{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T10:14:45Z","timestamp":1785838485746,"version":"3.56.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:00:00Z","timestamp":1741910400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:00:00Z","timestamp":1741910400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100015613","name":"Centre Hospitalier Universitaire de Lille","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100015613","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflamm. Res."],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective and design<\/jats:title>\n                    <jats:p>\n                      Airway remodelling (AR) is a disabling phenomenon in patients with severe asthma, yet suitable models are lacking. We previously developed a dog allergen-induced murine asthma model characterized by T2\n                      <jats:sup>low<\/jats:sup>\n                      Th17-driven neutrophilic airway inflammation and AR. To assess its relevance to human AR associated with T2\n                      <jats:sup>low<\/jats:sup>\n                      severe asthma, a condition characterised by poor response to inhaled steroids, we tested the steroid sensitivity of the key features of this model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material<\/jats:title>\n                    <jats:p>\n                      Asthma was induced in C57BL\/6\u00a0J mice by intranasal sensitization, followed by a three-week challenge with dog allergen.\n                      <jats:italic>Treatment<\/jats:italic>\n                      : Daily intraperitoneal 1\u00a0mg\u00a0kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      dexamethasone was administrated during the last week of challenge.\n                      <jats:italic>Methods<\/jats:italic>\n                      : We measured airway resistances in response to methacholine, cellular inflammation in bronchoalveolar lavage, lung cytokines, and quantified AR features, in response to dexamethasone.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Dexamethasone-treated mice showed persistent airway hyperresponsiveness, neutrophilic inflammation, and\n                      <jats:italic>Il17<\/jats:italic>\n                      a overexpression, whereas\n                      <jats:italic>Il22<\/jats:italic>\n                      expression was abrogated. Pathological AR features, including mucus hyperproduction, subepithelial fibrosis and smooth muscle hypertrophy were not eliminated by dexamethasone.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our dog allergen-induced murine model of asthma mirrors the steroid-insensitive traits of human severe T2\n                      <jats:sup>low<\/jats:sup>\n                      asthma with AR, making it a relevant tool for identifying novel therapeutic targets in this orphan asthma subset.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00011-025-02004-9","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T22:50:55Z","timestamp":1741906255000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dog allergen-induced asthma in mice: a relevant model of T2low severe asthma with airway remodelling"],"prefix":"10.1007","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9952-3570","authenticated-orcid":false,"given":"Victor","family":"Margelidon-Cozzolino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Balsamelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Carrard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saliha","family":"Ait Yahia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-H\u00e9l\u00e8ne","family":"Gevaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Demoulin-Alexikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Pichavant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Tsicopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Chenivesse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Lejeune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"de Nadai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,14]]},"reference":[{"key":"2004_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)02125-0","author":"C Porsbjerg","year":"2023","unstructured":"Porsbjerg C, Mel\u00e9n E, Lehtim\u00e4ki L, Shaw D. Asthma. The Lancet. 2023. https:\/\/doi.org\/10.1016\/S0140-6736(22)02125-0.","journal-title":"The Lancet"},{"key":"2004_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2015.09.009","author":"E Konstantellou","year":"2015","unstructured":"Konstantellou E, Papaioannou AI, Loukides S, Patentalakis G, Papaporfyriou A, Hillas G, Papiris S, Koulouris N, Bakakos P, Kostikas K. Persistent airflow obstruction in patients with asthma: characteristics of a distinct clinical phenotype. Respir Med. 2015. https:\/\/doi.org\/10.1016\/j.rmed.2015.09.009.","journal-title":"Respir Med"},{"key":"2004_CR3","doi-asserted-by":"publisher","DOI":"10.1159\/000102608","author":"MH Lavietes","year":"2007","unstructured":"Lavietes MH, Ameh J, Cherniack NS. Dyspnea and symptom amplification in asthma. Respiration. 2007. https:\/\/doi.org\/10.1159\/000102608.","journal-title":"Respiration"},{"key":"2004_CR4","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00077803","author":"D Bumbacea","year":"2004","unstructured":"Bumbacea D, Campbell D, Nguyen L, Carr D, Barnes PJ, Robinson D, Chung KF. Parameters associated with persistent airflow obstruction in chronic severe asthma. Eur Respir J. 2004. https:\/\/doi.org\/10.1183\/09031936.04.00077803.","journal-title":"Eur Respir J"},{"key":"2004_CR5","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.00191","author":"KP Hough","year":"2020","unstructured":"Hough KP, Curtiss ML, Blain TJ, Liu RM, Trevor J, Deshane JS, Thannickal VJ. Airway remodeling in asthma. Front Med. 2020. https:\/\/doi.org\/10.3389\/fmed.2020.00191.","journal-title":"Front Med"},{"key":"2004_CR6","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.1557","author":"J Chakir","year":"2003","unstructured":"Chakir J, Shannon J, Molet S, Fukakusa M, Elias J, Laviolette M, Boulet LP, Hamid Q. Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-\u03b2, IL-11, IL-17, and type I and type III collagen expression. J Allergy Clin Immunol. 2003. https:\/\/doi.org\/10.1067\/mai.2003.1557.","journal-title":"J Allergy Clin Immunol"},{"key":"2004_CR7","unstructured":"Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention, 2024. Updated May 2024. [Internet]. Available from: www.ginaasthma.org"},{"key":"2004_CR8","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00202013","author":"KF Chung","year":"2014","unstructured":"Chung KF, Wenzel SE, Brozek JL, Bush A, Castro M, Sterk PJ, Adcock IM, Bateman ED, Bel EH, Bleecker ER, Boulet LP, Brightling C, Chanez P, Dahlen SE, Djukanovic R, Frey U, Gaga M, Gibson P, Hamid Q, Jajour NN, Mauad T, Sorkness RL, Teague WG. International ERS\/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J. 2014. https:\/\/doi.org\/10.1183\/09031936.00202013.","journal-title":"Eur Respir J"},{"key":"2004_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2018.12.029","author":"A Bourdin","year":"2019","unstructured":"Bourdin A, Fabry-Vendrand C, Ostinelli J, Ait-Yahia M, Darnal E, Bouee S, Laurendeau C, Bureau I, Gourmelen J, Chouaid C. The burden of severe asthma in France: a case-control study using a medical claims database. J Allergy Clin Immunol Pract. 2019. https:\/\/doi.org\/10.1016\/j.jaip.2018.12.029.","journal-title":"J Allergy Clin Immunol Pract"},{"key":"2004_CR10","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.5.2011026","author":"A ten Brinke","year":"2001","unstructured":"ten Brinke A, Zwinderman AH, Sterk PJ, Rabe KF, Bel EH. Factors associated with persistent airflow limitation in severe asthma. Am J Respir Crit Care Med. 2001. https:\/\/doi.org\/10.1164\/ajrccm.164.5.2011026.","journal-title":"Am J Respir Crit Care Med"},{"key":"2004_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.11.544","author":"E Goleva","year":"2007","unstructured":"Goleva E, Hauk PJ, Boguniewicz J, Martin RJ, Leung DYM. Airway remodeling and lack of bronchodilator response in steroid resistant (SR) asthma. J Allergy Clin Immunol. 2007. https:\/\/doi.org\/10.1016\/j.jaci.2006.11.544.","journal-title":"J Allergy Clin Immunol"},{"key":"2004_CR12","doi-asserted-by":"publisher","DOI":"10.2147\/jir.s295038","author":"H Rupani","year":"2021","unstructured":"Rupani H, Fong WCG, Kyyaly MA, Kurukulaaratchy RJ. Recent insights into the management of inflammation in asthma. J Inflamm Res. 2021. https:\/\/doi.org\/10.2147\/jir.s295038.","journal-title":"J Inflamm Res"},{"key":"2004_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.114012","author":"R Tan","year":"2020","unstructured":"Tan R, Liew MF, Lim HF, Leung BP, Wong WSF. Promises and challenges of biologics for severe asthma. Biochem Pharmacol. 2020. https:\/\/doi.org\/10.1016\/j.bcp.2020.114012.","journal-title":"Biochem Pharmacol"},{"key":"2004_CR14","doi-asserted-by":"publisher","DOI":"10.3389\/falgy.2022.806391","author":"V Margelidon-Cozzolino","year":"2022","unstructured":"Margelidon-Cozzolino V, Tsicopoulos A, Chenivesse C, de Nadai P. Role of Th17 cytokines in airway remodeling in asthma and therapy perspectives. Front Allergy. 2022. https:\/\/doi.org\/10.3389\/falgy.2022.806391.","journal-title":"Front Allergy"},{"key":"2004_CR15","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2034975","author":"A Menzies-Gow","year":"2021","unstructured":"Menzies-Gow A, Corren J, Bourdin A, Chupp G, Israel E, Wechsler ME, Brightling CE, Griffiths JM, Hellqvist \u00c5, Bowen K, Kaur P, Almqvist G, Ponnarambil S, Colice G. Tezepelumab in adults and adolescents with severe. Uncontrolled Asthma N Engl J Med. 2021. https:\/\/doi.org\/10.1056\/nejmoa2034975.","journal-title":"Uncontrolled Asthma N Engl J Med"},{"key":"2004_CR16","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9111684","author":"FLM Ricciardolo","year":"2021","unstructured":"Ricciardolo FLM, Sprio AE, Baroso A, Gallo F, Riccardi E, Bertolini F, Carriero V, Arrigo E, Ciprandi G. Characterization of T2-Low and T2-High asthma phenotypes in real-life. Biomedicines. 2021. https:\/\/doi.org\/10.3390\/biomedicines9111684.","journal-title":"Biomedicines"},{"issue":"3","key":"2004_CR17","first-page":"266","volume":"29","author":"J Zhu","year":"2011","unstructured":"Zhu J, Cao Y, Li K, Wang Z, Zuo P, Xiong W, Xu Y, Xiong S. Increased expression of aryl hydrocarbon receptor and interleukin 22 in patients with allergic asthma. Asian Pac J Allergy Immunol. 2011;29(3):266.","journal-title":"Asian Pac J Allergy Immunol"},{"key":"2004_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.10.034","author":"FLM Ricciardolo","year":"2017","unstructured":"Ricciardolo FLM, Sorbello V, Folino A, Gallo F, Massaglia GM, Favat\u00e0 G, Conticello S, Vallese D, Gani F, Malerba M, Folkerts G, Rolla G, Profita M, Mauad T, Di Stefano A, Ciprandi G. Identification of IL-17F\/frequent exacerbator endotype in asthma. J Allergy Clin Immunol. 2017. https:\/\/doi.org\/10.1016\/j.jaci.2016.10.034.","journal-title":"J Allergy Clin Immunol"},{"key":"2004_CR19","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200507-1162OC","author":"G Cox","year":"2006","unstructured":"Cox G, Miller JD, McWilliams A, FitzGerald JM, Lam S. Bronchial thermoplasty for asthma. Am J Respir Crit Care Med. 2006. https:\/\/doi.org\/10.1164\/rccm.200507-1162OC.","journal-title":"Am J Respir Crit Care Med"},{"key":"2004_CR20","doi-asserted-by":"publisher","DOI":"10.1111\/all.14740","author":"M Bout\u00e9","year":"2021","unstructured":"Bout\u00e9 M, Ait Yahia S, Nanou J, Alvarez-Simon D, Audousset C, Vorng H, Balsamelli J, Ying F, Marquillies P, Werkmeister E, de Nadai P, Chenivesse C, Tsicopoulos A. Direct activation of the aryl hydrocarbon receptor by dog allergen participates in airway neutrophilic inflammation. Allergy. 2021. https:\/\/doi.org\/10.1111\/all.14740.","journal-title":"Allergy"},{"key":"2004_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.03.019","author":"L Everaere","year":"2016","unstructured":"Everaere L, Ait-Yahia S, Molendi-Coste O, Vorng H, Quemener S, LeVu P, Fleury S, Bouchaert E, Fan Y, Duez C, de Nadai P, Staels B, Dombrowicz D, Tsicopoulos A. Innate lymphoid cells contribute to allergic airway disease exacerbation by obesity. J Allergy Clin Immunol. 2016. https:\/\/doi.org\/10.1016\/j.jaci.2016.03.019.","journal-title":"J Allergy Clin Immunol"},{"key":"2004_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2017.07.005","author":"V Bergmeier","year":"2018","unstructured":"Bergmeier V, Etich J, Pitzler L, Frie C, Koch M, Fischer M, Rappl G, Abken H, Tomasek JJ, Brachvogel B. Identification of a myofibroblast-specific expression signature in skin wounds. Matrix Biol J Int Soc Matrix Biol. 2018. https:\/\/doi.org\/10.1016\/j.matbio.2017.07.005.","journal-title":"Matrix Biol J Int Soc Matrix Biol"},{"key":"2004_CR23","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00068-2019","author":"M Bullone","year":"2019","unstructured":"Bullone M, Carriero V, Bertolini F, Folino A, Mannelli A, Stefano AD, Gnemmi I, Torchio R, Ricciardolo FLM. Elevated serum IgE, oral corticosteroid dependence and IL-17\/22 expression in highly neutrophilic asthma. Eur Respir J. 2019. https:\/\/doi.org\/10.1183\/13993003.00068-2019.","journal-title":"Eur Respir J"},{"key":"2004_CR24","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.156.3.9610046","author":"SE Wenzel","year":"1997","unstructured":"Wenzel SE, Szefler SJ, Leung DYM, Sloan SI, Rex MD, Martin RJ. Bronchoscopic evaluation of severe asthma. Am J Respir Crit Care Med. 1997. https:\/\/doi.org\/10.1164\/ajrccm.156.3.9610046.","journal-title":"Am J Respir Crit Care Med"},{"key":"2004_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.12.769","author":"Y Xie","year":"2022","unstructured":"Xie Y, Abel PW, Casale TB, Tu Y. TH17 cells and corticosteroid insensitivity in severe asthma. J Allergy Clin Immunol. 2022. https:\/\/doi.org\/10.1016\/j.jaci.2021.12.769.","journal-title":"J Allergy Clin Immunol"},{"key":"2004_CR26","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-021-01743-7","author":"D Lamb","year":"2021","unstructured":"Lamb D, De Sousa D, Quast K, Fundel-Clemens K, Erjef\u00e4lt JS, Sand\u00e9n C, Hoffmann HJ, K\u00e4stle M. ROR\u03b3t inhibitors block both IL-17 and IL-22 conferring a potential advantage over anti-IL-17 alone to treat severe asthma. Respir Res. 2021. https:\/\/doi.org\/10.1186\/s12931-021-01743-7.","journal-title":"Respir Res"},{"key":"2004_CR27","doi-asserted-by":"publisher","DOI":"10.1164\/RCCM.200904-0573OC","author":"RH Wilson","year":"2009","unstructured":"Wilson RH, Whitehead GS, Nakano H, Free ME, Kolls JK, Cook DN. Allergic sensitization through the airway primes Th17-dependent Neutrophilia and airway hyperresponsiveness. Am J Respir Crit Care Med. 2009. https:\/\/doi.org\/10.1164\/RCCM.200904-0573OC.","journal-title":"Am J Respir Crit Care Med"},{"key":"2004_CR28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0154755","author":"RY Murcia","year":"2016","unstructured":"Murcia RY, Vargas A, Lavoie JP. The interleukin-17 induced activation and increased survival of equine neutrophils is insensitive to glucocorticoids. PLoS ONE. 2016. https:\/\/doi.org\/10.1371\/journal.pone.0154755.","journal-title":"PLoS ONE"},{"key":"2004_CR29","doi-asserted-by":"publisher","DOI":"10.1111\/all.15399","author":"JM Stark","year":"2022","unstructured":"Stark JM, Liu J, Tibbitt CA, Christian M, Ma J, Wintersand A, Dunst J, Kreslavsky T, Murrell B, Adner M, Gr\u00f6nlund H, Gafvelin G, Coquet JM. Recombinant multimeric dog allergen prevents airway hyperresponsiveness in a model of asthma marked by vigorous TH2 and TH17 cell responses. Allergy. 2022. https:\/\/doi.org\/10.1111\/all.15399.","journal-title":"Allergy"},{"key":"2004_CR30","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.717962","author":"Y Xue","year":"2021","unstructured":"Xue Y, Zhou Y, Bao W, Fu Q, Hao H, Han L, Zhang X, Tian X, Zhang M. STAT3 and IL-6 contribute to corticosteroid resistance in an OVA and ozone-induced asthma model with neutrophil infiltration. Front Mol Biosci. 2021. https:\/\/doi.org\/10.3389\/fmolb.2021.717962.","journal-title":"Front Mol Biosci"},{"key":"2004_CR31","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-012-9828-3","author":"A Vazquez-Tello","year":"2013","unstructured":"Vazquez-Tello A, Halwani R, Hamid Q, Al-Muhsen S. Glucocorticoid receptor-beta up-regulation and steroid resistance induction by IL-17 and IL-23 cytokine stimulation in peripheral mononuclear cells. J Clin Immunol. 2013. https:\/\/doi.org\/10.1007\/s10875-012-9828-3.","journal-title":"J Clin Immunol"},{"key":"2004_CR32","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00017911","author":"GJ Zijlstra","year":"2012","unstructured":"Zijlstra GJ, ten Hacken NHT, Hoffmann RF, van Oosterhout AJM, Heijink IH. Interleukin-17A induces glucocorticoid insensitivity in human bronchial epithelial cells. Eur Respir J. 2012. https:\/\/doi.org\/10.1183\/09031936.00017911.","journal-title":"Eur Respir J"},{"key":"2004_CR33","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-15393-2","author":"SF Rahmawati","year":"2022","unstructured":"Rahmawati SF, Vos R, Bos IST, Kerstjens HAM, Kistemaker LEM, Gosens R. Function-specific IL-17A and dexamethasone interactions in primary human airway epithelial cells. Sci Rep. 2022. https:\/\/doi.org\/10.1038\/s41598-022-15393-2.","journal-title":"Sci Rep"},{"key":"2004_CR34","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.6.4089","author":"L McKinley","year":"2008","unstructured":"McKinley L, Alcorn JF, Peterson A, DuPont RB, Kapadia S, Logar A, Henry A, Irvin CG, Piganelli JD, Ray A, Kolls JK. T H 17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice. J Immunol. 2008. https:\/\/doi.org\/10.4049\/jimmunol.181.6.4089.","journal-title":"J Immunol"},{"key":"2004_CR35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091223","author":"MJ Duechs","year":"2014","unstructured":"Duechs MJ, Tilp C, Tomsic C, Gantner F, Erb KJ. Development of a novel severe triple allergen asthma model in mice which is resistant to dexamethasone and partially resistant to TLR7 and TLR9 agonist treatment. PLoS ONE. 2014. https:\/\/doi.org\/10.1371\/journal.pone.0091223.","journal-title":"PLoS ONE"},{"key":"2004_CR36","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.113760","author":"M Kraft","year":"2001","unstructured":"Kraft M, Lewis C, Pham D, Chu HW. IL-4, IL-13, and dexamethasone augment fibroblast proliferation in asthma. J Allergy Clin Immunol. 2001. https:\/\/doi.org\/10.1067\/mai.2001.113760.","journal-title":"J Allergy Clin Immunol"},{"key":"2004_CR37","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-015-0307-2","author":"R Halwani","year":"2016","unstructured":"Halwani R, Sultana A, Al-Kufaidy R, Jamhawi A, Vazquez-Tello A, Al-Muhsen S. Th-17 regulatory cytokines inhibit corticosteroid induced airway structural cells apoptosis. Respir Res. 2016. https:\/\/doi.org\/10.1186\/s12931-015-0307-2.","journal-title":"Respir Res"},{"key":"2004_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2023.03.001","author":"M Hvidtfeldt","year":"2023","unstructured":"Hvidtfeldt M, Sverrild A, Pulga A, Fr\u00f8ssing L, Silberbrandt A, Hostrup M, Thomassen M, Sanden C, Clausson CM, Siddhuraj P, Bornesund D, Nieto-Fontarigo JJ, Uller L, Erjef\u00e4lt J, Porsbjerg C. Airway hyperresponsiveness reflects corticosteroid-sensitive mast cell involvement across asthma phenotypes. J Allergy Clin Immunol. 2023. https:\/\/doi.org\/10.1016\/j.jaci.2023.03.001.","journal-title":"J Allergy Clin Immunol"},{"key":"2004_CR39","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2018.5721","author":"QL Yu","year":"2018","unstructured":"Yu QL, Chen Z. Establishment of different experimental asthma models in mice. Exp Ther Med. 2018. https:\/\/doi.org\/10.3892\/etm.2018.5721.","journal-title":"Exp Ther Med"},{"key":"2004_CR40","doi-asserted-by":"publisher","DOI":"10.1080\/02770903.2020.1737710","author":"R Zheng","year":"2021","unstructured":"Zheng R, Wang F, Huang Y, Xiang Q, Dai H, Zhang W. Elevated Th17 cell frequencies and Th17\/Treg ratio are associated with airway hyperresponsiveness in asthmatic children. J Asthma Off J Assoc Care Asthma. 2021. https:\/\/doi.org\/10.1080\/02770903.2020.1737710.","journal-title":"J Asthma Off J Assoc Care Asthma"},{"key":"2004_CR41","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.8.4668","author":"DM Walter","year":"2001","unstructured":"Walter DM, McIntire JJ, Berry G, McKenzie ANJ, Donaldson DD, DeKruyff RH, Umetsu DT. Critical role for IL-13 in the development of allergen-induced airway hyperreactivity1. J Immunol. 2001. https:\/\/doi.org\/10.4049\/jimmunol.167.8.4668.","journal-title":"J Immunol"},{"key":"2004_CR42","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2009.03969.x","author":"E Ziesch\u00e9","year":"2009","unstructured":"Ziesch\u00e9 E, Scheiermann P, Bachmann M, Sadik CD, Hofstetter C, Zwissler B, Pfeilschifter J, M\u00fchl H. Dexamethasone suppresses interleukin-22 associated with bacterial infection in vitro and in vivo. Clin Exp Immunol. 2009. https:\/\/doi.org\/10.1111\/j.1365-2249.2009.03969.x.","journal-title":"Clin Exp Immunol"},{"issue":"4","key":"2004_CR43","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.4049\/jimmunol.1800484","volume":"201","author":"S Seshadri","year":"2018","unstructured":"Seshadri S, Pope RL, Zenewicz LA. Glucocorticoids inhibit group 3 innate lymphocyte IL-22 production. J Immunol. 2018;201(4):1267\u201374. https:\/\/doi.org\/10.4049\/jimmunol.1800484.","journal-title":"J Immunol"},{"key":"2004_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2018.11.012","author":"EO Gubernatorova","year":"2019","unstructured":"Gubernatorova EO, Namakanova OA, Tumanov AV, Drutskaya MS, Nedospasov SA. Mouse models of severe asthma for evaluation of therapeutic cytokine targeting. Immunol Lett. 2019. https:\/\/doi.org\/10.1016\/j.imlet.2018.11.012.","journal-title":"Immunol Lett"},{"issue":"3","key":"2004_CR45","doi-asserted-by":"publisher","first-page":"963","DOI":"10.4049\/jimmunol.1501531","volume":"196","author":"ML Manni","year":"2016","unstructured":"Manni ML, Mandalapu S, McHugh KJ, Merle Elloso M, Dudas PL, Alcorn JF. Molecular mechanisms of airway hyperresponsiveness in a murine model of steroid-resistant airway inflammation. J Immunol. 2016;196(3):963\u201377. https:\/\/doi.org\/10.4049\/jimmunol.1501531.","journal-title":"J Immunol"},{"key":"2004_CR46","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2011-200160","author":"AT Essilfie","year":"2012","unstructured":"Essilfie AT, Simpson JL, Dunkley ML, Morgan LC, Oliver BG, Gibson PG, Foster PS, Hansbro PM. Combined Haemophilus influenzae respiratory infection and allergic airways disease drives chronic infection and features of neutrophilic asthma. Thorax. 2012. https:\/\/doi.org\/10.1136\/thoraxjnl-2011-200160.","journal-title":"Thorax"},{"key":"2004_CR47","doi-asserted-by":"publisher","DOI":"10.1159\/000345861","author":"H Matsuse","year":"2013","unstructured":"Matsuse H, Fukushima C, Fukahori S, Tsuchida T, Kawano T, Nishino T, Kohno S. Differential effects of dexamethasone and itraconazole on Aspergillus fumigatus-exacerbated allergic airway inflammation in a murine model of mite-sensitized asthma. Respir Int Rev Thorac Dis. 2013. https:\/\/doi.org\/10.1159\/000345861.","journal-title":"Respir Int Rev Thorac Dis"},{"key":"2004_CR48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134219","author":"S Hadebe","year":"2015","unstructured":"Hadebe S, Kirstein F, Fierens K, Chen K, Drummond RA, Vautier S, Sajaniemi S, Murray G, Williams DL, Redelinghuys P, Reinhart TA, Junecko BAF, Kolls JK, Lambrecht BN, Brombacher F, Brown GD. Microbial ligand costimulation drives neutrophilic steroid-refractory asthma. PLoS ONE. 2015. https:\/\/doi.org\/10.1371\/journal.pone.0134219.","journal-title":"PLoS ONE"},{"key":"2004_CR49","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-013-9611-5","author":"R Liu","year":"2013","unstructured":"Liu R, Bai J, Xu G, Xuan L, Zhang T, Meng A, Hou Q. Multi-allergen challenge stimulates steriod-resistant airway inflammation via NF-\u03baB-mediated IL-8 expression. Inflammation. 2013. https:\/\/doi.org\/10.1007\/s10753-013-9611-5.","journal-title":"Inflammation"},{"key":"2004_CR50","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2008-0028OC","author":"K Ito","year":"2008","unstructured":"Ito K, Herbert C, Siegle JS, Vuppusetty C, Hansbro N, Thomas PS, Foster PS, Barnes PJ, Kumar RK. Steroid-resistant neutrophilic inflammation in a mouse model of an acute exacerbation of asthma. Am J Respir Cell Mol Biol. 2008. https:\/\/doi.org\/10.1165\/rcmb.2008-0028OC.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2004_CR51","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001039","author":"JJ Li","year":"2010","unstructured":"Li JJ, Wang W, Baines KJ, Bowden NA, Hansbro PM, Gibson PG, Kumar RK, Foster PS, Yang M. IL-27\/IFN-\u03b3 induce MyD88-dependent steroid-resistant airway hyperresponsiveness by inhibiting glucocorticoid signaling in macrophages. J Immunol. 2010. https:\/\/doi.org\/10.4049\/jimmunol.1001039.","journal-title":"J Immunol"},{"key":"2004_CR52","doi-asserted-by":"publisher","DOI":"10.1172\/JCI80911","author":"M Raundhal","year":"2015","unstructured":"Raundhal M, Morse C, Khare A, Oriss TB, Milosevic J, Trudeau J, Huff R, Pilewski J, Holguin F, Kolls J, Wenzel S, Ray P, Ray A. High IFN-\u03b3 and low SLPI mark severe asthma in mice and humans. J Clin Invest. 2015. https:\/\/doi.org\/10.1172\/JCI80911.","journal-title":"J Clin Invest"},{"key":"2004_CR53","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.94580","author":"M Gauthier","year":"2017","unstructured":"Gauthier M, Chakraborty K, Oriss TB, Raundhal M, Das S, Chen J, Huff R, Sinha A, Fajt M, Ray P, Wenzel SE, Ray A. Severe asthma in humans and mouse model suggests a CXCL10 signature underlies corticosteroid-resistant Th1 bias. JCI Insight. 2017. https:\/\/doi.org\/10.1172\/jci.insight.94580.","journal-title":"JCI Insight"},{"key":"2004_CR54","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2110084","author":"A Kibe","year":"2003","unstructured":"Kibe A, Inoue H, Fukuyama S, Machida K, Matsumoto K, Koto H, Ikegami T, Aizawa H, Hara N. Differential regulation by glucocorticoid of interleukin-13-induced eosinophilia, hyperresponsiveness, and goblet cell hyperplasia in mouse airways. Am J Respir Crit Care Med. 2003. https:\/\/doi.org\/10.1164\/rccm.2110084.","journal-title":"Am J Respir Crit Care Med"},{"key":"2004_CR55","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2007-0240OC","author":"AG Therien","year":"2008","unstructured":"Therien AG, Bernier V, Weicker S, Tawa P, Falgueyret JP, Mathieu MC, Honsberger J, Pomerleau V, Robichaud A, Stocco R, Dufresne L, Houshyar H, Lafleur J, Ramachandran C, O\u2019Neill GP, Slipetz D, Tan CM. Adenovirus IL-13-induced airway disease in mice: a corticosteroid-resistant model of severe asthma. Am J Respir Cell Mol Biol. 2008. https:\/\/doi.org\/10.1165\/rcmb.2007-0240OC.","journal-title":"Am J Respir Cell Mol Biol"}],"container-title":["Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-025-02004-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00011-025-02004-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-025-02004-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T16:55:40Z","timestamp":1767200140000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00011-025-02004-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,14]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["2004"],"URL":"https:\/\/doi.org\/10.1007\/s00011-025-02004-9","relation":{},"ISSN":["1023-3830","1420-908X"],"issn-type":[{"value":"1023-3830","type":"print"},{"value":"1420-908X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,14]]},"assertion":[{"value":"16 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 January 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 March 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"52"}}