{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:43:52Z","timestamp":1790790232676,"version":"4.1.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T00:00:00Z","timestamp":1568678400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T00:00:00Z","timestamp":1568678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"crossref","award":["21502026"],"award-info":[{"award-number":["21502026"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"China Postdoctoral Science Foundation Funded Project","award":["2017M620369"],"award-info":[{"award-number":["2017M620369"]}]},{"DOI":"10.13039\/501100010877","name":"Shenzhen Science and Technology Innovation Committee","doi-asserted-by":"crossref","award":["KQJSCX20170329152357439"],"award-info":[{"award-number":["KQJSCX20170329152357439"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100010877","name":"Shenzhen Science and Technology Innovation Committee","doi-asserted-by":"crossref","award":["JCYJ20160427152241973"],"award-info":[{"award-number":["JCYJ20160427152241973"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"crossref","award":["SZSM20151205"],"award-info":[{"award-number":["SZSM20151205"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflamm. Res."],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1007\/s00011-019-01284-2","type":"journal-article","created":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T10:04:35Z","timestamp":1568714675000},"page":"1025-1034","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Saikosaponin C exerts anti-HBV effects by attenuating HNF1\u03b1 and HNF4\u03b1 expression to suppress HBV pgRNA synthesis"],"prefix":"10.1007","volume":"68","author":[{"given":"Yanchao","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyi","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runze","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,9,17]]},"reference":[{"key":"1284_CR1","doi-asserted-by":"crossref","first-page":"S103","DOI":"10.1002\/hep.22956","volume":"49","author":"R Perrillo","year":"2009","unstructured":"Perrillo R. Benefits and risks of interferon therapy for hepatitis B. Hepatology. 2009;49:S103\u201311.","journal-title":"Hepatology"},{"key":"1284_CR2","doi-asserted-by":"crossref","first-page":"e01919-16","DOI":"10.1128\/JVI.01919-16","volume":"91","author":"X Yang","year":"2017","unstructured":"Yang X, Li H, Sun H, Fan H, Hu Y, Liu M, et al. Hepatitis B virus-encoded microrna controls viral replication. J Virol. 2017;91:e01919-16.","journal-title":"J Virol"},{"key":"1284_CR3","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1096\/fj.201801181R","volume":"33","author":"K Mouzannar","year":"2019","unstructured":"Mouzannar K, Fusil F, Lacombe B, Ollivier A, Menard C, Lotteau V, et al. Farnesoid X receptor-alpha is a proviral host factor for hepatitis B virus that is inhibited by ligands in vitro and in vivo. FASEB J. 2019;33:2472\u201383.","journal-title":"FASEB J."},{"key":"1284_CR4","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.antiviral.2018.08.014","volume":"158","author":"B Mitra","year":"2018","unstructured":"Mitra B, Thapa RJ, Guo H, Block TM. Host functions used by hepatitis B virus to complete its life cycle: implications for developing host-targeting agents to treat chronic hepatitis B. Antiviral Res. 2018;158:185\u201398.","journal-title":"Antiviral Res"},{"key":"1284_CR5","doi-asserted-by":"crossref","first-page":"7017","DOI":"10.3748\/wjg.v22.i31.7017","volume":"22","author":"DH Kim","year":"2016","unstructured":"Kim DH, Kang HS, Kim KH. Roles of hepatocyte nuclear factors in hepatitis B virus infection. World J Gastroenterol. 2016;22:7017\u201329.","journal-title":"World J Gastroenterol"},{"key":"1284_CR6","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1016\/j.celrep.2019.02.033","volume":"26","author":"HL Ko","year":"2019","unstructured":"Ko HL, Zhuo Z, Ren EC. Hnf4alpha combinatorial isoform heterodimers activate distinct gene targets that differ from their corresponding homodimers. Cell Rep. 2019;26:2549\u201357.","journal-title":"Cell Rep."},{"key":"1284_CR7","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1186\/s13059-016-1100-3","volume":"17","author":"CA Meddens","year":"2016","unstructured":"Meddens CA, Harakalova M, van den Dungen NA, Foroughi Asl H, Hijma HJ, Cuppen EP, et al. Systematic analysis of chromatin interactions at disease associated loci links novel candidate genes to inflammatory bowel disease. Genome Biol. 2016;17:247.","journal-title":"Genome Biol"},{"key":"1284_CR8","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3727\/105221615X14181438356292","volume":"16","author":"C Walesky","year":"2015","unstructured":"Walesky C, Apte U. Role of hepatocyte nuclear factor 4alpha (HNF4alpha) in cell proliferation and cancer. Gene Expr. 2015;16:101\u20138.","journal-title":"Gene Expr"},{"key":"1284_CR9","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1743-422X-9-23","volume":"9","author":"EQ Chen","year":"2012","unstructured":"Chen EQ, Sun H, Feng P, Gong DY, Liu C, Bai L, et al. Study of the expression levels of hepatocyte nuclear factor 4 alpha and 3 beta in patients with different outcome of HBV infection. Virol J. 2012;9:23.","journal-title":"Virol J."},{"key":"1284_CR10","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1111\/j.1365-2893.2009.01089.x","volume":"16","author":"Y Long","year":"2009","unstructured":"Long Y, Chen E, Liu C, Huang F, Zhou T, He F, et al. The correlation of hepatocyte nuclear factor 4 alpha and 3 beta with hepatitis B virus replication in the liver of chronic hepatitis B patients. J Viral Hepat. 2009;16:537\u201346.","journal-title":"J Viral Hepat."},{"key":"1284_CR11","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/j.1365-2893.2010.01315.x","volume":"17","author":"M Quasdorff","year":"2010","unstructured":"Quasdorff M, Protzer U. Control of hepatitis B virus at the level of transcription. J Viral Hepat. 2010;17:527\u201336.","journal-title":"J Viral Hepat."},{"key":"1284_CR12","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1111\/j.1478-3231.2011.02748.x","volume":"32","author":"F He","year":"2012","unstructured":"He F, Chen EQ, Liu L, Zhou TY, Liu C, Cheng X, et al. Inhibition of hepatitis B virus replication by hepatocyte nuclear factor 4-alpha specific short hairpin rna. Liver Int. 2012;32:742\u201351.","journal-title":"Liver Int."},{"key":"1284_CR13","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1186\/s12906-016-1333-4","volume":"16","author":"Y Zhao","year":"2016","unstructured":"Zhao Y, Wang YJ, Zhao RZ, Xiang FJ. Vinegar amount in the process affected the components of vinegar-baked Radix Bupleuri and its hepatoprotective effect. BMC Complement Altern Med. 2016;16:346.","journal-title":"BMC Complement Altern Med."},{"key":"1284_CR14","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1124\/dmd.112.048975","volume":"41","author":"G Liu","year":"2013","unstructured":"Liu G, Tian Y, Li G, Xu L, Song R, Zhang Z. Metabolism of saikosaponin a in rats: diverse oxidations on the aglycone moiety in liver and intestine in addition to hydrolysis of glycosidic bonds. Drug Metab Dispos. 2013;41:622\u201333.","journal-title":"Drug Metab Dispos"},{"key":"1284_CR15","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.jhep.2014.10.040","volume":"62","author":"LT Lin","year":"2015","unstructured":"Lin LT, Chung CY, Hsu WC, Chang SP, Hung TC, Shields J, et al. Saikosaponin b2 is a naturally occurring terpenoid that efficiently inhibits hepatitis C virus entry. J Hepatol. 2015;62:541\u20138.","journal-title":"J Hepatol"},{"key":"1284_CR16","first-page":"7597596","volume":"2017","author":"F Yang","year":"2017","unstructured":"Yang F, Dong X, Yin X, Wang W, You L, Ni J. Radix Bupleuri: a review of traditional uses, botany, phytochemistry, pharmacology, and toxicology. Biomed Res Int. 2017;2017:7597596.","journal-title":"Biomed Res Int"},{"key":"1284_CR17","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1080\/13880209.2016.1262433","volume":"55","author":"B Yuan","year":"2017","unstructured":"Yuan B, Yang R, Ma Y, Zhou S, Zhang X, Liu Y. A systematic review of the active saikosaponins and extracts isolated from Radix Bupleuri and their applications. Pharm Biol. 2017;55:620\u201335.","journal-title":"Pharm Biol."},{"key":"1284_CR18","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1055\/s-2003-42797","volume":"69","author":"LC Chiang","year":"2003","unstructured":"Chiang LC, Ng LT, Liu LT, Shieh DE, Lin CC. Cytotoxicity and anti-hepatitis B virus activities of saikosaponins from bupleurum species. Planta Med. 2003;69:705\u20139.","journal-title":"Planta Med"},{"key":"1284_CR19","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/aps.2008.5","volume":"30","author":"C Wohlfarth","year":"2009","unstructured":"Wohlfarth C, Efferth T. Natural products as promising drug candidates for the treatment of hepatitis B and C. Acta Pharmacol Sin. 2009;30:25\u201330.","journal-title":"Acta Pharmacol Sin"},{"key":"1284_CR20","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.cbi.2013.08.006","volume":"206","author":"L Chen","year":"2013","unstructured":"Chen L, Zhang F, Kong D, Zhu X, Chen W, Wang A, et al. Saikosaponin D disrupts platelet-derived growth factor-beta receptor\/p38 pathway leading to mitochondrial apoptosis in human LO2 hepatocyte cells: a potential mechanism of hepatotoxicity. Chem Biol Interact. 2013;206:76\u201382.","journal-title":"Chem Biol Interact"},{"key":"1284_CR21","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.bbrc.2014.02.046","volume":"445","author":"TH Lee","year":"2014","unstructured":"Lee TH, Chang J, Kim BM. Saikosaponin C inhibits lipopolysaccharide-induced apoptosis by suppressing caspase-3 activation and subsequent degradation of focal adhesion kinase in human umbilical vein endothelial cells. Biochem Biophys Res Commun. 2014;445:615\u201321.","journal-title":"Biochem Biophys Res Commun"},{"key":"1284_CR22","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.jhep.2016.05.029","volume":"65","author":"J Wang","year":"2016","unstructured":"Wang J, Shen T, Huang X, Kumar GR, Chen X, Zeng Z, et al. Serum hepatitis B virus rna is encapsidated pregenome RNA that may be associated with persistence of viral infection and rebound. J Hepatol. 2016;65:700\u201310.","journal-title":"J Hepatol"},{"key":"1284_CR23","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/nmeth.2633","volume":"10","author":"CM Hindson","year":"2013","unstructured":"Hindson CM, Chevillet JR, Briggs HA, Gallichotte EN, Ruf IK, Hindson BJ, et al. Absolute quantification by droplet digital pcr versus analog real-time pcr. Nat Methods. 2013;10:1003\u20135.","journal-title":"Nat Methods"},{"key":"1284_CR24","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1111\/j.1462-5822.2008.01141.x","volume":"10","author":"M Quasdorff","year":"2008","unstructured":"Quasdorff M, Hosel M, Odenthal M, Zedler U, Bohne F, Gripon P, et al. A concerted action of HNF4alpha and HNF1alpha links hepatitis B virus replication to hepatocyte differentiation. Cell Microbiol. 2008;10:1478\u201390.","journal-title":"Cell Microbiol"},{"key":"1284_CR25","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1046\/j.1365-2893.2002.00381.x","volume":"9","author":"N Moolla","year":"2002","unstructured":"Moolla N, Kew M, Arbuthnot P. Regulatory elements of hepatitis B virus transcription. J Viral Hepat. 2002;9:323\u201331.","journal-title":"J Viral Hepat."},{"key":"1284_CR26","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jhep.2010.08.006","volume":"54","author":"WQ Xiang","year":"2011","unstructured":"Xiang WQ, Feng WF, Ke W, Sun Z, Chen Z, Liu W. Hepatitis B virus x protein stimulates il-6 expression in hepatocytes via a myd88-dependent pathway. J Hepatol. 2011;54:26\u201333.","journal-title":"J Hepatol"},{"key":"1284_CR27","doi-asserted-by":"crossref","first-page":"e0142599","DOI":"10.1371\/journal.pone.0142599","volume":"10","author":"GA Palumbo","year":"2015","unstructured":"Palumbo GA, Scisciani C, Pediconi N, Lupacchini L, Alfalate D, Guerrieri F, et al. IL-6 inhibits HBV transcription by targeting the epigenetic control of the nuclear cccdna minichromosome. PLoS One. 2015;10:e0142599.","journal-title":"PLoS One"},{"key":"1284_CR28","first-page":"723","volume":"69","author":"Y Yang","year":"2014","unstructured":"Yang Y, Jiang HY, Shi Y, He JL, Su S, Chen Z. Chinese herbal medicine for carriers of the hepatitis B virus: an updated systematic review and meta-analysis. Pharmazie. 2014;69:723\u201330.","journal-title":"Pharmazie."},{"key":"1284_CR29","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1186\/s12906-018-2316-4","volume":"18","author":"YH Lai","year":"2018","unstructured":"Lai YH, Sun CP, Huang HC, Chen JC, Liu HK, Huang C. Epigallocatechin gallate inhibits hepatitis B virus infection in human liver chimeric mice. BMC Complement Altern Med. 2018;18:248.","journal-title":"BMC Complement Altern Med."},{"key":"1284_CR30","doi-asserted-by":"crossref","first-page":"6252","DOI":"10.3748\/wjg.v23.i34.6252","volume":"23","author":"ZQ Wei","year":"2017","unstructured":"Wei ZQ, Zhang YH, Ke CZ, Chen HX, Ren P, He YL, et al. Curcumin inhibits hepatitis B virus infection by down-regulating cccdna-bound histone acetylation. World J Gastroenterol. 2017;23:6252\u201360.","journal-title":"World J Gastroenterol"},{"key":"1284_CR31","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.antiviral.2018.04.017","volume":"155","author":"Y Liu","year":"2018","unstructured":"Liu Y, Yao W, Si L, Hou J, Wang J, Xu Z, et al. Chinese herbal extract su-duxing had potent inhibitory effects on both wild-type and entecavir-resistant hepatitis B virus (HBV) in vitro and effectively suppressed HBV replication in mouse model. Antiviral Res. 2018;155:39\u201347.","journal-title":"Antiviral Res"},{"key":"1284_CR32","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.antiviral.2006.04.006","volume":"72","author":"EH Kang","year":"2006","unstructured":"Kang EH, Kown TY, Oh GT, Park WF, Park SI, Park SK, et al. The flavonoid ellagic acid from a medicinal herb inhibits host immune tolerance induced by the hepatitis B virus-e antigen. Antiviral Res. 2006;72:100\u20136.","journal-title":"Antiviral Res"},{"key":"1284_CR33","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.antiviral.2005.07.005","volume":"68","author":"MR Romero","year":"2005","unstructured":"Romero MR, Efferth T, Serrano MA, Castano B, Macias RI, Briz O, et al. Effect of artemisinin\/artesunate as inhibitors of hepatitis B virus production in an \u201cin vitro\u201d replicative system. Antiviral Res. 2005;68:75\u201383.","journal-title":"Antiviral Res"},{"key":"1284_CR34","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1159\/000107690","volume":"53","author":"Z Li","year":"2007","unstructured":"Li Z, Li LJ, Sun Y, Li J. Identification of natural compounds with anti-hepatitis B virus activity from Rheum palmatum L ethanol extract. Chemotherapy. 2007;53:320\u20136.","journal-title":"Chemotherapy."},{"key":"1284_CR35","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.jep.2013.09.009","volume":"150","author":"Q Huang","year":"2013","unstructured":"Huang Q, Zhang S, Huang R, Wei L, Chen Y, Lv S, et al. Isolation and identification of an anti-hepatitis B virus compound from hydrocotyle sibthorpioides lam. J Ethnopharmacol. 2013;150:568\u201375.","journal-title":"J Ethnopharmacol"},{"key":"1284_CR36","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.antiviral.2007.12.011","volume":"77","author":"YP Tseng","year":"2008","unstructured":"Tseng YP, Kuo YH, Hu CP, Jeng KS, Janmanchi D, Lin CH, et al. The role of helioxanthin in inhibiting human hepatitis b viral replication and gene expression by interfering with the host transcriptional machinery of viral promoters. Antiviral Res. 2008;77:206\u201314.","journal-title":"Antiviral Res"},{"key":"1284_CR37","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.antiviral.2011.01.005","volume":"89","author":"YP Wang","year":"2011","unstructured":"Wang YP, Zhao W, Xue R, Zhou ZX, Liu F, Han YX, et al. Oxymatrine inhibits hepatitis B infection with an advantage of overcoming drug-resistance. Antiviral Res. 2011;89:227\u201331.","journal-title":"Antiviral Res"},{"key":"1284_CR38","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.lfs.2004.10.003","volume":"76","author":"KG Shyu","year":"2004","unstructured":"Shyu KG, Tsai SC, Wang BW, Liu YC, Lee CC. Saikosaponin c induces endothelial cells growth, migration and capillary tube formation. Life Sci. 2004;76:813\u201326.","journal-title":"Life Sci"},{"key":"1284_CR39","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.intimp.2015.01.010","volume":"25","author":"C Zhou","year":"2015","unstructured":"Zhou C, Liu W, He W, Wang H, Chen Q, Song H. Saikosaponin a inhibits RANKL-induced osteoclastogenesis by suppressing Nf-kappaB and MAPK pathways. Int Immunopharmacol. 2015;25:49\u201354.","journal-title":"Int Immunopharmacol"},{"key":"1284_CR40","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1248\/bpb.22.1385","volume":"22","author":"R Kyo","year":"1999","unstructured":"Kyo R, Nakahata N, Kodama Y, Nakai Y, Kubo M, Ohizumi Y. Antagonism of saikosaponin-induced prostaglandin E2 release by baicalein in C6 rat glioma cells. Biol Pharm Bull. 1999;22:1385\u20137.","journal-title":"Biol Pharm Bull"},{"key":"1284_CR41","first-page":"582437","volume":"2015","author":"JE Shin","year":"2015","unstructured":"Shin JE, Kim HJ, Kim KR, Lee SK, Park J, Kim H, et al. Type I saikosaponins a and d inhibit osteoclastogenesis in bone marrow-derived macrophages and osteolytic activity of metastatic breast cancer cells. Evid Based Complement Alternat Med. 2015;2015:582437.","journal-title":"Evid Based Complement Alternat Med."},{"key":"1284_CR42","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/1756-9966-29-159","volume":"29","author":"Q Wang","year":"2010","unstructured":"Wang Q, Zheng XL, Yang L, Shi F, Gao LB, Zhong YJ, et al. Reactive oxygen species-mediated apoptosis contributes to chemosensitization effect of saikosaponins on cisplatin-induced cytotoxicity in cancer cells. J Exp Clin Cancer Res. 2010;29:159.","journal-title":"J Exp Clin Cancer Res."},{"key":"1284_CR43","doi-asserted-by":"crossref","first-page":"176","DOI":"10.3109\/00498254.2016.1171932","volume":"47","author":"RP Ye","year":"2017","unstructured":"Ye RP, Chen ZD. Saikosaponin A, an active glycoside from Radix Bupleuri, reverses p-glycoprotein-mediated multidrug resistance in MCF-7\/ADR cells and HEPG2\/ADM cells. Xenobiotica. 2017;47:176\u201384.","journal-title":"Xenobiotica"},{"key":"1284_CR44","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.prp.2017.01.022","volume":"213","author":"C Li","year":"2017","unstructured":"Li C, Guan X, Xue H, Wang P, Wang M, Gai X. Reversal of P-glycoprotein-mediated multidrug resistance is induced by saikosaponin D in breast cancer MCF-7\/adriamycin cells. Pathol Res Pract. 2017;213:848\u201353.","journal-title":"Pathol Res Pract"},{"key":"1284_CR45","first-page":"745295","volume":"2013","author":"VK Wong","year":"2013","unstructured":"Wong VK, Zhang MM, Zhou H, Lam KY, Chan PL, Law CK, et al. Saikosaponin-d enhances the anticancer potency of TNF-alpha via overcoming its undesirable response of activating NF-kappa B signalling in cancer cells. Evid Based Complement Alternat Med. 2013;2013:745295.","journal-title":"Evid Based Complement Alternat Med."},{"key":"1284_CR46","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1186\/1472-6882-13-263","volume":"13","author":"BF Wang","year":"2013","unstructured":"Wang BF, Dai ZJ, Wang XJ, Bai MH, Lin S, Ma HB, et al. Saikosaponin-d increases the radiosensitivity of smmc-7721 hepatocellular carcinoma cells by adjusting the g0\/g1 and g2\/m checkpoints of the cell cycle. BMC Complement Altern Med. 2013;13:263.","journal-title":"BMC Complement Altern Med."},{"key":"1284_CR47","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1080\/01635581.2017.1285407","volume":"69","author":"H Ma","year":"2017","unstructured":"Ma H, Yokoyama S, Saiki I, Hayakawa Y. Chemosensitizing effect of saikosaponin B on B16F10 melanoma cells. Nutr Cancer. 2017;69:505\u201311.","journal-title":"Nutr Cancer"},{"key":"1284_CR48","doi-asserted-by":"crossref","first-page":"110092","DOI":"10.18632\/oncotarget.22639","volume":"8","author":"L Feng","year":"2017","unstructured":"Feng L, Liu L, Zhao Y, Zhao R. Saikosaponins A, C and D enhance liver-targeting effects of anticancer drugs by modulating drug transporters. Oncotarget. 2017;8:110092\u2013102.","journal-title":"Oncotarget."},{"key":"1284_CR49","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/hep.23952","volume":"53","author":"YF Liaw","year":"2011","unstructured":"Liaw YF, Sheen IS, Lee CM, Akarca US, Papatheodoridis GV, Suet-Hing Wong F, et al. Tenofovir disoproxil fumarate (TDF), emtricitabine\/TDF, and entecavir in patients with decompensated chronic hepatitis B liver disease. Hepatology. 2011;53:62\u201372.","journal-title":"Hepatology"},{"key":"1284_CR50","doi-asserted-by":"crossref","first-page":"590","DOI":"10.5009\/gnl16215","volume":"11","author":"TH Su","year":"2017","unstructured":"Su TH, Liu CJ. Combination therapy for chronic hepatitis B: current updates and perspectives. Gut Liver. 2017;11:590\u2013603.","journal-title":"Gut Liver."},{"key":"1284_CR51","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1142\/S0192415X91000193","volume":"19","author":"H Tajiri","year":"1991","unstructured":"Tajiri H, Kozaiwa K, Ozaki Y, Miki K, Shimuzu K, Okada S. Effect of sho-saiko-to(xiao-chai-hu-tang) on HBeAG clearance in children with chronic hepatitis b virus infection and with sustained liver disease. Am J Chin Med. 1991;19:121\u20139.","journal-title":"Am J Chin Med"},{"key":"1284_CR52","doi-asserted-by":"crossref","first-page":"995","DOI":"10.3389\/fphar.2017.00995","volume":"8","author":"X Gao","year":"2017","unstructured":"Gao X, Liang M, Fang Y, Zhao F, Tian J, Zhang X, et al. Deciphering the differential effective and toxic responses of Bupleuri Radix following the induction of chronic unpredictable mild stress and in healthy rats based on serum metabolic profiles. Front Pharmacol. 2017;8:995.","journal-title":"Front Pharmacol."}],"container-title":["Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-019-01284-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00011-019-01284-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-019-01284-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T22:16:09Z","timestamp":1744150569000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00011-019-01284-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,17]]},"references-count":52,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["1284"],"URL":"https:\/\/doi.org\/10.1007\/s00011-019-01284-2","relation":{},"ISSN":["1023-3830","1420-908X"],"issn-type":[{"value":"1023-3830","type":"print"},{"value":"1420-908X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,17]]},"assertion":[{"value":"16 May 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 September 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 September 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}