{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:15:41Z","timestamp":1789193741276,"version":"build-2803163510"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T00:00:00Z","timestamp":1583884800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T00:00:00Z","timestamp":1583884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["17-74-30030"],"award-info":[{"award-number":["17-74-30030"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Russian grant Program for Basic Science","award":["19-04-00109"],"award-info":[{"award-number":["19-04-00109"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflamm. Res."],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1007\/s00011-020-01329-x","type":"journal-article","created":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T04:53:03Z","timestamp":1583902383000},"page":"481-495","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["H2S counteracts proinflammatory effects of LPS through modulation of multiple pathways in human cells"],"prefix":"10.1007","volume":"69","author":[{"given":"M. M.","family":"Yurinskaya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. S.","family":"Krasnov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. A.","family":"Kulikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. G.","family":"Zatsepina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. G.","family":"Vinokurov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. N.","family":"Chuvakova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. P.","family":"Rezvykh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Y.","family":"Funikov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. V.","family":"Morozov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8554-2121","authenticated-orcid":false,"given":"M. B.","family":"Evgen\u2019ev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,3,11]]},"reference":[{"issue":"4","key":"1329_CR1","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1189\/jlb.3RU0316-151R","volume":"100","author":"RS Munford","year":"2016","unstructured":"Munford RS. Endotoxemia-menace, marker, or mistake? J Leukoc Biol. 2016;100(4):687\u201398. https:\/\/doi.org\/10.1189\/jlb.3RU0316-151R.","journal-title":"J Leukoc Biol"},{"issue":"12","key":"1329_CR2","doi-asserted-by":"publisher","first-page":"29554","DOI":"10.3390\/ijms161226190","volume":"16","author":"IJ Martins","year":"2015","unstructured":"Martins IJ. Overnutrition determines LPS regulation of mycotoxin induced neurotoxicity in neurodegenerative diseases. Int J Mol Sci. 2015;16(12):29554\u201373. https:\/\/doi.org\/10.3390\/ijms161226190.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"1329_CR3","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1186\/s12974-017-1002-7","volume":"14","author":"YW Wang","year":"2017","unstructured":"Wang YW, Zhou Q, Zhang X, Qian QQ, Xu JW, Ni PF, et al. Mild endoplasmic reticulum stress ameliorates lipopolysaccharide-induced neuroinflammation and cognitive impairment via regulation of microglial polarization. J Neuroinflamm. 2017;14(1):233. https:\/\/doi.org\/10.1186\/s12974-017-1002-7.","journal-title":"J Neuroinflamm"},{"key":"1329_CR4","doi-asserted-by":"publisher","unstructured":"Kimura H. Physiological roles of hydrogen sulfide and polysulfides. In: Moore P, Whiteman M, editors. Chemistry, biochemistry and pharmacology of hydrogen sulfide. Handbook of experimental pharmacology, vol. 230. Springer, Cham;2015. p. 61\u201381. https:\/\/doi.org\/10.1007\/978-3-319-18144-8_3.","DOI":"10.1007\/978-3-319-18144-8_3"},{"key":"1329_CR5","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/bs.mie.2014.11.014","volume":"554","author":"P Rose","year":"2015","unstructured":"Rose P, Dymock BW, Moore PK. GYY4137, a novel water-soluble, H2S-releasing molecule. Methods Enzymol. 2015;554:143\u201367. https:\/\/doi.org\/10.1016\/bs.mie.2014.11.014.","journal-title":"Methods Enzymol"},{"issue":"10","key":"1329_CR6","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1089\/ars.2009.2899","volume":"12","author":"M Whiteman","year":"2010","unstructured":"Whiteman M, Li L, Rose P, Tan CH, Parkinson DB, Moore PK. The effect of hydrogen sulfide donors on lipopolysaccharide-induced formation of inflammatory mediators in macrophages. Antioxid Redox Signal. 2010;12(10):1147\u201354. https:\/\/doi.org\/10.1089\/ars.2009.2899.","journal-title":"Antioxid Redox Signal"},{"issue":"3","key":"1329_CR7","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1111\/jcmm.12016","volume":"17","author":"L Li","year":"2013","unstructured":"Li L, Fox B, Keeble J, Salto-Tellez M, Winyard PG, Wood ME, et al. The complex effects of the slow-releasing hydrogen sulfide donor GYY4137 in a model of acute joint inflammation and in human cartilage cells. J Cell Mol Med. 2013;17(3):365\u201376. https:\/\/doi.org\/10.1111\/jcmm.12016.","journal-title":"J Cell Mol Med"},{"key":"1329_CR8","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.pupt.2017.06.006","volume":"45","author":"Y Kaya-Yasar","year":"2017","unstructured":"Kaya-Yasar Y, Karaman Y, Bozkurt TE, Onder SC, Sahin-Erdemli I. Effects of intranasal treatment with slow (GYY4137) and rapid (NaHS) donors of hydrogen sulfide in lipopolysaccharide-induced airway inflammation in mice. Pulm Pharmacol Ther. 2017;45:170\u201380. https:\/\/doi.org\/10.1016\/j.pupt.2017.06.006.","journal-title":"Pulm Pharmacol Ther"},{"issue":"3","key":"1329_CR9","doi-asserted-by":"publisher","first-page":"203","DOI":"10.7555\/jbr.28.20140037","volume":"29","author":"G Meng","year":"2015","unstructured":"Meng G, Wang J, Xiao Y, Bai W, Xie L, Shan L, et al. GYY4137 protects against myocardial ischemia and reperfusion injury by attenuating oxidative stress and apoptosis in rats. J Biomed Res. 2015;29(3):203\u201313. https:\/\/doi.org\/10.7555\/jbr.28.20140037.","journal-title":"J Biomed Res"},{"issue":"2","key":"1329_CR10","doi-asserted-by":"publisher","first-page":"425","DOI":"10.3233\/jad-130779","volume":"38","author":"NV Bobkova","year":"2014","unstructured":"Bobkova NV, Garbuz DG, Nesterova I, Medvinskaya N, Samokhin A, Alexandrova I, et al. Therapeutic effect of exogenous hsp70 in mouse models of Alzheimer\u2019s disease. J Alzheimer\u2019s Dis. 2014;38(2):425\u201335. https:\/\/doi.org\/10.3233\/jad-130779.","journal-title":"J Alzheimer\u2019s Dis"},{"issue":"52","key":"1329_CR11","doi-asserted-by":"publisher","first-page":"16006","DOI":"10.1073\/pnas.1516131112","volume":"112","author":"NV Bobkova","year":"2015","unstructured":"Bobkova NV, Evgen'ev M, Garbuz DG, Kulikov AM, Morozov A, Samokhin A, et al. Exogenous Hsp70 delays senescence and improves cognitive function in aging mice. Proc Natl Acad Sci USA. 2015;112(52):16006\u201311. https:\/\/doi.org\/10.1073\/pnas.1516131112.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1329_CR12","doi-asserted-by":"publisher","DOI":"10.1089\/rej.2018.2166","author":"Z Lu","year":"2019","unstructured":"Lu Z, Zhao T, Tao L, Yu Q, Yang Y, Cheng J, et al. Cystathionine beta-synthase-derived hydrogen sulfide correlates with successful aging in mice. Rejuvenation Res. 2019. https:\/\/doi.org\/10.1089\/rej.2018.2166.","journal-title":"Rejuvenation Res"},{"key":"1329_CR13","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/j.neuroscience.2015.07.036","volume":"303","author":"E Gerasimova","year":"2015","unstructured":"Gerasimova E, Lebedeva J, Yakovlev A, Zefirov A, Giniatullin R, Sitdikova G. Mechanisms of hydrogen sulfide (H2S) action on synaptic transmission at the mouse neuromuscular junction. Neuroscience. 2015;303:577\u201385. https:\/\/doi.org\/10.1016\/j.neuroscience.2015.07.036.","journal-title":"Neuroscience"},{"issue":"8","key":"1329_CR14","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1007\/s00011-016-0937-y","volume":"65","author":"CL Lakshmikanth","year":"2016","unstructured":"Lakshmikanth CL, Jacob SP, Chaithra VH, de Castro-Faria-Neto HC, Marathe GK. Sepsis: in search of cure. Inflamm Res. 2016;65(8):587\u2013602. https:\/\/doi.org\/10.1007\/s00011-016-0937-y.","journal-title":"Inflamm Res"},{"issue":"1","key":"1329_CR15","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1134\/s0026898419010130","volume":"53","author":"IY Petrushanko","year":"2019","unstructured":"Petrushanko IY, Melnikova EV, Yurinskaya MM, Vinokurov MG, Suslikov AV, Mitkevich VA, et al. Influence of the donor of hydrogen sulfide GYY4137 on the activation of human neutrophils by E. coli lipopolysaccharides. Mol Biol. 2019;53(1):101\u20138. https:\/\/doi.org\/10.1134\/s0026898419010130.","journal-title":"Mol Biol"},{"key":"1329_CR16","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1111\/j.1749-6632.2009.05375.x","volume":"1197","author":"E Rozhkova","year":"2010","unstructured":"Rozhkova E, Yurinskaya M, Zatsepina O, Garbuz D, Karpov V, Surkov S, et al. Exogenous mammalian extracellular HSP70 reduces endotoxin manifestations at the cellular and organism levels. Ann N Y Acad Sci. 2010;1197:94\u2013107. https:\/\/doi.org\/10.1111\/j.1749-6632.2009.05375.x.","journal-title":"Ann N Y Acad Sci"},{"issue":"1","key":"1329_CR17","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s12192-016-0743-z","volume":"22","author":"MM Yurinskaya","year":"2017","unstructured":"Yurinskaya MM, Kochetkova OY, Shabarchina LI, Antonova OY, Suslikov AV, Evgen'ev MB, et al. Encapsulated Hsp70 decreases endotoxin-induced production of ROS and TNFalpha in human phagocytes. Cell Stress Chaperones. 2017;22(1):163\u201371. https:\/\/doi.org\/10.1007\/s12192-016-0743-z.","journal-title":"Cell Stress Chaperones"},{"issue":"6","key":"1329_CR18","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.7868\/s0026898416060239","volume":"50","author":"MM Yurinskaya","year":"2016","unstructured":"Yurinskaya MM, Mit'kevich VA, Evgen'ev MB, Makarov AA, Vinokurov MG. Heat-shock protein HSP70 reduces the secretion of TNFalpha by neuroblastoma cells and human monocytes induced with beta-amyloid peptides. Mol Biol. 2016;50(6):1053\u20136. https:\/\/doi.org\/10.7868\/s0026898416060239.","journal-title":"Mol Biol"},{"issue":"15","key":"1329_CR19","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","volume":"30","author":"AM Bolger","year":"2014","unstructured":"Bolger AM, Lohse M, Usadel B. Trimmomatic: a flexible trimmer for Illumina sequence data. Bioinformatics. 2014;30(15):2114\u2013200. https:\/\/doi.org\/10.1093\/bioinformatics\/btu170.","journal-title":"Bioinformatics"},{"issue":"1","key":"1329_CR20","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","volume":"29","author":"A Dobin","year":"2013","unstructured":"Dobin A, Davis CA, Schlesinger F, Drenkow J, Zaleski C, Jha S, et al. STAR: ultrafast universal RNA-seq aligner. Bioinformatics. 2013;29(1):15\u2013211. https:\/\/doi.org\/10.1093\/bioinformatics\/bts635.","journal-title":"Bioinformatics"},{"issue":"7","key":"1329_CR21","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","volume":"30","author":"Y Liao","year":"2014","unstructured":"Liao Y, Smyth GK, Shi W. FeatureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Bioinformatics. 2014;30(7):923\u201330. https:\/\/doi.org\/10.1093\/bioinformatics\/btt656.","journal-title":"Bioinformatics"},{"issue":"16","key":"1329_CR22","doi-asserted-by":"publisher","first-page":"2184","DOI":"10.1093\/bioinformatics\/bts356","volume":"28","author":"L Wang","year":"2012","unstructured":"Wang L, Wang S, Li W. RSeQC: quality control of RNA-seq experiments. Bioinformatics. 2012;28(16):2184\u20135. https:\/\/doi.org\/10.1093\/bioinformatics\/bts356.","journal-title":"Bioinformatics"},{"issue":"9","key":"1329_CR23","doi-asserted-by":"publisher","first-page":"3729","DOI":"10.1021\/acs.jproteome.5b00490","volume":"14","author":"GS Krasnov","year":"2015","unstructured":"Krasnov GS, Dmitriev AA, Kudryavtseva AV, Shargunov AV, Karpov DS, Uroshlev LA, et al. PPLine: an automated pipeline for SNP, SAP, and splice variant detection in the context of proteogenomics. J Proteom Res. 2015;14(9):3729\u201337. https:\/\/doi.org\/10.1021\/acs.jproteome.5b00490.","journal-title":"J Proteom Res"},{"issue":"1","key":"1329_CR24","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","volume":"26","author":"MD Robinson","year":"2010","unstructured":"Robinson MD, McCarthy DJ, Smyth GK. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 2010;26(1):139\u201340. https:\/\/doi.org\/10.1093\/bioinformatics\/btp616.","journal-title":"Bioinformatics"},{"issue":"5","key":"1329_CR25","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu G, Wang LG, Han Y, He QY. clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS. 2012;16(5):284\u20137. https:\/\/doi.org\/10.1089\/omi.2011.0118.","journal-title":"OMICS"},{"key":"1329_CR26","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/b978-0-12-397863-9.00003-1","volume":"109","author":"DA Ferrington","year":"2012","unstructured":"Ferrington DA, Gregerson DS. Immunoproteasomes: structure, function, and antigen presentation. Prog Mol Biol Transl Sci. 2012;109:75\u2013112. https:\/\/doi.org\/10.1016\/b978-0-12-397863-9.00003-1.","journal-title":"Prog Mol Biol Transl Sci"},{"issue":"2","key":"1329_CR27","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/s11255-017-1689-5","volume":"50","author":"W Pan","year":"2018","unstructured":"Pan W, Kang Y. Gut microbiota and chronic kidney disease: implications for novel mechanistic insights and therapeutic strategies. Int Urol Nephrol. 2018;50(2):289\u201399. https:\/\/doi.org\/10.1007\/s11255-017-1689-5.","journal-title":"Int Urol Nephrol"},{"issue":"4","key":"1329_CR28","doi-asserted-by":"publisher","first-page":"34","DOI":"10.3390\/vaccines5040034","volume":"5","author":"NN Kuzmich","year":"2017","unstructured":"Kuzmich NN, Sivak KV, Chubarev VN, Porozov YB, Savateeva-Lyubimova TN, Peri F. TLR4 signaling pathway modulators as potential therapeutics in inflammation and sepsis. Vaccines. 2017;5(4):34\u201375. https:\/\/doi.org\/10.3390\/vaccines5040034.","journal-title":"Vaccines."},{"issue":"9","key":"1329_CR29","doi-asserted-by":"publisher","first-page":"6425","DOI":"10.1002\/jcp.26429","volume":"233","author":"A Shapouri-Moghaddam","year":"2018","unstructured":"Shapouri-Moghaddam A, Mohammadian S, Vazini H, Taghadosi M, Esmaeili SA, Mardani F, et al. Macrophage plasticity, polarization, and function in health and disease. J Cell Physiol. 2018;233(9):6425\u201340. https:\/\/doi.org\/10.1002\/jcp.26429.","journal-title":"J Cell Physiol"},{"key":"1329_CR30","doi-asserted-by":"publisher","first-page":"105360","DOI":"10.1016\/j.jsbmb.2019.04.009","volume":"191","author":"LS Chen","year":"2019","unstructured":"Chen LS, Singh SP, Schuster M, Grinenko T, Bornstein SR, Kanczkowski W. RNA-seq analysis of LPS-induced transcriptional changes and its possible implications for the adrenal gland dysregulation during sepsis. J Steroid Biochem Mol Biol. 2019;191:105360. https:\/\/doi.org\/10.1016\/j.jsbmb.2019.04.009.","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"2","key":"1329_CR31","doi-asserted-by":"publisher","first-page":"55","DOI":"10.5483\/bmbrep.2017.50.2.011","volume":"50","author":"SJ Kim","year":"2017","unstructured":"Kim SJ, Kim HM. Dynamic lipopolysaccharide transfer cascade to TLR4\/MD2 complex via LBP and CD14. BMB Rep. 2017;50(2):55\u20137. https:\/\/doi.org\/10.5483\/bmbrep.2017.50.2.011.","journal-title":"BMB Rep"},{"issue":"2","key":"1329_CR32","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1128\/mcb.00775-10","volume":"31","author":"JR Pfeiffer","year":"2011","unstructured":"Pfeiffer JR, McAvoy BL, Fecteau RE, Deleault KM, Brooks SA. CARHSP1 is required for effective tumor necrosis factor alpha mRNA stabilization and localizes to processing bodies and exosomes. Mol Cell Biol. 2011;31(2):277\u201386. https:\/\/doi.org\/10.1128\/mcb.00775-10.","journal-title":"Mol Cell Biol"},{"issue":"1","key":"1329_CR33","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.intimp.2011.10.010","volume":"12","author":"S Mouzaoui","year":"2012","unstructured":"Mouzaoui S, Rahim I, Djerdjouri B. Aminoguanidine and curcumin attenuated tumor necrosis factor (TNF)-alpha-induced oxidative stress, colitis and hepatotoxicity in mice. Int Immunopharmacol. 2012;12(1):302\u201311. https:\/\/doi.org\/10.1016\/j.intimp.2011.10.010.","journal-title":"Int Immunopharmacol"},{"issue":"4","key":"1329_CR34","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.tcb.2015.12.002","volume":"26","author":"H Blaser","year":"2016","unstructured":"Blaser H, Dostert C, Mak TW, Brenner D. TNF and ROS crosstalk in inflammation. Trends Cell Biol. 2016;26(4):249\u201361. https:\/\/doi.org\/10.1016\/j.tcb.2015.12.002.","journal-title":"Trends Cell Biol."},{"issue":"8","key":"1329_CR35","doi-asserted-by":"publisher","first-page":"e02244","DOI":"10.1016\/j.heliyon.2019.e02244","volume":"5","author":"S Sakuma","year":"2019","unstructured":"Sakuma S, Minamino S, Takase M, Ishiyama Y, Hosokura H, Kohda T, et al. Hydrogen sulfide donor GYY4137 suppresses proliferation of human colorectal cancer Caco-2 cells by inducing both cell cycle arrest and cell death. Heliyon. 2019;5(8):e02244. https:\/\/doi.org\/10.1016\/j.heliyon.2019.e02244.","journal-title":"Heliyon"},{"issue":"1","key":"1329_CR36","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/labinvest.3700366","volume":"86","author":"SM Dauphinee","year":"2006","unstructured":"Dauphinee SM, Karsan A. Lipopolysaccharide signaling in endothelial cells. Lab Investig. 2006;86(1):9\u201322. https:\/\/doi.org\/10.1038\/labinvest.3700366.","journal-title":"Lab Investig"},{"issue":"1\u20132","key":"1329_CR37","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/s12013-011-9182-8","volume":"60","author":"J Reis","year":"2011","unstructured":"Reis J, Guan XQ, Kisselev AF, Papasian CJ, Qureshi AA, Morrison DC, et al. LPS-induced formation of immunoproteasomes: TNF-alpha and nitric oxide production are regulated by altered composition of proteasome-active sites. Cell Biochem Biophys. 2011;60(1\u20132):77\u201388. https:\/\/doi.org\/10.1007\/s12013-011-9182-8.","journal-title":"Cell Biochem Biophys"},{"issue":"5","key":"1329_CR38","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1097\/01.shk.0000209554.46704.64","volume":"25","author":"J Shen","year":"2006","unstructured":"Shen J, Reis J, Morrison DC, Papasian C, Raghavakaimal S, Kolbert C, et al. Key inflammatory signaling pathways are regulated by the proteasome. Shock. 2006;25(5):472\u201384. https:\/\/doi.org\/10.1097\/01.shk.0000209554.46704.64.","journal-title":"Shock"},{"issue":"3","key":"1329_CR39","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1379\/csc-195r.1","volume":"11","author":"GA Kustanova","year":"2006","unstructured":"Kustanova GA, Murashev AN, Karpov VL, Margulis BA, Guzhova IV, Prokhorenko IR, et al. Exogenous heat shock protein 70 mediates sepsis manifestations and decreases the mortality rate in rats. Cell Stress Chaperones. 2006;11(3):276\u201386. https:\/\/doi.org\/10.1379\/csc-195r.1.","journal-title":"Cell Stress Chaperones"},{"key":"1329_CR40","doi-asserted-by":"publisher","first-page":"e1977","DOI":"10.1038\/cddis.2015.336","volume":"6","author":"MM Yurinskaya","year":"2015","unstructured":"Yurinskaya MM, Mitkevich VA, Kozin SA, Evgen'ev MB, Makarov AA, Vinokurov MG. HSP70 protects human neuroblastoma cells from apoptosis and oxidative stress induced by amyloid peptide isoAsp7-Abeta(1\u201342). Cell Death Dis. 2015;6:e1977. https:\/\/doi.org\/10.1038\/cddis.2015.336.","journal-title":"Cell Death Dis"},{"issue":"4","key":"1329_CR41","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.3233\/jad-170398","volume":"59","author":"MB Evgen'ev","year":"2017","unstructured":"Evgen'ev MB, Krasnov GS, Nesterova IV, Garbuz DG, Karpov VL, Morozov AV, et al. Molecular mechanisms underlying neuroprotective effect of intranasal administration of human Hsp70 in mouse model of Alzheimer\u2019s disease. J Alzheimer\u2019s Dis. 2017;59(4):1415\u201326. https:\/\/doi.org\/10.3233\/jad-170398.","journal-title":"J Alzheimer\u2019s Dis"},{"issue":"32","key":"1329_CR42","doi-asserted-by":"publisher","first-page":"13143","DOI":"10.1074\/jbc.M117.778654","volume":"292","author":"V Yadav","year":"2017","unstructured":"Yadav V, Gao XH, Willard B, Hatzoglou M, Banerjee R, Kabil O. Hydrogen sulfide modulates eukaryotic translation initiation factor 2alpha (eIF2alpha) phosphorylation status in the integrated stress-response pathway. J Biol Chem. 2017;292(32):13143\u201353. https:\/\/doi.org\/10.1074\/jbc.M117.778654.","journal-title":"J Biol Chem"},{"issue":"10","key":"1329_CR43","doi-asserted-by":"publisher","first-page":"7184","DOI":"10.4049\/jimmunol.177.10.7184","volume":"177","author":"R Aneja","year":"2006","unstructured":"Aneja R, Odoms K, Dunsmore K, Shanley TP, Wong HR. Extracellular heat shock protein-70 induces endotoxin tolerance in THP-1 cells. J Immunol. 2006;177(10):7184\u201392. https:\/\/doi.org\/10.4049\/jimmunol.177.10.7184.","journal-title":"J Immunol"},{"issue":"4","key":"1329_CR44","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/74697","volume":"6","author":"A Asea","year":"2000","unstructured":"Asea A, Kraeft SK, Kurt-Jones EA, Stevenson MA, Chen LB, Finberg RW, et al. HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine. Nat Med. 2000;6(4):435\u201342. https:\/\/doi.org\/10.1038\/74697.","journal-title":"Nat Med"},{"issue":"5","key":"1329_CR45","doi-asserted-by":"publisher","first-page":"524","DOI":"10.2174\/1567201812666150724094207","volume":"12","author":"M Yurinskaya","year":"2015","unstructured":"Yurinskaya M, Zatsepina OG, Vinokurov MG, Bobkova NV, Garbuz DG, Morozov AV, et al. The fate of exogenous human HSP70 introduced into animal cells by different means. Curr Drug Deliv. 2015;12(5):524\u201332.","journal-title":"Curr Drug Deliv"},{"issue":"1738","key":"1329_CR46","doi-asserted-by":"publisher","first-page":"20160522","DOI":"10.1098\/rstb.2016.0522","volume":"373","author":"AG Pockley","year":"2018","unstructured":"Pockley AG, Henderson B. Extracellular cell stress (Heat shock) proteins\u2014immune responses and disease: an overview. Philos Trans R Soc Lond Ser B Biol Sci. 2018;373(1738):20160522. https:\/\/doi.org\/10.1098\/rstb.2016.0522.","journal-title":"Philos Trans R Soc Lond Ser B Biol Sci."},{"issue":"3","key":"1329_CR47","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1021\/acs.chemrev.7b00205","volume":"118","author":"MR Filipovic","year":"2018","unstructured":"Filipovic MR, Zivanovic J, Alvarez B, Banerjee R. Chemical biology of H2S signaling through persulfidation. Chem Rev. 2018;118(3):1253\u2013337. https:\/\/doi.org\/10.1021\/acs.chemrev.7b00205.","journal-title":"Chem Rev"},{"issue":"3","key":"1329_CR48","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1007\/s12192-017-0847-0","volume":"23","author":"A Hulina","year":"2018","unstructured":"Hulina A, Grdic Rajkovic M, Jaksic Despot D, Jelic D, Dojder A, Cepelak I, et al. Extracellular Hsp70 induces inflammation and modulates LPS\/LTA-stimulated inflammatory response in THP-1 cells. Cell Stress Chaperones. 2018;23(3):373\u201384. https:\/\/doi.org\/10.1007\/s12192-017-0847-0.","journal-title":"Cell Stress Chaperones"},{"issue":"1","key":"1329_CR49","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.yexcr.2012.09.018","volume":"319","author":"KH Lee","year":"2013","unstructured":"Lee KH, Jeong J, Yoo CG. Positive feedback regulation of heat shock protein 70 (Hsp70) is mediated through toll-like receptor 4-PI3K\/Akt-glycogen synthase kinase-3beta pathway. Exp Cell Res. 2013;319(1):88\u201395. https:\/\/doi.org\/10.1016\/j.yexcr.2012.09.018.","journal-title":"Exp Cell Res"},{"issue":"1","key":"1329_CR50","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.1038\/s41467-017-02229-1","volume":"8","author":"M Du","year":"2017","unstructured":"Du M, Yuan L, Tan X, Huang D, Wang X, Zheng Z, et al. The LPS-inducible lncRNA Mirt2 is a negative regulator of inflammation. Nat Commun. 2017;8(1):2049. https:\/\/doi.org\/10.1038\/s41467-017-02229-1.","journal-title":"Nat Commun"},{"key":"1329_CR51","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.brainresbull.2015.12.007","volume":"121","author":"K Ji","year":"2016","unstructured":"Ji K, Xue L, Cheng J, Bai Y. Preconditioning of H2S inhalation protects against cerebral ischemia\/reperfusion injury by induction of HSP70 through PI3K\/Akt\/Nrf2 pathway. Brain Res Bull. 2016;121:68\u201374. https:\/\/doi.org\/10.1016\/j.brainresbull.2015.12.007.","journal-title":"Brain Res Bull"}],"container-title":["Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-020-01329-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00011-020-01329-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-020-01329-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T00:15:10Z","timestamp":1615421710000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00011-020-01329-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,11]]},"references-count":51,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["1329"],"URL":"https:\/\/doi.org\/10.1007\/s00011-020-01329-x","relation":{},"ISSN":["1023-3830","1420-908X"],"issn-type":[{"value":"1023-3830","type":"print"},{"value":"1420-908X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,11]]},"assertion":[{"value":"18 November 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 February 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 February 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}