{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T06:16:33Z","timestamp":1794464193092,"version":"4.9.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflamm. Res."],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s00011-025-01999-5","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T12:39:19Z","timestamp":1741091959000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The relationship between the dynamic trajectory of inflammatory markers in VA-ECMO patients and the 28-day survival rate, as well as mediating causal analysis"],"prefix":"10.1007","volume":"74","author":[{"given":"You","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayan","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhui","family":"li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leiming","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,4]]},"reference":[{"key":"1999_CR1","doi-asserted-by":"crossref","unstructured":"Luciano G, Eleonora C, Thomas L. Clinical review: extracorporeal membrane oxygenation. Crit Care. 2011;15(6).","DOI":"10.1186\/cc10490"},{"issue":"1","key":"1999_CR2","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/s13054-015-0806-z","volume":"16","author":"M Schmidt","year":"2015","unstructured":"Schmidt M, Hodgson C, Combes A. Extracorporeal gas exchange for acute respiratory failure in adult patients: a systematic review. Crit Care. 2015;16(1):99.","journal-title":"Crit Care"},{"key":"1999_CR3","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/s13054-016-1261-1","volume":"5","author":"S Aso","year":"2016","unstructured":"Aso S, Matsui H, Fushimi K, Yasunaga H. In-hospital mortality and successful weaning from venoarterial extracorporeal membrane oxygenation: analysis of 5,263 patients using a national inpatient database in Japan. Crit Care. 2016;5:20:80.","journal-title":"Crit Care"},{"issue":"2","key":"1999_CR4","first-page":"0","volume":"21","author":"DP T M Y","year":"2002","unstructured":"T M Y DP. Cardiopulmonary bypass induced inflammation: pathophysiology and treatment. An update. Eur J Cardiothorac Surg. 2002;21(2):0.","journal-title":"Eur J Cardiothorac Surg"},{"issue":"1","key":"1999_CR5","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1186\/s13054-016-1570-4","volume":"28","author":"JE Millar","year":"2016","unstructured":"Millar JE, Fanning JP, McDonald CI, McAuley DF, Fraser JF. The inflammatory response to extracorporeal membrane oxygenation (ECMO): a review of the pathophysiology. Crit Care. 2016;28(1):387.","journal-title":"Crit Care"},{"issue":"9","key":"1999_CR6","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1056\/NEJMra1208623","volume":"29","author":"DC Angus","year":"2013","unstructured":"Angus DC, van der Poll T. Severe sepsis and septic shock. N Engl J Med. 2013;29(9):840\u201351.","journal-title":"N Engl J Med"},{"key":"1999_CR7","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/s13054-016-1270-0","volume":"9","author":"MH Bernardi","year":"2016","unstructured":"Bernardi MH, Rinoesl H, Dragosits K, et al. Effect of hemoadsorption during cardiopulmonary bypass surgery\u2014a blinded, randomized, controlled pilot study using a novel adsorbent. Crit Care. 2016;9:20:96.","journal-title":"Crit Care"},{"key":"1999_CR8","doi-asserted-by":"publisher","first-page":"479","DOI":"10.3389\/fimmu.2016.00479","volume":"7","author":"H Hasegawa","year":"2016","unstructured":"Hasegawa H, Mizoguchi I, Chiba Y, Ohashi M, Xu M, Yoshimoto T. Expanding diversity in molecular structures and functions of the IL-6\/IL-12 heterodimeric cytokine family. Front Immunol. 2016;7:479.","journal-title":"Front Immunol"},{"key":"1999_CR9","doi-asserted-by":"crossref","unstructured":"C PD. A, J K, Urine interleukin-6 is an early biomarker of acute kidney injury in children undergoing cardiac surgery. Crit Care 2010;14(5).","DOI":"10.1186\/cc9289"},{"issue":"5","key":"1999_CR10","first-page":"557","volume":"20","author":"JI Salluh","year":"2014","unstructured":"Salluh JI, Soares M. ICU severity of illness scores: APACHE, SAPS and MPM. Curr Opin Crit Care. 2014;20(5):557\u201365.","journal-title":"Curr Opin Crit Care"},{"issue":"6","key":"1999_CR11","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1007\/s00134-020-06010-9","volume":"46","author":"CL Auriemma","year":"2020","unstructured":"Auriemma CL, Zhuo H, Delucchi K, et al. Acute respiratory distress syndrome-attributable mortality in critically ill patients with sepsis. Intensive Care Med. 2020;46(6):1222\u201331.","journal-title":"Intensive Care Med"},{"key":"1999_CR12","doi-asserted-by":"crossref","unstructured":"Yoshino A, Nakamura Y, Hashiguchi S et al. The Association between the oral-gut Axis and the outcomes of severe COVID-19 patients receiving extracorporeal membrane oxygenation: a case-control study. J Clin Med. 2022;11(5).","DOI":"10.3390\/jcm11051167"},{"issue":"5","key":"1999_CR13","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.hrtlng.2016.06.004","volume":"45","author":"K Thangappan","year":"2016","unstructured":"Thangappan K, Cavarocchi NC, Baram M, Thoma B, Hirose H. Systemic inflammatory response syndrome (SIRS) after extracorporeal membrane oxygenation (ECMO): incidence, risks and survivals. Heart Lung. 2016;45(5):449\u201353.","journal-title":"Heart Lung"},{"key":"1999_CR14","first-page":"2694499","volume":"2022","author":"YZ Guan","year":"2022","unstructured":"Guan YZ, Yin RX, Zheng PF, Liu CX, Wei BL, Deng GX. Association of RDW, NLR, and PLR with atrial fibrillation in critical care patients: a retrospective study based on propensity score matching. Dis Mark. 2022;2022:2694499.","journal-title":"Dis Mark"},{"issue":"10","key":"1999_CR15","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1016\/j.jclinepi.2004.02.012","volume":"57","author":"K Leffondre","year":"2004","unstructured":"Leffondre K, Abrahamowicz M, Regeasse A, et al. Statistical measures were proposed for identifying longitudinal patterns of change in quantitative health indicators. J Clin Epidemiol. 2004;57(10):1049\u201362.","journal-title":"J Clin Epidemiol"},{"key":"1999_CR16","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.2147\/CLEP.S265287","volume":"12","author":"HL Nguena Nguefack","year":"2020","unstructured":"Nguena Nguefack HL, Page MG, Katz J, et al. Trajectory modelling techniques useful to epidemiological research: a comparative narrative review of approaches. Clin Epidemiol. 2020;12:1205\u201322.","journal-title":"Clin Epidemiol"},{"key":"1999_CR17","unstructured":"Daniel SN, Bobby LJ, Jonathan E. Recent advances in group-based trajectory modeling for clinical research. Annu Rev Clin Psychol. 2024;20(1)."},{"issue":"6","key":"1999_CR18","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1037\/0022-3514.51.6.1173","volume":"51","author":"RM Baron","year":"1986","unstructured":"Baron RM, Kenny DA. The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. J Pers Soc Psychol. 1986;51(6):1173.","journal-title":"Pers Soc Psychol"},{"issue":"1","key":"1999_CR19","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/s10238-024-01450-9","volume":"7","author":"A He","year":"2024","unstructured":"He A, Liu J, Qiu J, et al. Risk and mediation analyses of hemoglobin glycation index and survival prognosis in patients with sepsis. Clin Exp Med. 2024;7(1):183.","journal-title":"Clin Exp Med"},{"issue":"1","key":"1999_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00134-021-06514-y","volume":"48","author":"D Abrams","year":"2022","unstructured":"Abrams D, MacLaren G, Lorusso R, et al. Extracorporeal cardiopulmonary resuscitation in adults: evidence and implications. Intensive Care Med. 2022;48(1):1\u201315.","journal-title":"Intensive Care Med"},{"issue":"1","key":"1999_CR21","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s12871-024-02416-w","volume":"31","author":"M Liu","year":"2024","unstructured":"Liu M, Li X, Zhou R. Severe coagulopathy and inflammation occurred after resection of giant right ventricular intimal sarcoma with cardiopulmonary bypass: a case report. BMC Anesthesiol. 2024;31(1):43.","journal-title":"BMC Anesthesiol"},{"issue":"2","key":"1999_CR22","doi-asserted-by":"publisher","first-page":"445","DOI":"10.21037\/jtd.2018.12.121","volume":"11","author":"WT Ng","year":"2019","unstructured":"Ng WT, Ling L, Joynt GM, Chan KM. An audit of mortality by using ECMO specific scores and APACHE II scoring system in patients receiving extracorporeal membrane oxygenation in a tertiary intensive care unit in Hong Kong. J Thorac Dis. 2019;11(2):445\u201355.","journal-title":"J Thorac Dis"},{"issue":"8","key":"1999_CR23","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1097\/MAT.0000000000000895","volume":"65","author":"L Masha","year":"2019","unstructured":"Masha L, Peerbhai S, Boone D, et al. Yellow means caution: correlations between liver injury and mortality with the use of VA-ECMO. ASAIO J. 2019;65(8):812\u20138.","journal-title":"ASAIO J"},{"issue":"2","key":"1999_CR24","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1038\/s41390-021-01817-8","volume":"92","author":"SD Caprarola","year":"2022","unstructured":"Caprarola SD, Ng DK, Carroll MK, et al. Pediatric ECMO: unfavorable outcomes are associated with inflammation and endothelial activation. Pediatr Res. 2022;92(2):549\u201356.","journal-title":"Pediatr Res"},{"issue":"1","key":"1999_CR25","doi-asserted-by":"publisher","first-page":"14284","DOI":"10.1038\/s41598-022-17227-7","volume":"22","author":"M Panigada","year":"2022","unstructured":"Panigada M, Spinelli E, De Falco S, et al. The relationship between antithrombin administration and inflammation during veno-venous ECMO. Sci Rep. 2022;22(1):14284.","journal-title":"Sci Rep"},{"issue":"10","key":"1999_CR26","doi-asserted-by":"publisher","first-page":"a016295","DOI":"10.1101\/cshperspect.a016295","volume":"4","author":"T Tanaka","year":"2014","unstructured":"Tanaka T, Narazaki M, Kishimoto T. IL-6 in inflammation, immunity, and disease. Cold Spring Harb Perspect Biol. 2014;4(10):a016295.","journal-title":"Cold Spring Harb Perspect Biol"}],"container-title":["Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-025-01999-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00011-025-01999-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-025-01999-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T16:55:59Z","timestamp":1767200159000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00011-025-01999-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,4]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["1999"],"URL":"https:\/\/doi.org\/10.1007\/s00011-025-01999-5","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-5305017\/v1","asserted-by":"object"}]},"ISSN":["1023-3830","1420-908X"],"issn-type":[{"value":"1023-3830","type":"print"},{"value":"1420-908X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,4]]},"assertion":[{"value":"21 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 January 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Binhai County People\u2019s Hospital (Approval No. 2024-BHKYLL-018).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All the authors of the article agree to participate in the journal submission. Data was released with patient consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"45"}}