{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T04:03:24Z","timestamp":1791864204988,"version":"4.3.4"},"reference-count":223,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2024,4,14]],"date-time":"2024-04-14T00:00:00Z","timestamp":1713052800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,4,14]],"date-time":"2024-04-14T00:00:00Z","timestamp":1713052800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Rui E Emergency Medicine Research Special Fund","award":["No. 22222012021"],"award-info":[{"award-number":["No. 22222012021"]}]},{"name":"Shandong Province Medical and Health Technology Development Plan Project","award":["No. 202210000429"],"award-info":[{"award-number":["No. 202210000429"]}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Found","doi-asserted-by":"crossref","award":["item2020M670045ZX"],"award-info":[{"award-number":["item2020M670045ZX"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100018546","name":"Postdoctoral Innovation Project of Shandong Province","doi-asserted-by":"crossref","award":["item202003026"],"award-info":[{"award-number":["item202003026"]}],"id":[{"id":"10.13039\/501100018546","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Taishan Scholar","award":["NO.tsqn202103183"],"award-info":[{"award-number":["NO.tsqn202103183"]}]},{"name":"National Multidisciplinary Innovation Team Project of Traditional Chinese Medicine","award":["No. ZYYCXTD-D-202201"],"award-info":[{"award-number":["No. ZYYCXTD-D-202201"]}]},{"name":"Shandong Traditional Chinese Medicine Science and Technology Project","award":["Z-2023036"],"award-info":[{"award-number":["Z-2023036"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation","doi-asserted-by":"crossref","award":["No. 82374234"],"award-info":[{"award-number":["No. 82374234"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflamm. Res."],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1007\/s00011-024-01879-4","type":"journal-article","created":{"date-parts":[[2024,4,14]],"date-time":"2024-04-14T15:01:41Z","timestamp":1713106901000},"page":"997-1018","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Acute lung injury: a view from the perspective of necroptosis"],"prefix":"10.1007","volume":"73","author":[{"given":"Jinyan","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenli","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingkuo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongtao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohan","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,14]]},"reference":[{"key":"1879_CR1","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1016\/S2213-2600(16)30305-8","volume":"4","author":"AS Neto","year":"2016","unstructured":"Neto AS, Barbas CSV, Simonis FD, Artigas-Ravent\u00f3s A, Canet J, Determann RM, et al. Epidemiological characteristics, practice of ventilation, and clinical outcome in patients at risk of acute respiratory distress syndrome in intensive care units from 16 countries (PRoVENT): an international, multicentre, prospective study. Lancet Respir Med. 2016;4:882\u201393. https:\/\/doi.org\/10.1016\/S2213-2600(16)30305-8.","journal-title":"Lancet Respir Med"},{"key":"1879_CR2","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1001\/jama.2016.0291","volume":"315","author":"G Bellani","year":"2016","unstructured":"Bellani G, Laffey JG, Pham T, Fan E, Brochard L, Esteban A, et al. Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. JAMA. 2016;315:788.","journal-title":"JAMA"},{"key":"1879_CR3","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/S0140-6736(21)00439-6","volume":"398","author":"NJ Meyer","year":"2021","unstructured":"Meyer NJ, Gattinoni L, Calfee CS. Acute respiratory distress syndrome. Lancet. 2021;398:622\u201337. https:\/\/doi.org\/10.1016\/S0140-6736(21)00439-6.","journal-title":"Lancet"},{"key":"1879_CR4","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/BF01704707","volume":"20","author":"GR Bernard","year":"1994","unstructured":"Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, et al. Report of the American-European consensus conference on ARDS: definitions, mechanisms, relevant outcomes and clinical trial coordination. Consensus Committee Intens Care Med. 1994;20:225\u201332. https:\/\/doi.org\/10.1007\/BF01704707.","journal-title":"Consensus Committee Intens Care Med"},{"key":"1879_CR5","doi-asserted-by":"publisher","first-page":"2526","DOI":"10.1001\/jama.2012.5669","volume":"307","author":"ARDS Definition Task Force","year":"2012","unstructured":"Definition Task Force ARDS, Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E, et al. Acute respiratory distress syndrome: the Berlin Definition. JAMA. 2012;307:2526\u201333. https:\/\/doi.org\/10.1001\/jama.2012.5669.","journal-title":"JAMA"},{"key":"1879_CR6","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1164\/rccm.202303-0558WS","volume":"209","author":"MA Matthay","year":"2024","unstructured":"Matthay MA, Arabi Y, Arroliga AC, Bernard G, Bersten AD, Brochard LJ, et al. A new global definition of acute respiratory distress syndrome. Am J Resp Crit Care. 2024;209:37\u201347. https:\/\/doi.org\/10.1164\/rccm.202303-0558WS.","journal-title":"Am J Resp Crit Care"},{"key":"1879_CR7","doi-asserted-by":"publisher","first-page":"L215","DOI":"10.1152\/ajplung.00065.2019","volume":"318","author":"H Faust","year":"2020","unstructured":"Faust H, Mangalmurti NS. Collateral damage: necroptosis in the development of lung injury. Am J Physiol Lung Cell Mol Physiol. 2020;318:L215\u201325. https:\/\/doi.org\/10.1152\/ajplung.00065.2019.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"1879_CR8","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1056\/NEJMra1310050","volume":"370","author":"A Linkermann","year":"2014","unstructured":"Linkermann A, Green DR. Necroptosis. N Engl J Med. 2014;370:455\u201365. https:\/\/doi.org\/10.1056\/NEJMra1310050.","journal-title":"N Engl J Med"},{"key":"1879_CR9","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1038\/82732","volume":"1","author":"N Holler","year":"2000","unstructured":"Holler N, Zaru R, Micheau O, Thome M, Attinger A, Valitutti S, et al. Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat Immunol. 2000;1:489\u201395. https:\/\/doi.org\/10.1038\/82732.","journal-title":"Nat Immunol"},{"key":"1879_CR10","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.1038\/cdd.2012.90","volume":"19","author":"S Jouan-Lanhouet","year":"2012","unstructured":"Jouan-Lanhouet S, Arshad MI, Piquet-Pellorce C, Martin-Chouly C, Le Moigne-Muller G, Van Herreweghe F, et al. TRAIL induces necroptosis involving RIPK1\/RIPK3-dependent PARP-1 activation. Cell Death Differ. 2012;19:2003\u201314. https:\/\/doi.org\/10.1038\/cdd.2012.90.","journal-title":"Cell Death Differ"},{"key":"1879_CR11","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1038\/nature09857","volume":"471","author":"WJ Kaiser","year":"2011","unstructured":"Kaiser WJ, Upton JW, Long AB, Livingston-Rosanoff D, Daley LP, Hakem R, et al. RIP3 mediates the embryonic lethality of caspase-8-deficient mice. Nature. 2011;471:368\u201372. https:\/\/doi.org\/10.1038\/nature09857.","journal-title":"Nature"},{"key":"1879_CR12","doi-asserted-by":"publisher","first-page":"9384","DOI":"10.1158\/0008-5472.CAN-08-2655","volume":"68","author":"J Lu","year":"2008","unstructured":"Lu J, Bai L, Sun H, Nikolovska-Coleska Z, McEachern D, Qiu S, et al. SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1\/2 and XIAP. Cancer Res. 2008;68:9384\u201393. https:\/\/doi.org\/10.1158\/0008-5472.CAN-08-2655.","journal-title":"Cancer Res"},{"key":"1879_CR13","doi-asserted-by":"publisher","first-page":"11778","DOI":"10.1073\/pnas.0711122105","volume":"105","author":"DJ Mahoney","year":"2008","unstructured":"Mahoney DJ, Cheung HH, Mrad RL, Plenchette S, Simard C, Enwere E, et al. Both cIAP1 and cIAP2 regulate TNF\u03b1-mediated NF-\u03baB activation. P Natl Acad Sci Usa. 2008;105:11778\u201383. https:\/\/doi.org\/10.1073\/pnas.0711122105.","journal-title":"P Natl Acad Sci Usa"},{"key":"1879_CR14","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1038\/cdd.2017.46","volume":"24","author":"M Lork","year":"2017","unstructured":"Lork M, Verhelst K, Beyaert R. CYLD, A20 and OTULIN deubiquitinases in NF-\u03baB signaling and cell death: so similar, yet so different. Cell Death Differ. 2017;24:1172\u201383. https:\/\/doi.org\/10.1038\/cdd.2017.46.","journal-title":"Cell Death Differ"},{"key":"1879_CR15","doi-asserted-by":"publisher","first-page":"2449","DOI":"10.1016\/j.celrep.2016.05.032","volume":"15","author":"D Legarda","year":"2016","unstructured":"Legarda D, Justus SJ, Ang RL, Rikhi N, Li W, Moran TM, et al. CYLD proteolysis protects macrophages from tnf-mediated auto-necroptosis induced by LPS and licensed by type I IFN. Cell Rep. 2016;15:2449\u201361. https:\/\/doi.org\/10.1016\/j.celrep.2016.05.032.","journal-title":"Cell Rep"},{"key":"1879_CR16","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1038\/s41586-019-1828-5","volume":"577","author":"N Lalaoui","year":"2020","unstructured":"Lalaoui N, Boyden SE, Oda H, Wood GM, Stone DL, Chau D, et al. Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease. Nature. 2020;577:103\u20138. https:\/\/doi.org\/10.1038\/s41586-019-1828-5.","journal-title":"Nature"},{"key":"1879_CR17","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1038\/s41418-022-00938-9","volume":"29","author":"X Li","year":"2022","unstructured":"Li X, Li F, Zhang X, Zhang H, Zhao Q, Li M, et al. Caspase-8 auto-cleavage regulates programmed cell death and collaborates with RIPK3\/MLKL to prevent lymphopenia. Cell Death Differ. 2022;29:1500\u201312. https:\/\/doi.org\/10.1038\/s41418-022-00938-9.","journal-title":"Cell Death Differ"},{"key":"1879_CR18","doi-asserted-by":"publisher","first-page":"a036368","DOI":"10.1101\/cshperspect.a036368","volume":"12","author":"K Newton","year":"2020","unstructured":"Newton K. Multitasking kinase RIPK1 regulates cell death and inflammation. Csh Perspect Biol. 2020;12:a036368. https:\/\/doi.org\/10.1101\/cshperspect.a036368.","journal-title":"Csh Perspect Biol"},{"key":"1879_CR19","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/cmi.2012.68","volume":"10","author":"S Liang","year":"2013","unstructured":"Liang S, Qin X. Critical role of type I interferon-induced macrophage necroptosis during infection with Salmonella enterica serovar Typhimurium. Cell Mol Immunol. 2013;10:99\u2013100. https:\/\/doi.org\/10.1038\/cmi.2012.68.","journal-title":"Cell Mol Immunol"},{"key":"1879_CR20","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.cell.2020.11.025","volume":"184","author":"R Karki","year":"2021","unstructured":"Karki R, Sharma BR, Tuladhar S, Williams EP, Zalduondo L, Samir P, et al. Synergism of TNF-\u03b1 and IFN-\u03b3 triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes. Cell. 2021;184:149-168.e17. https:\/\/doi.org\/10.1016\/j.cell.2020.11.025.","journal-title":"Cell"},{"key":"1879_CR21","doi-asserted-by":"publisher","first-page":"31268","DOI":"10.1074\/jbc.M113.462341","volume":"288","author":"WJ Kaiser","year":"2013","unstructured":"Kaiser WJ, Sridharan H, Huang C, Mandal P, Upton JW, Gough PJ, et al. Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL. J Biol Chem. 2013;288:31268\u201379. https:\/\/doi.org\/10.1074\/jbc.M113.462341.","journal-title":"J Biol Chem"},{"key":"1879_CR22","doi-asserted-by":"publisher","first-page":"20054","DOI":"10.1073\/pnas.1116302108","volume":"108","author":"S He","year":"2011","unstructured":"He S, Liang Y, Shao F, Wang X. Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway. P Natl Acad Sci Usa. 2011;108:20054\u20139. https:\/\/doi.org\/10.1073\/pnas.1116302108.","journal-title":"P Natl Acad Sci Usa"},{"key":"1879_CR23","doi-asserted-by":"publisher","first-page":"2529","DOI":"10.15252\/embj.201796476","volume":"36","author":"J Maelfait","year":"2017","unstructured":"Maelfait J, Liverpool L, Bridgeman A, Ragan KB, Upton JW, Rehwinkel J. Sensing of viral and endogenous RNA by ZBP1\/DAI induces necroptosis. EMBO J. 2017;36:2529\u201343. https:\/\/doi.org\/10.15252\/embj.201796476.","journal-title":"EMBO J"},{"key":"1879_CR24","doi-asserted-by":"publisher","first-page":"e20221156","DOI":"10.1084\/jem.20221156","volume":"220","author":"J Maelfait","year":"2023","unstructured":"Maelfait J, Rehwinkel J. The Z-nucleic acid sensor ZBP1 in health and disease. J Exp Med. 2023;220:e20221156. https:\/\/doi.org\/10.1084\/jem.20221156.","journal-title":"J Exp Med"},{"key":"1879_CR25","doi-asserted-by":"publisher","first-page":"1886","DOI":"10.1038\/s41418-023-01181-6","volume":"30","author":"M Ekhlak","year":"2023","unstructured":"Ekhlak M, Kulkarni PP, Singh V, Chaurasia SN, Mohapatra SK, Chaurasia RN, et al. Necroptosis executioner MLKL plays pivotal roles in agonist-induced platelet prothrombotic responses and lytic cell death in a temporal order. Cell Death Differ. 2023;30:1886\u201399. https:\/\/doi.org\/10.1038\/s41418-023-01181-6.","journal-title":"Cell Death Differ"},{"key":"1879_CR26","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.molcel.2019.05.022","volume":"75","author":"A Najafov","year":"2019","unstructured":"Najafov A, Mookhtiar AK, Luu HS, Ordureau A, Pan H, Amin PP, et al. TAM kinases promote necroptosis by regulating oligomerization of MLKL. Mol Cell. 2019;75:457-468.e4. https:\/\/doi.org\/10.1016\/j.molcel.2019.05.022.","journal-title":"Mol Cell"},{"key":"1879_CR27","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1016\/j.molcel.2018.05.010","volume":"70","author":"CM Dovey","year":"2018","unstructured":"Dovey CM, Diep J, Clarke BP, Hale AT, McNamara DE, Guo H, et al. MLKL requires the inositol phosphate code to execute necroptosis. Mol Cell. 2018;70:936-948.e7. https:\/\/doi.org\/10.1016\/j.molcel.2018.05.010.","journal-title":"Mol Cell"},{"key":"1879_CR28","doi-asserted-by":"publisher","first-page":"e2051","DOI":"10.1038\/cddis.2015.386","volume":"7","author":"AV Jacobsen","year":"2016","unstructured":"Jacobsen AV, Lowes KN, Tanzer MC, Lucet IS, Hildebrand JM, Petrie EJ, et al. HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death. Cell Death Dis. 2016;7:e2051. https:\/\/doi.org\/10.1038\/cddis.2015.386.","journal-title":"Cell Death Dis"},{"key":"1879_CR29","doi-asserted-by":"publisher","first-page":"6521","DOI":"10.1073\/pnas.1916503117","volume":"117","author":"AN Johnston","year":"2020","unstructured":"Johnston AN, Ma Y, Liu H, Liu S, Hanna-Addams S, Chen S, et al. Necroptosis-blocking compound NBC1 targets heat shock protein 70 to inhibit MLKL polymerization and necroptosis. P Natl Acad Sci Usa. 2020;117:6521\u201330. https:\/\/doi.org\/10.1073\/pnas.1916503117.","journal-title":"P Natl Acad Sci Usa"},{"key":"1879_CR30","doi-asserted-by":"publisher","first-page":"3151","DOI":"10.1038\/s41467-020-16887-1","volume":"11","author":"AL Samson","year":"2020","unstructured":"Samson AL, Zhang Y, Geoghegan ND, Gavin XJ, Davies KA, Mlodzianoski MJ, et al. MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis. Nat Commun. 2020;11:3151. https:\/\/doi.org\/10.1038\/s41467-020-16887-1.","journal-title":"Nat Commun"},{"key":"1879_CR31","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/ncb2883","volume":"16","author":"Z Cai","year":"2014","unstructured":"Cai Z, Jitkaew S, Zhao J, Chiang H-C, Choksi S, Liu J, et al. Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis. Nat Cell Biol. 2014;16:55\u201365. https:\/\/doi.org\/10.1038\/ncb2883.","journal-title":"Nat Cell Biol"},{"key":"1879_CR32","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1021\/acschembio.3c00603","volume":"19","author":"AJ Pradhan","year":"2024","unstructured":"Pradhan AJ, Chitkara S, Ramirez RX, Monje-Galvan V, Sancak Y, Atilla-Gokcumen GE. Acylation of MLKL Impacts Its Function in Necroptosis. ACS Chem Biol. 2024;19:407\u201318. https:\/\/doi.org\/10.1021\/acschembio.3c00603.","journal-title":"ACS Chem Biol"},{"key":"1879_CR33","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1038\/s41419-024-06447-6","volume":"15","author":"N Weinelt","year":"2024","unstructured":"Weinelt N, W\u00e4chtersh\u00e4user KN, Celik G, Jeiler B, Gollin I, Zein L, et al. LUBAC-mediated M1 Ub regulates necroptosis by segregating the cellular distribution of active MLKL. Cell Death Dis. 2024;15:77. https:\/\/doi.org\/10.1038\/s41419-024-06447-6.","journal-title":"Cell Death Dis"},{"key":"1879_CR34","doi-asserted-by":"publisher","first-page":"3423","DOI":"10.1126\/scisignal.aaw3423","volume":"12","author":"W Fan","year":"2019","unstructured":"Fan W, Guo J, Gao B, Zhang W, Ling L, Xu T, et al. Flotillin-mediated endocytosis and ALIX-syntenin-1-mediated exocytosis protect the cell membrane from damage caused by necroptosis. Sci Signal. 2019;12:3423. https:\/\/doi.org\/10.1126\/scisignal.aaw3423.","journal-title":"Sci Signal"},{"key":"1879_CR35","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.cell.2017.03.020","volume":"169","author":"Y-N Gong","year":"2017","unstructured":"Gong Y-N, Guy C, Olauson H, Becker JU, Yang M, Fitzgerald P, et al. ESCRT-III acts downstream of MLKL to regulate necroptotic cell death and its consequences. Cell. 2017;169:286-300.e16. https:\/\/doi.org\/10.1016\/j.cell.2017.03.020.","journal-title":"Cell"},{"key":"1879_CR36","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-023-01237-7","author":"S Liu","year":"2023","unstructured":"Liu S, Perez P, Sun X, Chen K, Fatirkhorani R, Mammadova J, et al. MLKL polymerization-induced lysosomal membrane permeabilization promotes necroptosis. Cell Death Differ. 2023. https:\/\/doi.org\/10.1038\/s41418-023-01237-7.","journal-title":"Cell Death Differ"},{"key":"1879_CR37","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1080\/15548627.2021.2002109","volume":"18","author":"J Lou","year":"2022","unstructured":"Lou J, Wang X, Zhang H, Yu G, Ding J, Zhu X, et al. Inhibition of PLA2G4E\/cPLA2 promotes survival of random skin flaps by alleviating Lysosomal membrane permeabilization-Induced necroptosis. Autophagy. 2022;18:1841\u201363. https:\/\/doi.org\/10.1080\/15548627.2021.2002109.","journal-title":"Autophagy"},{"key":"1879_CR38","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1038\/cdd.2015.92","volume":"23","author":"S Yoon","year":"2016","unstructured":"Yoon S, Bogdanov K, Kovalenko A, Wallach D. Necroptosis is preceded by nuclear translocation of the signaling proteins that induce it. Cell Death Differ. 2016;23:253\u201360. https:\/\/doi.org\/10.1038\/cdd.2015.92.","journal-title":"Cell Death Differ"},{"key":"1879_CR39","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.jphs.2022.12.009","volume":"151","author":"S Ino","year":"2023","unstructured":"Ino S, Yano T, Kuno A, Tanno M, Kouzu H, Sato T, et al. Nuclear translocation of MLKL enhances necroptosis by a RIP1\/RIP3-independent mechanism in H9c2 cardiomyoblasts. J Pharmacol Sci. 2023;151:134\u201343. https:\/\/doi.org\/10.1016\/j.jphs.2022.12.009.","journal-title":"J Pharmacol Sci"},{"key":"1879_CR40","doi-asserted-by":"publisher","first-page":"920464","DOI":"10.3389\/fimmu.2022.920464","volume":"13","author":"J Sun","year":"2022","unstructured":"Sun J, Li Y. Pyroptosis and respiratory diseases: a review of current knowledge. Front Immunol. 2022;13:920464. https:\/\/doi.org\/10.3389\/fimmu.2022.920464.","journal-title":"Front Immunol"},{"key":"1879_CR41","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.2147\/JIR.S398203","volume":"16","author":"J-Y Dong","year":"2023","unstructured":"Dong J-Y, Yin H-L, Hao H, Liu Y. Research progress on autophagy regulation by active ingredients of traditional Chinese medicine in the treatment of acute lung injury. J Inflamm Res. 2023;16:1671\u201391. https:\/\/doi.org\/10.2147\/JIR.S398203.","journal-title":"J Inflamm Res"},{"key":"1879_CR42","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/s0092-8674(00)81266-0","volume":"85","author":"M Muzio","year":"1996","unstructured":"Muzio M, Chinnaiyan AM, Kischkel FC, O\u2019Rourke K, Shevchenko A, Ni J, et al. FLICE, a novel FADD-homologous ICE\/CED-3-like protease, is recruited to the CD95 (Fas\/APO-1) death\u2013inducing signaling complex. Cell. 1996;85:817\u201327. https:\/\/doi.org\/10.1016\/s0092-8674(00)81266-0.","journal-title":"Cell"},{"key":"1879_CR43","doi-asserted-by":"publisher","first-page":"9714","DOI":"10.1073\/pnas.1901179116","volume":"116","author":"A Degterev","year":"2019","unstructured":"Degterev A, Ofengeim D, Yuan J. Targeting RIPK1 for the treatment of human diseases. P Natl Acad Sci Usa. 2019;116:9714\u201322. https:\/\/doi.org\/10.1073\/pnas.1901179116.","journal-title":"P Natl Acad Sci Usa"},{"key":"1879_CR44","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/j.cub.2007.01.027","volume":"17","author":"MA O\u2019Donnell","year":"2007","unstructured":"O\u2019Donnell MA, Legarda-Addison D, Skountzos P, Yeh WC, Ting AT. Ubiquitination of RIP1 regulates an NF-kappaB-independent cell-death switch in TNF signaling. Curr Biol. 2007;17:418\u201324. https:\/\/doi.org\/10.1016\/j.cub.2007.01.027.","journal-title":"Curr Biol"},{"key":"1879_CR45","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1038\/nature09852","volume":"471","author":"A Oberst","year":"2011","unstructured":"Oberst A, Dillon CP, Weinlich R, McCormick LL, Fitzgerald P, Pop C, et al. Catalytic activity of the caspase-8-FLIPL complex inhibits RIPK3-dependent necrosis. Nature. 2011;471:363\u20137. https:\/\/doi.org\/10.1038\/nature09852.","journal-title":"Nature"},{"key":"1879_CR46","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1038\/s41586-019-1548-x","volume":"574","author":"K Newton","year":"2019","unstructured":"Newton K, Wickliffe KE, Dugger DL, Maltzman A, Roose-Girma M, Dohse M, et al. Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis. Nature. 2019;574:428\u201331. https:\/\/doi.org\/10.1038\/s41586-019-1548-x.","journal-title":"Nature"},{"key":"1879_CR47","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1042\/BJ20101738","volume":"433","author":"C Pop","year":"2011","unstructured":"Pop C, Oberst A, Drag M, Van Raam BJ, Riedl SJ, Green DR, et al. FLIPL induces caspase-8 activity in the absence of interdomain caspase-8 cleavage and alters substrate specificity. Biochem J. 2011;433:447\u201357. https:\/\/doi.org\/10.1042\/BJ20101738.","journal-title":"Biochem J"},{"key":"1879_CR48","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1038\/ncb2362","volume":"13","author":"MA O\u2019Donnell","year":"2011","unstructured":"O\u2019Donnell MA, Perez-Jimenez E, Oberst A, Ng A, Massoumi R, Xavier R, et al. CASPASE 8 inhibits programmed necrosis by processing CYLD. Nat Cell Biol. 2011;13:1437\u201342. https:\/\/doi.org\/10.1038\/ncb2362.","journal-title":"Nat Cell Biol"},{"key":"1879_CR49","doi-asserted-by":"publisher","first-page":"4246","DOI":"10.1111\/febs.15260","volume":"287","author":"P Smyth","year":"2020","unstructured":"Smyth P, Sessler T, Scott CJ, Longley DB. FLIP(L): the pseudo-caspase. FEBS J. 2020;287:4246\u201360. https:\/\/doi.org\/10.1111\/febs.15260.","journal-title":"FEBS J"},{"key":"1879_CR50","doi-asserted-by":"publisher","first-page":"30321","DOI":"10.3390\/ijms161226232","volume":"16","author":"Y Tsuchiya","year":"2015","unstructured":"Tsuchiya Y, Nakabayashi O, Nakano H. FLIP the switch: regulation of apoptosis and necroptosis by cFLIP. Int J Mol Sci. 2015;16:30321\u201341. https:\/\/doi.org\/10.3390\/ijms161226232.","journal-title":"Int J Mol Sci"},{"key":"1879_CR51","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1038\/nature20559","volume":"540","author":"K Newton","year":"2016","unstructured":"Newton K, Wickliffe KE, Maltzman A, Dugger DL, Strasser A, Pham VC, et al. RIPK1 inhibits ZBP1-driven necroptosis during development. Nature. 2016;540:129\u201333. https:\/\/doi.org\/10.1038\/nature20559.","journal-title":"Nature"},{"key":"1879_CR52","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1038\/nature20558","volume":"540","author":"J Lin","year":"2016","unstructured":"Lin J, Kumari S, Kim C, Van T-M, Wachsmuth L, Polykratis A, et al. RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation. Nature. 2016;540:124\u20138. https:\/\/doi.org\/10.1038\/nature20558.","journal-title":"Nature"},{"key":"1879_CR53","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1038\/cdd.2014.76","volume":"21","author":"S Orozco","year":"2014","unstructured":"Orozco S, Yatim N, Werner MR, Tran H, Gunja SY, Tait SWG, et al. RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis. Cell Death Differ. 2014;21:1511\u201321. https:\/\/doi.org\/10.1038\/cdd.2014.76.","journal-title":"Cell Death Differ"},{"key":"1879_CR54","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1126\/science.1249361","volume":"343","author":"K Newton","year":"2014","unstructured":"Newton K, Dugger DL, Wickliffe KE, Kapoor N, de Almagro MC, Vucic D, et al. Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis. Science. 2014;343:1357\u201360. https:\/\/doi.org\/10.1126\/science.1249361.","journal-title":"Science"},{"key":"1879_CR55","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1038\/cr.2015.139","volume":"25","author":"W He","year":"2015","unstructured":"He W, Wan H, Hu L, Chen P, Wang X, Huang Z, et al. Gasdermin D is an executor of pyroptosis and required for interleukin-1\u03b2 secretion. Cell Res. 2015;25:1285\u201398. https:\/\/doi.org\/10.1038\/cr.2015.139.","journal-title":"Cell Res"},{"key":"1879_CR56","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/j.gendis.2023.01.009","volume":"11","author":"X Que","year":"2023","unstructured":"Que X, Zheng S, Song Q, Pei H, Zhang P. Fantastic voyage: the journey of NLRP3 inflammasome activation. Genes Dis. 2023;11:819\u201329. https:\/\/doi.org\/10.1016\/j.gendis.2023.01.009.","journal-title":"Genes Dis"},{"key":"1879_CR57","doi-asserted-by":"publisher","first-page":"3995","DOI":"10.4049\/jimmunol.1301681","volume":"191","author":"T Fernandes-Alnemri","year":"2013","unstructured":"Fernandes-Alnemri T, Kang S, Anderson C, Sagara J, Fitzgerald KA, Alnemri ES. Cutting edge: TLR signaling licenses IRAK1 for rapid activation of the NLRP3 inflammasome. J Immunol. 2013;191:3995\u20139. https:\/\/doi.org\/10.4049\/jimmunol.1301681.","journal-title":"J Immunol"},{"key":"1879_CR58","doi-asserted-by":"publisher","first-page":"E10888","DOI":"10.1073\/pnas.1809548115","volume":"115","author":"J Sarhan","year":"2018","unstructured":"Sarhan J, Liu BC, Muendlein HI, Li P, Nilson R, Tang AY, et al. Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection. P Natl Acad Sci Usa. 2018;115:E10888\u201397. https:\/\/doi.org\/10.1073\/pnas.1809548115.","journal-title":"P Natl Acad Sci Usa"},{"key":"1879_CR59","doi-asserted-by":"publisher","first-page":"20191644","DOI":"10.1084\/jem.20191644","volume":"217","author":"RKS Malireddi","year":"2020","unstructured":"Malireddi RKS, Gurung P, Kesavardhana S, Samir P, Burton A, Mummareddy H, et al. Innate immune priming in the absence of TAK1 drives RIPK1 kinase activity-independent pyroptosis, apoptosis, necroptosis, and inflammatory disease. J Exp Med. 2020;217:20191644. https:\/\/doi.org\/10.1084\/jem.20191644.","journal-title":"J Exp Med"},{"key":"1879_CR60","doi-asserted-by":"publisher","first-page":"7515","DOI":"10.1038\/ncomms8515","volume":"6","author":"S Kang","year":"2015","unstructured":"Kang S, Fernandes-Alnemri T, Rogers C, Mayes L, Wang Y, Dillon C, et al. Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3. Nat Commun. 2015;6:7515. https:\/\/doi.org\/10.1038\/ncomms8515.","journal-title":"Nat Commun"},{"key":"1879_CR61","doi-asserted-by":"publisher","first-page":"2156","DOI":"10.4049\/jimmunol.1601757","volume":"198","author":"KD Gutierrez","year":"2017","unstructured":"Gutierrez KD, Davis MA, Daniels BP, Olsen TM, Ralli-Jain P, Tait SWG, et al. MLKL activation triggers NLRP3-mediated processing and release of IL-1\u03b2 independently of gasdermin-D. J Immunol. 2017;198:2156\u201364. https:\/\/doi.org\/10.4049\/jimmunol.1601757.","journal-title":"J Immunol"},{"key":"1879_CR62","doi-asserted-by":"publisher","first-page":"E961","DOI":"10.1073\/pnas.1613305114","volume":"114","author":"SA Conos","year":"2017","unstructured":"Conos SA, Chen KW, De Nardo D, Hara H, Whitehead L, N\u00fa\u00f1ez G, et al. Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner. P Natl Acad Sci USA. 2017;114:E961\u20139. https:\/\/doi.org\/10.1073\/pnas.1613305114.","journal-title":"P Natl Acad Sci USA"},{"key":"1879_CR63","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.4049\/jimmunol.1402167","volume":"194","author":"K Moriwaki","year":"2015","unstructured":"Moriwaki K, Bertin J, Gough PJ, Chan FK-M. A RIPK3-caspase 8 complex mediates atypical pro-IL-1\u03b2 processing. J Immunol. 2015;194:1938\u201344. https:\/\/doi.org\/10.4049\/jimmunol.1402167.","journal-title":"J Immunol"},{"key":"1879_CR64","doi-asserted-by":"publisher","first-page":"6282","DOI":"10.1038\/ncomms7282","volume":"6","author":"KE Lawlor","year":"2015","unstructured":"Lawlor KE, Khan N, Mildenhall A, Gerlic M, Croker BA, D\u2019Cruz AA, et al. RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL. Nat Commun. 2015;6:6282. https:\/\/doi.org\/10.1038\/ncomms7282.","journal-title":"Nat Commun"},{"key":"1879_CR65","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.immuni.2012.09.015","volume":"38","author":"T-B Kang","year":"2013","unstructured":"Kang T-B, Yang S-H, Toth B, Kovalenko A, Wallach D. Caspase-8 blocks kinase RIPK3-mediated activation of the NLRP3 inflammasome. Immunity. 2013;38:27\u201340. https:\/\/doi.org\/10.1016\/j.immuni.2012.09.015.","journal-title":"Immunity"},{"key":"1879_CR66","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1016\/j.jhep.2020.03.023","volume":"73","author":"X Wu","year":"2020","unstructured":"Wu X, Poulsen KL, Sanz-Garcia C, Huang E, McMullen MR, Roychowdhury S, et al. MLKL-dependent signaling regulates autophagic flux in a murine model of non-alcohol-associated fatty liver and steatohepatitis. J Hepatol. 2020;73:616\u201327. https:\/\/doi.org\/10.1016\/j.jhep.2020.03.023.","journal-title":"J Hepatol"},{"key":"1879_CR67","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1038\/s41418-018-0235-z","volume":"26","author":"F-X Guo","year":"2019","unstructured":"Guo F-X, Wu Q, Li P, Zheng L, Ye S, Dai X-Y, et al. The role of the LncRNA-FA2H-2-MLKL pathway in atherosclerosis by regulation of autophagy flux and inflammation through mTOR-dependent signaling. Cell Death Differ. 2019;26:1670\u201387. https:\/\/doi.org\/10.1038\/s41418-018-0235-z.","journal-title":"Cell Death Differ"},{"key":"1879_CR68","doi-asserted-by":"publisher","first-page":"3992","DOI":"10.1080\/15548627.2021.1899667","volume":"17","author":"W Wu","year":"2021","unstructured":"Wu W, Wang X, Sun Y, Berleth N, Deitersen J, Schl\u00fctermann D, et al. TNF-induced necroptosis initiates early autophagy events via RIPK3-dependent AMPK activation, but inhibits late autophagy. Autophagy. 2021;17:3992\u20134009. https:\/\/doi.org\/10.1080\/15548627.2021.1899667.","journal-title":"Autophagy"},{"key":"1879_CR69","doi-asserted-by":"publisher","first-page":"3640","DOI":"10.1083\/jcb.201711002","volume":"217","author":"J Mejlvang","year":"2018","unstructured":"Mejlvang J, Olsvik H, Svenning S, Bruun J-A, Abudu YP, Larsen KB, et al. Starvation induces rapid degradation of selective autophagy receptors by endosomal microautophagy. J Cell Biol. 2018;217:3640\u201355. https:\/\/doi.org\/10.1083\/jcb.201711002.","journal-title":"J Cell Biol"},{"key":"1879_CR70","doi-asserted-by":"publisher","unstructured":"Zhan Q, Jeon J, Li Y, Huang Y, Xiong J, Wang Q, et al. CAMK2\/CaMKII activates MLKL in short-term starvation to facilitate autophagic flux. Autophagy, 18:726\u201344. https:\/\/doi.org\/10.1080\/15548627.2021.1954348","DOI":"10.1080\/15548627.2021.1954348"},{"key":"1879_CR71","doi-asserted-by":"publisher","first-page":"2855","DOI":"10.1038\/s41467-018-05254-w","volume":"9","author":"Y Takahashi","year":"2018","unstructured":"Takahashi Y, He H, Tang Z, Hattori T, Liu Y, Young MM, et al. An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure. Nat Commun. 2018;9:2855. https:\/\/doi.org\/10.1038\/s41467-018-05254-w.","journal-title":"Nat Commun"},{"key":"1879_CR72","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1126\/science.aaf6136","volume":"354","author":"K Tsuboyama","year":"2016","unstructured":"Tsuboyama K, Koyama-Honda I, Sakamaki Y, Koike M, Morishita H, Mizushima N. The ATG conjugation systems are important for degradation of the inner autophagosomal membrane. Science. 2016;354:1036\u201341. https:\/\/doi.org\/10.1126\/science.aaf6136.","journal-title":"Science"},{"key":"1879_CR73","doi-asserted-by":"publisher","first-page":"2054","DOI":"10.1080\/15548627.2020.1810918","volume":"17","author":"X Chen","year":"2021","unstructured":"Chen X, Li J, Kang R, Klionsky DJ, Tang D. Ferroptosis: machinery and regulation. Autophagy. 2021;17:2054\u201381. https:\/\/doi.org\/10.1080\/15548627.2020.1810918.","journal-title":"Autophagy"},{"key":"1879_CR74","doi-asserted-by":"publisher","first-page":"4073","DOI":"10.2147\/JIR.S420676","volume":"16","author":"Y Wang","year":"2023","unstructured":"Wang Y, Zhao Z, Xiao Z. The emerging roles of ferroptosis in pathophysiology and treatment of acute lung injury. J Inflamm Res. 2023;16:4073\u201385. https:\/\/doi.org\/10.2147\/JIR.S420676.","journal-title":"J Inflamm Res"},{"key":"1879_CR75","doi-asserted-by":"publisher","first-page":"e2716","DOI":"10.1038\/cddis.2017.133","volume":"8","author":"F Basit","year":"2017","unstructured":"Basit F, van Oppen LM, Sch\u00f6ckel L, Bossenbroek HM, van Emst-de Vries SE, Hermeling JC, et al. Mitochondrial complex I inhibition triggers a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis in melanoma cells. Cell Death Dis. 2017;8:e2716. https:\/\/doi.org\/10.1038\/cddis.2017.133.","journal-title":"Cell Death Dis"},{"key":"1879_CR76","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1161\/STROKEAHA.116.015609","volume":"48","author":"M Zille","year":"2017","unstructured":"Zille M, Karuppagounder SS, Chen Y, Gough PJ, Bertin J, Finger J, et al. Neuronal death after hemorrhagic stroke in vitro and in vivo shares features of ferroptosis and necroptosis. Stroke. 2017;48:1033\u201343. https:\/\/doi.org\/10.1161\/STROKEAHA.116.015609.","journal-title":"Stroke"},{"key":"1879_CR77","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s40659-021-00361-3","volume":"54","author":"P Maniam","year":"2021","unstructured":"Maniam P, Essilfie A-T, Kalimutho M, Ling D, Frazer DM, Phipps S, et al. Increased susceptibility of cystic fibrosis airway epithelial cells to ferroptosis. Biol Res. 2021;54:38. https:\/\/doi.org\/10.1186\/s40659-021-00361-3.","journal-title":"Biol Res"},{"key":"1879_CR78","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.neuro.2022.11.003","volume":"94","author":"S Naderi","year":"2023","unstructured":"Naderi S, Khodagholi F, Pourbadie HG, Naderi N, Rafiei S, Janahmadi M, et al. Role of amyloid beta (25\u201335) neurotoxicity in the ferroptosis and necroptosis as modalities of regulated cell death in Alzheimer\u2019s disease. Neurotoxicology. 2023;94:71\u201386. https:\/\/doi.org\/10.1016\/j.neuro.2022.11.003.","journal-title":"Neurotoxicology"},{"key":"1879_CR79","doi-asserted-by":"publisher","first-page":"14329","DOI":"10.1038\/ncomms14329","volume":"8","author":"Y Zhang","year":"2017","unstructured":"Zhang Y, Su SS, Zhao S, Yang Z, Zhong CQ, Chen X, et al. RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome. Nat Commun. 2017;8:14329. https:\/\/doi.org\/10.1038\/ncomms14329.","journal-title":"Nat Commun"},{"key":"1879_CR80","doi-asserted-by":"publisher","first-page":"102840","DOI":"10.1016\/j.redox.2023.102840","volume":"65","author":"Y Tong","year":"2023","unstructured":"Tong Y, Wu Y, Ma J, Ikeda M, Ide T, Griffin CT, et al. Comparative mechanistic study of RPE cell death induced by different oxidative stresses. Redox Biol. 2023;65:102840. https:\/\/doi.org\/10.1016\/j.redox.2023.102840.","journal-title":"Redox Biol"},{"key":"1879_CR81","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1182\/blood-2023-173275","volume":"142","author":"K Ventura","year":"2023","unstructured":"Ventura K, Prokopec J, Neupane B, Gao Z, Du W, Gong Y, et al. A necroptosis inhibitor functions as a ferroptosis inducer in drug-resistant myeloid malignancies. Blood. 2023;142:413. https:\/\/doi.org\/10.1182\/blood-2023-173275.","journal-title":"Blood"},{"key":"1879_CR82","doi-asserted-by":"publisher","first-page":"114069","DOI":"10.1016\/j.fct.2023.114069","volume":"181","author":"HM Mansour","year":"2023","unstructured":"Mansour HM, Mohamed AF, Khattab MM, El-Khatib AS. Pazopanib ameliorates rotenone-induced Parkinsonism in rats by suppressing multiple regulated cell death mechanisms. Food Chem Toxicol. 2023;181:114069. https:\/\/doi.org\/10.1016\/j.fct.2023.114069.","journal-title":"Food Chem Toxicol"},{"key":"1879_CR83","doi-asserted-by":"publisher","first-page":"10519","DOI":"10.1074\/jbc.275.14.10519","volume":"275","author":"J Lewis","year":"2000","unstructured":"Lewis J, Devin A, Miller A, Lin Y, Rodriguez Y, Neckers L, et al. Disruption of hsp90 function results in degradation of the death domain kinase, receptor-interacting protein (RIP), and blockage of tumor necrosis factor-induced nuclear factor-kappaB activation. J Biol Chem. 2000;275:10519\u201326. https:\/\/doi.org\/10.1074\/jbc.275.14.10519.","journal-title":"J Biol Chem"},{"key":"1879_CR84","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1007\/s00109-020-01886-y","volume":"98","author":"X Yu","year":"2020","unstructured":"Yu X, Mao M, Liu X, Shen T, Li T, Yu H, et al. A cytosolic heat shock protein 90 and co-chaperone p23 complex activates RIPK3\/MLKL during necroptosis of endothelial cells in acute respiratory distress syndrome. J Mol Med (Berl). 2020;98:569\u201383. https:\/\/doi.org\/10.1007\/s00109-020-01886-y.","journal-title":"J Mol Med (Berl)"},{"key":"1879_CR85","doi-asserted-by":"publisher","first-page":"e2089","DOI":"10.1038\/cddis.2015.390","volume":"7","author":"XM Zhao","year":"2016","unstructured":"Zhao XM, Chen Z, Zhao JB, Zhang PP, Pu YF, Jiang SH, et al. Hsp90 modulates the stability of MLKL and is required for TNF-induced necroptosis. Cell Death Dis. 2016;7:e2089. https:\/\/doi.org\/10.1038\/cddis.2015.390.","journal-title":"Cell Death Dis"},{"key":"1879_CR86","doi-asserted-by":"publisher","first-page":"2996","DOI":"10.1073\/pnas.1819728116","volume":"116","author":"Z Wu","year":"2019","unstructured":"Wu Z, Geng Y, Lu X, Shi Y, Wu G, Zhang M, et al. Chaperone-mediated autophagy is involved in the execution of ferroptosis. Proc Natl Acad Sci USA. 2019;116:2996\u20133005. https:\/\/doi.org\/10.1073\/pnas.1819728116.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1879_CR87","doi-asserted-by":"publisher","first-page":"114588","DOI":"10.18632\/oncotarget.23055","volume":"8","author":"M-S Chen","year":"2017","unstructured":"Chen M-S, Wang S-F, Hsu C-Y, Yin P-H, Yeh T-S, Lee H-C, et al. CHAC1 degradation of glutathione enhances cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2\u03b1-ATF4 pathway. Oncotarget. 2017;8:114588\u2013602.","journal-title":"Oncotarget"},{"key":"1879_CR88","doi-asserted-by":"publisher","first-page":"3631","DOI":"10.1007\/s00018-017-2547-4","volume":"74","author":"T M\u00fcller","year":"2017","unstructured":"M\u00fcller T, Dewitz C, Schmitz J, Schr\u00f6der AS, Br\u00e4sen JH, Stockwell BR, et al. Necroptosis and ferroptosis are alternative cell death pathways that operate in acute kidney failure. Cell Mol Life Sci. 2017;74:3631\u201345. https:\/\/doi.org\/10.1007\/s00018-017-2547-4.","journal-title":"Cell Mol Life Sci"},{"key":"1879_CR89","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.3390\/ijms25031464","volume":"25","author":"X Zhou","year":"2024","unstructured":"Zhou X, Jin J, Lv T, Song Y. A narrative review: the role of NETs in acute respiratory distress syndrome\/acute lung injury. Int J Mol Sci. 2024;25:1464. https:\/\/doi.org\/10.3390\/ijms25031464.","journal-title":"Int J Mol Sci"},{"key":"1879_CR90","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.chom.2012.05.015","volume":"12","author":"T Saitoh","year":"2012","unstructured":"Saitoh T, Komano J, Saitoh Y, Misawa T, Takahama M, Kozaki T, et al. Neutrophil extracellular traps mediate a host defense response to human immunodeficiency virus-1. Cell Host Microbe. 2012;12:109\u201316. https:\/\/doi.org\/10.1016\/j.chom.2012.05.015.","journal-title":"Cell Host Microbe"},{"key":"1879_CR91","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1126\/science.1092385","volume":"303","author":"V Brinkmann","year":"2004","unstructured":"Brinkmann V, Reichard U, Goosmann C, Fauler B, Uhlemann Y, Weiss DS, et al. Neutrophil extracellular traps kill bacteria. Science. 2004;303:1532\u20135. https:\/\/doi.org\/10.1126\/science.1092385.","journal-title":"Science"},{"key":"1879_CR92","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1111\/j.1462-5822.2005.00659.x","volume":"8","author":"CF Urban","year":"2006","unstructured":"Urban CF, Reichard U, Brinkmann V, Zychlinsky A. Neutrophil extracellular traps capture and kill Candida albicans yeast and hyphal forms. Cell Microbiol. 2006;8:668\u201376. https:\/\/doi.org\/10.1111\/j.1462-5822.2005.00659.x.","journal-title":"Cell Microbiol"},{"key":"1879_CR93","doi-asserted-by":"publisher","first-page":"7326","DOI":"10.1073\/pnas.1909546117","volume":"117","author":"HR Thiam","year":"2020","unstructured":"Thiam HR, Wong SL, Qiu R, Kittisopikul M, Vahabikashi A, Goldman AE, et al. NETosis proceeds by cytoskeleton and endomembrane disassembly and PAD4-mediated chromatin decondensation and nuclear envelope rupture. P Natl Acad Sci Usa. 2020;117:7326\u201337. https:\/\/doi.org\/10.1073\/pnas.1909546117.","journal-title":"P Natl Acad Sci Usa"},{"key":"1879_CR94","doi-asserted-by":"publisher","first-page":"7413","DOI":"10.4049\/jimmunol.1000675","volume":"185","author":"FH Pilsczek","year":"2010","unstructured":"Pilsczek FH, Salina D, Poon KKH, Fahey C, Yipp BG, Sibley CD, et al. A novel mechanism of rapid nuclear neutrophil extracellular trap formation in response to Staphylococcus aureus. J Immunol. 2010;185:7413\u201325. https:\/\/doi.org\/10.4049\/jimmunol.1000675.","journal-title":"J Immunol"},{"key":"1879_CR95","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1083\/jcb.200606027","volume":"176","author":"TA Fuchs","year":"2007","unstructured":"Fuchs TA, Abed U, Goosmann C, Hurwitz R, Schulze I, Wahn V, et al. Novel cell death program leads to neutrophil extracellular traps. J Cell Biol. 2007;176:231\u201341. https:\/\/doi.org\/10.1083\/jcb.200606027.","journal-title":"J Cell Biol"},{"key":"1879_CR96","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1146\/annurev-cellbio-020520-111016","volume":"36","author":"HR Thiam","year":"2020","unstructured":"Thiam HR, Wong SL, Wagner DD, Waterman CM. Cellular mechanisms of NETosis. Annu Rev Cell Dev Bi. 2020;36:191\u2013218. https:\/\/doi.org\/10.1146\/annurev-cellbio-020520-111016.","journal-title":"Annu Rev Cell Dev Bi"},{"key":"1879_CR97","doi-asserted-by":"publisher","first-page":"E9618","DOI":"10.1073\/pnas.1708247114","volume":"114","author":"A Schreiber","year":"2017","unstructured":"Schreiber A, Rousselle A, Becker JU, von M\u00e4ssenhausen A, Linkermann A, Kettritz R. Necroptosis controls NET generation and mediates complement activation, endothelial damage, and autoimmune vasculitis. P Natl Acad Sci USA. 2017;114:E9618\u201325. https:\/\/doi.org\/10.1073\/pnas.1708247114.","journal-title":"P Natl Acad Sci USA"},{"key":"1879_CR98","doi-asserted-by":"publisher","first-page":"15003","DOI":"10.1038\/s41598-017-15106-0","volume":"7","author":"J Desai","year":"2017","unstructured":"Desai J, Foresto-Neto O, Honarpisheh M, Steiger S, Nakazawa D, Popper B, et al. Particles of different sizes and shapes induce neutrophil necroptosis followed by the release of neutrophil extracellular trap-like chromatin. Sci Rep. 2017;7:15003. https:\/\/doi.org\/10.1038\/s41598-017-15106-0.","journal-title":"Sci Rep"},{"key":"1879_CR99","doi-asserted-by":"publisher","first-page":"4743975","DOI":"10.1155\/2023\/4743975","volume":"2023","author":"X Han","year":"2023","unstructured":"Han X, Zhang X, Song R, Li S, Zou S, Tan Q, et al. Necrostatin-1 alleviates diffuse pulmonary haemorrhage by preventing the release of NETs via inhibiting NE\/GSDMD activation in murine lupus. J Immunol Res. 2023;2023:4743975. https:\/\/doi.org\/10.1155\/2023\/4743975.","journal-title":"J Immunol Res"},{"key":"1879_CR100","doi-asserted-by":"publisher","first-page":"11163","DOI":"10.18632\/aging.103528","volume":"12","author":"RKS Malireddi","year":"2020","unstructured":"Malireddi RKS, Tweedell RE, Kanneganti T-D. PANoptosis components, regulation, and implications. Aging (Albany NY). 2020;12:11163\u20134. https:\/\/doi.org\/10.18632\/aging.103528.","journal-title":"Aging (Albany NY)"},{"key":"1879_CR101","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.mib.2020.07.012","volume":"59","author":"DE Place","year":"2021","unstructured":"Place DE, Lee S, Kanneganti T-D. PANoptosis in microbial infection. Curr Opin Microbiol. 2021;59:42\u20139. https:\/\/doi.org\/10.1016\/j.mib.2020.07.012.","journal-title":"Curr Opin Microbiol"},{"key":"1879_CR102","doi-asserted-by":"publisher","first-page":"406","DOI":"10.3389\/fcimb.2019.00406","volume":"9","author":"RKS Malireddi","year":"2019","unstructured":"Malireddi RKS, Kesavardhana S, Kanneganti T-D. ZBP1 and TAK1: master regulators of NLRP3 inflammasome\/pyroptosis, apoptosis, and necroptosis (PAN-optosis). Front Cell Infect Mi. 2019;9:406. https:\/\/doi.org\/10.3389\/fcimb.2019.00406.","journal-title":"Front Cell Infect Mi"},{"key":"1879_CR103","doi-asserted-by":"publisher","first-page":"568","DOI":"10.4049\/immunohorizons.2100059","volume":"5","author":"RK Subbarao Malireddi","year":"2021","unstructured":"Subbarao Malireddi RK, Karki R, Sundaram B, Kancharana B, Lee S, Samir P, et al. Inflammatory cell death, PANoptosis, mediated by cytokines in diverse cancer lineages inhibits tumor growth. Immunohorizons. 2021;5:568\u201380. https:\/\/doi.org\/10.4049\/immunohorizons.2100059.","journal-title":"Immunohorizons"},{"key":"1879_CR104","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.3390\/cells11091495","volume":"11","author":"JM Gullett","year":"2022","unstructured":"Gullett JM, Tweedell RE, Kanneganti T-D. It\u2019s all in the PAN: crosstalk, plasticity, redundancies, switches, and interconnectedness encompassed by panoptosis underlying the totality of cell death-associated biological effects. Cells-Basel. 2022;11:1495. https:\/\/doi.org\/10.3390\/cells11091495.","journal-title":"Cells-Basel"},{"key":"1879_CR105","doi-asserted-by":"publisher","first-page":"109858","DOI":"10.1016\/j.celrep.2021.109858","volume":"37","author":"R Karki","year":"2021","unstructured":"Karki R, Sundaram B, Sharma BR, Lee S, Malireddi RKS, Nguyen LN, et al. ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis. Cell Rep. 2021;37:109858. https:\/\/doi.org\/10.1016\/j.celrep.2021.109858.","journal-title":"Cell Rep"},{"key":"1879_CR106","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/s41586-021-03875-8","volume":"597","author":"S Lee","year":"2021","unstructured":"Lee S, Karki R, Wang Y, Nguyen LN, Kalathur RC, Kanneganti T-D. AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence. Nature. 2021;597:415\u20139. https:\/\/doi.org\/10.1038\/s41586-021-03875-8.","journal-title":"Nature"},{"key":"1879_CR107","doi-asserted-by":"publisher","first-page":"789","DOI":"10.4049\/immunohorizons.2000097","volume":"4","author":"RKS Malireddi","year":"2020","unstructured":"Malireddi RKS, Kesavardhana S, Karki R, Kancharana B, Burton AR, Kanneganti T-D. RIPK1 distinctly regulates Yersinia-induced inflammatory cell death. PANoptosis Immunohorizons. 2020;4:789\u201396. https:\/\/doi.org\/10.4049\/immunohorizons.2000097.","journal-title":"PANoptosis Immunohorizons"},{"key":"1879_CR108","doi-asserted-by":"publisher","first-page":"2783","DOI":"10.1016\/j.cell.2023.05.005","volume":"186","author":"B Sundaram","year":"2023","unstructured":"Sundaram B, Pandian N, Mall R, Wang Y, Sarkar R, Kim HJ, et al. NLRP12-PANoptosome activates PANoptosis and pathology in response to heme and PAMPs. Cell. 2023;186:2783-2801.e20. https:\/\/doi.org\/10.1016\/j.cell.2023.05.005.","journal-title":"Cell"},{"key":"1879_CR109","doi-asserted-by":"publisher","first-page":"238","DOI":"10.3389\/fcimb.2020.00238","volume":"10","author":"P Samir","year":"2020","unstructured":"Samir P, Malireddi RKS, Kanneganti T-D. The PANoptosome: a deadly protein complex driving pyroptosis, apoptosis, and necroptosis (PANoptosis). Front Cell Infect Mi. 2020;10:238. https:\/\/doi.org\/10.3389\/fcimb.2020.00238.","journal-title":"Front Cell Infect Mi"},{"issue":"e99692","key":"1879_CR110","doi-asserted-by":"publisher","first-page":"99692","DOI":"10.1172\/jci.insight.99692","volume":"3","author":"KC Ma","year":"2018","unstructured":"Ma KC, Schenck EJ, Siempos II, Cloonan SM, Finkelsztein EJ, Pabon MA, et al. Circulating RIPK3 levels are associated with mortality and organ failure during critical illness. JCI Insight. 2018;3(e99692):99692. https:\/\/doi.org\/10.1172\/jci.insight.99692.","journal-title":"JCI Insight"},{"key":"1879_CR111","doi-asserted-by":"publisher","first-page":"588","DOI":"10.3390\/ijms19020588","volume":"19","author":"C-Y Yang","year":"2018","unstructured":"Yang C-Y, Chen C-S, Yiang G-T, Cheng Y-L, Yong S-B, Wu M-Y, et al. New insights into the immune molecular regulation of the pathogenesis of acute respiratory distress syndrome. Int J Mol Sci. 2018;19:588. https:\/\/doi.org\/10.3390\/ijms19020588.","journal-title":"Int J Mol Sci"},{"key":"1879_CR112","doi-asserted-by":"publisher","first-page":"2568","DOI":"10.1038\/s41418-020-0524-1","volume":"27","author":"H Chen","year":"2020","unstructured":"Chen H, Li Y, Wu J, Li G, Tao X, Lai K, et al. RIPK3 collaborates with GSDMD to drive tissue injury in lethal polymicrobial sepsis. Cell Death Differ. 2020;27:2568\u201385. https:\/\/doi.org\/10.1038\/s41418-020-0524-1.","journal-title":"Cell Death Differ"},{"key":"1879_CR113","doi-asserted-by":"publisher","first-page":"166613","DOI":"10.1016\/j.bbadis.2022.166613","volume":"1869","author":"H Li","year":"2023","unstructured":"Li H, Guan J, Chen J, Sun W, Chen H, Wen Y, et al. Necroptosis signaling and NLRP3 inflammasome cross-talking in epithelium facilitate Pseudomonas aeruginosa mediated lung injury. Biochim Biophys Acta Mol Basis Dis. 2023;1869:166613. https:\/\/doi.org\/10.1016\/j.bbadis.2022.166613.","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"1879_CR114","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1038\/s41419-018-0524-y","volume":"9","author":"K Zhu","year":"2018","unstructured":"Zhu K, Liang W, Ma Z, Xu D, Cao S, Lu X, et al. Necroptosis promotes cell-autonomous activation of proinflammatory cytokine gene expression. Cell Death Dis. 2018;9:500. https:\/\/doi.org\/10.1038\/s41419-018-0524-y.","journal-title":"Cell Death Dis"},{"key":"1879_CR115","doi-asserted-by":"publisher","first-page":"2275","DOI":"10.1016\/j.celrep.2019.07.077","volume":"28","author":"SL Orozco","year":"2019","unstructured":"Orozco SL, Daniels BP, Yatim N, Messmer MN, Quarato G, Chen-Harris H, et al. RIPK3 activation leads to cytokine synthesis that continues after loss of cell membrane integrity. Cell Rep. 2019;28:2275-2287.e5. https:\/\/doi.org\/10.1016\/j.celrep.2019.07.077.","journal-title":"Cell Rep"},{"key":"1879_CR116","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1165\/rcmb.2019-0337TR","volume":"62","author":"S Minagawa","year":"2020","unstructured":"Minagawa S, Yoshida M, Araya J, Hara H, Imai H, Kuwano K. Regulated necrosis in pulmonary disease a focus on necroptosis and ferroptosis. Am J Resp Cell Mol. 2020;62:554\u201362. https:\/\/doi.org\/10.1165\/rcmb.2019-0337TR.","journal-title":"Am J Resp Cell Mol"},{"key":"1879_CR117","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1189\/jlb.3HI0517-173R","volume":"103","author":"Y Jiao","year":"2018","unstructured":"Jiao Y, Li Z, Loughran PA, Fan EK, Scott MJ, Li Y, et al. Frontline science: macrophage-derived exosomes promote neutrophil necroptosis following hemorrhagic shock. J Leukocyte Biol. 2018;103:175\u201383. https:\/\/doi.org\/10.1189\/jlb.3HI0517-173R.","journal-title":"J Leukocyte Biol"},{"key":"1879_CR118","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1164\/rccm.201406-1095OC","volume":"190","author":"DY Qing","year":"2014","unstructured":"Qing DY, Conegliano D, Shashaty MGS, Seo J, Reilly JP, Worthen GS, et al. Red blood cells induce necroptosis of lung endothelial cells and increase susceptibility to lung inflammation. Am J Resp Crit Care. 2014;190:1243\u201354. https:\/\/doi.org\/10.1164\/rccm.201406-1095OC.","journal-title":"Am J Resp Crit Care"},{"key":"1879_CR119","doi-asserted-by":"publisher","first-page":"803","DOI":"10.3390\/biomedicines9070803","volume":"9","author":"R Sanwal","year":"2021","unstructured":"Sanwal R, Joshi K, Ditmans M, Tsai SSH, Lee WL. Ultrasound and microbubbles for targeted drug delivery to the lung endothelium in ARDS: cellular mechanisms and therapeutic opportunities. Biomedicines. 2021;9:803. https:\/\/doi.org\/10.3390\/biomedicines9070803.","journal-title":"Biomedicines"},{"key":"1879_CR120","doi-asserted-by":"publisher","first-page":"1702","DOI":"10.1007\/s00134-004-2370-x","volume":"30","author":"SE Orfanos","year":"2004","unstructured":"Orfanos SE, Mavrommati I, Korovesi I, Roussos C. Pulmonary endothelium in acute lung injury: from basic science to the critically ill. Intens Care Med. 2004;30:1702\u201314. https:\/\/doi.org\/10.1007\/s00134-004-2370-x.","journal-title":"Intens Care Med"},{"key":"1879_CR121","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1146\/annurev-physiol-030212-183756","volume":"75","author":"J Bhattacharya","year":"2013","unstructured":"Bhattacharya J, Matthay MA. Regulation and repair of the alveolar-capillary barrier in acute lung injury. Annu Rev Physiol. 2013;75:593\u2013615. https:\/\/doi.org\/10.1146\/annurev-physiol-030212-183756.","journal-title":"Annu Rev Physiol"},{"key":"1879_CR122","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.vph.2008.06.009","volume":"49","author":"NA Maniatis","year":"2008","unstructured":"Maniatis NA, Kotanidou A, Catravas JD, Orfanos SE. Endothelial pathomechanisms in acute lung injury. Vasc Pharmacol. 2008;49:119\u201333. https:\/\/doi.org\/10.1016\/j.vph.2008.06.009.","journal-title":"Vasc Pharmacol"},{"key":"1879_CR123","doi-asserted-by":"publisher","first-page":"2064","DOI":"10.1172\/JCI96147","volume":"128","author":"M Zelic","year":"2018","unstructured":"Zelic M, Roderick JE, O\u2019Donnell JA, Lehman J, Lim SE, Janardhan HP, et al. RIP kinase 1-dependent endothelial necroptosis underlies systemic inflammatory response syndrome. J Clin Invest. 2018;128:2064\u201375. https:\/\/doi.org\/10.1172\/JCI96147.","journal-title":"J Clin Invest"},{"key":"1879_CR124","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1016\/j.ajpath.2022.04.002","volume":"192","author":"DR Price","year":"2022","unstructured":"Price DR, Benedetti E, Hoffman KL, Gomez-Escobar L, Alvarez-Mulett S, Capili A, et al. Angiopoietin 2 is associated with vascular necroptosis induction in coronavirus disease 2019 acute respiratory distress syndrome. Am J Pathol. 2022;192:1001\u201315. https:\/\/doi.org\/10.1016\/j.ajpath.2022.04.002.","journal-title":"Am J Pathol"},{"key":"1879_CR125","doi-asserted-by":"publisher","first-page":"109902","DOI":"10.1016\/j.intimp.2023.109902","volume":"117","author":"H Zhang","year":"2023","unstructured":"Zhang H, Zhang X, Ling C, Liu C, Hua S, Xiong Z, et al. EGFR-TNFR1 pathway in endothelial cell facilitates acute lung injury by NF-\u03baB\/MAPK-mediated inflammation and RIP3-dependent necroptosis. Int Immunopharmacol. 2023;117:109902. https:\/\/doi.org\/10.1016\/j.intimp.2023.109902.","journal-title":"Int Immunopharmacol"},{"key":"1879_CR126","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1513\/pats.200803-028HR","volume":"5","author":"EL Herzog","year":"2008","unstructured":"Herzog EL, Brody AR, Colby TV, Mason R, Williams MC. Knowns and unknowns of the alveolus. Proc Am Thorac Soc. 2008;5:778\u201382. https:\/\/doi.org\/10.1513\/pats.200803-028HR.","journal-title":"Proc Am Thorac Soc"},{"key":"1879_CR127","doi-asserted-by":"publisher","first-page":"2566","DOI":"10.3390\/ijms22052566","volume":"22","author":"B Ruaro","year":"2021","unstructured":"Ruaro B, Salton F, Braga L, Wade B, Confalonieri P, Volpe MC, et al. The history and mystery of alveolar epithelial type II cells: focus on their physiologic and pathologic role in lung. Int J Mol Sci. 2021;22:2566. https:\/\/doi.org\/10.3390\/ijms22052566.","journal-title":"Int J Mol Sci"},{"key":"1879_CR128","doi-asserted-by":"publisher","first-page":"105748","DOI":"10.1016\/j.isci.2022.105748","volume":"26","author":"K Tojo","year":"2023","unstructured":"Tojo K, Yamamoto N, Tamada N, Mihara T, Abe M, Nishii M, et al. Early alveolar epithelial cell necrosis is a potential driver of COVID-19-induced acute respiratory distress syndrome. Science. 2023;26:105748. https:\/\/doi.org\/10.1016\/j.isci.2022.105748.","journal-title":"Science"},{"key":"1879_CR129","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1097\/SHK.0000000000001425","volume":"54","author":"N Tamada","year":"2020","unstructured":"Tamada N, Tojo K, Yazawa T, Goto T. Necrosis rather than apoptosis is the dominant form of alveolar epithelial cell death in lipopolysaccharide-induced experimental acute respiratory distress syndrome model. Shock. 2020;54:128\u201339. https:\/\/doi.org\/10.1097\/SHK.0000000000001425.","journal-title":"Shock"},{"key":"1879_CR130","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1038\/s42003-022-03481-y","volume":"5","author":"T Gong","year":"2022","unstructured":"Gong T, Zhang X, Peng Z, Ye Y, Liu R, Yang Y, et al. Macrophage-derived exosomal aminopeptidase N aggravates sepsis-induced acute lung injury by regulating necroptosis of lung epithelial cell. Commun Biol. 2022;5:543. https:\/\/doi.org\/10.1038\/s42003-022-03481-y.","journal-title":"Commun Biol"},{"key":"1879_CR131","doi-asserted-by":"publisher","first-page":"3030","DOI":"10.1002\/jcp.30766","volume":"237","author":"H-L Jiang","year":"2022","unstructured":"Jiang H-L, Yang H-H, Liu Y-B, Zhang C-Y, Zhong W-J, Guan X-X, et al. L-OPA1 deficiency aggravates necroptosis of alveolar epithelial cells through impairing mitochondrial function during acute lung injury in mice. J Cell Physiol. 2022;237:3030\u201343. https:\/\/doi.org\/10.1002\/jcp.30766.","journal-title":"J Cell Physiol"},{"key":"1879_CR132","doi-asserted-by":"publisher","first-page":"e31169","DOI":"10.1002\/jcp.31169","volume":"239","author":"H-L Jiang","year":"2024","unstructured":"Jiang H-L, Yang H-H, Liu Y-B, Duan J-X, Guan X-X, Zhang C-Y, et al. CGRP is essential for protection against alveolar epithelial cell necroptosis by activating the AMPK\/L-OPA1 signaling pathway during acute lung injury. J Cell Physiol. 2024;239:e31169. https:\/\/doi.org\/10.1002\/jcp.31169.","journal-title":"J Cell Physiol"},{"key":"1879_CR133","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1097\/SHK.0000000000002006","volume":"58","author":"Y Zhao","year":"2022","unstructured":"Zhao Y, Zhang J, Lu H, Mao Y, Qin J, Wang Y, et al. Cardiopulmonary bypass-derived plasma exosomal hmgb1 contributes to alveolar epithelial cell necroptosis via mtDNA\/CGAS\/sting pathway. Shock. 2022;58:534\u201341. https:\/\/doi.org\/10.1097\/SHK.0000000000002006.","journal-title":"Shock"},{"key":"1879_CR134","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s12931-018-0756-5","volume":"19","author":"EKY Fan","year":"2018","unstructured":"Fan EKY, Fan J. Regulation of alveolar macrophage death in acute lung inflammation. Resp Res. 2018;19:50. https:\/\/doi.org\/10.1186\/s12931-018-0756-5.","journal-title":"Resp Res"},{"key":"1879_CR135","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.3389\/fimmu.2018.01777","volume":"9","author":"B Allard","year":"2018","unstructured":"Allard B, Panariti A, Martin JG. Alveolar macrophages in the resolution of inflammation, tissue repair, and tolerance to infection. Front Immunol. 2018;9:1777. https:\/\/doi.org\/10.3389\/fimmu.2018.01777.","journal-title":"Front Immunol"},{"key":"1879_CR136","doi-asserted-by":"publisher","first-page":"2003764","DOI":"10.1183\/13993003.03764-2020","volume":"57","author":"LD Santos","year":"2021","unstructured":"Santos LD, Antunes KH, Muraro SP, de Souza GF, da Silva AG, de Felipe J, S, et al. TNF-mediated alveolar macrophage necroptosis drives disease pathogenesis during respiratory syncytial virus infection. Eur Respir J. 2021;57:2003764. https:\/\/doi.org\/10.1183\/13993003.03764-2020.","journal-title":"Eur Respir J"},{"key":"1879_CR137","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.molimm.2020.11.001","volume":"129","author":"Q Hao","year":"2021","unstructured":"Hao Q, Kundu S, Kleam J, Zhao ZJ, Idell S, Tang H. Enhanced RIPK3 kinase activity-dependent lytic cell death in M1 but not M2 macrophages. Mol Immunol. 2021;129:86\u201393. https:\/\/doi.org\/10.1016\/j.molimm.2020.11.001.","journal-title":"Mol Immunol"},{"key":"1879_CR138","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1186\/s12967-023-04027-4","volume":"21","author":"W-J Zhong","year":"2023","unstructured":"Zhong W-J, Zhang J, Duan J-X, Zhang C-Y, Ma S-C, Li Y-S, et al. TREM-1 triggers necroptosis of macrophages through mTOR-dependent mitochondrial fission during acute lung injury. J Transl Med. 2023;21:179. https:\/\/doi.org\/10.1186\/s12967-023-04027-4.","journal-title":"J Transl Med"},{"key":"1879_CR139","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1038\/cdd.2016.51","volume":"23","author":"B Shutinoski","year":"2016","unstructured":"Shutinoski B, Alturki NA, Rijal D, Bertin J, Gough PJ, Schlossmacher MG, et al. K45A mutation of RIPK1 results in poor necroptosis and cytokine signaling in macrophages, which impacts inflammatory responses in vivo. Cell Death Differ. 2016;23:1628\u201337. https:\/\/doi.org\/10.1038\/cdd.2016.51.","journal-title":"Cell Death Differ"},{"key":"1879_CR140","doi-asserted-by":"publisher","first-page":"293","DOI":"10.2119\/molmed.2010.00138","volume":"17","author":"J Grommes","year":"2011","unstructured":"Grommes J, Soehnlein O. Contribution of neutrophils to acute lung injury. Mol Med. 2011;17:293\u2013307. https:\/\/doi.org\/10.2119\/molmed.2010.00138.","journal-title":"Mol Med"},{"issue":"63","key":"1879_CR141","doi-asserted-by":"publisher","first-page":"1806","DOI":"10.1152\/jappl.1987.63.5.1806","volume":"1987","author":"CM Doerschuk","year":"1985","unstructured":"Doerschuk CM, Allard MF, Martin BA, MacKenzie A, Autor AP, Hogg JC. Marginated pool of neutrophils in rabbit lungs. J Appl Physiol. 1985;1987(63):1806\u201315. https:\/\/doi.org\/10.1152\/jappl.1987.63.5.1806.","journal-title":"J Appl Physiol"},{"key":"1879_CR142","doi-asserted-by":"publisher","first-page":"4095","DOI":"10.1007\/s00018-021-03768-z","volume":"78","author":"W-C Lin","year":"2021","unstructured":"Lin W-C, Fessler MB. Regulatory mechanisms of neutrophil migration from the circulation to the airspace. Cell Mol Life Sci. 2021;78:4095\u2013124. https:\/\/doi.org\/10.1007\/s00018-021-03768-z.","journal-title":"Cell Mol Life Sci"},{"key":"1879_CR143","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1097\/ALN.0000000000002619","volume":"130","author":"I Bendib","year":"2019","unstructured":"Bendib I, de Chaisemartin L, Granger V, Schlemmer F, Maitre B, H\u00fce S, et al. Neutrophil extracellular traps are elevated in patients with pneumonia-related acute respiratory distress syndrome. Anesthesiology. 2019;130:581\u201391. https:\/\/doi.org\/10.1097\/ALN.0000000000002619.","journal-title":"Anesthesiology"},{"key":"1879_CR144","doi-asserted-by":"publisher","first-page":"e2111537119","DOI":"10.1073\/pnas.2111537119","volume":"119","author":"W Li","year":"2022","unstructured":"Li W, Terada Y, Tyurina YY, Tyurin VA, Bery AI, Gauthier JM, et al. Necroptosis triggers spatially restricted neutrophil-mediated vascular damage during lung ischemia reperfusion injury. P Natl Acad Sci USA. 2022;119:e2111537119. https:\/\/doi.org\/10.1073\/pnas.2111537119.","journal-title":"P Natl Acad Sci USA"},{"key":"1879_CR145","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1016\/j.cell.2020.02.050","volume":"180","author":"T Zhang","year":"2020","unstructured":"Zhang T, Yin C, Boyd DF, Quarato G, Ingram JP, Shubina M, et al. Influenza Virus Z-RNAs induce ZBP1-mediated necroptosis. Cell. 2020;180:1115-1129.e13. https:\/\/doi.org\/10.1016\/j.cell.2020.02.050.","journal-title":"Cell"},{"key":"1879_CR146","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1056\/NEJMoa2015432","volume":"383","author":"M Ackermann","year":"2020","unstructured":"Ackermann M, Verleden SE, Kuehnel M, Haverich A, Welte T, Laenger F, et al. Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19. N Engl J Med. 2020;383:120\u20138. https:\/\/doi.org\/10.1056\/NEJMoa2015432.","journal-title":"N Engl J Med"},{"key":"1879_CR147","doi-asserted-by":"publisher","first-page":"2011","DOI":"10.1182\/blood-2010-01-261669","volume":"116","author":"SP Jackson","year":"2010","unstructured":"Jackson SP, Schoenwaelder SM. Procoagulant platelets: are they necrotic? Blood. 2010;116:2011\u20138. https:\/\/doi.org\/10.1182\/blood-2010-01-261669.","journal-title":"Blood"},{"key":"1879_CR148","doi-asserted-by":"publisher","first-page":"2964","DOI":"10.1073\/pnas.1610963114","volume":"114","author":"Y Zhang","year":"2017","unstructured":"Zhang Y, Zhang J, Yan R, Tian J, Zhang Y, Zhang J, et al. Receptor-interacting protein kinase 3 promotes platelet activation and thrombosis. P Natl Acad Sci Usa. 2017;114:2964\u20139. https:\/\/doi.org\/10.1073\/pnas.1610963114.","journal-title":"P Natl Acad Sci Usa"},{"key":"1879_CR149","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1038\/s41420-018-0073-2","volume":"4","author":"D Nakazawa","year":"2018","unstructured":"Nakazawa D, Desai J, Steiger S, M\u00fcller S, Devarapu SK, Mulay SR, et al. Activated platelets induce MLKL-driven neutrophil necroptosis and release of neutrophil extracellular traps in venous thrombosis. Cell Death Discov. 2018;4:6. https:\/\/doi.org\/10.1038\/s41420-018-0073-2.","journal-title":"Cell Death Discov"},{"key":"1879_CR150","doi-asserted-by":"publisher","first-page":"e1357","DOI":"10.1002\/cti2.1357","volume":"10","author":"TA Schweizer","year":"2021","unstructured":"Schweizer TA, Mairpady Shambat S, Vulin C, Hoeller S, Acevedo C, Huemer M, et al. Blunted sFasL signalling exacerbates TNF-driven neutrophil necroptosis in critically ill COVID-19 patients. Clin Transl Immunol. 2021;10:e1357. https:\/\/doi.org\/10.1002\/cti2.1357.","journal-title":"Clin Transl Immunol"},{"key":"1879_CR151","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1182\/blood.2020007008","volume":"136","author":"EA Middleton","year":"2020","unstructured":"Middleton EA, He X-Y, Denorme F, Campbell RA, Ng D, Salvatore SP, et al. Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome. Blood. 2020;136:1169\u201379. https:\/\/doi.org\/10.1182\/blood.2020007008.","journal-title":"Blood"},{"key":"1879_CR152","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1161\/ATVBAHA.120.315267","volume":"41","author":"H Ng","year":"2021","unstructured":"Ng H, Havervall S, Rosell A, Aguilera K, Parv K, von Meijenfeldt FA, et al. Circulating markers of neutrophil extracellular traps are of prognostic value in patients with COVID-19. Arterioscl Throm Vas. 2021;41:988\u201394. https:\/\/doi.org\/10.1161\/ATVBAHA.120.315267.","journal-title":"Arterioscl Throm Vas"},{"key":"1879_CR153","doi-asserted-by":"publisher","first-page":"3852","DOI":"10.1016\/j.cell.2021.06.024","volume":"184","author":"MV Plikus","year":"2021","unstructured":"Plikus MV, Wang X, Sinha S, Forte E, Thompson SM, Herzog EL, et al. Fibroblasts: origins, definitions, and functions in health and disease. Cell. 2021;184:3852\u201372. https:\/\/doi.org\/10.1016\/j.cell.2021.06.024.","journal-title":"Cell"},{"key":"1879_CR154","doi-asserted-by":"publisher","first-page":"1850","DOI":"10.1038\/s41467-019-09709-6","volume":"10","author":"P Pakshir","year":"2019","unstructured":"Pakshir P, Alizadehgiashi M, Wong B, Coelho NM, Chen X, Gong Z, et al. Dynamic fibroblast contractions attract remote macrophages in fibrillar collagen matrix. Nat Commun. 2019;10:1850. https:\/\/doi.org\/10.1038\/s41467-019-09709-6.","journal-title":"Nat Commun"},{"key":"1879_CR155","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.jid.2016.11.035","volume":"137","author":"RA Ferrer","year":"2017","unstructured":"Ferrer RA, Saalbach A, Gr\u00fcnwedel M, Lohmann N, Forstreuter I, Saupe S, et al. Dermal fibroblasts promote alternative macrophage activation improving impaired wound healing. J Invest Dermatol. 2017;137:941\u201350. https:\/\/doi.org\/10.1016\/j.jid.2016.11.035.","journal-title":"J Invest Dermatol"},{"key":"1879_CR156","doi-asserted-by":"publisher","first-page":"e170499","DOI":"10.1172\/JCI170499","volume":"133","author":"MA Ghonim","year":"2023","unstructured":"Ghonim MA, Boyd DF, Flerlage T, Thomas PG. Pulmonary inflammation and fibroblast immunoregulation: from bench to bedside. J Clin Invest. 2023;133:e170499. https:\/\/doi.org\/10.1172\/JCI170499.","journal-title":"J Clin Invest"},{"key":"1879_CR157","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1038\/s41586-020-2877-5","volume":"587","author":"DF Boyd","year":"2020","unstructured":"Boyd DF, Allen EK, Randolph AG, Guo XZJ, Weng Y, Sanders CJ, et al. Exuberant fibroblast activity compromises lung function via ADAMTS4. Nature. 2020;587:466\u201371. https:\/\/doi.org\/10.1038\/s41586-020-2877-5.","journal-title":"Nature"},{"key":"1879_CR158","doi-asserted-by":"publisher","first-page":"802","DOI":"10.3390\/cells12050802","volume":"12","author":"M Bedeschi","year":"2023","unstructured":"Bedeschi M, Marino N, Cavassi E, Piccinini F, Tesei A. Cancer-associated fibroblast: role in prostate cancer progression to metastatic disease and therapeutic resistance. Cells-Basel. 2023;12:802. https:\/\/doi.org\/10.3390\/cells12050802.","journal-title":"Cells-Basel"},{"key":"1879_CR159","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1002\/path.1427","volume":"200","author":"G Gabbiani","year":"2003","unstructured":"Gabbiani G. The myofibroblast in wound healing and fibrocontractive diseases. J Pathol. 2003;200:500\u20133. https:\/\/doi.org\/10.1002\/path.1427.","journal-title":"J Pathol"},{"key":"1879_CR160","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1183\/09031936.00196412","volume":"43","author":"EL Burnham","year":"2014","unstructured":"Burnham EL, Janssen WJ, Riches DWH, Moss M, Downey GP. The fibroproliferative response in acute respiratory distress syndrome: mechanisms and clinical significance. Eur Respir J. 2014;43:276\u201385. https:\/\/doi.org\/10.1183\/09031936.00196412.","journal-title":"Eur Respir J"},{"key":"1879_CR161","doi-asserted-by":"publisher","first-page":"eab05070","DOI":"10.1126\/scitranslmed.abo5070","volume":"14","author":"KH Dinnon","year":"2022","unstructured":"Dinnon KH, Leist SR, Okuda K, Dang H, Fritch EJ, Gully KL, et al. SARS-CoV-2 infection produces chronic pulmonary epithelial and immune cell dysfunction with fibrosis in mice. Sci Transl Med. 2022;14:eab05070. https:\/\/doi.org\/10.1126\/scitranslmed.abo5070.","journal-title":"Sci Transl Med"},{"key":"1879_CR162","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1165\/rcmb.2017-0034OC","volume":"59","author":"J-M Lee","year":"2018","unstructured":"Lee J-M, Yoshida M, Kim M-S, Lee J-H, Baek A-R, Jang AS, et al. Involvement of alveolar epithelial cell necroptosis in idiopathic pulmonary fibrosis pathogenesis. Am J Resp Cell Mol. 2018;59:215\u201324. https:\/\/doi.org\/10.1165\/rcmb.2017-0034OC.","journal-title":"Am J Resp Cell Mol"},{"key":"1879_CR163","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.bcp.2018.01.025","volume":"153","author":"M Hussain","year":"2018","unstructured":"Hussain M, Zimmermann V, van Wijk SJL, Fulda S. Mouse lung fibroblasts are highly susceptible to necroptosis in a reactive oxygen species-dependent manner. Biochem Pharmacol. 2018;153:242\u20137. https:\/\/doi.org\/10.1016\/j.bcp.2018.01.025.","journal-title":"Biochem Pharmacol"},{"key":"1879_CR164","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s00109-020-02001-x","volume":"99","author":"K Araki","year":"2021","unstructured":"Araki K, Kinoshita R, Tomonobu N, Gohara Y, Tomida S, Takahashi Y, et al. The heterodimer S100A8\/A9 is a potent therapeutic target for idiopathic pulmonary fibrosis. J Mol Med (Berl). 2021;99:131\u201345. https:\/\/doi.org\/10.1007\/s00109-020-02001-x.","journal-title":"J Mol Med (Berl)"},{"key":"1879_CR165","doi-asserted-by":"publisher","first-page":"C570","DOI":"10.1152\/ajpcell.00291.2019","volume":"318","author":"GJ Grant","year":"2020","unstructured":"Grant GJ, Liou TG, Paine R, Helms MN. High-mobility group box-1 increases epithelial sodium channel activity and inflammation via the receptor for advanced glycation end products. Am J Physiol Cell Physiol. 2020;318:C570\u201380. https:\/\/doi.org\/10.1152\/ajpcell.00291.2019.","journal-title":"Am J Physiol Cell Physiol"},{"key":"1879_CR166","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.3389\/fimmu.2018.01776","volume":"9","author":"Y Li","year":"2018","unstructured":"Li Y, Bao J, Bian Y, Erben U, Wang P, Song K, et al. S100A4+ macrophages are necessary for pulmonary fibrosis by activating lung fibroblasts. Front Immunol. 2018;9:1776. https:\/\/doi.org\/10.3389\/fimmu.2018.01776.","journal-title":"Front Immunol"},{"key":"1879_CR167","doi-asserted-by":"publisher","first-page":"651360","DOI":"10.3389\/fcell.2021.651360","volume":"9","author":"X Chen","year":"2021","unstructured":"Chen X, Deng Z, Feng J, Chang Q, Lu F, Yuan Y. Necroptosis in macrophage foam cells promotes fat graft fibrosis in mice. Front Cell Dev Biol. 2021;9:651360. https:\/\/doi.org\/10.3389\/fcell.2021.651360.","journal-title":"Front Cell Dev Biol"},{"key":"1879_CR168","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/nchembio.83","volume":"4","author":"A Degterev","year":"2008","unstructured":"Degterev A, Hitomi J, Germscheid M, Ch\u2019en IL, Korkina O, Teng X, et al. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol. 2008;4:313\u201321. https:\/\/doi.org\/10.1038\/nchembio.83.","journal-title":"Nat Chem Biol"},{"key":"1879_CR169","doi-asserted-by":"publisher","first-page":"1602","DOI":"10.1016\/j.bbrc.2016.08.163","volume":"478","author":"L Pan","year":"2016","unstructured":"Pan L, Yao D-C, Yu Y-Z, Li S-J, Chen B-J, Hu G-H, et al. Necrostatin-1 protects against oleic acid-induced acute respiratory distress syndrome in rats. Biochem Biophys Res Commun. 2016;478:1602\u20138. https:\/\/doi.org\/10.1016\/j.bbrc.2016.08.163.","journal-title":"Biochem Biophys Res Commun"},{"key":"1879_CR170","doi-asserted-by":"publisher","first-page":"2171","DOI":"10.3892\/mmr.2020.11010","volume":"21","author":"B Lin","year":"2020","unstructured":"Lin B, Jin Z, Chen X, Zhao L, Weng C, Chen B, et al. Necrostatin-1 protects mice from acute lung injury by suppressing necroptosis and reactive oxygen species. Mol Med Rep. 2020;21:2171\u201381. https:\/\/doi.org\/10.3892\/mmr.2020.11010.","journal-title":"Mol Med Rep"},{"key":"1879_CR171","doi-asserted-by":"publisher","first-page":"2178","DOI":"10.1016\/j.bbrc.2017.12.100","volume":"495","author":"CH Han","year":"2018","unstructured":"Han CH, Guan ZB, Zhang PX, Fang HL, Li L, Zhang HM, et al. Oxidative stress induced necroptosis activation is involved in the pathogenesis of hyperoxic acute lung injury. Biochem Bioph Res Co. 2018;495:2178\u201383. https:\/\/doi.org\/10.1016\/j.bbrc.2017.12.100.","journal-title":"Biochem Bioph Res Co"},{"key":"1879_CR172","doi-asserted-by":"publisher","first-page":"3139","DOI":"10.3390\/cells11193139","volume":"11","author":"L Dong","year":"2022","unstructured":"Dong L, Liang F, Lou Z, Li Y, Li J, Chen Y, et al. Necrostatin-1 alleviates lung ischemia-reperfusion injury via inhibiting necroptosis and apoptosis of lung epithelial cells. Cells-Basel. 2022;11:3139. https:\/\/doi.org\/10.3390\/cells11193139.","journal-title":"Cells-Basel"},{"key":"1879_CR173","doi-asserted-by":"publisher","first-page":"e437","DOI":"10.1038\/cddis.2012.176","volume":"3","author":"N Takahashi","year":"2012","unstructured":"Takahashi N, Duprez L, Grootjans S, Cauwels A, Nerinckx W, DuHadaway JB, et al. Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models. Cell Death Dis. 2012;3:e437. https:\/\/doi.org\/10.1038\/cddis.2012.176.","journal-title":"Cell Death Dis"},{"key":"1879_CR174","doi-asserted-by":"publisher","first-page":"105297","DOI":"10.1016\/j.phrs.2020.105297","volume":"163","author":"L Cao","year":"2021","unstructured":"Cao L, Mu W. Necrostatin-1 and necroptosis inhibition: Pathophysiology and therapeutic implications. Pharmacol Res. 2021;163:105297. https:\/\/doi.org\/10.1016\/j.phrs.2020.105297.","journal-title":"Pharmacol Res"},{"key":"1879_CR175","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.3390\/antiox10091347","volume":"10","author":"H Yuk","year":"2021","unstructured":"Yuk H, Abdullah M, Kim D-H, Lee H, Lee S-J. Necrostatin-1 prevents ferroptosis in a RIPK1- and IDO-independent manner in hepatocellular carcinoma. Antioxidants (Basel). 2021;10:1347. https:\/\/doi.org\/10.3390\/antiox10091347.","journal-title":"Antioxidants (Basel)"},{"key":"1879_CR176","doi-asserted-by":"publisher","first-page":"2545","DOI":"10.1016\/j.cclet.2021.09.059","volume":"33","author":"L Xu","year":"2022","unstructured":"Xu L, Tu Y, Li J, Zhang W, Wang Z, Zhuang C, et al. Structure-based optimizations of a necroptosis inhibitor (SZM594) as novel protective agents of acute lung injury. Chinese Chem Lett. 2022;33:2545\u20139. https:\/\/doi.org\/10.1016\/j.cclet.2021.09.059.","journal-title":"Chinese Chem Lett"},{"key":"1879_CR177","doi-asserted-by":"publisher","first-page":"5261","DOI":"10.1021\/acs.jmedchem.3c00197","volume":"66","author":"X Zhang","year":"2023","unstructured":"Zhang X, Han Q, Hou R, Xu L, Zhang W, Xing C, et al. Targeting receptor-interacting protein kinase 1 by novel benzothiazole derivatives: treatment of acute lung injury through the necroptosis pathway. J Med Chem. 2023;66:5261\u201378. https:\/\/doi.org\/10.1021\/acs.jmedchem.3c00197.","journal-title":"J Med Chem"},{"key":"1879_CR178","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1124\/pharmrev.121.000564","volume":"74","author":"Z Yuan","year":"2022","unstructured":"Yuan Z, De La Cruz LK, Yang X, Wang B. Carbon monoxide signaling: examining its engagement with various molecular targets in the context of binding affinity, concentration, and biologic response. Pharmacol Rev. 2022;74:825\u201375. https:\/\/doi.org\/10.1124\/pharmrev.121.000564.","journal-title":"Pharmacol Rev"},{"key":"1879_CR179","doi-asserted-by":"publisher","first-page":"6255","DOI":"10.12659\/MSM.917751","volume":"25","author":"W Li","year":"2019","unstructured":"Li W, Wu F, Chen L, Li Q, Ma J, Li M, et al. Carbon monoxide attenuates lipopolysaccharides (LPS)-induced acute lung injury in neonatal rats via downregulation of Cx43 to reduce necroptosis. Med Sci Monit. 2019;25:6255\u201363. https:\/\/doi.org\/10.12659\/MSM.917751.","journal-title":"Med Sci Monit"},{"key":"1879_CR180","doi-asserted-by":"publisher","first-page":"2273","DOI":"10.1021\/acs.accounts.0c00402","volume":"53","author":"LS Lazarus","year":"2020","unstructured":"Lazarus LS, Benninghoff AD, Berreau LM. Development of triggerable, trackable and targetable carbon monoxide releasing molecules. Acc Chem Res. 2020;53:2273\u201385. https:\/\/doi.org\/10.1021\/acs.accounts.0c00402.","journal-title":"Acc Chem Res"},{"key":"1879_CR181","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1039\/C3MD00278K","volume":"5","author":"D Liao","year":"2014","unstructured":"Liao D, Sun L, Liu W, He S, Wang X, Lei X. Necrosulfonamide inhibits necroptosis by selectively targeting the mixed lineage kinase domain-like protein. Med Chem Commun. 2014;5:333\u20137. https:\/\/doi.org\/10.1039\/C3MD00278K.","journal-title":"Med Chem Commun"},{"key":"1879_CR182","doi-asserted-by":"publisher","first-page":"e113","DOI":"10.1016\/j.jtcvs.2021.01.037","volume":"163","author":"S Ueda","year":"2022","unstructured":"Ueda S, Chen-Yoshikawa TF, Tanaka S, Yamada Y, Nakajima D, Ohsumi A, et al. Protective effect of necrosulfonamide on rat pulmonary ischemia-reperfusion injury via inhibition of necroptosis. J Thorac Cardiovasc Surg. 2022;163:e113\u201322. https:\/\/doi.org\/10.1016\/j.jtcvs.2021.01.037.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"1879_CR183","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1038\/s42003-023-05353-5","volume":"6","author":"F Huang","year":"2023","unstructured":"Huang F, Liang J, Lin Y, Chen Y, Hu F, Feng J, et al. Repurposing of ibrutinib and quizartinib as potent inhibitors of necroptosis. Commun Biol. 2023;6:972. https:\/\/doi.org\/10.1038\/s42003-023-05353-5.","journal-title":"Commun Biol"},{"key":"1879_CR184","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1093\/intimm\/dxac061","volume":"35","author":"Y Yu","year":"2023","unstructured":"Yu Y, Li M, Fu S, He X, Hu X, Zhu G, et al. Repurposing crizotinib to target RIPK1-dependent cell death. Int Immunol. 2023;35:221\u201330. https:\/\/doi.org\/10.1093\/intimm\/dxac061.","journal-title":"Int Immunol"},{"key":"1879_CR185","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1186\/s12931-024-02670-z","volume":"25","author":"P-F Clot","year":"2024","unstructured":"Clot P-F, Farenc C, Suratt BT, Krahnke T, Tardat A, Florian P, et al. Immunomodulatory and clinical effects of receptor-interacting protein kinase 1 (RIPK1) inhibitor eclitasertib (SAR443122) in patients with severe COVID-19: a phase 1b, randomized, double-blinded, placebo-controlled study. Resp Res. 2024;25:107. https:\/\/doi.org\/10.1186\/s12931-024-02670-z.","journal-title":"Resp Res"},{"key":"1879_CR186","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.tibs.2018.06.011","volume":"43","author":"N V\u00e1zquez-Laslop","year":"2018","unstructured":"V\u00e1zquez-Laslop N, Mankin AS. How Macrolide Antibiotics Work. Trends Biochem Sci. 2018;43:668\u201384. https:\/\/doi.org\/10.1016\/j.tibs.2018.06.011.","journal-title":"Trends Biochem Sci"},{"key":"1879_CR187","doi-asserted-by":"publisher","first-page":"105949","DOI":"10.1016\/j.ijantimicag.2020.105949","volume":"56","author":"P Gautret","year":"2020","unstructured":"Gautret P, Lagier J-C, Parola P, Hoang VT, Meddeb L, Mailhe M, et al. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. Int J Antimicrob Agents. 2020;56:105949. https:\/\/doi.org\/10.1016\/j.ijantimicag.2020.105949.","journal-title":"Int J Antimicrob Agents"},{"key":"1879_CR188","doi-asserted-by":"publisher","first-page":"52","DOI":"10.3390\/ph16010052","volume":"16","author":"EHM Hassanein","year":"2022","unstructured":"Hassanein EHM, Sayed GA, Alzoghaibi AM, Alammar AS, Abdel-Wahab BA, Abd El-Ghafar OAM, et al. Azithromycin mitigates cisplatin-induced lung oxidative stress, inflammation and necroptosis by upregulating SIRT1, PPAR\u03b3, and Nrf2\/HO-1 signaling. Pharmaceuticals-Base. 2022;16:52. https:\/\/doi.org\/10.3390\/ph16010052.","journal-title":"Pharmaceuticals-Base"},{"key":"1879_CR189","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.taap.2015.04.004","volume":"285","author":"W Jing","year":"2015","unstructured":"Jing W, Chunhua M, Shumin W. Effects of acteoside on lipopolysaccharide-induced inflammation in acute lung injury via regulation of NF-\u03baB pathway in vivo and in vitro. Toxicol Appl Pharm. 2015;285:128\u201335. https:\/\/doi.org\/10.1016\/j.taap.2015.04.004.","journal-title":"Toxicol Appl Pharm"},{"key":"1879_CR190","doi-asserted-by":"publisher","first-page":"870928","DOI":"10.3389\/fphar.2022.870928","volume":"13","author":"X Ling","year":"2022","unstructured":"Ling X, Zhou J, Jin T, Xu W, Sun X, Li W, et al. Acteoside attenuates RSV-induced lung injury by suppressing necroptosis and regulating metabolism. Front Pharmacol. 2022;13:870928. https:\/\/doi.org\/10.3389\/fphar.2022.870928.","journal-title":"Front Pharmacol"},{"key":"1879_CR191","doi-asserted-by":"publisher","first-page":"538137","DOI":"10.3389\/fphar.2020.538137","volume":"11","author":"H Zhou","year":"2020","unstructured":"Zhou H, Li J, Sun F, Wang F, Li M, Dong Y, et al. A review on recent advances in aloperine research: pharmacological activities and underlying biological mechanisms. Front Pharmacol. 2020;11:538137. https:\/\/doi.org\/10.3389\/fphar.2020.538137.","journal-title":"Front Pharmacol"},{"key":"1879_CR192","doi-asserted-by":"publisher","first-page":"154074","DOI":"10.1016\/j.phymed.2022.154074","volume":"100","author":"Y-R Cui","year":"2022","unstructured":"Cui Y-R, Qu F, Zhong W-J, Yang H-H, Zeng J, Huang J-H, et al. Beneficial effects of aloperine on inflammation and oxidative stress by suppressing necroptosis in lipopolysaccharide-induced acute lung injury mouse model. Phytomedicine. 2022;100:154074. https:\/\/doi.org\/10.1016\/j.phymed.2022.154074.","journal-title":"Phytomedicine"},{"key":"1879_CR193","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.3390\/plants11091244","volume":"11","author":"C Burlou-Nagy","year":"2022","unstructured":"Burlou-Nagy C, B\u0103nic\u0103 F, Jurca T, Vica\u0219 LG, Marian E, Muresan ME, et al. Echinacea purpurea (L.) Moench: biological and pharmacological properties. A review. Plants (Basel). 2022;11:1244. https:\/\/doi.org\/10.3390\/plants11091244.","journal-title":"Plants (Basel)"},{"key":"1879_CR194","doi-asserted-by":"publisher","first-page":"7289","DOI":"10.1021\/acs.jafc.2c08382","volume":"71","author":"J Guo","year":"2023","unstructured":"Guo J, Luo Y, Zuo J, Teng J, Shen B, Liu X. Echinacea polyphenols inhibit NLRP3-dependent pyroptosis, apoptosis, and necroptosis via suppressing NO production during lipopolysaccharide-induced acute lung injury. J Agric Food Chem. 2023;71:7289\u201398. https:\/\/doi.org\/10.1021\/acs.jafc.2c08382.","journal-title":"J Agric Food Chem"},{"key":"1879_CR195","doi-asserted-by":"publisher","first-page":"107396","DOI":"10.1016\/j.pharmthera.2019.107396","volume":"203","author":"J-F Goossens","year":"2019","unstructured":"Goossens J-F, Bailly C. Ursodeoxycholic acid and cancer: from chemoprevention to chemotherapy. Pharmacol Therapeut. 2019;203:107396. https:\/\/doi.org\/10.1016\/j.pharmthera.2019.107396.","journal-title":"Pharmacol Therapeut"},{"key":"1879_CR196","doi-asserted-by":"publisher","first-page":"111161","DOI":"10.1016\/j.intimp.2023.111161","volume":"125","author":"Y-Q He","year":"2023","unstructured":"He Y-Q, Deng J-L, Zhou C-C, Jiang S-G, Zhang F, Tao X, et al. Ursodeoxycholic acid alleviates sepsis-induced lung injury by blocking PANoptosis via STING pathway. Int Immunopharmacol. 2023;125:111161. https:\/\/doi.org\/10.1016\/j.intimp.2023.111161.","journal-title":"Int Immunopharmacol"},{"key":"1879_CR197","doi-asserted-by":"publisher","first-page":"745683","DOI":"10.3389\/fphar.2021.745683","volume":"12","author":"Z-L Guo","year":"2021","unstructured":"Guo Z-L, Li M-X, Li X-L, Wang P, Wang W-G, Du W-Z, et al. Crocetin: a systematic review. Front Pharmacol. 2021;12:745683. https:\/\/doi.org\/10.3389\/fphar.2021.745683.","journal-title":"Front Pharmacol"},{"key":"1879_CR198","doi-asserted-by":"publisher","first-page":"112899","DOI":"10.1016\/j.biopha.2022.112899","volume":"149","author":"Y Ding","year":"2022","unstructured":"Ding Y, Ma L, He L, Xu Q, Zhang Z, Zhang Z, et al. A strategy for attenuation of acute radiation-induced lung injury using crocetin from gardenia fruit. Biomed Pharmacother. 2022;149:112899. https:\/\/doi.org\/10.1016\/j.biopha.2022.112899.","journal-title":"Biomed Pharmacother"},{"key":"1879_CR199","doi-asserted-by":"publisher","first-page":"6553","DOI":"10.1080\/07391102.2020.1803135","volume":"39","author":"S Ahmed","year":"2021","unstructured":"Ahmed S, Moni DA, Sonawane KD, Paek KY, Shohael AM. A comprehensive in silico exploration of pharmacological properties, bioactivities and COX-2 inhibitory potential of eleutheroside B from Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. J Biomol Struct Dyn. 2021;39:6553\u201366. https:\/\/doi.org\/10.1080\/07391102.2020.1803135.","journal-title":"J Biomol Struct Dyn"},{"key":"1879_CR200","doi-asserted-by":"publisher","first-page":"113982","DOI":"10.1016\/j.biopha.2022.113982","volume":"156","author":"Y Wang","year":"2022","unstructured":"Wang Y, Shen Z, Pei C, Zhao S, Jia N, Huang D, et al. Eleutheroside B ameliorated high altitude pulmonary edema by attenuating ferroptosis and necroptosis through Nrf2-antioxidant response signaling. Biomed Pharmacother. 2022;156:113982. https:\/\/doi.org\/10.1016\/j.biopha.2022.113982.","journal-title":"Biomed Pharmacother"},{"key":"1879_CR201","doi-asserted-by":"publisher","unstructured":"ESICM LIVES (2019) Intens Care Med Exp 7: 55. https:\/\/doi.org\/10.1186\/s40635-019-0265-y","DOI":"10.1186\/s40635-019-0265-y"},{"key":"1879_CR202","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/S2213-2600(21)00461-6","volume":"10","author":"MV Maddali","year":"2022","unstructured":"Maddali MV, Churpek M, Pham T, Rezoagli E, Zhuo H, Zhao W, et al. Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis. Lancet Respir Med. 2022;10:367\u201377. https:\/\/doi.org\/10.1016\/S2213-2600(21)00461-6.","journal-title":"Lancet Respir Med"},{"key":"1879_CR203","doi-asserted-by":"publisher","unstructured":"Siempos II, Ma KC, Imamura M, Baron RM, Fredenburgh LE, Huh J-W, et al. RIPK3 mediates pathogenesis of experimental ventilator-induced lung injury. Jci Insight n.d.;3: e97102. https:\/\/doi.org\/10.1172\/jci.insight.97102","DOI":"10.1172\/jci.insight.97102"},{"key":"1879_CR204","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1186\/s13054-019-2482-x","volume":"23","author":"MGS Shashaty","year":"2019","unstructured":"Shashaty MGS, Reilly JP, Faust HE, Forker CM, Ittner CAG, Zhang PX, et al. Plasma receptor interacting protein kinase-3 levels are associated with acute respiratory distress syndrome in sepsis and trauma: a cohort study. Crit Care. 2019;23:235. https:\/\/doi.org\/10.1186\/s13054-019-2482-x.","journal-title":"Crit Care"},{"key":"1879_CR205","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1186\/s13054-020-03209-6","volume":"24","author":"H Nakamura","year":"2020","unstructured":"Nakamura H, Kinjo T, Arakaki W, Miyagi K, Tateyama M, Fujita J. Serum levels of receptor-interacting protein kinase-3 in patients with COVID-19. Crit Care. 2020;24:484. https:\/\/doi.org\/10.1186\/s13054-020-03209-6.","journal-title":"Crit Care"},{"key":"1879_CR206","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1165\/rcmb.2022-0039LE","volume":"67","author":"K Ruskowski","year":"2022","unstructured":"Ruskowski K, Neb H, Talbot SR, Choorapoikayil S, Adam EH, von Knethen A, et al. Persistently elevated plasma concentrations of RIPK3, MLKL, HMGB1, and RIPK1 in patients with COVID-19 in the intensive care unit. Am J Resp Cell Mol. 2022;67:405\u20138. https:\/\/doi.org\/10.1165\/rcmb.2022-0039LE.","journal-title":"Am J Resp Cell Mol"},{"key":"1879_CR207","doi-asserted-by":"publisher","first-page":"1983421","DOI":"10.1155\/2018\/1983421","volume":"2018","author":"M Vucur","year":"2018","unstructured":"Vucur M, Roderburg C, Kaiser L, Schneider AT, Roy S, Loosen SH, et al. Elevated serum levels of mixed lineage kinase domain-like protein predict survival of patients during intensive care unit treatment. Dis Markers. 2018;2018:1983421. https:\/\/doi.org\/10.1155\/2018\/1983421.","journal-title":"Dis Markers"},{"key":"1879_CR208","doi-asserted-by":"publisher","first-page":"84066","DOI":"10.18632\/oncotarget.21099","volume":"8","author":"B Wang","year":"2017","unstructured":"Wang B, Li J, Gao H-M, Xing Y-H, Lin Z, Li H-J, et al. Necroptosis regulated proteins expression is an early prognostic biomarker in patient with sepsis: a prospective observational study. Oncotarget. 2017;8:84066\u201373. https:\/\/doi.org\/10.18632\/oncotarget.21099.","journal-title":"Oncotarget"},{"key":"1879_CR209","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1080\/13543776.2023.2195548","volume":"33","author":"L Xu","year":"2023","unstructured":"Xu L, Zhang W, Zhuang C. Receptor-interacting protein kinase 1 (RIPK1) inhibitor: a review of the patent literature (2018-present). Expert Opin Ther Pat. 2023;33:101\u201324. https:\/\/doi.org\/10.1080\/13543776.2023.2195548.","journal-title":"Expert Opin Ther Pat"},{"key":"1879_CR210","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.apsb.2023.10.021","volume":"14","author":"Y Qin","year":"2024","unstructured":"Qin Y, Li D, Qi C, Xiang H, Meng H, Liu J, et al. Structure-based development of potent and selective type-II kinase inhibitors of RIPK1. Acta Pharm Sin B. 2024;14:319\u201334. https:\/\/doi.org\/10.1016\/j.apsb.2023.10.021.","journal-title":"Acta Pharm Sin B"},{"key":"1879_CR211","doi-asserted-by":"publisher","DOI":"10.1111\/cts.13580","author":"J Lickliter","year":"2023","unstructured":"Lickliter J, Wang S, Zhang W, Zhu H, Wang J, Zhao C, et al. A phase I randomized, double-blinded, placebo-controlled study assessing the safety and pharmacokinetics of RIPK1 inhibitor GFH312 in healthy subjects. Clin Transl Sci. 2023. https:\/\/doi.org\/10.1111\/cts.13580.","journal-title":"Clin Transl Sci"},{"key":"1879_CR212","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.1111\/cts.13607","volume":"16","author":"NS Jones","year":"2023","unstructured":"Jones NS, Kshirsagar S, Mohanan V, Ramakrishnan V, Di Nucci F, Ma L, et al. A phase I, randomized, ascending-dose study to assess safety, pharmacokinetics, and activity of GDC-8264, a RIP1 inhibitor, in healthy volunteers. Clin Transl Sci. 2023;16:1997. https:\/\/doi.org\/10.1111\/cts.13607.","journal-title":"Clin Transl Sci"},{"key":"1879_CR213","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1038\/s41419-023-06065-8","volume":"14","author":"M Sun","year":"2023","unstructured":"Sun M, Ma X, Mu W, Li H, Zhao X, Zhu T, et al. Vemurafenib inhibits necroptosis in normal and pathological conditions as a RIPK1 antagonist. Cell Death Dis. 2023;14:555. https:\/\/doi.org\/10.1038\/s41419-023-06065-8.","journal-title":"Cell Death Dis"},{"key":"1879_CR214","doi-asserted-by":"publisher","first-page":"7059304","DOI":"10.1155\/2020\/7059304","volume":"2020","author":"L Wang","year":"2020","unstructured":"Wang L, Chen B, Xiong X, Chen S, Jin L, Zhu M. Necrostatin-1 synergizes the pan caspase inhibitor to attenuate lung injury induced by ischemia reperfusion in rats. Mediat Inflamm. 2020;2020:7059304. https:\/\/doi.org\/10.1155\/2020\/7059304.","journal-title":"Mediat Inflamm"},{"key":"1879_CR215","doi-asserted-by":"publisher","first-page":"173999","DOI":"10.1016\/j.ejphar.2021.173999","volume":"898","author":"H Tu","year":"2021","unstructured":"Tu H, Zhou Y-J, Tang LJ, Xiong XM, Zhang XJ, et al. Combination of ponatinib with deferoxamine synergistically mitigates ischemic heart injury via simultaneous prevention of necroptosis and ferroptosis. Eur J Pharmacol. 2021;898:173999. https:\/\/doi.org\/10.1016\/j.ejphar.2021.173999.","journal-title":"Eur J Pharmacol"},{"key":"1879_CR216","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1089\/ars.2022.0209","volume":"39","author":"S Rius-P\u00e9rez","year":"2023","unstructured":"Rius-P\u00e9rez S, P\u00e9rez S, Toledano MB, Sastre J. Mitochondrial reactive oxygen species and lytic programmed cell death in acute inflammation. Antioxid Redox Sign. 2023;39:708\u201327. https:\/\/doi.org\/10.1089\/ars.2022.0209.","journal-title":"Antioxid Redox Sign"},{"key":"1879_CR217","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.it.2019.03.006","volume":"40","author":"N Peltzer","year":"2019","unstructured":"Peltzer N, Walczak H. Cell death and inflammation\u2014a vital but dangerous liaison. Trends Immunol. 2019;40:387\u2013402. https:\/\/doi.org\/10.1016\/j.it.2019.03.006.","journal-title":"Trends Immunol"},{"key":"1879_CR218","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1038\/s41580-020-0270-8","volume":"21","author":"S Bedoui","year":"2020","unstructured":"Bedoui S, Herold MJ, Strasser A. Emerging connectivity of programmed cell death pathways and its physiological implications. Nat Rev Mol Cell Biol. 2020;21:678\u201395. https:\/\/doi.org\/10.1038\/s41580-020-0270-8.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1879_CR219","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/s41420-023-01369-2","volume":"9","author":"Y Zheng","year":"2023","unstructured":"Zheng Y, Huang Y, Xu Y, Sang L, Liu X, Li Y. Ferroptosis, pyroptosis and necroptosis in acute respiratory distress syndrome. Cell Death Discov. 2023;9:91. https:\/\/doi.org\/10.1038\/s41420-023-01369-2.","journal-title":"Cell Death Discov"},{"key":"1879_CR220","doi-asserted-by":"publisher","first-page":"11626","DOI":"10.1021\/acsnano.3c02075","volume":"17","author":"C Liu","year":"2023","unstructured":"Liu C, Xi L, Liu Y, Mak JCW, Mao S, Wang Z, et al. An inhalable hybrid biomimetic nanoplatform for sequential drug release and remodeling lung immune homeostasis in acute lung injury treatment. ACS Nano. 2023;17:11626\u201344. https:\/\/doi.org\/10.1021\/acsnano.3c02075.","journal-title":"ACS Nano"},{"key":"1879_CR221","doi-asserted-by":"publisher","first-page":"12714","DOI":"10.3390\/ijms232112714","volume":"23","author":"HS Chaouhan","year":"2022","unstructured":"Chaouhan HS, Vinod C, Mahapatra N, Yu S-H, Wang I-K, Chen K-B, et al. Necroptosis: a pathogenic negotiator in human diseases. Int J Mol Sci. 2022;23:12714. https:\/\/doi.org\/10.3390\/ijms232112714.","journal-title":"Int J Mol Sci"},{"key":"1879_CR222","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1038\/s41419-020-02941-9","volume":"11","author":"S-Y Park","year":"2020","unstructured":"Park S-Y, Park H-H, Park S-Y, Hong SM, Yoon S, Morgan MJ, et al. Reduction in MLKL-mediated endosomal trafficking enhances the TRAIL-DR4\/5 signal to increase cancer cell death. Cell Death Dis. 2020;11:744. https:\/\/doi.org\/10.1038\/s41419-020-02941-9.","journal-title":"Cell Death Dis"},{"key":"1879_CR223","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.immuni.2017.06.001","volume":"47","author":"S Yoon","year":"2017","unstructured":"Yoon S, Kovalenko A, Bogdanov K, Wallach D. MLKL, the protein that mediates necroptosis, also regulates endosomal trafficking and extracellular vesicle generation. Immunity. 2017;47:51-65.e7. https:\/\/doi.org\/10.1016\/j.immuni.2017.06.001.","journal-title":"Immunity"}],"container-title":["Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-024-01879-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00011-024-01879-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-024-01879-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T02:07:32Z","timestamp":1716257252000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00011-024-01879-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,14]]},"references-count":223,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["1879"],"URL":"https:\/\/doi.org\/10.1007\/s00011-024-01879-4","relation":{},"ISSN":["1023-3830","1420-908X"],"issn-type":[{"value":"1023-3830","type":"print"},{"value":"1420-908X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,14]]},"assertion":[{"value":"4 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 March 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 April 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that there are no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}}]}}