{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T16:22:21Z","timestamp":1792858941128,"version":"4.5.0"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T00:00:00Z","timestamp":1594598400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T00:00:00Z","timestamp":1594598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Incyte Research Institute"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflamm. Res."],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1007\/s00011-020-01381-7","type":"journal-article","created":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T16:02:31Z","timestamp":1594656151000},"page":"967-973","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Transcriptomic analysis of hidradenitis suppurativa skin suggests roles for multiple inflammatory pathways in disease pathogenesis"],"prefix":"10.1007","volume":"69","author":[{"given":"Beth E.","family":"Rumberger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika L.","family":"Boarder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherry L.","family":"Owens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1767-5157","authenticated-orcid":false,"given":"Michael D.","family":"Howell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,13]]},"reference":[{"key":"1381_CR1","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/s41572-020-0149-1","volume":"6","author":"R Sabat","year":"2020","unstructured":"Sabat R, Jemec GBE, Matusiak L, Kimball AB, Prens E, Wolk K. Hidradenitis suppurativa. Nat Rev Dis Primers. 2020;6:18.","journal-title":"Nat Rev Dis Primers"},{"key":"1381_CR2","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1016\/j.jaad.2015.08.052","volume":"73","author":"S Hessam","year":"2015","unstructured":"Hessam S, Sand M, Gambichler T, et al. Correlation of inflammatory serum markers with disease severity in subjects with hidradenitis suppurativa (HS). J Am Acad Dermatol. 2015;73:998\u20131005.","journal-title":"J Am Acad Dermatol"},{"key":"1381_CR3","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1016\/j.jaad.2016.10.042","volume":"76","author":"L Matusiak","year":"2017","unstructured":"Matusiak L, Szczech J, Bieniek A, et al. Increased interleukin (IL)-17 serum levels in subjects with hidradenitis suppurativa: implications for treatment with anti-IL-17 agents. J Am Acad Dermatol. 2017;76:670\u20135.","journal-title":"J Am Acad Dermatol"},{"key":"1381_CR4","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1056\/NEJMoa1504370","volume":"375","author":"AB Kimball","year":"2016","unstructured":"Kimball AB, Okun MM, Williams DA, et al. Two phase 3 trials of adalimumab for hidradenitis suppurativa. N Engl J Med. 2016;375:422\u201334.","journal-title":"N Engl J Med"},{"issue":"3","key":"1381_CR5","doi-asserted-by":"crossref","first-page":"2","DOI":"10.5070\/D3223030360","volume":"22","author":"N Scheinfeld","year":"2016","unstructured":"Scheinfeld N, Sundaram M, Teixeira H, et al. Reduction in pain scores and improvement in depressive symptoms in subjects with hidradenitis suppurativa treated with adalimumab in a phase 2, randomized, placebo-controlled trial. Dermatol Online J. 2016;22(3):2.","journal-title":"Dermatol Online J"},{"key":"1381_CR6","doi-asserted-by":"publisher","first-page":"2389","DOI":"10.1016\/j.jid.2017.05.033","volume":"137","author":"B Moran","year":"2017","unstructured":"Moran B, Sweeney CM, Hughes R, et al. Hidradenitis suppurativa is characterised by dysregulation of the Th17: Treg cell axis which is corrected by anti-TNF therapy. J Invest Dermatol. 2017;137:2389\u201395.","journal-title":"J Invest Dermatol"},{"issue":"9","key":"1381_CR7","doi-asserted-by":"publisher","first-page":"e0203672","DOI":"10.1371\/journal.pone.0203672","volume":"13","author":"LK Hoffman","year":"2018","unstructured":"Hoffman LK, Tomalin LE, Schultz G, et al. Integrating the skin and blood transcriptomes and serum proteome in hidradenitis suppurativa reveals complement dysregulation and plasma cell signature. PLoS ONE. 2018;13(9):e0203672.","journal-title":"PLoS ONE"},{"key":"1381_CR8","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1111\/ced.13959","volume":"44","author":"VK Shanmugam","year":"2019","unstructured":"Shanmugam VK, Jones D, McNish S, et al. Transcriptome patterns in hidradenitis suppurativa: support for the role of antimicrobial peptides and interferon pathways in disease pathogenesis. Clin Exp Derm. 2019;44:882\u201392.","journal-title":"Clin Exp Derm"},{"key":"1381_CR9","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1111\/jdv.16147","volume":"34","author":"CC Zouboulis","year":"2020","unstructured":"Zouboulis CC, Nogueira da Costa A, Makrantonaki E, et al. Alterations in innate immunity and epithelial cell differentiation are the molecular pillars of hidradenitis suppurativa. J Eur Acad Dermatol Venereol. 2020;34:846\u201361.","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"1381_CR10","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1016\/j.jaad.2019.08.089","volume":"82","author":"SR Goldburg","year":"2020","unstructured":"Goldburg SR, Strober BE, Payette MJ. Hidradenitis suppurativa: current and emerging treatments. J Am Acad Dermatol. 2020;82:1061\u201382.","journal-title":"J Am Acad Dermatol"}],"container-title":["Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-020-01381-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00011-020-01381-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-020-01381-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T19:13:47Z","timestamp":1626117227000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00011-020-01381-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,13]]},"references-count":10,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["1381"],"URL":"https:\/\/doi.org\/10.1007\/s00011-020-01381-7","relation":{},"ISSN":["1023-3830","1420-908X"],"issn-type":[{"value":"1023-3830","type":"print"},{"value":"1420-908X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,13]]},"assertion":[{"value":"17 March 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 June 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}