{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T10:27:58Z","timestamp":1760524078047,"version":"3.37.3"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T00:00:00Z","timestamp":1600992000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T00:00:00Z","timestamp":1600992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100010268","name":"National Council for Scientific and Technological Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010268","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Coordinate Improvement of Higher Education Personnel"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflamm. Res."],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1007\/s00011-020-01403-4","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T15:04:02Z","timestamp":1601046242000},"page":"1245-1256","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Biochanin A attenuates zymosan-induced arthritis in mice similarly to 17-\u03b2 estradiol: an alternative to hormone replacement therapy?"],"prefix":"10.1007","volume":"69","author":[{"given":"Franciel Batista","family":"Felix","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica Maria Dantas","family":"Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elindayane Vieira","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Pinho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enilton Aparecido","family":"Camargo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiane Bani","family":"Corr\u00eaa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3644-7632","authenticated-orcid":false,"given":"Renata","family":"Grespan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,9,25]]},"reference":[{"key":"1403_CR1","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1056\/NEJMra1004965","volume":"365","author":"IB McInnes","year":"2011","unstructured":"McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. N Engl J Med. 2011;365:2205\u201319.","journal-title":"N Engl J Med"},{"key":"1403_CR2","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1042\/CS20030317","volume":"106","author":"M Ishizuka","year":"2004","unstructured":"Ishizuka M, Hatori M, Suzuki T, Miki Y, Darnel AD, Tazawa C, et al. Sex steroid receptors in rheumatoid arthritis. Clin Sci. 2004;106:293\u2013300.","journal-title":"Clin Sci"},{"key":"1403_CR3","doi-asserted-by":"crossref","first-page":"821","DOI":"10.18433\/J3VW2F","volume":"16","author":"S Harirforoosh","year":"2013","unstructured":"Harirforoosh S, Asghar W, Jamali F. Adverse effects of nonsteroidal antiinflammatory drugs: an update of gastrointestinal, cardiovascular and renal complications. J Pharm Pharm Sci. 2013;16:821\u201347.","journal-title":"J Pharm Pharm Sci"},{"key":"1403_CR4","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1136\/ard.53.1.54","volume":"53","author":"AG MacDonald","year":"1994","unstructured":"MacDonald AG, Murphy EA, Capell HA, Bankowska UZ, Rakston SH. Effects of hormone replacement therapy in rheumatoid arthritis: a double blind placebo-controlled study. Ann Rheum Dis. 1994;53:54\u20137.","journal-title":"Ann Rheum Dis"},{"key":"1403_CR5","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.coph.2007.03.002","volume":"7","author":"D Khanna","year":"2007","unstructured":"Khanna D, Sethi G, Ahn KS, Pandey MK, Kunnumakkara AB, Sung B, Aggarwal A, Aggarwal BB. Natural products as a gold mine for arthritis treatment. Curr Opin Pharmacol. 2007;7:344\u201351.","journal-title":"Curr Opin Pharmacol"},{"key":"1403_CR6","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.jsbmb.2004.12.038","volume":"94","author":"V Beck","year":"2005","unstructured":"Beck V, Rohr U, Jungbauer A. Phytoestrogens derived from red clover: an alternative to estrogen replacement therapy? J Steroid Biochem Mol Biol. 2005;94:499\u2013518.","journal-title":"J Steroid Biochem Mol Biol"},{"key":"1403_CR7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphar.2019.00001","volume":"10","author":"C Yu","year":"2019","unstructured":"Yu C, Zhang P, Lou L, Wang Y. Perspectives regarding the role of biochanin A in humans. Front Pharmacol. 2019;10:1\u201311.","journal-title":"Front Pharmacol"},{"key":"1403_CR8","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.3390\/molecules24061076","volume":"24","author":"L K\u0159\u00ed\u017eov\u00e1","year":"2019","unstructured":"K\u0159\u00ed\u017eov\u00e1 L, Dad\u00e1kov\u00e1 K, Ka\u0161parovsk\u00e1 J, Ka\u0161parovsk\u00fd T. Isoflavones. Molecules. 2019;24:1076.","journal-title":"Molecules"},{"key":"1403_CR9","doi-asserted-by":"crossref","first-page":"137907","DOI":"10.1016\/j.scitotenv.2020.137907","volume":"722","author":"A Sarfraz","year":"2020","unstructured":"Sarfraz A, Javeed M, Shah MA, Hussain G, Shafiq N, Sarfraz I, Riaz A, Sadiqa A, Zara R, Zafar S, Kanwal L, Sarker SD, Rasul A. Biochanin A: a novel bioactive multifunctional compound from nature. Sci Total Environ. 2020;722:137907.","journal-title":"Sci Total Environ"},{"key":"1403_CR10","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.tifs.2018.07.001","volume":"79","author":"S Raheja","year":"2018","unstructured":"Raheja S, Girdhar A, Lather V, Pandita D. Biochanin A: a phytoestrogen with therapeutic potential. Trends Food Sci Technol. 2018;79:55\u201366.","journal-title":"Trends Food Sci Technol"},{"key":"1403_CR11","first-page":"1","volume":"2013","author":"SJ Su","year":"2013","unstructured":"Su SJ, Yeh YT, Shyu HW. The preventive effect of biochanin A on bone loss in ovariectomized rats: involvement in regulation of growth and activity of osteoblasts and osteoclasts. Evid Based Complement Altern Med. 2013;2013:1\u201310.","journal-title":"Evid Based Complement Altern Med"},{"key":"1403_CR12","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1097\/01.gme.0000185941.63497.10","volume":"13","author":"S Schrepfer","year":"2006","unstructured":"Schrepfer S, Deuse T, M\u00fcnzel T, Sch\u00e4fer H, Braendle W, Reichenspurner H. The selective estrogen receptor-\u03b2 agonist biochanin A shows vasculoprotective effects without uterotrophic activity. Menopause. 2006;13:489\u201399.","journal-title":"Menopause"},{"key":"1403_CR13","first-page":"1063","volume":"83","author":"N Du","year":"2020","unstructured":"Du N, Song L, Li Y, Wang T, Fang Q, Ou J, Nandakumar KS. Phytoestrogens protect joints in collagen induced arthritis by increasing IgG glycosylation and reducing osteoclast activation. Int Immunopharmacol. 2020;83:1063\u201387.","journal-title":"Int Immunopharmacol"},{"key":"1403_CR14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1472-6882-14-1","volume":"14","author":"DQ Wu","year":"2014","unstructured":"Wu DQ, Zhong HM, Ding QH, Ba L. Protective effects of biochanin A on articular cartilage: in vitro and in vivo studies. BMC Complement Altern Med. 2014;14:1\u201310.","journal-title":"BMC Complement Altern Med."},{"key":"1403_CR15","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.lfs.2015.06.015","volume":"136","author":"X Ming","year":"2015","unstructured":"Ming X, Ding M, Zhai B, Xiao L, Piao T, Liu M. Biochanin A inhibits lipopolysaccharide-induced inflammation in human umbilical vein endothelial cells. Life Sci. 2015;136:36\u201341.","journal-title":"Life Sci"},{"key":"1403_CR16","first-page":"217","volume":"5","author":"L Qiu","year":"2012","unstructured":"Qiu L, Lin B, Lin Z, Lin Y, Lin M, Yang X. Biochanin A ameliorates the cytokine secretion profile of lipopolysaccharide-stimulated macrophages by a PPAR\u03b3-dependent pathway. Mol Med Rep. 2012;5:217\u201322.","journal-title":"Mol Med Rep."},{"key":"1403_CR17","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1207\/S15327914NC4501_13","volume":"45","author":"SJ Su","year":"2003","unstructured":"Su SJ, Chow NH, Kung ML, Hung TC, Chang KL. Effects of soy isoflavones on apoptosis induction and G2-M arrest in human hepatoma cells involvement of caspase-3 activation, Bcl-2 and Bcl-xL downregulation, and Cdc2 kinase activity. Nutr Cancer. 2003;45:113\u201323.","journal-title":"Nutr Cancer"},{"key":"1403_CR18","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1002\/ptr.3498","volume":"25","author":"TA Mansoor","year":"2011","unstructured":"Mansoor TA, Ramalho RM, Luo X, Ramalhete C, Rodrigues CMP, Ferreira MJU. Isoflavones as apoptosis inducers in human hepatoma HuH-7 cells. Phyther Res. 2011;25:1819\u201324.","journal-title":"Phyther Res."},{"key":"1403_CR19","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1615\/JEnvironPatholToxicolOncol.2013007280","volume":"32","author":"A Puthli","year":"2013","unstructured":"Puthli A, Tiwari R, Mishra KP. Biochanin A enhances the radiotoxicity in colon tumor cells in vitro. J Environ Pathol Toxicol Oncol. 2013;32:189\u2013203.","journal-title":"J Environ Pathol Toxicol Oncol"},{"key":"1403_CR20","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.4049\/jimmunol.167.3.1601","volume":"167","author":"BT Wipke","year":"2001","unstructured":"Wipke BT, Allen PM. Essential role of neutrophils in the initiation and progression of a murine model of rheumatoid arthritis. J Immunol. 2001;167:1601\u20138.","journal-title":"J Immunol."},{"key":"1403_CR21","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nrrheum.2016.193","volume":"13","author":"M Perretti","year":"2017","unstructured":"Perretti M, Cooper D, Dalli J, Norling LV. Immune resolution mechanisms in inflammatory arthritis. Nat Rev Rheumatol. 2017;13:87\u201399.","journal-title":"Nat Rev Rheumatol"},{"key":"1403_CR22","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1136\/thoraxjnl-2017-210134","volume":"73","author":"RD Gray","year":"2018","unstructured":"Gray RD, Hardisty G, Regan KH, Smith M, Robb CT, Duffin R, MacKellar A, Felton JM, Paemka L, McCullagh BN, Lucas CD, Dorward DA, McKone EF, Cooke G, Donnelly SC, Singh PK, Stoltz DA, Haslett C, McCray PB, Whyte MKB, Rossi AG, Davidson DJ. Delayed neutrophil apoptosis enhances NET formation in cystic fibrosis. Thorax. 2018;73:134\u201344.","journal-title":"Thorax"},{"key":"1403_CR23","first-page":"1","volume":"9","author":"TM Caro","year":"2014","unstructured":"Caro TM, Hermosilla C, Silva LMR, Cortes H, Taubert A. Neutrophil extracellular traps as innate immune reaction against the emerging apicomplexan parasite besnoitia besnoiti. PLoS One. 2014;9:1\u20139.","journal-title":"PLoS One"},{"key":"1403_CR24","doi-asserted-by":"crossref","first-page":"915","DOI":"10.3390\/cells9040915","volume":"9","author":"E Fousert","year":"2020","unstructured":"Fousert E, Toes R, Desai J. Neutrophil extracellular traps (NETs) take the central stage in driving autoimmune responses. Cells. 2020;9:915.","journal-title":"Cells"},{"key":"1403_CR25","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/S8756-3282(01)00426-4","volume":"28","author":"D Yamasaki","year":"2001","unstructured":"Yamasaki D, Enokida M, Okano T, Hagino H, Teshima R. Effects of ovariectomy and estrogen replacement therapy on arthritis and bone mineral density in rats with collagen-induced arthritis. Bone. 2001;28:634\u201340.","journal-title":"Bone"},{"key":"1403_CR26","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1142\/S0192415X13500614","volume":"41","author":"AN Yamada","year":"2013","unstructured":"Yamada AN, Grespan R, Yamada \u00c1T, Silva EL, Silva-Filho SE, Dami\u00e3o MJ, De Oliveira Dalalio MM, Bersani-Amado CA, Cuman RKN. Anti-inflammatory activity of Ocimum americanum L. essential oil in experimental model of zymosan-induced arthritis. Am J Chin Med. 2013;41:913\u201326.","journal-title":"Am J Chin Med."},{"key":"1403_CR27","first-page":"2","volume":"53","author":"JMD Ara\u00fajo","year":"2020","unstructured":"Ara\u00fajo JMD, Silva LAS, Felix FB, Camargo EA, Grespan R. CCR3 antagonist impairs estradiol-induced eosinophil migration to the uterus in ovariectomized mice. Braz J Med Biol Res. 2020;53:2\u20138.","journal-title":"Braz J Med Biol Res."},{"key":"1403_CR28","first-page":"587","volume":"72","author":"I Kaczmarczyk-Sedlak","year":"2015","unstructured":"Kaczmarczyk-Sedlak I, Zych M, Wojnar W, Ozimina-Kami-Ska E, Dudek S, Chada\u0142a N, et al. Biochanin a shows no effect on skeletal system in ovariectomized rats, when administered in moderate dose. Acta Pol Pharm Drug Res. 2015;72:587\u201396.","journal-title":"Acta Pol Pharm Drug Res"},{"key":"1403_CR29","doi-asserted-by":"publisher","DOI":"10.1080\/13813455.2020.1741644","author":"H Jdidi","year":"2020","unstructured":"Jdidi H, Ghorbel Koubaa F, Aoiadni N, Elleuch A, Makni-Ayadi F, El Feki A. Effect of Medicago sativa compared to 17\u03b2-oestradiol on osteoporosis in ovariectomized mice. Arch Physiol Biochem. 2020. https:\/\/doi.org\/10.1080\/13813455.2020.1741644.","journal-title":"Arch Physiol Biochem."},{"key":"1403_CR30","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1463-1326.2011.01532.x","volume":"14","author":"CC Lee","year":"2012","unstructured":"Lee CC, Bloem CJ, Kasa-Vubu JZ, Liang LJ. Effect of oral phytoestrogen on androgenicity and insulin sensitivity in postmenopausal women. Diabetes Obes Metab. 2012;14:315\u20139.","journal-title":"Diabetes Obes Metab"},{"key":"1403_CR31","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.plefa.2008.08.001","volume":"79","author":"NK Jain","year":"2008","unstructured":"Jain NK, Ishikawa TO, Spigelman I, Herschman HR. COX-2 expression and function in the hyperalgesic response to paw inflammation in mice. Prostaglandins Leukot Essent Fatty Acids. 2008;79:183\u201390.","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"1403_CR32","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0022-1759(74)90109-4","volume":"5","author":"D English","year":"1974","unstructured":"English D, Andersen BR. Single-step separation of red blood cells, granulocytes and mononuclear leukocytes on discontinuous density gradients of Ficoll-Hypaque. J Immunol Methods. 1974;5:249\u201352.","journal-title":"J Immunol Methods"},{"key":"1403_CR33","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1189\/jlb.0704386","volume":"77","author":"V Pinho","year":"2005","unstructured":"Pinho V, Souza DG, Barsante MM, Hamer FP, De Freitas MS, Rossi AG, Teixeira MM. Phosphoinositide-3 kinases critically regulate the recruitment and survival of eosinophils in vivo: importance for the resolution of allergic inflammation. J Leukoc Biol. 2005;77:800\u201310.","journal-title":"J Leukoc Biol"},{"key":"1403_CR34","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s00011-020-01338-w","volume":"69","author":"P Ganova","year":"2020","unstructured":"Ganova P, Zhivkova R, Kolarov A, Ivanovska N. Influence of estradiol treatment on bone marrow cell differentiation in collagenase-induced arthritis. Inflamm Res. 2020;69:533\u201343.","journal-title":"Inflamm Res"},{"key":"1403_CR35","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.intimp.2019.04.048","volume":"72","author":"AH Schneider","year":"2019","unstructured":"Schneider AH, Kanashiro A, Dutra SG, de Souza RD, Veras FP, deQueiroz Cunha F, Ulloa L, Mecawi AS, Reis LC, do Carmo Malvar D. Estradiol replacement therapy regulates innate immune response in ovariectomized arthritic mice. Int Immunopharmacol. 2019;72:504\u201310.","journal-title":"Int Immunopharmacol."},{"key":"1403_CR36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/ar4612","volume":"16","author":"C Engdahl","year":"2014","unstructured":"Engdahl C, B\u00f6rjesson AE, Forsman HF, Andersson A, Stubelius A, Krust A, Chambon P, Islander U, Ohlsson C, Carlsten H, Lagerquist MK. The role of total and cartilage-specific estrogen receptor alpha expression for the ameliorating effect of estrogen treatment on arthritis. Arthritis Res Ther. 2014;16:1\u201311.","journal-title":"Arthritis Res Ther."},{"key":"1403_CR37","doi-asserted-by":"crossref","first-page":"4252","DOI":"10.1210\/endo.139.10.6216","volume":"139","author":"GGJM Kuiper","year":"1998","unstructured":"Kuiper GGJM, Lemmen JG, Carlsson B, Corton JC, Safe SH, Van Der Saag PT, Van Der Burg B, Gustafsson J\u00c5. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor \u03b2. Endocrinology. 1998;139:4252\u201363.","journal-title":"Endocrinology"},{"issue":"10","key":"1403_CR38","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/nrrheum.2014.80","volume":"2014","author":"HL Wright","year":"2014","unstructured":"Wright HL, Moots RJ, Edwards SW. The multifactorial role of neutrophils in rheumatoid arthritis. Nat Rev Rheumatol. 2014;2014(10):593\u2013601.","journal-title":"Nat Rev Rheumatol"},{"key":"1403_CR39","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1189\/jlb.1207827","volume":"84","author":"FD de Conte","year":"2008","unstructured":"de Conte FD, Barja-Fidalgo C, Verri WA Jr, Cunha FQ, Rae GA, Penido C, das Henriques MD. Endothelins modulate inflammatory reaction in zymosan-induced arthritis: participation of LTB 4, TNF-\u03b1, and CXCL-1. J Leukoc Biol. 2008;84:652\u201360.","journal-title":"J Leukoc Biol"},{"key":"1403_CR40","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1002\/eji.200939578","volume":"39","author":"DL Asquith","year":"2009","unstructured":"Asquith DL, Miller AM, McInnes IB, Liew FY. Animal models of rheumatoid arthritis. Eur J Immunol. 2009;39:2040\u20134.","journal-title":"Eur J Immunol"},{"key":"1403_CR41","first-page":"1038","volume":"138","author":"X Hu","year":"2020","unstructured":"Hu X, Qin H, Li Y, Li J, Fu L, Li M, et al. Biochanin A protect against lipopolysaccharide-induced acute lung injury in mice by regulating TLR4\/NF-\u03baB and PPAR-\u03b3 pathway. Microb Pathog. 2020;138:1038\u201346.","journal-title":"Microb Pathog."},{"key":"1403_CR42","first-page":"635","volume":"2011","author":"WC Ko","year":"2011","unstructured":"Ko WC, Lin LH, Shen HY, Lai CY, Chen CM, Shih CH. Biochanin a, a phytoestrogenic isoflavone with selective inhibition of phosphodiesterase 4, suppresses ovalbumin-induced airway hyperresponsiveness. Evid Based Complement Altern Med. 2011;2011:635\u201358.","journal-title":"Evid Based Complement Altern Med."},{"key":"1403_CR43","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ejphar.2010.11.026","volume":"653","author":"L Kole","year":"2011","unstructured":"Kole L, Giri B, Manna SK, Pal B, Ghosh S. Biochanin-A, an isoflavon, showed anti-proliferative and anti-inflammatory activities through the inhibition of iNOS expression, p38-MAPK and ATF-2 phosphorylation and blocking NF\u03baB nuclear translocation. Eur J Pharmacol. 2011;653:8\u201315.","journal-title":"Eur J Pharmacol"},{"key":"1403_CR44","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.bbrc.2016.06.126","volume":"477","author":"JS Oh","year":"2016","unstructured":"Oh JS, Cho IA, Kang KR, You JS, Yu SJ, Lee GJ, Seo YS, Kim CS, Kim DK, Kim SG, Seo YW, Im HJ, Kim JS. Biochanin-A antagonizes the interleukin-1\u03b2-induced catabolic inflammation through the modulation of NF\u03baB cellular signaling in primary rat chondrocytes. Biochem Biophys Res Commun. 2016;477:723\u201330.","journal-title":"Biochem Biophys Res Commun"},{"key":"1403_CR45","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.neulet.2006.11.045","volume":"417","author":"HQ Chen","year":"2007","unstructured":"Chen HQ, Jin ZY, Li GH. Biochanin A protects dopaminergic neurons against lipopolysaccharide-induced damage through inhibition of microglia activation and proinflammatory factors generation. Neurosci Lett. 2007;417:112\u20137.","journal-title":"Neurosci Lett"},{"key":"1403_CR46","first-page":"935","volume":"187","author":"O Meyer","year":"2003","unstructured":"Meyer O. Role of TNF-alpha and cytokines in the physiopathology of rheumatoid arthritis. Therapeutic perspectives. Bull Acad Natl Med. 2003;187:935\u201355.","journal-title":"Bull Acad Natl Med."},{"key":"1403_CR47","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/mt.2012.131","volume":"21","author":"G Garaulet","year":"2013","unstructured":"Garaulet G, Alfranca A, Torrente M, Escolano A, L\u00f3pez-Fontal R, Hortelano S, Redondo JM, Rodr\u00edguez A. IL10 released by a new inflammation-regulated lentiviral system efficiently attenuates zymosan-induced arthritis. Mol Ther. 2013;21:119\u201330.","journal-title":"Mol Ther"},{"key":"1403_CR48","doi-asserted-by":"crossref","first-page":"178ra40","DOI":"10.1126\/scitranslmed.3005580","volume":"5","author":"R Khandpur","year":"2013","unstructured":"Khandpur R, Carmona-rivera C, Vivekanandan-giri A, Yalavarthi S, Knight JS, Friday S, Li S, Patel RM, Subramanian V, Thompson P, Chen P, Fox D, Kaplan MJ. NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis. Sci Transl Med. 2013;5:178ra40.","journal-title":"Sci Transl Med."},{"key":"1403_CR49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2017.00081","volume":"8","author":"V Delgado-Rizo","year":"2017","unstructured":"Delgado-Rizo V, Mart\u00ednez-Guzm\u00e1n MA, I\u00f1iguez-Gutierrez L, Garc\u00eda-Orozco A, Alvarado-Navarro A, Fafutis-Morris M. Neutrophil extracellular traps and its implications in inflammation: an overview. Front Immunol. 2017;8:1\u201320.","journal-title":"Front Immunol."},{"key":"1403_CR50","doi-asserted-by":"crossref","first-page":"105919","DOI":"10.1016\/j.intimp.2019.105919","volume":"77","author":"F Yang","year":"2019","unstructured":"Yang F, Luo X, Luo G, Zhai Z, Zhuang J, He J, Han J, Zhang Y, Zhuang L, Sun E, He Y. Inhibition of NET formation by polydatin protects against collagen-induced arthritis. Int Immunopharmacol. 2019;77:105919.","journal-title":"Int Immunopharmacol"},{"key":"1403_CR51","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.molimm.2019.05.010","volume":"112","author":"M Zhu","year":"2019","unstructured":"Zhu M, Yuan K, Lu Q, Zhu Q, Zhang S, Li X, et al. Emodin ameliorates rheumatoid arthritis by promoting neutrophil apoptosis and inhibiting neutrophil extracellular trap formation. Mol Immunol. 2019;112:188\u201397.","journal-title":"Mol Immunol"},{"key":"1403_CR52","doi-asserted-by":"crossref","first-page":"108454","DOI":"10.1016\/j.jnutbio.2020.108454","volume":"84","author":"K Yuan","year":"2020","unstructured":"Yuan K, Zhu Q, Lu Q, Jiang H, Zhu M, Li X, et al. Quercetin alleviates rheumatoid arthritis by inhibiting neutrophil inflammatory activities. J Nutr Biochem. 2020;84:108454.","journal-title":"J Nutr Biochem"},{"key":"1403_CR53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/jci.insight.134796","volume":"5","author":"T Josefs","year":"2020","unstructured":"Josefs T, Barrett TJ, Brown EJ, Quezada A, Wu X, Voisin M, Amengual J, Fisher EA. Neutrophil extracellular traps promote macrophage inflammation and impair atherosclerosis resolution in diabetic mice. JCI Insight. 2020;5:1\u201310.","journal-title":"JCI Insight"},{"key":"1403_CR54","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/nri3607","volume":"14","author":"IKH Poon","year":"2014","unstructured":"Poon IKH, Lucas CD, Rossi AG, Ravichandran KS. Apoptotic cell clearance: basic biology and therapeutic potential. Nat Rev Immunol. 2014;14:166\u201380.","journal-title":"Nat Rev Immunol"},{"key":"1403_CR55","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/01926230701320337","volume":"35","author":"Elmore S Apoptosis","year":"2007","unstructured":"Apoptosis Elmore S. A review of programmed cell death. Toxicol Pathol. 2007;35:495\u2013516.","journal-title":"Toxicol Pathol."}],"container-title":["Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-020-01403-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00011-020-01403-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-020-01403-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,25]],"date-time":"2021-09-25T01:10:37Z","timestamp":1632532237000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00011-020-01403-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,25]]},"references-count":55,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["1403"],"URL":"https:\/\/doi.org\/10.1007\/s00011-020-01403-4","relation":{},"ISSN":["1023-3830","1420-908X"],"issn-type":[{"type":"print","value":"1023-3830"},{"type":"electronic","value":"1420-908X"}],"subject":[],"published":{"date-parts":[[2020,9,25]]},"assertion":[{"value":"25 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 September 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 September 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}