{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:12:41Z","timestamp":1786979561821,"version":"build-2736575974"},"reference-count":83,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T00:00:00Z","timestamp":1738022400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T00:00:00Z","timestamp":1738022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Sichuan Provincial Administration of Traditional Chinese Medicine Special Topics in Traditional Chinese Medicine","award":["2023MS019"],"award-info":[{"award-number":["2023MS019"]}]},{"name":"Luzhou's major scientific and technology research and development project","award":["2022-SYF-42"],"award-info":[{"award-number":["2022-SYF-42"]}]},{"name":"Joint Innovation Special of the Sichuan Provincial Science and Technology Plan","award":["2022YFS0609\/2022YFS0609-B3"],"award-info":[{"award-number":["2022YFS0609\/2022YFS0609-B3"]}]},{"name":"Luzhou Municipal People's Government-Southwest Medical University Science and Technology Strategic Cooperation Climbing Plan Project","award":["2021LZXNYD-D02"],"award-info":[{"award-number":["2021LZXNYD-D02"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflamm. Res."],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s00011-025-02003-w","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T21:51:15Z","timestamp":1738014675000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["ASIC1a mediated nucleus pulposus cells pyroptosis and glycolytic crosstalk as a molecular basis for intervertebral disc degeneration"],"prefix":"10.1007","volume":"74","author":[{"given":"Chao","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daqian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongliang","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangchao","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houyin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianlin","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongchao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,28]]},"reference":[{"key":"2003_CR1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.spinee.2023.10.021","volume":"24","author":"W Guo","year":"2024","unstructured":"Guo W, Li BL, Zhao JY, Li XM, Wang LF. Causal associations between modifiable risk factors and intervertebral disc degeneration. Spine J. 2024;24:195\u2013209.","journal-title":"Spine J"},{"key":"2003_CR2","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1186\/s13018-023-04187-5","volume":"18","author":"L Yang","year":"2023","unstructured":"Yang L, Li W, Yang Y, Zhao H, Yu X. The correlation between the lumbar disc MRI high-intensity zone and discogenic low back pain: a systematic review and meta-analysis. J Orthop Surg Res. 2023;18:758.","journal-title":"J Orthop Surg Res"},{"key":"2003_CR3","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1186\/s12891-020-3188-6","volume":"21","author":"M Taso","year":"2020","unstructured":"Taso M, Sommernes JH, Kolstad F, Sundseth J, Bjorland S, Pripp AH, et al. A randomised controlled trial comparing the effectiveness of surgical and nonsurgical treatment for cervical radiculopathy. BMC Musculoskelet Disord. 2020;21:171.","journal-title":"BMC Musculoskelet Disord"},{"key":"2003_CR4","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.actbio.2023.02.019","volume":"160","author":"M Mirzaeipoueinak","year":"2023","unstructured":"Mirzaeipoueinak M, Mordechai HS, Bangar SS, Sharabi M, Tipper JL, Tavakoli J. Structure-function characterization of the transition zone in the intervertebral disc. Acta Biomater. 2023;160:164\u201375.","journal-title":"Acta Biomater"},{"key":"2003_CR5","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1042\/bst0300858","volume":"30","author":"JP Urban","year":"2002","unstructured":"Urban JP. The role of the physicochemical environment in determining disc cell behaviour. Biochem Soc Trans. 2002;30:858\u201364.","journal-title":"Biochem Soc Trans"},{"key":"2003_CR6","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.2174\/1389201024666221021142904","volume":"24","author":"R Staszkiewicz","year":"2023","unstructured":"Staszkiewicz R, G\u0142adysz D, Gralewski M, Garczarek M, Gadzieli\u0144ski M, Grabarek BO. Pathomechanism of the IVDs degeneration and the role of neurotrophic factors and concentration of selected elements in Genesis of Low Back Pain. Curr Pharm Biotechnol. 2023;24:1164\u201377.","journal-title":"Curr Pharm Biotechnol"},{"key":"2003_CR7","doi-asserted-by":"crossref","first-page":"153","DOI":"10.22203\/eCM.v041a11","volume":"41","author":"J Gansau","year":"2021","unstructured":"Gansau J, Buckley CT. Priming as a strategy to overcome detrimental pH effects on cells for intervertebral disc regeneration. Eur Cell Mater. 2021;41:153\u201369.","journal-title":"Eur Cell Mater"},{"issue":"Suppl 2","key":"2003_CR8","first-page":"30","volume":"88","author":"T Grunhagen","year":"2006","unstructured":"Grunhagen T, Wilde G, Soukane DM, Shirazi-Adl SA, Urban JP. Nutrient supply and intervertebral disc metabolism. J Bone Joint Surg Am. 2006;88(Suppl 2):30\u20135.","journal-title":"J Bone Joint Surg Am"},{"key":"2003_CR9","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1159\/000016340","volume":"10","author":"S Razaq","year":"2000","unstructured":"Razaq S, Urban JP, Wilkins RJ. Regulation of intracellular pH by bovine intervertebral disc cells. Cell Physiol Biochem. 2000;10:109\u201315.","journal-title":"Cell Physiol Biochem"},{"key":"2003_CR10","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s00018-023-05094-y","volume":"81","author":"Y Zhang","year":"2024","unstructured":"Zhang Y, Liu L, Qi Y, Lou J, Chen Y, Liu C, et al. Lactic acid promotes nucleus pulposus cell senescence and corresponding intervertebral disc degeneration via interacting with Akt. Cell Mol Life Sci. 2024;81:24.","journal-title":"Cell Mol Life Sci"},{"key":"2003_CR11","doi-asserted-by":"crossref","first-page":"491","DOI":"10.14336\/AD.2015.1213","volume":"7","author":"RP Zhou","year":"2016","unstructured":"Zhou RP, Wu XS, Wang ZS, Xie YY, Ge JF, Chen FH. Novel insights into acid-sensing Ion channels: implications for degenerative diseases. Aging Dis. 2016;7:491\u2013501.","journal-title":"Aging Dis"},{"key":"2003_CR12","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.neuropharm.2014.12.007","volume":"94","author":"D Omerba\u0161i\u0107","year":"2015","unstructured":"Omerba\u0161i\u0107 D, Schuhmacher LN, Bernal Sierra YA, Smith ES, Lewin GR. ASICs and mammalian mechanoreceptor function. Neuropharmacology. 2015;94:80\u20136.","journal-title":"Neuropharmacology"},{"key":"2003_CR13","first-page":"449","volume":"30","author":"RE Abdelhamid","year":"2015","unstructured":"Abdelhamid RE, Sluka KA. ASICs mediate Pain and inflammation in Musculoskeletal diseases. Physiol (Bethesda). 2015;30:449\u201359.","journal-title":"Physiol (Bethesda)"},{"key":"2003_CR14","doi-asserted-by":"crossref","first-page":"37360","DOI":"10.1038\/srep37360","volume":"6","author":"HTJ Gilbert","year":"2016","unstructured":"Gilbert HTJ, Hodson N, Baird P, Richardson SM, Hoyland JA. Acidic pH promotes intervertebral disc degeneration: acid-sensing ion channel\u2013\u20093 as a potential therapeutic target. Sci Rep. 2016;6:37360.","journal-title":"Sci Rep"},{"key":"2003_CR15","doi-asserted-by":"crossref","unstructured":"Ruan N, Tribble J, Peterson AM, Jiang Q, Wang JQ, Chu XP. Acid-sensing Ion channels and mechanosensation. Int J Mol Sci 2021; 22:4810.","DOI":"10.3390\/ijms22094810"},{"key":"2003_CR16","doi-asserted-by":"crossref","first-page":"e1233","DOI":"10.1002\/jsp2.1233","volume":"5","author":"C Song","year":"2022","unstructured":"Song C, Cai W, Liu F, Cheng K, Guo D, Liu Z. An in-depth analysis of the immunomodulatory mechanisms of intervertebral disc degeneration. JOR Spine. 2022;5:e1233.","journal-title":"JOR Spine"},{"key":"2003_CR17","doi-asserted-by":"crossref","first-page":"112181","DOI":"10.1016\/j.exger.2023.112181","volume":"177","author":"H Li","year":"2023","unstructured":"Li H, Wang X, Pan H, Xiao C, Wang C, Guo S, et al. The mechanisms and functions of IL-1\u03b2 in intervertebral disc degeneration. Exp Gerontol. 2023;177:112181.","journal-title":"Exp Gerontol"},{"key":"2003_CR18","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.cca.2015.08.029","volume":"450","author":"W Yang","year":"2015","unstructured":"Yang W, Yu XH, Wang C, He WS, Zhang SJ, Yan YG, et al. Interleukin-1\u03b2 in intervertebral disk degeneration. Clin Chim Acta. 2015;450:262\u201372.","journal-title":"Clin Chim Acta"},{"key":"2003_CR19","doi-asserted-by":"crossref","first-page":"110844","DOI":"10.1016\/j.intimp.2023.110844","volume":"124","author":"D Guo","year":"2023","unstructured":"Guo D, Cheng K, Song C, Liu F, Cai W, Chen J, et al. Mechanisms of inhibition of nucleus pulposus cells pyroptosis through SDF1\/CXCR4-NFkB-NLRP3 axis in the treatment of intervertebral disc degeneration by Duhuo Jisheng Decoction. Int Immunopharmacol. 2023;124:110844.","journal-title":"Int Immunopharmacol"},{"key":"2003_CR20","doi-asserted-by":"crossref","first-page":"e14226","DOI":"10.1111\/eci.14226","volume":"54","author":"D Zhou","year":"2024","unstructured":"Zhou D, Mei Y, Song C, Cheng K, Cai W, Guo D, et al. Exploration of the mode of death and potential death mechanisms of nucleus pulposus cells. Eur J Clin Invest. 2024;54:e14226.","journal-title":"Eur J Clin Invest"},{"key":"2003_CR21","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1038\/aps.2018.36","volume":"39","author":"ZC Liu","year":"2018","unstructured":"Liu ZC, Wang ZL, Huang CY, Fu ZJ, Liu Y, Wei ZC, et al. Duhuo Jisheng Decoction inhibits SDF-1-induced inflammation and matrix degradation in human degenerative nucleus pulposus cells in vitro through the CXCR4\/NF-\u03baB pathway. Acta Pharmacol Sin. 2018;39:912\u201322.","journal-title":"Acta Pharmacol Sin"},{"key":"2003_CR22","doi-asserted-by":"crossref","first-page":"112380","DOI":"10.1016\/j.exger.2024.112380","volume":"188","author":"N Wang","year":"2024","unstructured":"Wang N, Rong W, Xie Y, Chen S, Xi Z, Deng R. Visualizing the bibliometrics of the inflammatory mechanisms in intervertebral disc degeneration. Exp Gerontol. 2024;188:112380.","journal-title":"Exp Gerontol"},{"key":"2003_CR23","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.tips.2022.04.003","volume":"43","author":"RC Coll","year":"2022","unstructured":"Coll RC, Schroder K, Pelegr\u00edn P. NLRP3 and pyroptosis blockers for treating inflammatory diseases. Trends Pharmacol Sci. 2022;43:653\u201368.","journal-title":"Trends Pharmacol Sci"},{"key":"2003_CR24","doi-asserted-by":"crossref","first-page":"8813","DOI":"10.7150\/thno.62521","volume":"11","author":"SK Hsu","year":"2021","unstructured":"Hsu SK, Li CY, Lin IL, Syue WJ, Chen YF, Cheng KC, et al. Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment. Theranostics. 2021;11:8813\u201335.","journal-title":"Theranostics"},{"key":"2003_CR25","doi-asserted-by":"crossref","first-page":"101781","DOI":"10.1016\/j.smim.2023.101781","volume":"69","author":"SO Vasudevan","year":"2023","unstructured":"Vasudevan SO, Behl B, Rathinam VA. Pyroptosis-induced inflammation and tissue damage. Semin Immunol. 2023;69:101781.","journal-title":"Semin Immunol"},{"key":"2003_CR26","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/s41419-023-05634-1","volume":"14","author":"J Zhou","year":"2023","unstructured":"Zhou J, Qiu J, Song Y, Liang T, Liu S, Ren C, et al. Pyroptosis and degenerative diseases of the elderly. Cell Death Dis. 2023;14:94.","journal-title":"Cell Death Dis"},{"key":"2003_CR27","doi-asserted-by":"crossref","first-page":"167301","DOI":"10.1016\/j.jmb.2021.167301","volume":"434","author":"Y Wei","year":"2022","unstructured":"Wei Y, Yang L, Pandeya A, Cui J, Zhang Y, Li Z. Pyroptosis-Induced inflammation and tissue damage. J Mol Biol. 2022;434:167301.","journal-title":"J Mol Biol"},{"key":"2003_CR28","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1016\/j.immuni.2023.10.004","volume":"56","author":"R Miao","year":"2023","unstructured":"Miao R, Jiang C, Chang WY, Zhang H, An J, Ho F, et al. Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis. Immunity. 2023;56:2523\u2013e25418.","journal-title":"Immunity"},{"key":"2003_CR29","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.tibs.2016.10.004","volume":"42","author":"J Shi","year":"2017","unstructured":"Shi J, Gao W, Shao F. Pyroptosis: gasdermin-mediated programmed necrotic cell death. Trends Biochem Sci. 2017;42:245\u201354.","journal-title":"Trends Biochem Sci"},{"key":"2003_CR30","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.7150\/ijbs.60292","volume":"17","author":"H Yan","year":"2021","unstructured":"Yan H, Luo B, Wu X, Guan F, Yu X, Zhao L, et al. Cisplatin induces pyroptosis via activation of MEG3\/NLRP3\/caspase-1\/GSDMD pathway in Triple-negative breast Cancer. Int J Biol Sci. 2021;17:2606\u201321.","journal-title":"Int J Biol Sci"},{"key":"2003_CR31","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1016\/j.cellsig.2013.07.022","volume":"25","author":"F Okajima","year":"2013","unstructured":"Okajima F. Regulation of inflammation by extracellular acidification and proton-sensing GPCRs. Cell Signal. 2013;25:2263\u201371.","journal-title":"Cell Signal"},{"key":"2003_CR32","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1038\/s41590-022-01231-0","volume":"23","author":"X Chen","year":"2022","unstructured":"Chen X, Jaiswal A, Costliow Z, Herbst P, Creasey EA, Oshiro-Rapley N, et al. pH sensing controls tissue inflammation by modulating cellular metabolism and endo-lysosomal function of immune cells. Nat Immunol. 2022;23:1063\u201375.","journal-title":"Nat Immunol"},{"key":"2003_CR33","doi-asserted-by":"crossref","first-page":"110243","DOI":"10.1016\/j.cellsig.2022.110243","volume":"91","author":"WY Dai","year":"2022","unstructured":"Dai WY, Luo ZP. Paeoniflorin inhibits pyroptosis of nucleus pulposus cells in an acidic environment and alleviates the degeneration of the intervertebral disc in rats. Cell Signal. 2022;91:110243.","journal-title":"Cell Signal"},{"key":"2003_CR34","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1002\/jor.24682","volume":"39","author":"JD Stover","year":"2021","unstructured":"Stover JD, Lawrence B, Bowles RD. Degenerative IVD conditioned media and acidic pH sensitize sensory neurons to cyclic tensile strain. J Orthop Res. 2021;39:1192\u2013203.","journal-title":"J Orthop Res"},{"key":"2003_CR35","doi-asserted-by":"crossref","first-page":"852","DOI":"10.5195\/jmla.2023.1803","volume":"111","author":"T Gotschall","year":"2023","unstructured":"Gotschall T, Resource Review. EndNote 21 desktop version. J Med Libr Assoc. 2023;111:852\u20133.","journal-title":"J Med Libr Assoc"},{"key":"2003_CR36","doi-asserted-by":"crossref","first-page":"5499","DOI":"10.1038\/s41598-018-23672-0","volume":"8","author":"D Vella","year":"2018","unstructured":"Vella D, Marini S, Vitali F, Di Silvestre D, Mauri G, Bellazzi R. MTGO: PPI Network Analysis Via Topological and Functional Module Identification. Sci Rep. 2018;8:5499.","journal-title":"Sci Rep"},{"key":"2003_CR37","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41467-023-44313-9","volume":"15","author":"F Chen","year":"2024","unstructured":"Chen F, Lei L, Chen S, Zhao Z, Huang Y, Jiang G, et al. Serglycin secreted by late-stage nucleus pulposus cells is a biomarker of intervertebral disc degeneration. Nat Commun. 2024;15:47.","journal-title":"Nat Commun"},{"key":"2003_CR38","doi-asserted-by":"crossref","first-page":"113528","DOI":"10.1016\/j.intimp.2024.113528","volume":"143","author":"D Zhou","year":"2024","unstructured":"Zhou D, Lv J, Mei Y, Song C, Liu T, Cheng K, et al. Analysis of the role of PANoptosis in intervertebral disk degeneration via integrated bioinformatics analysis and experimental validation. Int Immunopharmacol. 2024;143:113528.","journal-title":"Int Immunopharmacol"},{"key":"2003_CR39","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.bbrc.2020.03.161","volume":"526","author":"D He","year":"2020","unstructured":"He D, Zhou M, Bai Z, Wen Y, Shen J, Hu Z. Propionibacterium acnes induces intervertebral disc degeneration by promoting nucleus pulposus cell pyroptosis via NLRP3-dependent pathway. Biochem Biophys Res Commun. 2020;526:772\u20139.","journal-title":"Biochem Biophys Res Commun"},{"key":"2003_CR40","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1080\/19336950.2019.1664038","volume":"13","author":"Y Guo","year":"2019","unstructured":"Guo Y, Meng Y, Liu H, Wang B, Ding C, Rong X, et al. Acid-sensing ion channels mediate the degeneration of intervertebral disc via various pathways-A systematic review. Channels (Austin). 2019;13:367\u201373.","journal-title":"Channels (Austin)"},{"key":"2003_CR41","doi-asserted-by":"crossref","unstructured":"Shnayder NA, Ashhotov AV, Trefilova VV, Nurgaliev ZA, Novitsky MA, Vaiman EE et al. Cytokine Imbalance as a biomarker of intervertebral disk degeneration. Int J Mol Sci 2023; 24:2360.","DOI":"10.3390\/ijms24032360"},{"key":"2003_CR42","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1002\/jbmr.3908","volume":"35","author":"ES Silagi","year":"2020","unstructured":"Silagi ES, Novais EJ, Bisetto S, Telonis AG, Snuggs J, Le Maitre CL, et al. Lactate Efflux from intervertebral disc cells is Required for Maintenance of Spine Health. J Bone Min Res. 2020;35:550\u201370.","journal-title":"J Bone Min Res"},{"key":"2003_CR43","doi-asserted-by":"crossref","first-page":"110660","DOI":"10.1016\/j.biopha.2020.110660","volume":"131","author":"Y Wang","year":"2020","unstructured":"Wang Y, Che M, Xin J, Zheng Z, Li J, Zhang S. The role of IL-1\u03b2 and TNF-\u03b1 in intervertebral disc degeneration. Biomed Pharmacother. 2020;131:110660.","journal-title":"Biomed Pharmacother"},{"key":"2003_CR44","doi-asserted-by":"crossref","first-page":"783","DOI":"10.3892\/mmr.2016.5341","volume":"14","author":"Z Liu","year":"2016","unstructured":"Liu Z, Ma C, Shen J, Wang D, Hao J, Hu Z. SDF\u20131\/CXCR4 axis induces apoptosis of human degenerative nucleus pulposus cells via the NF\u2013\u03baB pathway. Mol Med Rep. 2016;14:783\u20139.","journal-title":"Mol Med Rep"},{"key":"2003_CR45","doi-asserted-by":"crossref","first-page":"27","DOI":"10.7150\/thno.48987","volume":"11","author":"A Kamali","year":"2021","unstructured":"Kamali A, Ziadlou R, Lang G, Pfannkuche J, Cui S, Li Z, et al. Small molecule-based treatment approaches for intervertebral disc degeneration: current options and future directions. Theranostics. 2021;11:27\u201347.","journal-title":"Theranostics"},{"key":"2003_CR46","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/s12276-022-00729-9","volume":"54","author":"W Zhang","year":"2022","unstructured":"Zhang W, Li G, Luo R, Lei J, Song Y, Wang B, et al. Cytosolic escape of mitochondrial DNA triggers cGAS-STING-NLRP3 axis-dependent nucleus pulposus cell pyroptosis. Exp Mol Med. 2022;54:129\u201342.","journal-title":"Exp Mol Med"},{"key":"2003_CR47","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nature11588","volume":"492","author":"GS Lee","year":"2012","unstructured":"Lee GS, Subramanian N, Kim AI, Aksentijevich I, Goldbach-Mansky R, Sacks DB, et al. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2\u2009+\u2009and cAMP. Nature. 2012;492:123\u20137.","journal-title":"Nature"},{"key":"2003_CR48","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/s41374-018-0135-3","volume":"99","author":"X Wu","year":"2019","unstructured":"Wu X, Ren G, Zhou R, Ge J, Chen FH. The role of ca(2+) in acid-sensing ion channel 1a-mediated chondrocyte pyroptosis in rat adjuvant arthritis. Lab Invest. 2019;99:499\u2013513.","journal-title":"Lab Invest"},{"key":"2003_CR49","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.neuropharm.2014.12.015","volume":"94","author":"G Dussor","year":"2015","unstructured":"Dussor G. ASICs as therapeutic targets for migraine. Neuropharmacology. 2015;94:64\u201371.","journal-title":"Neuropharmacology"},{"key":"2003_CR50","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s11010-017-3223-6","volume":"443","author":"YY Xie","year":"2018","unstructured":"Xie YY, Li Y, Zhou RP, Dai BB, Qian YJ, Wu XS, et al. Effects of autophagy on acid-sensing ion channel 1a-mediated apoptosis in rat articular chondrocytes. Mol Cell Biochem. 2018;443:181\u201391.","journal-title":"Mol Cell Biochem"},{"key":"2003_CR51","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1089\/biores.2017.0049","volume":"7","author":"ZY Xie","year":"2018","unstructured":"Xie ZY, Chen L, Zhang C, Liu L, Wang F, Cai F, et al. Acid-sensing Ion Channel 1a regulates fate of Rat Nucleus Pulposus cells in acid stimulus through endoplasmic reticulum stress. Biores Open Access. 2018;7:2\u20139.","journal-title":"Biores Open Access"},{"key":"2003_CR52","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1016\/j.joca.2018.05.022","volume":"26","author":"F Wang","year":"2018","unstructured":"Wang F, Zhang C, Shi R, Xie ZY, Chen L, Wang K, et al. The embryonic and evolutionary boundaries between notochord and cartilage: a new look at nucleus pulposus-specific markers. Osteoarthritis Cartilage. 2018;26:1274\u201382.","journal-title":"Osteoarthritis Cartilage"},{"key":"2003_CR53","doi-asserted-by":"crossref","first-page":"831830","DOI":"10.3389\/fphys.2022.831830","volume":"13","author":"DM MacLean","year":"2022","unstructured":"MacLean DM, Soto E, Editorial. ASICs: structure, function, and Pharmacology. Front Physiol. 2022;13:831830.","journal-title":"Front Physiol"},{"key":"2003_CR54","doi-asserted-by":"crossref","first-page":"10703","DOI":"10.18632\/aging.202850","volume":"13","author":"J Ding","year":"2021","unstructured":"Ding J, Zhang R, Li H, Ji Q, Cheng X, Thorne RF, et al. ASIC1 and ASIC3 mediate cellular senescence of human nucleus pulposus mesenchymal stem cells during intervertebral disc degeneration. Aging. 2021;13:10703\u201323.","journal-title":"Aging"},{"key":"2003_CR55","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.intimp.2015.08.044","volume":"29","author":"R Zhou","year":"2015","unstructured":"Zhou R, Wu X, Wang Z, Ge J, Chen F. Interleukin-6 enhances acid-induced apoptosis via upregulating acid-sensing ion channel 1a expression and function in rat articular chondrocytes. Int Immunopharmacol. 2015;29:748\u201360.","journal-title":"Int Immunopharmacol"},{"key":"2003_CR56","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1007\/s00011-023-01813-0","volume":"72","author":"C Song","year":"2023","unstructured":"Song C, Xu Y, Peng Q, Chen R, Zhou D, Cheng K, et al. Mitochondrial dysfunction: a new molecular mechanism of intervertebral disc degeneration. Inflamm Res. 2023;72:2249\u201360.","journal-title":"Inflamm Res"},{"key":"2003_CR57","doi-asserted-by":"crossref","unstructured":"Li Y, Liu S, Pan D, Xu B, Xing X, Zhou H et al. The potential role and trend of HIF\u20131\u03b1 in intervertebral disc degeneration: friend or foe? (review). Mol Med Rep 2021; 23:1.","DOI":"10.3892\/mmr.2021.11878"},{"key":"2003_CR58","doi-asserted-by":"crossref","first-page":"107119","DOI":"10.1016\/j.phrs.2024.107119","volume":"202","author":"C Song","year":"2024","unstructured":"Song C, Hu P, Peng R, Li F, Fang Z, Xu Y. Bioenergetic dysfunction in the pathogenesis of intervertebral disc degeneration. Pharmacol Res. 2024;202:107119.","journal-title":"Pharmacol Res"},{"key":"2003_CR59","doi-asserted-by":"crossref","first-page":"e12779","DOI":"10.1111\/cpr.12779","volume":"53","author":"L Kang","year":"2020","unstructured":"Kang L, Liu S, Li J, Tian Y, Xue Y, Liu X. The mitochondria-targeted anti-oxidant MitoQ protects against intervertebral disc degeneration by ameliorating mitochondrial dysfunction and redox imbalance. Cell Prolif. 2020;53:e12779.","journal-title":"Cell Prolif"},{"key":"2003_CR60","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cca.2020.04.016","volume":"508","author":"GZ Zhang","year":"2020","unstructured":"Zhang GZ, Deng YJ, Xie QQ, Ren EH, Ma ZJ, He XG, et al. Sirtuins and intervertebral disc degeneration: roles in inflammation, oxidative stress, and mitochondrial function. Clin Chim Acta. 2020;508:33\u201342.","journal-title":"Clin Chim Acta"},{"key":"2003_CR61","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1002\/jbmr.4019","volume":"35","author":"V Madhu","year":"2020","unstructured":"Madhu V, Boneski PK, Silagi E, Qiu Y, Kurland I, Guntur AR, et al. Hypoxic regulation of mitochondrial metabolism and Mitophagy in Nucleus Pulposus cells is dependent on HIF-1\u03b1-BNIP3 Axis. J Bone Min Res. 2020;35:1504\u201324.","journal-title":"J Bone Min Res"},{"key":"2003_CR62","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s13075-021-02501-2","volume":"23","author":"D Wang","year":"2021","unstructured":"Wang D, Hartman R, Han C, Zhou CM, Couch B, Malkamaki M, et al. Lactate oxidative phosphorylation by annulus fibrosus cells: evidence for lactate-dependent metabolic symbiosis in intervertebral discs. Arthritis Res Ther. 2021;23:145.","journal-title":"Arthritis Res Ther"},{"key":"2003_CR63","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cytogfr.2022.11.001","volume":"68","author":"L Ye","year":"2022","unstructured":"Ye L, Jiang Y, Zhang M. Crosstalk between glucose metabolism, lactate production and immune response modulation. Cytokine Growth Factor Rev. 2022;68:81\u201392.","journal-title":"Cytokine Growth Factor Rev"},{"key":"2003_CR64","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.4049\/jimmunol.0902584","volume":"184","author":"K Dietl","year":"2010","unstructured":"Dietl K, Renner K, Dettmer K, Timischl B, Eberhart K, Dorn C, et al. Lactic acid and acidification inhibit TNF secretion and glycolysis of human monocytes. J Immunol. 2010;184:1200\u20139.","journal-title":"J Immunol"},{"key":"2003_CR65","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1002\/cac2.12158","volume":"41","author":"JZ Wang","year":"2021","unstructured":"Wang JZ, Zhu W, Han J, Yang X, Zhou R, Lu HC, et al. The role of the HIF-1\u03b1\/ALYREF\/PKM2 axis in glycolysis and tumorigenesis of bladder cancer. Cancer Commun (Lond). 2021;41:560\u201375.","journal-title":"Cancer Commun (Lond)"},{"key":"2003_CR66","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00428-010-0938-0","volume":"457","author":"CL Chen","year":"2010","unstructured":"Chen CL, Chu JS, Su WC, Huang SC, Lee WY. Hypoxia and metabolic phenotypes during breast carcinogenesis: expression of HIF-1alpha, GLUT1, and CAIX. Virchows Arch. 2010;457:53\u201361.","journal-title":"Virchows Arch"},{"key":"2003_CR67","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s00441-008-0656-y","volume":"334","author":"MN Galardo","year":"2008","unstructured":"Galardo MN, Riera MF, Pellizzari EH, Chemes HE, Venara MC, Cigorraga SB, et al. Regulation of expression of sertoli cell glucose transporters 1 and 3 by FSH, IL1 beta, and bFGF at two different time-points in pubertal development. Cell Tissue Res. 2008;334:295\u2013304.","journal-title":"Cell Tissue Res"},{"key":"2003_CR68","doi-asserted-by":"crossref","unstructured":"Johnston SN, Silagi ES, Madhu V, Nguyen DH, Shapiro IM, Risbud MV. GLUT1 is redundant in hypoxic and glycolytic nucleus pulposus cells of the intervertebral disc. JCI Insight 2023; 8:e164883.","DOI":"10.1172\/jci.insight.164883"},{"key":"2003_CR69","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3389\/fendo.2018.00129","volume":"9","author":"ES Goetzman","year":"2018","unstructured":"Goetzman ES, Prochownik EV. The role for Myc in coordinating glycolysis, oxidative phosphorylation, Glutaminolysis, and fatty acid metabolism in normal and neoplastic tissues. Front Endocrinol (Lausanne). 2018;9:129.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2003_CR70","doi-asserted-by":"crossref","unstructured":"Tyszka-Czochara M, Bukowska-Strakova K, Kocemba-Pilarczyk KA, Majka M. Caffeic acid targets AMPK Signaling and regulates tricarboxylic acid cycle anaplerosis while Metformin Downregulates HIF-1\u03b1-Induced glycolytic enzymes in human cervical squamous cell carcinoma lines. Nutrients 2018; 10:841.","DOI":"10.3390\/nu10070841"},{"key":"2003_CR71","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/s00774-017-0845-4","volume":"36","author":"J Zou","year":"2018","unstructured":"Zou J, Li XL, Shi ZM, Xue JF. Effects of C-myc gene silencing on interleukin-1\u03b2-induced rat chondrocyte cell proliferation, apoptosis and cytokine expression. J Bone Min Metab. 2018;36:286\u201396.","journal-title":"J Bone Min Metab"},{"key":"2003_CR72","doi-asserted-by":"crossref","unstructured":"Wu L, Shen J, Zhang X, Hu Z. LDHA-Mediated Glycolytic Metabolism in Nucleus Pulposus Cells Is a Potential Therapeutic Target for Intervertebral Disc Degeneration. Biomed Res Int. 2021; 2021:9914417.","DOI":"10.1155\/2021\/9914417"},{"key":"2003_CR73","doi-asserted-by":"crossref","unstructured":"Wang W, Li P, Xu J, Wu X, Guo Z, Fan L et al. Resveratrol attenuates high glucose-induced nucleus pulposus cell apoptosis and senescence through activating the ROS-mediated PI3K\/Akt pathway. Biosci Rep 2018; 38:BSR20171454.","DOI":"10.1042\/BSR20171454"},{"key":"2003_CR74","first-page":"371","volume":"70","author":"X Xiong","year":"2023","unstructured":"Xiong X, Wu Y, Long H, Liang T, Liang W, Huang X, et al. Endoplasmic reticulum stress involves the high glucose-induced nucleus pulposus cell pyroptosis. Acta Biochim Pol. 2023;70:371\u20137.","journal-title":"Acta Biochim Pol"},{"key":"2003_CR75","doi-asserted-by":"crossref","first-page":"114711","DOI":"10.1016\/j.biopha.2023.114711","volume":"162","author":"C Song","year":"2023","unstructured":"Song C, Zhou Y, Cheng K, Liu F, Cai W, Zhou D, et al. Cellular senescence - molecular mechanisms of intervertebral disc degeneration from an immune perspective. Biomed Pharmacother. 2023;162:114711.","journal-title":"Biomed Pharmacother"},{"key":"2003_CR76","doi-asserted-by":"crossref","first-page":"e1311","DOI":"10.1002\/jsp2.1311","volume":"7","author":"C Song","year":"2024","unstructured":"Song C, Zhou D, Cheng K, Liu F, Cai W, Mei Y, et al. Bioinformatics-based discovery of intervertebral disc degeneration biomarkers and immune-inflammatory infiltrates. JOR Spine. 2024;7:e1311.","journal-title":"JOR Spine"},{"key":"2003_CR77","doi-asserted-by":"crossref","first-page":"580936","DOI":"10.3389\/fimmu.2020.580936","volume":"11","author":"Y Xu","year":"2020","unstructured":"Xu Y, Chen F. Acid-sensing Ion Channel-1a in articular chondrocytes and synovial fibroblasts: a Novel Therapeutic Target for Rheumatoid Arthritis. Front Immunol. 2020;11:580936.","journal-title":"Front Immunol"},{"key":"2003_CR78","doi-asserted-by":"crossref","first-page":"106340","DOI":"10.1016\/j.intimp.2020.106340","volume":"82","author":"X Wei","year":"2020","unstructured":"Wei X, Sun C, Zhou RP, Ma GG, Yang Y, Lu C, et al. Nerve growth factor promotes ASIC1a expression via the NF-\u03baB pathway and enhances acid-induced chondrocyte apoptosis. Int Immunopharmacol. 2020;82:106340.","journal-title":"Int Immunopharmacol"},{"key":"2003_CR79","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1039\/C9BM01288E","volume":"8","author":"MD Harmon","year":"2020","unstructured":"Harmon MD, Ramos DM, Nithyadevi D, Bordett R, Rudraiah S, Nukavarapu SP, et al. Growing a backbone - functional biomaterials and structures for intervertebral disc (IVD) repair and regeneration: challenges, innovations, and future directions. Biomater Sci. 2020;8:1216\u201339.","journal-title":"Biomater Sci"},{"key":"2003_CR80","first-page":"153","volume":"12","author":"J Shen","year":"2022","unstructured":"Shen J, Chen A, Cai Z, Chen Z, Cao R, Liu Z, et al. Exhausted local lactate accumulation via injectable nanozyme-functionalized hydrogel microsphere for inflammation relief and tissue regeneration. Bioact Mater. 2022;12:153\u201368.","journal-title":"Bioact Mater"},{"key":"2003_CR81","doi-asserted-by":"crossref","first-page":"e0196894","DOI":"10.1371\/journal.pone.0196894","volume":"13","author":"AJ Krauson","year":"2018","unstructured":"Krauson AJ, Rooney JG, Carattino MD. Molecular basis of inhibition of acid sensing ion channel 1A by diminazene. PLoS ONE. 2018;13:e0196894.","journal-title":"PLoS ONE"},{"key":"2003_CR82","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1111\/cns.12524","volume":"22","author":"TD Leng","year":"2016","unstructured":"Leng TD, Si HF, Li J, Yang T, Zhu M, Wang B, et al. Amiloride Analogs as ASIC1a inhibitors. CNS Neurosci Ther. 2016;22:468\u201376.","journal-title":"CNS Neurosci Ther"},{"key":"2003_CR83","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1039\/C8TB02566E","volume":"7","author":"Z Zheng","year":"2019","unstructured":"Zheng Z, Chen A, He H, Chen Y, Chen J, Albashari AA, et al. pH and enzyme dual-responsive release of hydrogen sulfide for disc degeneration therapy. J Mater Chem B. 2019;7:611\u20138.","journal-title":"J Mater Chem B"}],"container-title":["Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-025-02003-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00011-025-02003-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-025-02003-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T16:55:01Z","timestamp":1767200101000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00011-025-02003-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,28]]},"references-count":83,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["2003"],"URL":"https:\/\/doi.org\/10.1007\/s00011-025-02003-w","relation":{},"ISSN":["1023-3830","1420-908X"],"issn-type":[{"value":"1023-3830","type":"print"},{"value":"1420-908X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,28]]},"assertion":[{"value":"12 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"29"}}