{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T04:03:23Z","timestamp":1791864203525,"version":"4.3.4"},"reference-count":87,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:00:00Z","timestamp":1741910400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:00:00Z","timestamp":1741910400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"crossref","award":["RSPD2024R1089"],"award-info":[{"award-number":["RSPD2024R1089"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"crossref","award":["RSPD2024R1089"],"award-info":[{"award-number":["RSPD2024R1089"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"crossref","award":["RSPD2024R1089"],"award-info":[{"award-number":["RSPD2024R1089"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"crossref","award":["RSPD2024R1089"],"award-info":[{"award-number":["RSPD2024R1089"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"crossref","award":["RSPD2024R1089"],"award-info":[{"award-number":["RSPD2024R1089"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"crossref","award":["RSPD2024R1089"],"award-info":[{"award-number":["RSPD2024R1089"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"crossref","award":["RSPD2024R1089"],"award-info":[{"award-number":["RSPD2024R1089"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"crossref","award":["RSPD2024R1089"],"award-info":[{"award-number":["RSPD2024R1089"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"crossref","award":["RSPD2024R1089"],"award-info":[{"award-number":["RSPD2024R1089"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflamm. Res."],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s00011-025-02009-4","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T22:40:35Z","timestamp":1741905635000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Vitamin D3 suppresses NLRP3 inflammasome pathway and enhances steroid sensitivity in a neutrophilic steroid hyporesponsive asthma mouse model"],"prefix":"10.1007","volume":"74","author":[{"given":"Bariaa","family":"Khalil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narjes Saheb","family":"Sharif-Askari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balachandar","family":"Selvakumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bushra","family":"Mdkhana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Hachim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel","family":"Zakri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Hundt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qutayba","family":"Hamid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabih","family":"Halwani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,14]]},"reference":[{"issue":"2","key":"2009_CR1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s12016-018-8712-1","volume":"56","author":"ME Kuruvilla","year":"2019","unstructured":"Kuruvilla ME, Lee FE, Lee GB. Understanding asthma phenotypes, endotypes, and mechanisms of disease. Clin Rev Allergy Immunol. 2019;56(2):219\u201333.","journal-title":"Clin Rev Allergy Immunol"},{"issue":"2","key":"2009_CR2","doi-asserted-by":"crossref","DOI":"10.1016\/j.opresp.2022.100231","volume":"5","author":"V Plaza","year":"2023","unstructured":"Plaza V, et al. Efficacy and potential positioning of tezepelumab in the treatment of severe asthma. Open Respir Arch. 2023;5(2): 100231.","journal-title":"Open Respir Arch"},{"issue":"3","key":"2009_CR3","first-page":"81","volume":"43","author":"MS Ehlayel","year":"2011","unstructured":"Ehlayel MS, Bener A, Sabbah A. Is high prevalence of vitamin D deficiency evidence for asthma and allergy risks? Eur Ann Allergy Clin Immunol. 2011;43(3):81\u20138.","journal-title":"Eur Ann Allergy Clin Immunol"},{"issue":"1","key":"2009_CR4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1465-9921-14-25","volume":"14","author":"S Korn","year":"2013","unstructured":"Korn S, et al. Severe and uncontrolled adult asthma is associated with vitamin D insufficiency and deficiency. Respir Res. 2013;14(1):25.","journal-title":"Respir Res"},{"issue":"5","key":"2009_CR5","doi-asserted-by":"crossref","first-page":"283","DOI":"10.4168\/aair.2013.5.5.283","volume":"5","author":"F Montero-Arias","year":"2013","unstructured":"Montero-Arias F, Sedo-Mejia G, Ramos-Esquivel A. Vitamin d insufficiency and asthma severity in adults from costa rica. Allergy Asthma Immunol Res. 2013;5(5):283\u20138.","journal-title":"Allergy Asthma Immunol Res"},{"issue":"9","key":"2009_CR6","doi-asserted-by":"crossref","first-page":"950","DOI":"10.3109\/02770903.2014.930883","volume":"51","author":"NM Salas","year":"2014","unstructured":"Salas NM, Luo L, Harkins MS. Vitamin D deficiency and adult asthma exacerbations. J Asthma. 2014;51(9):950\u20135.","journal-title":"J Asthma"},{"issue":"9","key":"2009_CR7","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.3390\/biomedicines11092542","volume":"11","author":"G Sapartini","year":"2023","unstructured":"Sapartini G, et al. The association between vitamin D, interleukin-4, and interleukin-10 levels and CD23+ expression with bronchial asthma in stunted children. Biomedicines. 2023;11(9):2542.","journal-title":"Biomedicines"},{"key":"2009_CR8","doi-asserted-by":"crossref","first-page":"9947370","DOI":"10.1155\/2021\/9947370","volume":"2021","author":"B Mahboub","year":"2021","unstructured":"Mahboub B, et al. Vitamin D regulates the expression of glucocorticoid receptors in blood of severe asthmatic patients. J Immunol Res. 2021;2021:9947370.","journal-title":"J Immunol Res"},{"issue":"3","key":"2009_CR9","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/s10753-013-9790-0","volume":"37","author":"T Wei-hong","year":"2014","unstructured":"Wei-hong T, et al. Pharmacological and pharmacokinetic studies with vitamin D-loaded nanoemulsions in asthma model. Inflammation. 2014;37(3):723\u20138.","journal-title":"Inflammation"},{"issue":"7","key":"2009_CR10","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1007\/s12098-013-1268-4","volume":"81","author":"M Yadav","year":"2014","unstructured":"Yadav M, Mittal K. Effect of vitamin D supplementation on moderate to severe bronchial asthma. Indian J Pediatr. 2014;81(7):650\u20134.","journal-title":"Indian J Pediatr"},{"key":"2009_CR11","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.intimp.2018.12.061","volume":"68","author":"Y Huang","year":"2019","unstructured":"Huang Y, et al. Vitamin D alleviates airway remodeling in asthma by down-regulating the activity of Wnt\/beta-catenin signaling pathway. Int Immunopharmacol. 2019;68:88\u201394.","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"2009_CR12","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12931-016-0490-9","volume":"18","author":"SH Kim","year":"2017","unstructured":"Kim SH, et al. Effect of active vitamin D3 on VEGF-induced ADAM33 expression and proliferation in human airway smooth muscle cells: implications for asthma treatment. Respir Res. 2017;18(1):7.","journal-title":"Respir Res"},{"issue":"5","key":"2009_CR13","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.jaci.2010.03.008","volume":"125","author":"DA Searing","year":"2010","unstructured":"Searing DA, et al. Decreased serum vitamin D levels in children with asthma are associated with increased corticosteroid use. J Allergy Clin Immunol. 2010;125(5):995\u20131000.","journal-title":"J Allergy Clin Immunol"},{"issue":"7","key":"2009_CR14","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1164\/rccm.200911-1710OC","volume":"181","author":"ER Sutherland","year":"2010","unstructured":"Sutherland ER, et al. Vitamin D levels, lung function, and steroid response in adult asthma. Am J Respir Crit Care Med. 2010;181(7):699\u2013704.","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"2009_CR15","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.jaci.2011.09.034","volume":"129","author":"R Du","year":"2012","unstructured":"Du R, et al. Genome-wide association study reveals class I MHC-restricted T cell-associated molecule gene (CRTAM) variants interact with vitamin D levels to affect asthma exacerbations. J Allergy Clin Immunol. 2012;129(2):368-373.e5.","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"2009_CR16","doi-asserted-by":"crossref","first-page":"574","DOI":"10.21037\/apm-21-3797","volume":"11","author":"L He","year":"2022","unstructured":"He L, et al. The association between vitamin D receptor gene polymorphisms and asthma: a systematic review and meta-analysis. Ann Palliat Med. 2022;11(2):574\u201387.","journal-title":"Ann Palliat Med"},{"issue":"13","key":"2009_CR17","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1056\/NEJMoa0906312","volume":"363","author":"MF Moffatt","year":"2010","unstructured":"Moffatt MF, et al. A large-scale, consortium-based genomewide association study of asthma. N Engl J Med. 2010;363(13):1211\u201321.","journal-title":"N Engl J Med"},{"issue":"4","key":"2009_CR18","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1111\/all.15666","volume":"78","author":"BS Stikker","year":"2023","unstructured":"Stikker BS, Hendriks RW, Stadhouders R. Decoding the genetic and epigenetic basis of asthma. Allergy. 2023;78(4):940\u201356.","journal-title":"Allergy"},{"issue":"6","key":"2009_CR19","doi-asserted-by":"crossref","first-page":"831","DOI":"10.4049\/jimmunol.2400078","volume":"213","author":"B Biswas","year":"2024","unstructured":"Biswas B, Chattopadhyay S, Hazra S, Goswami R. Calcitriol impairs the secretion of IL-4 and IL-13 in Th2 cells via modulating the VDR-Gata3-Gfi1. Axis J Immunol. 2024;213(6):831\u201342.","journal-title":"Axis J Immunol"},{"issue":"3","key":"2009_CR20","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/s11914-022-00732-z","volume":"20","author":"DD Bikle","year":"2022","unstructured":"Bikle DD. Vitamin D regulation of immune function. Curr Osteoporos Rep. 2022;20(3):186\u201393.","journal-title":"Curr Osteoporos Rep"},{"issue":"6","key":"2009_CR21","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.mam.2008.04.004","volume":"29","author":"MT Cantorna","year":"2008","unstructured":"Cantorna MT, Yu S, Bruce D. The paradoxical effects of vitamin D on type 1 mediated immunity. Mol Aspects Med. 2008;29(6):369\u201375.","journal-title":"Mol Aspects Med"},{"issue":"11","key":"2009_CR22","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.steroids.2012.05.006","volume":"77","author":"V Gonzalez-Pardo","year":"2012","unstructured":"Gonzalez-Pardo V, et al. NF\u03baB pathway is down-regulated by 1\u03b1,25(OH)(2)-vitamin D(3) in endothelial cells transformed by Kaposi sarcoma-associated herpes virus G protein coupled receptor. Steroids. 2012;77(11):1025\u201332.","journal-title":"Steroids"},{"issue":"9","key":"2009_CR23","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1096\/fj.04-3284com","volume":"19","author":"AF Gombart","year":"2005","unstructured":"Gombart AF, Borregaard N, Koeffler HP. Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3. Faseb J. 2005;19(9):1067\u201377.","journal-title":"Faseb J"},{"issue":"4","key":"2009_CR24","doi-asserted-by":"crossref","first-page":"e318","DOI":"10.1002\/mco2.318","volume":"4","author":"M Chen","year":"2023","unstructured":"Chen M, et al. Vitamin D3 attenuates SARS-CoV-2 nucleocapsid protein-caused hyperinflammation by inactivating the NLRP3 inflammasome through the VDR-BRCC3 signaling pathway in vitro and in vivo. MedComm. 2023;4(4):e318.","journal-title":"MedComm"},{"issue":"2","key":"2009_CR25","doi-asserted-by":"crossref","first-page":"e312","DOI":"10.1002\/ctm2.312","volume":"11","author":"X Dong","year":"2021","unstructured":"Dong X, et al. Vitamin D3 ameliorates nitrogen mustard-induced cutaneous inflammation by inactivating the NLRP3 inflammasome through the SIRT3-SOD2-mtROS signaling pathway. Clin Transl Med. 2021;11(2):e312.","journal-title":"Clin Transl Med"},{"key":"2009_CR26","first-page":"8193523","volume":"2018","author":"L Lu","year":"2018","unstructured":"Lu L, et al. Vitamin D(3) protects against diabetic retinopathy by inhibiting high-glucose-induced activation of the ROS\/TXNIP\/NLRP3 inflammasome pathway. J Diabetes Res. 2018;2018:8193523.","journal-title":"J Diabetes Res"},{"key":"2009_CR27","doi-asserted-by":"crossref","first-page":"103286","DOI":"10.1016\/j.jri.2021.103286","volume":"144","author":"ML Matias","year":"2021","unstructured":"Matias ML, et al. Progesterone and vitamin D downregulate the activation of the NLRP1\/NLRP3 inflammasomes and TLR4-MyD88-NF-\u03baB pathway in monocytes from pregnant women with preeclampsia. J Reprod Immunol. 2021;144:103286.","journal-title":"J Reprod Immunol"},{"issue":"1","key":"2009_CR28","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.humimm.2021.10.002","volume":"83","author":"PR Nunes","year":"2022","unstructured":"Nunes PR, et al. Vitamin D decreases expression of NLRP1 and NLRP3 inflammasomes in placental explants from women with preeclampsia cultured with hydrogen peroxide. Hum Immunol. 2022;83(1):74\u201380.","journal-title":"Hum Immunol"},{"issue":"8","key":"2009_CR29","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1093\/jnen\/nlad047","volume":"82","author":"J Qiao","year":"2023","unstructured":"Qiao J, et al. Vitamin D alleviates neuronal injury in cerebral ischemia-reperfusion via enhancing the Nrf2\/HO-1 antioxidant pathway to counteract NLRP3-mediated pyroptosis. J Neuropathol Exp Neurol. 2023;82(8):722\u201333.","journal-title":"J Neuropathol Exp Neurol"},{"key":"2009_CR30","doi-asserted-by":"crossref","first-page":"111596","DOI":"10.1016\/j.mce.2022.111596","volume":"547","author":"M Wu","year":"2022","unstructured":"Wu M, et al. Vitamin D protects against high glucose-induced pancreatic \u03b2-cell dysfunction via AMPK-NLRP3 inflammasome pathway. Mol Cell Endocrinol. 2022;547:111596.","journal-title":"Mol Cell Endocrinol"},{"issue":"23","key":"2009_CR31","doi-asserted-by":"crossref","first-page":"8462","DOI":"10.3390\/app10238462","volume":"10","author":"M Tunbridge","year":"2020","unstructured":"Tunbridge M, Fran\u00e7a Gois PH. Vitamin D and the NLRP3 Inflammasome. Appl Sci. 2020;10(23):8462.","journal-title":"Appl Sci"},{"issue":"2","key":"2009_CR32","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","volume":"10","author":"F Martinon","year":"2002","unstructured":"Martinon F, Burns K, Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell. 2002;10(2):417\u201326.","journal-title":"Mol Cell"},{"issue":"7","key":"2009_CR33","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nm.3893","volume":"21","author":"H Guo","year":"2015","unstructured":"Guo H, Callaway JB, Ting JP. Inflammasomes: mechanism of action, role in disease, and therapeutics. Nat Med. 2015;21(7):677\u201387.","journal-title":"Nat Med"},{"key":"2009_CR34","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.879021","volume":"14","author":"HM Blevins","year":"2022","unstructured":"Blevins HM, et al. The NLRP3 inflammasome pathway: a review of mechanisms and inhibitors for the treatment of inflammatory diseases. Front Aging Neurosci. 2022;14: 879021.","journal-title":"Front Aging Neurosci"},{"issue":"6","key":"2009_CR35","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","volume":"140","author":"O Takeuchi","year":"2010","unstructured":"Takeuchi O, Akira S. Pattern recognition receptors and inflammation. Cell. 2010;140(6):805\u201320.","journal-title":"Cell"},{"issue":"2","key":"2009_CR36","doi-asserted-by":"crossref","first-page":"787","DOI":"10.4049\/jimmunol.0901363","volume":"183","author":"FG Bauernfeind","year":"2009","unstructured":"Bauernfeind FG, et al. Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J Immunol. 2009;183(2):787\u201391.","journal-title":"J Immunol"},{"issue":"43","key":"2009_CR37","doi-asserted-by":"crossref","first-page":"36617","DOI":"10.1074\/jbc.M112.407130","volume":"287","author":"C Juliana","year":"2012","unstructured":"Juliana C, et al. Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation. J Biol Chem. 2012;287(43):36617\u201322.","journal-title":"J Biol Chem"},{"issue":"5","key":"2009_CR38","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.tcb.2014.12.009","volume":"25","author":"SK Vanaja","year":"2015","unstructured":"Vanaja SK, Rathinam VA, Fitzgerald KA. Mechanisms of inflammasome activation: recent advances and novel insights. Trends Cell Biol. 2015;25(5):308\u201315.","journal-title":"Trends Cell Biol"},{"issue":"6","key":"2009_CR39","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","volume":"140","author":"K Schroder","year":"2010","unstructured":"Schroder K, Tschopp J. The inflammasomes. Cell. 2010;140(6):821\u201332.","journal-title":"Cell"},{"key":"2009_CR40","doi-asserted-by":"crossref","DOI":"10.1016\/j.crimmu.2023.100061","volume":"4","author":"BA Khalil","year":"2023","unstructured":"Khalil BA, Sharif-Askari NS, Halwani R. Role of inflammasome in severe, steroid-resistant asthma. Curr Res Immunol. 2023;4: 100061.","journal-title":"Curr Res Immunol"},{"issue":"2","key":"2009_CR41","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.jaci.2017.02.045","volume":"141","author":"C Rossios","year":"2018","unstructured":"Rossios C, et al. Sputum transcriptomics reveal upregulation of IL-1 receptor family members in patients with severe asthma. J Allergy Clin Immunol. 2018;141(2):560\u201370.","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"2009_CR42","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1136\/thx.2006.061358","volume":"62","author":"JL Simpson","year":"2007","unstructured":"Simpson JL, et al. Innate immune activation in neutrophilic asthma and bronchiectasis. Thorax. 2007;62(3):211\u20138.","journal-title":"Thorax"},{"issue":"4","key":"2009_CR43","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1183\/09031936.00105013","volume":"43","author":"JL Simpson","year":"2014","unstructured":"Simpson JL, et al. Elevated expression of the NLRP3 inflammasome in neutrophilic asthma. Eur Respir J. 2014;43(4):1067\u201376.","journal-title":"Eur Respir J"},{"issue":"3","key":"2009_CR44","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1165\/ajrcmb.25.3.4445","volume":"25","author":"T Fujii","year":"2001","unstructured":"Fujii T, et al. Particulate matter induces cytokine expression in human bronchial epithelial cells. Am J Respir Cell Mol Biol. 2001;25(3):265\u201371.","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"6","key":"2009_CR45","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1165\/rcmb.2002-0095OC","volume":"28","author":"J Reibman","year":"2003","unstructured":"Reibman J, et al. Airway epithelial cells release MIP-3alpha\/CCL20 in response to cytokines and ambient particulate matter. Am J Respir Cell Mol Biol. 2003;28(6):648\u201354.","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"4","key":"2009_CR46","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1165\/rcmb.2001-0005OC","volume":"27","author":"J Reibman","year":"2002","unstructured":"Reibman J, et al. Size fractions of ambient particulate matter induce granulocyte macrophage colony-stimulating factor in human bronchial epithelial cells by mitogen-activated protein kinase pathways. Am J Respir Cell Mol Biol. 2002;27(4):455\u201362.","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"1","key":"2009_CR47","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1165\/rcmb.2014-0158OC","volume":"52","author":"JA Hirota","year":"2015","unstructured":"Hirota JA, et al. The nucleotide-binding domain, leucine-rich repeat protein 3 inflammasome\/IL-1 receptor I axis mediates innate, but not adaptive, immune responses after exposure to particulate matter under 10 mum. Am J Respir Cell Mol Biol. 2015;52(1):96\u2013105.","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"3","key":"2009_CR48","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1164\/rccm.201609-1830OC","volume":"196","author":"RY Kim","year":"2017","unstructured":"Kim RY, et al. Role for NLRP3 inflammasome-mediated, IL-1beta-dependent responses in severe, steroid-resistant asthma. Am J Respir Crit Care Med. 2017;196(3):283\u201397.","journal-title":"Am J Respir Crit Care Med"},{"key":"2009_CR49","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.3389\/fimmu.2019.02783","volume":"10","author":"Z Rao","year":"2019","unstructured":"Rao Z, et al. Vitamin D receptor inhibits NLRP3 activation by impeding Its BRCC3-mediated deubiquitination. Front Immunol. 2019;10:2783.","journal-title":"Front Immunol"},{"issue":"1","key":"2009_CR50","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/JLB.3MA0320-406RR","volume":"108","author":"R Cao","year":"2020","unstructured":"Cao R, et al. 1,25(OH)(2) D(3) alleviates DSS-induced ulcerative colitis via inhibiting NLRP3 inflammasome activation. J Leukoc Biol. 2020;108(1):283\u201395.","journal-title":"J Leukoc Biol"},{"issue":"2","key":"2009_CR51","doi-asserted-by":"crossref","first-page":"1602135","DOI":"10.1183\/13993003.02135-2016","volume":"49","author":"CS Kuo","year":"2017","unstructured":"Kuo CS, Pavlidis S, Loza M, Baribaud F, Rowe A, Pandis I, Sousa A, Corfield J, Djukanovic R, Lutter R, Sterk PJ, Auffray C, Guo Y, Adcock IM, Chung KF, U-BIOPRED Study Group. T-helper cell type 2 (Th2) and non-Th2 molecular phenotypes of asthma using sputum transcriptomics in U-BIOPRED. Eur Respir J. 2017;49(2):1602135.","journal-title":"Eur Respir J"},{"issue":"1","key":"2009_CR52","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/all.14573","volume":"76","author":"N Zounemat Kermani","year":"2021","unstructured":"Zounemat Kermani N, et al. Type 2-low asthma phenotypes by integration of sputum transcriptomics and serum proteomics. Allergy. 2021;76(1):380\u20133.","journal-title":"Allergy"},{"key":"2009_CR53","doi-asserted-by":"crossref","unstructured":"Kwak DW, Park D, Kim JH. Leukotriene B(4) receptors are necessary for the stimulation of NLRP3 inflammasome and IL-1beta synthesis in neutrophil-dominant asthmatic airway inflammation. Biomedicines, 2021. 9(5).","DOI":"10.3390\/biomedicines9050535"},{"issue":"3","key":"2009_CR54","doi-asserted-by":"crossref","first-page":"537","DOI":"10.4168\/aair.2020.12.3.537","volume":"12","author":"SC Park","year":"2020","unstructured":"Park SC, et al. An alternative dendritic cell-induced murine model of asthma exhibiting a robust Th2\/Th17-skewed response. Allergy Asthma Immunol Res. 2020;12(3):537\u201355.","journal-title":"Allergy Asthma Immunol Res"},{"issue":"8","key":"2009_CR55","doi-asserted-by":"crossref","first-page":"e0237404","DOI":"10.1371\/journal.pone.0237404","volume":"15","author":"ME Martinez","year":"2020","unstructured":"Martinez ME, Harder OE, Rosas LE, Joseph L, Davis IC, Niewiesk S. Pulmonary function analysis in cotton rats after respiratory syncytial virus infection. PLoS ONE. 2020;15(8):e0237404.","journal-title":"PLoS ONE"},{"issue":"1","key":"2009_CR56","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/s41392-021-00650-z","volume":"6","author":"Y Li","year":"2021","unstructured":"Li Y, et al. Inflammasomes as therapeutic targets in human diseases. Signal Transduct Target Ther. 2021;6(1):247.","journal-title":"Signal Transduct Target Ther"},{"key":"2009_CR57","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1084\/jem.20050584","volume":"201","author":"JA Boyce","year":"2005","unstructured":"Boyce JA, Austen KF. No audible wheezing: nuggets and conundrums from mouse asthma models. J Exp Med. 2005;201:1869\u201373.","journal-title":"J Exp Med"},{"key":"2009_CR58","doi-asserted-by":"crossref","first-page":"485","DOI":"10.2174\/138945008784533561","volume":"9","author":"RK Kumar","year":"2008","unstructured":"Kumar RK, Herbert C, Foster PS. The \u2018classical\u2019 ovalbumin challenge model of asthma in mice. Curr Drug Targets. 2008;9:485\u201394.","journal-title":"Curr Drug Targets"},{"issue":"4\u20135","key":"2009_CR59","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1242\/dmm.000323","volume":"1","author":"AT Nials","year":"2008","unstructured":"Nials AT, Uddin S. Mouse models of allergic asthma: acute and chronic allergen challenge. Dis Model Mech. 2008;1(4\u20135):213\u201320.","journal-title":"Dis Model Mech"},{"key":"2009_CR60","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1164\/rccm.200308-1094OC","volume":"169","author":"JR Johnson","year":"2004","unstructured":"Johnson JR, Wiley RE, Fattouh R, Swirski FK, Gajewska BU, Coyle AJ, Guttierrez-Ramos JC, Ellis R, Inman MD, Jordana M. Continuous exposure to house dust mite elicits chronic airway inflammation and structural remodelling. Am J Respir Crit Care Med. 2004;169:378\u201385.","journal-title":"Am J Respir Crit Care Med"},{"key":"2009_CR61","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1159\/000074902","volume":"132","author":"SB Sarpong","year":"2003","unstructured":"Sarpong SB, Zhang L, Kleeberger SR. A novel mouse model of experimental asthma. Int Arch Allergy Immunol. 2003;132:346\u201354.","journal-title":"Int Arch Allergy Immunol"},{"issue":"8","key":"2009_CR62","doi-asserted-by":"crossref","first-page":"5107","DOI":"10.4049\/jimmunol.0803468","volume":"182","author":"M Yang","year":"2009","unstructured":"Yang M, Kumar RK, Foster PS. Pathogenesis of steroid-resistant airway hyperresponsiveness: interaction between IFN-gamma and TLR4\/MyD88 pathways. J Immunol. 2009;182(8):5107\u201315.","journal-title":"J Immunol"},{"issue":"6 Pt 1","key":"2009_CR63","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1164\/ajrccm.154.6.8970348","volume":"154","author":"O Michel","year":"1996","unstructured":"Michel O, et al. Severity of asthma is related to endotoxin in house dust. Am J Respir Crit Care Med. 1996;154(6 Pt 1):1641\u20136.","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"2009_CR64","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/j.1365-2222.1991.tb01684.x","volume":"21","author":"O Michel","year":"1991","unstructured":"Michel O, et al. Domestic endotoxin exposure and clinical severity of asthma. Clin Exp Allergy. 1991;21(4):441\u20138.","journal-title":"Clin Exp Allergy"},{"issue":"1","key":"2009_CR65","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1186\/s12890-019-1001-9","volume":"19","author":"DI Kim","year":"2019","unstructured":"Kim DI, Song MK, Lee K. Comparison of asthma phenotypes in OVA-induced mice challenged via inhaled and intranasal routes. BMC Pulm Med. 2019;19(1):241.","journal-title":"BMC Pulm Med"},{"key":"2009_CR66","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1100\/tsw.2006.274","volume":"6","author":"K Ito","year":"2006","unstructured":"Ito K, Getting SJ, Charron CE. Mode of glucocorticoid actions in airway disease. Sci World J. 2006;6:1750\u201369.","journal-title":"Sci World J"},{"issue":"9","key":"2009_CR67","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1210\/me.2009-0411","volume":"24","author":"TD Hinds Jr","year":"2010","unstructured":"Hinds TD Jr, et al. Discovery of glucocorticoid receptor-beta in mice with a role in metabolism. Mol Endocrinol. 2010;24(9):1715\u201327.","journal-title":"Mol Endocrinol"},{"issue":"39","key":"2009_CR68","doi-asserted-by":"crossref","first-page":"27857","DOI":"10.1074\/jbc.274.39.27857","volume":"274","author":"RH Oakley","year":"1999","unstructured":"Oakley RH, et al. The dominant negative activity of the human glucocorticoid receptor beta isoform. Specificity and mechanisms of action. J Biol Chem. 1999;274(39):27857\u201366.","journal-title":"J Biol Chem"},{"issue":"3","key":"2009_CR69","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1067\/mai.2000.109054","volume":"106","author":"P Christodoulopoulos","year":"2000","unstructured":"Christodoulopoulos P, et al. Increased number of glucocorticoid receptor-beta-expressing cells in the airways in fatal asthma. J Allergy Clin Immunol. 2000;106(3):479\u201384.","journal-title":"J Allergy Clin Immunol"},{"issue":"Pt 3","key":"2009_CR70","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1042\/bj20021321","volume":"370","author":"AJ de Ruijter","year":"2003","unstructured":"de Ruijter AJ, et al. Histone deacetylases (HDACs): characterization of the classical HDAC family. Biochem J. 2003;370(Pt 3):737\u201349.","journal-title":"Biochem J"},{"issue":"1","key":"2009_CR71","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1084\/jem.20050466","volume":"203","author":"K Ito","year":"2006","unstructured":"Ito K, et al. Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kappaB suppression. J Exp Med. 2006;203(1):7\u201313.","journal-title":"J Exp Med"},{"issue":"2","key":"2009_CR72","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.jaci.2013.03.037","volume":"132","author":"AM Nanzer","year":"2013","unstructured":"Nanzer AM, et al. Enhanced production of IL-17A in patients with severe asthma is inhibited by 1\u03b1,25-dihydroxyvitamin D3 in a glucocorticoid-independent fashion. J Allergy Clin Immunol. 2013;132(2):297-304.e3.","journal-title":"J Allergy Clin Immunol"},{"issue":"6","key":"2009_CR73","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1067\/mai.2003.1557","volume":"111","author":"J Chakir","year":"2003","unstructured":"Chakir J, et al. Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-beta, IL-11, IL-17, and type I and type III collagen expression. J Allergy Clin Immunol. 2003;111(6):1293\u20138.","journal-title":"J Allergy Clin Immunol"},{"key":"2009_CR74","first-page":"3743048","volume":"2017","author":"H Gao","year":"2017","unstructured":"Gao H, Ying S, Dai Y. Pathological roles of neutrophil-mediated inflammation in asthma and its potential for therapy as a target. J Immunol Res. 2017;2017:3743048.","journal-title":"J Immunol Res"},{"issue":"3","key":"2009_CR75","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.intimp.2013.06.034","volume":"17","author":"K Futosi","year":"2013","unstructured":"Futosi K, Fodor S, M\u00f3csai A. Neutrophil cell surface receptors and their intracellular signal transduction pathways. Int Immunopharmacol. 2013;17(3):638\u201350.","journal-title":"Int Immunopharmacol"},{"issue":"10","key":"2009_CR76","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0141746","volume":"10","author":"H Matsuzaki","year":"2015","unstructured":"Matsuzaki H, et al. Interleukin-17A and toll-like receptor 3 ligand Poly(I:C) synergistically induced neutrophil chemoattractant production by bronchial epithelial cells. PLoS ONE. 2015;10(10): e0141746.","journal-title":"PLoS ONE"},{"issue":"3","key":"2009_CR77","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1159\/000049511","volume":"126","author":"A Lind\u00e9n","year":"2001","unstructured":"Lind\u00e9n A. Role of interleukin-17 and the neutrophil in asthma. Int Arch Allergy Immunol. 2001;126(3):179\u201384.","journal-title":"Int Arch Allergy Immunol"},{"issue":"2","key":"2009_CR78","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1182\/blood-2009-04-216085","volume":"115","author":"M Pelletier","year":"2010","unstructured":"Pelletier M, et al. Evidence for a cross-talk between human neutrophils and Th17 cells. Blood. 2010;115(2):335\u201343.","journal-title":"Blood"},{"issue":"11","key":"2009_CR79","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1038\/ni1261","volume":"6","author":"H Park","year":"2005","unstructured":"Park H, et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol. 2005;6(11):1133\u201341.","journal-title":"Nat Immunol"},{"issue":"15","key":"2009_CR80","doi-asserted-by":"crossref","first-page":"8806","DOI":"10.3390\/ijms23158806","volume":"23","author":"I Cho","year":"2022","unstructured":"Cho I, et al. Neuroprotective effect of dexmedetomidine against postoperative cognitive decline via NLRP3 inflammasome signaling pathway. Int J Mol Sci. 2022;23(15):8806.","journal-title":"Int J Mol Sci"},{"key":"2009_CR81","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.106017","volume":"78","author":"M Guan","year":"2020","unstructured":"Guan M, et al. Dexamethasone alleviate allergic airway inflammation in mice by inhibiting the activation of NLRP3 inflammasome. Int Immunopharmacol. 2020;78: 106017.","journal-title":"Int Immunopharmacol"},{"issue":"21","key":"2009_CR82","doi-asserted-by":"crossref","first-page":"12716","DOI":"10.1111\/jcmm.15849","volume":"24","author":"JW Yang","year":"2020","unstructured":"Yang JW, et al. Corticosteroids alleviate lipopolysaccharide-induced inflammation and lung injury via inhibiting NLRP3-inflammasome activation. J Cell Mol Med. 2020;24(21):12716\u201325.","journal-title":"J Cell Mol Med"},{"issue":"3","key":"2009_CR83","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.3390\/ijms23031849","volume":"23","author":"F Caruso","year":"2022","unstructured":"Caruso F, et al. Mechanism of caspase-1 inhibition by four anti-inflammatory drugs used in COVID-19 treatment. Int J Mol Sci. 2022;23(3):1849.","journal-title":"Int J Mol Sci"},{"issue":"641","key":"2009_CR84","doi-asserted-by":"crossref","first-page":"eabl8146","DOI":"10.1126\/scitranslmed.abl8146","volume":"14","author":"R Guidi","year":"2022","unstructured":"Guidi R, et al. Steroid-induced fibroblast growth factors drive an epithelial-mesenchymal inflammatory axis in severe asthma. Sci Transl Med. 2022;14(641):eabl8146.","journal-title":"Sci Transl Med"},{"issue":"2","key":"2009_CR85","doi-asserted-by":"crossref","first-page":"534","DOI":"10.4049\/jimmunol.159.2.534","volume":"159","author":"Y Wang","year":"1997","unstructured":"Wang Y, et al. Dexamethasone potently enhances phorbol ester-induced IL-1beta gene expression and nuclear factor NF-kappaB activation. J Immunol. 1997;159(2):534\u20137.","journal-title":"J Immunol"},{"issue":"3","key":"2009_CR86","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nm.3806","volume":"21","author":"RC Coll","year":"2015","unstructured":"Coll RC, et al. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat Med. 2015;21(3):248\u201355.","journal-title":"Nat Med"},{"key":"2009_CR87","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3389\/fphar.2020.00200","volume":"11","author":"X Wang","year":"2020","unstructured":"Wang X, et al. Calcipotriol inhibits NLRP3 signal through YAP1 activation to alleviate cholestatic liver injury and fibrosis. Front Pharmacol. 2020;11:200.","journal-title":"Front Pharmacol"}],"container-title":["Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-025-02009-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00011-025-02009-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-025-02009-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T16:55:51Z","timestamp":1767200151000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00011-025-02009-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,14]]},"references-count":87,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["2009"],"URL":"https:\/\/doi.org\/10.1007\/s00011-025-02009-4","relation":{},"ISSN":["1023-3830","1420-908X"],"issn-type":[{"value":"1023-3830","type":"print"},{"value":"1420-908X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,14]]},"assertion":[{"value":"24 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 January 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 February 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 March 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"51"}}