{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:38:06Z","timestamp":1790786286973,"version":"4.1.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T00:00:00Z","timestamp":1588204800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T00:00:00Z","timestamp":1588204800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin","doi-asserted-by":"crossref","award":["18JCYBJC93700"],"award-info":[{"award-number":["18JCYBJC93700"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81601667"],"award-info":[{"award-number":["81601667"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81671888"],"award-info":[{"award-number":["81671888"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81772043"],"award-info":[{"award-number":["81772043"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin City","doi-asserted-by":"publisher","award":["17JCYBJC24800"],"award-info":[{"award-number":["17JCYBJC24800"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Support Key Program Affiliated to the Key Research and Development Plan of Tianjin Science and Technology Project","award":["18YFZCSY00560"],"award-info":[{"award-number":["18YFZCSY00560"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflamm. Res."],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1007\/s00011-020-01347-9","type":"journal-article","created":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T02:02:45Z","timestamp":1588212165000},"page":"697-710","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Hydrogen attenuates sepsis-associated encephalopathy by NRF2 mediated NLRP3 pathway inactivation"],"prefix":"10.1007","volume":"69","author":[{"given":"Keliang","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyin","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongguang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,4,30]]},"reference":[{"key":"1347_CR1","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1097\/WCO.0b013e32832b3101","volume":"22","author":"P Pytel","year":"2009","unstructured":"Pytel P, Alexander JJ. Pathogenesis of septic encephalopathy. Curr Opin Neurol. 2009;22:283\u20137.","journal-title":"Curr Opin Neurol."},{"key":"1347_CR2","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1097\/00003246-200107000-00002","volume":"29","author":"DC Angus","year":"2001","unstructured":"Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med. 2001;29:1303\u201310.","journal-title":"Crit Care Med."},{"key":"1347_CR3","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1097\/01.CCM.0000298158.12101.41","volume":"36","author":"RP Dellinger","year":"2008","unstructured":"Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med. 2008;36:296\u201332727.","journal-title":"Crit Care Med."},{"key":"1347_CR4","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","volume":"140","author":"K Schroder","year":"2010","unstructured":"Schroder K, Tschopp J. The inflammasomes. Cell. 2010;140:821\u201332.","journal-title":"Cell"},{"key":"1347_CR5","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1038\/nature04515","volume":"440","author":"S Mariathasan","year":"2006","unstructured":"Mariathasan S, Weiss DS, Newton K, McBride J, O'Rourke K, Roose-Girma M, et al. Cryopyrin activates the inflammasome in response to toxins and ATP. Nature. 2006;440:228\u201332.","journal-title":"Nature"},{"key":"1347_CR6","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/s41531-017-0032-2","volume":"3","author":"S Sarkar","year":"2017","unstructured":"Sarkar S, Malovic E, Harishchandra DS, Ghaisas S, Panicker N, Charli A, et al. Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease. NPJ Parkinsons Dis. 2017;3:30.","journal-title":"NPJ Parkinsons Dis."},{"key":"1347_CR7","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/j.redox.2017.04.020","volume":"12","author":"LR Hoyt","year":"2017","unstructured":"Hoyt LR, Randall MJ, Ather JL, DePuccio DP, Landry CC, Qian X, et al. Mitochondrial ROS induced by chronic ethanol exposure promote hyper-activation of the NLRP3 inflammasome. Redox Biol. 2017;12:883\u201396.","journal-title":"Redox Biol."},{"key":"1347_CR8","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1007\/s10753-018-0894-4","volume":"42","author":"Q Fu","year":"2019","unstructured":"Fu Q, Wu J, Zhou XY, Ji MH, Mao QH, Li Q, et al. NLRP3\/caspase-1 pathway-induced pyroptosis mediated cognitive deficits in a mouse model of sepsis-associated encephalopathy. Inflammation. 2019;42:306\u201318.","journal-title":"Inflammation"},{"key":"1347_CR9","doi-asserted-by":"crossref","unstructured":"Xu XE, Liu L, Wang YC, Wang CT, Zheng Q, Liu QX, et al. Caspase-1 inhibitor exerts brain-protective effects against sepsis-associated encephalopathy and cognitive impairments in a mouse model of sepsis. Brain, behavior, and immunity 2019.","DOI":"10.1016\/j.bbi.2019.05.038"},{"key":"1347_CR10","doi-asserted-by":"crossref","unstructured":"Zong MM, Zhou ZQ, Ji MH, Jia M, Tang H, Yang JJ. Activation of \u03b22-Adrenoceptor Attenuates Sepsis-Induced Hippocampus-Dependent Cognitive Impairments by Reversing Neuroinflammation and Synaptic Abnormalities. Frontiers in cellular neuroscience 2019.","DOI":"10.3389\/fncel.2019.00293"},{"key":"1347_CR11","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/ki.2009.432","volume":"77","author":"JF George","year":"2010","unstructured":"George JF, Agarwal A. Hydrogen: another gas with therapeutic potential. Kidney Int. 2010;77:85\u20137.","journal-title":"Kidney Int."},{"key":"1347_CR12","first-page":"807635","volume":"2014","author":"K Xie","year":"2014","unstructured":"Xie K, Liu L, Yu Y, Wang G. Hydrogen gas presents a promising therapeutic strategy for sepsis. Biomed Res Int. 2014;2014:807635.","journal-title":"Biomed Res Int."},{"key":"1347_CR13","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1186\/s12974-015-0401-x","volume":"12","author":"MH Ji","year":"2015","unstructured":"Ji MH, Qiu LL, Tang H, Ju LS, Sun XR, Zhang H, et al. Sepsis-induced selective parvalbumin interneuron phenotype loss and cognitive impairments may be mediated by NADPH oxidase 2 activation in mice. J Neuroinflammation. 2015;12:182.","journal-title":"J Neuroinflammation."},{"key":"1347_CR14","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.bbi.2014.07.002","volume":"43","author":"M Michels","year":"2015","unstructured":"Michels M, Vieira AS, Vuolo F, Zapelini HG, Mendonca B, Mina F, et al. The role of microglia activation in the development of sepsis-induced long-term cognitive impairment. Brain Behav Immun. 2015;43:54\u20139.","journal-title":"Brain Behav Immun."},{"key":"1347_CR15","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.brainres.2014.09.030","volume":"1589","author":"L Liu","year":"2014","unstructured":"Liu L, Xie K, Chen H, Dong X, Li Y, Yu Y, et al. Inhalation of hydrogen gas attenuates brain injury in mice with cecal ligation and puncture via inhibiting neuroinflammation, oxidative stress and neuronal apoptosis. Brain Res. 2014;1589:78\u201392.","journal-title":"Brain Res."},{"key":"1347_CR16","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.freeradbiomed.2019.01.003","volume":"134","author":"LL Xu","year":"2019","unstructured":"Xu LL, Wu YF, Yan F, Li CC, Dai Z, You QD, et al. 5-(3,4-Difluorophenyl)-3-(6-methylpyridin-3-yl)-1,2,4-oxadiazole (DDO-7263), a novel Nrf2 activator targeting brain tissue, protects against MPTP-induced subacute Parkinson's disease in mice by inhibiting the NLRP3 inflammasome and protects PC12 cells against oxidative stress. Free Radic Biol Med. 2019;134:288\u2013303.","journal-title":"Free Radic Biol Med."},{"key":"1347_CR17","first-page":"104557","volume":"216","author":"DM Sui","year":"2016","unstructured":"Sui DM, Xie Q, Yi WJ, Gupta S, Yu XY, Li JB, et al. Resveratrol protects against sepsis-associated encephalopathy and inhibits the NLRP3\/IL-1\u03b2 axis in microglia. Mediat Inflamm. 2016;216:104557.","journal-title":"Mediat Inflamm."},{"key":"1347_CR18","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1007\/s12035-014-8918-z","volume":"52","author":"J Wu","year":"2015","unstructured":"Wu J, Zhang M, Hao S, Jia M, Ji M, Qiu L, et al. Mitochondria-targeted peptide reverses mitochondrial dysfunction and cognitive deficits in sepsis-associated encephalopathy. Mol Neurobiol. 2015;52:783\u201391.","journal-title":"Mol Neurobiol."},{"key":"1347_CR19","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1186\/s12933-018-0803-z","volume":"17","author":"X Zhang","year":"2018","unstructured":"Zhang X, Zhang Z, Yang Y, Suo Y, Liu R, Qiu J, et al. Alogliptin prevents diastolic dysfunction and preserves left ventricular mitochondrial function in diabetic rabbits. Cardiovasc Diabetol. 2018;17:160.","journal-title":"Cardiovasc Diabetol."},{"key":"1347_CR20","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/nrneurol.2012.183","volume":"8","author":"TE Gofton","year":"2012","unstructured":"Gofton TE, Young GB. Sepsis-associated encephalopathy. Nat Rev Neurol. 2012;8:557\u201366.","journal-title":"Nat Rev Neurol."},{"key":"1347_CR21","doi-asserted-by":"publisher","first-page":"2163","DOI":"10.1159\/000493819","volume":"49","author":"P Wang","year":"2018","unstructured":"Wang P, Hu Y, Yao D, Li Y. Omi\/HtrA2 regulates a mitochondria-dependent apoptotic pathway in a murine model of septic encephalopathy. Cell Physiol Biochem. 2018;49:2163\u201373.","journal-title":"Cell Physiol Biochem"},{"key":"1347_CR22","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1146\/annurev-immunol-031210-101405","volume":"29","author":"BK Davis","year":"2011","unstructured":"Davis BK, Wen H, Ting JP. The inflammasome NLRs in immunity, inflammation, and associated diseases. Annu Rev Immunol. 2011;29:707\u201335.","journal-title":"Annu Rev Immunol."},{"key":"1347_CR23","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.it.2011.05.004","volume":"32","author":"D De Nardo","year":"2011","unstructured":"De Nardo D, Latz E. NLRP3 inflammasomes link inflammation and metabolic disease. Trends Immunol. 2011;32:373\u20139.","journal-title":"Trends Immunol."},{"key":"1347_CR24","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1101\/gad.225680.113","volume":"27","author":"MC Jaramillo","year":"2013","unstructured":"Jaramillo MC, Zhang DD. The emerging role of the Nrf2-Keap1 signaling pathway in cancer. Genes Dev. 2013;27:2179\u201391.","journal-title":"Genes Dev."},{"key":"1347_CR25","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1089\/ars.2015.6615","volume":"26","author":"X Liu","year":"2017","unstructured":"Liu X, Zhang X, Ding Y, Zhou W, Tao L, Lu P, et al. Nuclear Factor E2-related factor-2 negatively regulates NLRP3 inflammasome activity by inhibiting reactive oxygen species-induced NLRP3 priming. Antioxid Redox Signal. 2017;26:28\u201343.","journal-title":"Antioxid Redox Signal."},{"key":"1347_CR26","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.redox.2017.03.001","volume":"12","author":"H Lv","year":"2017","unstructured":"Lv H, Liu Q, Wen Z, Feng H, Deng X, Ci X. Xanthohumol ameliorates lipopolysaccharide (LPS)-induced acute lung injury via induction of AMPK\/GSK3beta-Nrf2 signal axis. Redox Biol. 2017;12:311\u201324.","journal-title":"Redox Biol."},{"key":"1347_CR27","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1111\/j.1365-2443.2010.01473.x","volume":"16","author":"K Taguchi","year":"2011","unstructured":"Taguchi K, Motohashi H, Yamamoto M. Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution. Genes Cells. 2011;16:123\u201340.","journal-title":"Genes Cells."},{"key":"1347_CR28","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.bbadis.2016.11.005","volume":"1863","author":"SM Ahmed","year":"2017","unstructured":"Ahmed SM, Luo L, Namani A, Wang XJ, Tang X. Nrf2 signaling pathway: pivotal roles in inflammation. Biochim Biophys Acta Mol Basis Dis. 2017;1863:585\u201397.","journal-title":"Biochim Biophys Acta Mol Basis Dis."},{"key":"1347_CR29","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.ejphar.2018.07.059","volume":"835","author":"Z Wang","year":"2018","unstructured":"Wang Z, Zhang A, Meng W, Wang T, Li D, Liu Z, et al. Ozone protects the rat lung from ischemia-reperfusion injury by attenuating NLRP3-mediated inflammation, enhancing Nrf2 antioxidant activity and inhibiting apoptosis. Eur J Pharmacol. 2018;835:82\u201393.","journal-title":"Eur J Pharmacol."},{"key":"1347_CR30","doi-asserted-by":"publisher","first-page":"157","DOI":"10.4062\/biomolther.2016.234","volume":"26","author":"Q Liu","year":"2018","unstructured":"Liu Q, Ci X, Wen Z, Peng L. Diosmetin alleviates lipopolysaccharide-induced acute lung injury through activating the Nrf2 pathway and inhibiting the NLRP3 inflammasome. Biomol Ther (Seoul). 2018;26:157\u201366.","journal-title":"Biomol Ther (Seoul)."},{"key":"1347_CR31","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1186\/s13075-015-0844-6","volume":"17","author":"SM Ka","year":"2015","unstructured":"Ka SM, Lin JC, Lin TJ, Liu FC, Chao LK, Ho CL, et al. Citral alleviates an accelerated and severe lupus nephritis model by inhibiting the activation signal of NLRP3 inflammasome and enhancing Nrf2 activation. Arthritis Res Ther. 2015;17:331.","journal-title":"Arthritis Res Ther."},{"key":"1347_CR32","doi-asserted-by":"publisher","first-page":"2776","DOI":"10.4049\/jimmunol.1401611","volume":"194","author":"NK Maier","year":"2015","unstructured":"Maier NK, Leppla SH, Moayeri M. The cyclopentenone prostaglandin 15d-PGJ2 inhibits the NLRP1 and NLRP3 inflammasomes. J Immunol. 2015;194:2776\u2013855.","journal-title":"J Immunol."},{"key":"1347_CR33","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.ijsu.2013.10.007","volume":"11","author":"HG Chen","year":"2013","unstructured":"Chen HG, Xie KL, Han HZ, Wang WN, Liu DQ, Wang GL, et al. Heme oxygenase-1 mediates the anti-inflammatory effect of molecular hydrogen in LPS-stimulated RAW 264.7 macrophages. Int J Surg. 2013;11:1060\u20136.","journal-title":"Int J Surg."},{"key":"1347_CR34","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1097\/SHK.0b013e3182758646","volume":"38","author":"K Xie","year":"2012","unstructured":"Xie K, Fu W, Xing W, Li A, Chen H, Han H, et al. Combination therapy with molecular hydrogen and hyperoxia in a murine model of polymicrobial sepsis. Shock. 2012;38:656\u201363.","journal-title":"Shock."},{"key":"1347_CR35","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1097\/SHK.0b013e3181cdc4ae","volume":"34","author":"K Xie","year":"2010","unstructured":"Xie K, Yu Y, Pei Y, Hou L, Chen S, Xiong L, et al. Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and HMGB1 release. Shock. 2010;34:90\u20137.","journal-title":"Shock."},{"key":"1347_CR36","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.bbrc.2008.05.165","volume":"373","author":"K Hayashida","year":"2008","unstructured":"Hayashida K, Sano M, Ohsawa I, Shinmura K, Tamaki K, Kimura K, et al. Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. Biochem Biophys Res Commun. 2008;373:30\u20135.","journal-title":"Biochem Biophys Res Commun."},{"key":"1347_CR37","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.3892\/ijmm.2013.1334","volume":"31","author":"H Jiang","year":"2013","unstructured":"Jiang H, Yu P, Qian DH, Qin ZX, Sun XJ, Yu J, et al. Hydrogen-rich medium suppresses the generation of reactive oxygen species, elevates the Bcl-2\/Bax ratio and inhibits advanced glycation end product-induced apoptosis. Int J Mol Med. 2013;31:1381\u20137.","journal-title":"Int J Mol Med."},{"key":"1347_CR38","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.jss.2018.03.024","volume":"228","author":"J Yuan","year":"2018","unstructured":"Yuan J, Wang D, Liu Y, Chen X, Zhang H, Shen F, et al. Hydrogen-rich water attenuates oxidative stress in rats with traumatic brain injury via Nrf2 pathway. J Surg Res. 2018;228:238\u201346.","journal-title":"J Surg Res."},{"key":"1347_CR39","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/j.intimp.2015.07.034","volume":"28","author":"H Chen","year":"2015","unstructured":"Chen H, Xie K, Han H, Li Y, Liu L, Yang T, et al. Molecular hydrogen protects mice against polymicrobial sepsis by ameliorating endothelial dysfunction via an Nrf2\/HO-1 signaling pathway. Int Immunopharmacol. 2015;28:643\u201354.","journal-title":"Int Immunopharmacol."},{"key":"1347_CR40","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1097\/SHK.0000000000000856","volume":"48","author":"Y Yu","year":"2017","unstructured":"Yu Y, Yang Y, Bian Y, Li Y, Liu L, Zhang H, et al. Hydrogen gas protects against intestinal injury in wild type but not NRF2 knockout mice with severe sepsis by regulating HO-1 and HMGB1 release. Shock. 2017;48:364\u201370.","journal-title":"Shock."},{"key":"1347_CR41","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.intimp.2019.01.022","volume":"69","author":"Y Yu","year":"2019","unstructured":"Yu Y, Yang Y, Yang M, Wang C, Xie K, Yu Y. Hydrogen gas reduces HMGB1 release in lung tissues of septic mice in an Nrf2\/HO-1-dependent pathway. Int Immunopharmacol. 2019;69:11\u20138.","journal-title":"Int Immunopharmacol"}],"container-title":["Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-020-01347-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00011-020-01347-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-020-01347-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T23:04:43Z","timestamp":1619737483000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00011-020-01347-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,30]]},"references-count":41,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["1347"],"URL":"https:\/\/doi.org\/10.1007\/s00011-020-01347-9","relation":{},"ISSN":["1023-3830","1420-908X"],"issn-type":[{"value":"1023-3830","type":"print"},{"value":"1420-908X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,30]]},"assertion":[{"value":"21 April 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 March 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no relevant conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}