflammatory response through Toll-like receptors 2, 4, and 9 in species-specific patterns. J Leukoc Biol. 2006;80:267\u201377.","journal-title":"J Leukoc Biol"},{"key":"1158_CR20","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","volume":"124","author":"S Akira","year":"2006","unstructured":"Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell. 2006;124:783\u2013801.","journal-title":"Cell"},{"key":"1158_CR21","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.immuni.2007.12.012","volume":"28","author":"YG Kim","year":"2008","unstructured":"Kim YG, Park JH, Shaw MH, Franchi L, Inohara N, Nunez G. The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to toll-like receptor ligands. Immunity. 2008;28:246\u201357.","journal-title":"Immunity"},{"key":"1158_CR22","doi-asserted-by":"publisher","first-page":"29054","DOI":"10.1074\/jbc.M602638200","volume":"281","author":"M Hasegawa","year":"2006","unstructured":"Hasegawa M, Yang K, Hashimoto M, Park JH, Kim YG, Fujimoto Y, Nunez G, Fukase K, Inohara N. Differential release and distribution of Nod1 and Nod2 immunostimulatory molecules among bacterial species and environments. J Biol Chem. 2006;281:29054\u201363.","journal-title":"J Biol Chem"},{"key":"1158_CR23","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/nri1086","volume":"3","author":"N Inohara","year":"2003","unstructured":"Inohara N, Nunez G. NODs: intracellular proteins involved in inflammation and apoptosis. Nat Rev Immunol. 2003;3:371\u201382.","journal-title":"Nat Rev Immunol"},{"key":"1158_CR24","doi-asserted-by":"publisher","first-page":"R227","DOI":"10.1186\/cc9377","volume":"14","author":"SJ Chapman","year":"2010","unstructured":"Chapman SJ, Khor CC, Vannberg FO, Rautanen A, Walley A, Segal S, Moore CE, Davies RJ, Day NP, Peshu N, Crook DW, Berkley JA, Williams TN, Scott JA, Hill AV. Common NFKBIL2 polymorphisms and susceptibility to pneumococcal disease: a genetic association study. Crit Care. 2010;14:R227.","journal-title":"Crit Care"},{"key":"1158_CR25","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1038\/ng1976","volume":"39","author":"CC Khor","year":"2007","unstructured":"Khor CC, Chapman SJ, Vannberg FO, Dunne A, Murphy C, Ling EY, Frodsham AJ, Walley AJ, Kyrieleis O, Khan A, Aucan C, Segal S, Moore CE, Knox K, Campbell SJ, Lienhardt C, Scott A, Aaby P, Sow OY, Grignani RT, Sillah J, Sirugo G, Peshu N, Williams TN, Maitland K, Davies RJ, Kwiatkowski DP, Day NP, Yala D, Crook DW, Marsh K, Berkley JA, O\u2019Neill LA, Hill AV. A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis. Nat Genet. 2007;39:523\u20138.","journal-title":"Nat Genet"},{"key":"1158_CR26","doi-asserted-by":"publisher","first-page":"2076","DOI":"10.1126\/science.1081902","volume":"299","author":"C Picard","year":"2003","unstructured":"Picard C, Puel A, Bonnet M, Ku CL, Bustamante J, Yang K, Soudais CM, Dupuis S, Feinberg J, Fieschi C, et al. Pyogenic bacterial infections in humans with IRAK-4 deficiency. Science. 2003;299:2076\u20139. \n                    https:\/\/doi.org\/10.1126\/science.108190\n                    \n                  .","journal-title":"Science"},{"key":"1158_CR27","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1084\/jem.20030701","volume":"198","author":"AE Medvedev","year":"2003","unstructured":"Medvedev AE, Lentschat A, Kuhns DB, Blanco JC, Salkowski C, Zhang S, Arditi M, Gallin JI, Vogel SN. Distinct mutations in IRAK-4 confer hyporesponsiveness to lipopolysaccharide and interleukin-1 in a patient with recurrent bacterial infections. J Exp Med. 2003;198:521\u201331.","journal-title":"J Exp Med"},{"key":"1158_CR28","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.micinf.2006.10.002","volume":"9","author":"L Moens","year":"2007","unstructured":"Moens L, Verhaegen J, Pierik M, Vermeire S, De BK, Peetermans WE, Bossuyt X. Toll-like receptor 2 and toll-like receptor 4 polymorphisms in invasive pneumococcal disease. Microbes Infect. 2007;9:15\u201320.","journal-title":"Microbes Infect"},{"key":"1158_CR29","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1038\/sj.icb.7100155","volume":"86","author":"FF Yuan","year":"2008","unstructured":"Yuan FF, Marks K, Wong M, Watson S, de Leon E, et al. Clinical relevance of TLR2, TLR4, CD14 and FcgammaRIIA gene polymorphisms in Streptococcus pneumoniae infection. Immunol Cell Biol. 2008;86:268\u201370.","journal-title":"Immunol Cell Biol"},{"key":"1158_CR30","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1097\/01.inf.0000195595.22547.fe","volume":"25","author":"J Faber","year":"2006","unstructured":"Faber J, Meyer CU, Gemmer C, Russo A, Finn A, Murdoch C, Zenz W, Mannhalter C, Zabel BU, Schmitt HJ, Habermehl P, Zepp F, Knuf M. Human toll-like receptor 4 mutations are associated with susceptibility to invasive meningococcal disease in infancy. Pediatr Infect Dis J. 2006;25:80\u20131.","journal-title":"Pediatr Infect Dis J"},{"key":"1158_CR31","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/j.medin.2013.08.006","volume":"38","author":"JJ Teller\u00eda-Orriols","year":"2014","unstructured":"Teller\u00eda-Orriols JJ, Garc\u00eda-Salido A, Varillas D, Serrano-Gonz\u00e1lez A, Casado-Flores J. TLR2-TLR4\/CD14 polymorphisms and predisposition to severe invasive infections by Neisseria meningitidis and Streptococcus pneumoniae. Med Intensiva. 2014;38:356\u201362.","journal-title":"Med Intensiva"},{"key":"1158_CR32","doi-asserted-by":"crossref","unstructured":"Smirnova I, Mann N, Dols A, Derkx HH, Hibberd ML, Levin M, Beutler B. Assay of locus-specific genetic load implicates rare toll-like receptor 4 mutations in meningococcal susceptibility. Proc Natl Acad Sci. 2003;100:6075\u20136080.","DOI":"10.1073\/pnas.1031605100"},{"key":"1158_CR33","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1086\/322798","volume":"184","author":"RC Read","year":"2001","unstructured":"Read RC, Pullin J, Gregory S, Borrow R, Kaczmarski EB, Giovine FS, Dower SK, Cannings C, Ailson AG. A functional polymorphism of toll-like receptor 4 is not associated with likelihood or severity of meningococcal disease. J Infect Dis. 2001;184:640\u20132.","journal-title":"J Infect Dis"},{"key":"1158_CR34","doi-asserted-by":"publisher","first-page":"7374","DOI":"10.1371\/journal.pone.0007374","volume":"4","author":"A Biebl","year":"2009","unstructured":"Biebl A, Muendlein A, Kazakbaeva Z, Heuberger S, Sonderegger G, Drexel H, Lau S, Nickel R, Kabesch M, Simma B. CD14 C-159T and toll-like receptor 4 Asp299Gly polymorphisms in surviving meningococcal disease patients. PLoS One. 2009;4:7374.","journal-title":"PLoS One"},{"key":"1158_CR35","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1097\/01.inf.0000095431.15606.68","volume":"22","author":"A Allen","year":"2003","unstructured":"Allen A, Obaro S, Bojang K, Awomoyi AA, Greenwood BM, Whittle H, et al. Variation in toll-like receptor 4 and susceptibility to group A meningococcal meningitis inGambian children. Pediatr Infect Dis J. 2003;22:1018\u20139.","journal-title":"Pediatr Infect Dis J"},{"key":"1158_CR36","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1371\/journal.pone.0064252","volume":"8","author":"GT Well van","year":"2013","unstructured":"van Well GT, Sanders MS, Ouburg S, Kumar V, van Furth AM, Morre SA. Single nucleotide polymorphisms in pathogen recognition receptor genes are associated with susceptibility to meningococcal meningitis in a pediatric cohort. PLoS One. 2013;8:20.","journal-title":"PLoS One"},{"key":"1158_CR37","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1093\/cid\/ciq155","volume":"52","author":"MS Sanders","year":"2011","unstructured":"Sanders MS, van Well GT, Ouburg S, Lundberg PS, van Furth AM, Morre SA. Single nucleotide polymorphisms in TLR9 are highly associated with susceptibility to bacterial meningitis in children. Clin Infect Dis. 2011;52:475\u201380.","journal-title":"Clin Infect Dis"},{"key":"1158_CR38","doi-asserted-by":"publisher","first-page":"42796","DOI":"10.1038\/srep42796","volume":"7","author":"PN ZhangZhang","year":"2017","unstructured":"Zhang, PZhang N, Liu L, Zheng K, Zhu L, Zhu J, Cao L, Jiang Y, Liu G, He Q. Polymorphisms of toll-like receptors 2 and 9 and severity and prognosis of bacterial meningitis in Chinese children. Sci Rep. 2017;7:42796.","journal-title":"Sci Rep"},{"key":"1158_CR39","first-page":"93","volume":"3","author":"LF Lundbo","year":"2016","unstructured":"Lundbo LF, Harboe ZB, Clausen LN, Hollegaard MV, Sorensen HT, Hougaard DM, Konradsen HB, Norgaard M, Benfield T. Genetic variation in NFKBIE is associated with increased risk of pneumococcal meningitis in children. BioMedicine. 2016;3:93\u20139.","journal-title":"BioMedicine"},{"key":"1158_CR40","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1038\/gene.2009.76","volume":"11","author":"SJ Chapman","year":"2010","unstructured":"Chapman SJ, Khor CC, Vannberg FO, Rautanen A, Segal S, Moore CE, Davies RJ, Day NP, Peshu N, Crook DW, Berkley JA, Williams TN, Scott AJ, Hill AVS. NFKBIZ polymorphisms and susceptibility to pneumococcal disease in European and African populations. Genes Immun. 2010;11:319\u201325.","journal-title":"Genes Immun"}],"container-title":["Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00011-018-1158-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-018-1158-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-018-1158-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T19:26:42Z","timestamp":1557602802000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00011-018-1158-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,12]]},"references-count":40,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["1158"],"URL":"https:\/\/doi.org\/10.1007\/s00011-018-1158-3","relation":{},"ISSN":["1023-3830","1420-908X"],"issn-type":[{"value":"1023-3830","type":"print"},{"value":"1420-908X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,12]]},"assertion":[{"value":"5 September 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 May 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 May 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}