{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T23:21:38Z","timestamp":1793575298747,"version":"4.5.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T00:00:00Z","timestamp":1589932800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T00:00:00Z","timestamp":1589932800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflamm. Res."],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1007\/s00011-020-01355-9","type":"journal-article","created":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T00:42:59Z","timestamp":1589935379000},"page":"779-787","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["The protective effects of phoenixin-14 against lipopolysaccharide-induced inflammation and inflammasome activation in astrocytes"],"prefix":"10.1007","volume":"69","author":[{"given":"Jian","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0806-233X","authenticated-orcid":false,"given":"Jianhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,5,20]]},"reference":[{"key":"1355_CR1","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1016\/j.it.2016.06.006","volume":"37","author":"E Colombo","year":"2016","unstructured":"Colombo E, Farina C. Astrocytes: key regulators of neuroinflammation. Trends Immunol. 2016;37:608\u201320.","journal-title":"Trends Immunol"},{"key":"1355_CR2","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/S0074-7742(07)82003-4","volume":"82","author":"S Vesce","year":"2007","unstructured":"Vesce S, Rossi D, Brambilla L, Volterra A. Glutamate release from astrocytes in physiological conditions and in neurodegenerative disorders characterized by neuroinflammation. Int Rev Neurobiol. 2007;82:57\u201371.","journal-title":"Int Rev Neurobiol"},{"key":"1355_CR3","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1007\/s13311-016-0477-8","volume":"13","author":"E Cekanaviciute","year":"2016","unstructured":"Cekanaviciute E, Buckwalter MS. Astrocytes: integrative regulators of neuroinflammation in stroke and other neurological diseases. Neurotherapeutics. 2016;13:685\u2013701.","journal-title":"Neurotherapeutics"},{"key":"1355_CR4","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.cnr.2006.09.004","volume":"6","author":"MJ Carson","year":"2006","unstructured":"Carson MJ, Thrash JC, Walter B. The cellular response in neuroinflammation: the role of leukocytes, microglia and astrocytes in neuronal death and survival. Clin Neurosci Res. 2006;6:237\u201345.","journal-title":"Clin Neurosci Res"},{"key":"1355_CR5","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1002\/glia.20467","volume":"55","author":"L Qin","year":"2007","unstructured":"Qin L, Wu X, Block ML, Liu Y, Breese GR, Hong JS, Knapp DJ, Crews FT. Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration. Glia. 2007;55:453\u201362.","journal-title":"Glia"},{"key":"1355_CR6","first-page":"1759","volume":"11","author":"B Hauss-Wegrzyniak","year":"2000","unstructured":"Hauss-Wegrzyniak B, Vraniak PD, Wenk GL. LPS-induced neuroinflammatory effects do not recover with time. Neuro Report. 2000;11:1759\u201363.","journal-title":"Neuro Report"},{"key":"1355_CR7","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1038\/sj.bjp.0707337","volume":"151","author":"G Esposito","year":"2007","unstructured":"Esposito G, Scuderi C, Savani C, Steardo L Jr, De Filippis D, Cottone P, Iuvone T, Cuomo V, Steardo L. Cannabidiol in vivo blunts \u03b2-amyloid induced neuroinflammation by suppressing IL-1\u03b2 and iNOS expression. Br J Pharmacol. 2007;151:1272\u20139.","journal-title":"Br J Pharmacol"},{"key":"1355_CR8","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.tins.2005.06.008","volume":"28","author":"U Felderhoff-Mueser","year":"2005","unstructured":"Felderhoff-Mueser U, Schmidt OI, Oberholzer A, B\u00fchrer C, Stahel PF. IL-18: a key player in neuroinflammation and neurodegeneration? Trends Neurosci. 2005;28:487\u201393.","journal-title":"Trends Neurosci"},{"key":"1355_CR9","doi-asserted-by":"publisher","first-page":"7683","DOI":"10.1093\/nar\/gkt563","volume":"41","author":"W Bchir","year":"2013","unstructured":"Bchir W, Maurin AC, Carraro V, Averous J, Jousse C, Muranishi Y, Parry L, Stepien G, Fafournoux P, Bruhat A. The eIF2\u03b1\/ATF4 pathway is essential for stress-induced autophagy gene expression. Nucleic Acids Res. 2013;41:7683\u201399.","journal-title":"Nucleic Acids Res."},{"key":"1355_CR10","doi-asserted-by":"publisher","first-page":"527","DOI":"10.3390\/cells8060527","volume":"8","author":"T Inoue","year":"2019","unstructured":"Inoue T, Yamakage H, Tanaka M, Kusakabe T, Shimatsu A, Satoh-Asahara N. Oxytocin suppresses inflammatory responses induced by lipopolysaccharide through Inhibition of the eIF-2\u2013ATF4 pathway in mouse microglia. Cells. 2019;8:527.","journal-title":"Cells"},{"key":"1355_CR11","doi-asserted-by":"publisher","first-page":"S217","DOI":"10.3233\/JAD-2012-111728","volume":"30","author":"SM de la Monte","year":"2012","unstructured":"de la Monte SM, Re E, Longato L, Tong M. Dysfunctional pro-ceramide, ER stress, and insulin\/IGF signaling networks with progression of Alzheimer\u2019s disease. J Alzheimers Dis. 2012;30:S217\u2013229.","journal-title":"J Alzheimers Dis"},{"issue":"9","key":"1355_CR12","doi-asserted-by":"publisher","first-page":"4788","DOI":"10.4049\/jimmunol.1004111","volume":"187","author":"AM Deslauriers","year":"2011","unstructured":"Deslauriers AM, Afkhami-Goli A, Paul AM, Bhat RK, Acharjee S, Ellestad KK, Noorbakhsh F, Michalak M, Power C. Neuroinflammation and endoplasmic reticulum stress are coregulated by crocin to prevent demyelination and neurodegeneration. J Immunol. 2011;187(9):4788\u201399.","journal-title":"J Immunol"},{"issue":"2","key":"1355_CR13","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.cmet.2012.07.007","volume":"16","author":"AG Lerner","year":"2012","unstructured":"Lerner AG, Upton JP, Praveen PV, Ghosh R, Nakagawa Y, Igbaria A, Shen S, Nguyen V, Backes BJ, Heiman M, Heintz N. IRE1\u03b1 induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. Cell Metab. 2012;16(2):250\u201364.","journal-title":"Cell Metab"},{"key":"1355_CR14","doi-asserted-by":"publisher","first-page":"e1879","DOI":"10.1038\/cddis.2015.248","volume":"6","author":"C Lebeaupin","year":"2015","unstructured":"Lebeaupin C, Proics E, De Bieville CH, Rousseau D, Bonnafous S, Patouraux S, Adam G, Lavallard VJ, Rovere C, Le Thuc O, Saint-Paul MC. ER stress induces NLRP3 inflammasome activation and hepatocyte death. Cell Death Dis. 2015;6:e1879.","journal-title":"Cell Death Dis"},{"key":"1355_CR15","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1111\/j.1365-2826.2012.02381.x","volume":"25","author":"GL Yosten","year":"2013","unstructured":"Yosten GL, Lyu RM, Hsueh AJ, Avsian-Kretchmer O, Chang JK, Tullock CW, Dun SL, Dun N, Samson WK. A novel reproductive peptide, phoenixin. J Neuroendocrinol. 2013;25:206\u201315.","journal-title":"J Neuroendocrinol"},{"key":"1355_CR16","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/j.neuroscience.2013.07.057","volume":"250","author":"RM Lyu","year":"2013","unstructured":"Lyu RM, Huang XF, Zhang Y, Dun SL, Luo JJ, Chang JK, et al. Phoenixin: a novel peptide in rodent sensory ganglia. Neuroscience. 2013;250:622\u201331.","journal-title":"Neuroscience"},{"key":"1355_CR17","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.bbr.2015.02.011","volume":"286","author":"JH Jiang","year":"2015","unstructured":"Jiang JH, He Z, Peng YL, Jin WD, Mu J, Xue HX, Wang Z, Chang M, Wang R. Effects of Phoenixin-14 on anxiolytic-like behavior in mice. Behav Brain Res. 2015;286:39\u201348.","journal-title":"Behav Brain Res"},{"issue":"5","key":"1355_CR18","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1038\/aps.2018.13","volume":"39","author":"EK Mcilwraith","year":"2018","unstructured":"Mcilwraith EK, Belsham DD. Phoenixin: uncovering its receptor, signaling and functions. Acta Pharmacol Sin. 2018;39(5):774\u20138.","journal-title":"Acta Pharmacol Sin"},{"key":"1355_CR19","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1007\/s00018-017-2661-3","volume":"75","author":"C Rocca","year":"2018","unstructured":"Rocca C, Scavello F, Granieri MC, Pasqua T, Amodio N, Imbrogno S, Gattuso A, Mazza R, Cerra MC, Angelone T. Phoenixin-14: detection and novel physiological implications in cardiac modulation and cardioprotection. Cell Mol Life Sci. 2018;75:743\u201356.","journal-title":"Cell Mol Life Sci"},{"issue":"3","key":"1355_CR20","doi-asserted-by":"publisher","first-page":"R489","DOI":"10.1152\/ajpregu.00191.2016","volume":"311","author":"LM Stein","year":"2016","unstructured":"Stein LM, Tullock CW, Mathews SK, Garcia-Galiano D, Elias CF, Samson WK, Yosten GL. Hypothalamic action of phoenixin to control reproductive hormone secretion in females: importance of the orphan G protein-coupled receptor Gpr173. Am J Physiol Regul Integr Comp Physiol. 2016;311(3):R489\u2013R496496.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"7","key":"1355_CR21","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1111\/jne.12405","volume":"28","author":"LM Rudolph","year":"2016","unstructured":"Rudolph LM, Bentley GE, Calandra RS, Paredes AH, Tesone M, Wu TJ, Micevych PE. Peripheral and central mechanisms involved in the hormonal control of male and female reproduction. J Neuroendocrinol. 2016;28(7):12\u201323. https:\/\/doi.org\/10.1111\/jne.12405.","journal-title":"J Neuroendocrinol."},{"key":"1355_CR22","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1083\/jcb.85.3.890","volume":"85","author":"KD McCarthy","year":"1980","unstructured":"McCarthy KD. Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J Cell Biol. 1980;85:890\u2013902.","journal-title":"J Cell Biol"},{"key":"1355_CR23","first-page":"130","volume":"21","author":"ZYP Kakkar","year":"1984","unstructured":"Kakkar ZYP, Das B. Viswanathan PN a modified spectrophotometric assay of superoxide dismutase (SOD). Ind J Biochem Biophys. 1984;21:130\u20132.","journal-title":"Ind J Biochem Biophys."},{"key":"1355_CR24","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1038\/s42003-018-0106-7","volume":"1","author":"AT Ehrlich","year":"2018","unstructured":"Ehrlich AT, Maroteaux G, Robe A, Venteo L, Nasseef MT, van Kempen LC, Mechawar N, Turecki G, Darcq E, Kieffer BL. Expression map of 78 brain-expressed mouse orphan GPCRs provides a translational resource for neuropsychiatric research. Commun Biol. 2018;1:102.","journal-title":"Commun Biol"},{"key":"1355_CR25","doi-asserted-by":"publisher","first-page":"427","DOI":"10.3389\/fnmol.2017.00427","volume":"10","author":"RE Gonz\u00e1lez-Reyes","year":"2017","unstructured":"Gonz\u00e1lez-Reyes RE, Nava-Mesa MO, Vargas-S\u00e1nchez K, Ariza-Salamanca D, Mora-Mu\u00f1oz L. Involvement of astrocytes in Alzheimer\u2019s disease from a neuroinflammatory and oxidative stress perspective. Front Mol Neurosci. 2017;10:427.","journal-title":"Front Mol Neurosci"},{"key":"1355_CR26","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.bbi.2015.10.009","volume":"55","author":"MG Frank","year":"2016","unstructured":"Frank MG, Weber MD, Fonken LK, Hershman SA, Watkins LR, Maier SF. The redox state of the alarmin HMGB1 is a pivotal factor in neuroinflammatory and microglial priming: a role for the NLRP3 inflammasome. Brain Behav Immun. 2016;55:215\u201324.","journal-title":"Brain Behav Immun"},{"key":"1355_CR27","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1016\/j.bbamem.2006.10.021","volume":"1768","author":"BK Kobilka","year":"2007","unstructured":"Kobilka BK. G protein coupled receptor structure and activation. Biochim Biophys Acta. 2007;1768:794\u2013807.","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"1355_CR28","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1186\/s13075-018-1590-3","volume":"20","author":"H Zhang","year":"2018","unstructured":"Zhang H, Zhang Y, Wang YF, Morris D, Hirankarn N, Sheng Y, Shen J, Pan HF, Yang J, Yang S, Cui Y. Meta-analysis of GWAS on both Chinese and European populations identifies GPR173 as a novel X chromosome susceptibility gene for SLE. Arthritis Res Ther. 2018;20(1):92.","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"1355_CR29","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1530\/REP-19-0025","volume":"158","author":"XP Nguyen","year":"2019","unstructured":"Nguyen XP, Nakamura T, Osuka S, Bayasula B, Nakanishi N, Kasahara Y, Muraoka A, Hayashi S, Nagai T, Murase T, Goto M. Effect of the neuropeptide phoenixin and its receptor GPR173 during folliculogenesis. Reproduction. 2019;158(1):25\u201334.","journal-title":"Reproduction"},{"issue":"2","key":"1355_CR30","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1210\/en.2012-1746","volume":"154","author":"DO Larco","year":"2013","unstructured":"Larco DO, Cho-Clark M, Mani SK, Wu TJ. The metabolite GnRH-(1\u20135) inhibits the migration of immortalized GnRH neurons. Endocrinology. 2013;154(2):783\u201395.","journal-title":"Endocrinology"},{"issue":"2","key":"1355_CR31","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1007\/s12020-014-0492-7","volume":"49","author":"DO Larco","year":"2015","unstructured":"Larco DO, Williams M, Schmidt L, Sabel N, Lange J, Woller MJ, Wu TJ. Autoshortloop feedback regulation of pulsatile gonadotropin-releasing hormone (GnRH) secretion by its metabolite, GnRH-(1\u20135). Endocrine. 2015;49(2):470\u20138.","journal-title":"Endocrine"},{"issue":"12","key":"1355_CR32","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1016\/j.bbalip.2018.09.006","volume":"1863","author":"M Billert","year":"2018","unstructured":"Billert M, Wojciechowicz T, Jasaszwili M, Szczepankiewicz D, Wa\u015bko J, Ka\u017amierczak S, Strowski MZ, Nowak KW, Skrzypski M. Phoenixin-14 stimulates differentiation of 3T3-L1 preadipocytes via cAMP\/Epac-dependent mechanism. Biochim Biophys Acta Mol Cell Biol Lipids. 2018;1863(12):1449\u2013577.","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"issue":"12","key":"1355_CR33","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.bbamcr.2019.118533","volume":"1866","author":"M Billert","year":"2019","unstructured":"Billert M, Ko\u0142odziejski PA, Strowski MZ, Nowak KW, Skrzypski M. Phoenixin-14 stimulates proliferation and insulin secretion in insulin producing INS-1E cells. Biochim Biophys Acta Mol Cell Res. 2019;1866(12):118\u2013533.","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"issue":"5","key":"1355_CR34","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1038\/aps.2017.195","volume":"39","author":"RM Lyu","year":"2018","unstructured":"Lyu RM, Cowan A, Zhang Y, Chen YH, Dun SL, Chang JK, Dun NJ, Luo JJ. Phoenixin: a novel brain-gut-skin peptide with multiple bioactivity. Acta Pharmacol Sin. 2018;39(5):770\u20133.","journal-title":"Acta Pharmacol Sin"},{"key":"1355_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/1028415X.2019.1692494","volume":"18","author":"A Pa\u0142asz","year":"2019","unstructured":"Pa\u0142asz A, Tyszkiewicz-Nwafor M, Suszka-\u015awitek A, Bacopoulou F, Dmitrzak-W\u0119glarz M, Dutkiewicz A, S\u0142opie\u0144 A, Janas-Kozik M, Wilczy\u0144ski KM, Filipczyk \u0141, Bogus K. Longitudinal study on novel neuropeptides phoenixin, spexin and kisspeptin in adolescent inpatients with anorexia nervosa\u2013association with psychiatric symptoms. Nutr Neurosci. 2019;18:1\u201311.","journal-title":"Nutr Neurosci"},{"key":"1355_CR36","first-page":"49","volume":"20","author":"J Hong","year":"2017","unstructured":"Hong J, Kim K, Kim JH, Park Y. The role of endoplasmic reticulum stress in cardiovascular disease and exercise. Int J Vasc Med. 2017;20:49\u2013217.","journal-title":"Int J Vasc Med"},{"key":"1355_CR37","doi-asserted-by":"publisher","first-page":"342931","DOI":"10.1155\/2013\/342931","volume":"2013","author":"A Shastri","year":"2013","unstructured":"Shastri A, Bonifati DM, Kishore U. Innate immunity and neuroinflammation. Mediators Inflamm. 2013;2013:342931.","journal-title":"Mediators Inflamm"},{"key":"1355_CR38","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.brainres.2016.04.064","volume":"1648","author":"V Valenzuela","year":"2016","unstructured":"Valenzuela V, Mart\u00ednez G, Duran-Aniotz C, Hetz C. Gene therapy to target ER stress in brain diseases. Brain Res. 2016;1648:561\u201370.","journal-title":"Brain Res"},{"key":"1355_CR39","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1084\/jem.20150237","volume":"214","author":"L Freeman","year":"2017","unstructured":"Freeman L, Guo H, David CN, Brickey WJ, Jha S, Ting JP. NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes. J Exp Med. 2017;214:1351\u201370.","journal-title":"J Exp Med"},{"key":"1355_CR40","doi-asserted-by":"publisher","first-page":"A80","DOI":"10.1136\/archdischild-2019-316891","volume":"104","author":"E Ryan","year":"2019","unstructured":"Ryan E, Duff E, Huggard D, Bates M, Doherty DG, Melo AM, Molloy E. GP123 Altered systemic inflammatory response in pediatric mild traumatic brain injury. Arch Dis Child. 2019;104:A80.","journal-title":"Arch Dis Child"}],"container-title":["Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-020-01355-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00011-020-01355-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-020-01355-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T03:27:30Z","timestamp":1621481250000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00011-020-01355-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,20]]},"references-count":40,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["1355"],"URL":"https:\/\/doi.org\/10.1007\/s00011-020-01355-9","relation":{},"ISSN":["1023-3830","1420-908X"],"issn-type":[{"value":"1023-3830","type":"print"},{"value":"1420-908X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,20]]},"assertion":[{"value":"21 February 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}