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Western blotting, flow\u00a0cytometry, qRT-PCR, ELISA, PAS staining and immunohistochemical staining were used for assessment of TAB1\/nuclear factor-\u03baB (NF-\u03baB)\/hypoxia-inducible factor-1\u03b1 (HIF-1\u03b1), iNOS, glycolysis, inflammation and the clinical and pathological manifestations of diabetic nephropathy.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>We found that TAB1\/NF-\u03baB\/HIF-1\u03b1, iNOS and glycolysis were up-regulated in BMMs under HG conditions, leading to release of further inflammatory factors, Downregulation of TAB1 could inhibit glycolysis\/polarization of macrophages and inflammation in vivo and in vitro. Furthermore, albuminuria, the tubulointerstitial damage index and glomerular mesangial expansion index of STZ-induced diabetic nephropathy mice were decreased by TAB1 knockdown.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Our results suggest that the TAB1\/NF-\u03baB\/HIF-1\u03b1 signaling pathway regulates glycolysis and activation of macrophages in DN.<\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s00011-020-01411-4","type":"journal-article","created":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T14:02:43Z","timestamp":1602511363000},"page":"1215-1234","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["TAB1 regulates glycolysis and activation of macrophages in diabetic nephropathy"],"prefix":"10.1007","volume":"69","author":[{"given":"Hanxu","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangming","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingxin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6434-4759","authenticated-orcid":false,"given":"Yonggui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,10,12]]},"reference":[{"key":"1411_CR1","doi-asserted-by":"publisher","first-page":"900","DOI":"10.3389\/fphar.2018.00900","volume":"9","author":"Z Yang","year":"2018","unstructured":"Yang Z, Guo Z, Dong J, Sheng S, Wang Y, Yu L, et al. miR-374a regulates inflammatory response in diabetic nephropathy by targeting MCP-1 expression. 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