{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T19:30:03Z","timestamp":1793388603955,"version":"4.5.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Zhejiang Chinese Medical University Postgraduate Scientific Research Fund Project","award":["No.2023YKJ11"],"award-info":[{"award-number":["No.2023YKJ11"]}]},{"name":"National Natural Science Foundation of China Joint Fund Project","award":["NO. U22A20310"],"award-info":[{"award-number":["NO. U22A20310"]}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"crossref","award":["ZCLY24H1101"],"award-info":[{"award-number":["ZCLY24H1101"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflamm. Res."],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s00011-025-02035-2","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T05:51:30Z","timestamp":1745905890000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The IL-6 autocrine loop promoting IFN-\u03b3-induced fibroblast senescence is involved in psychological stress-mediated exacerbation of vitiligo"],"prefix":"10.1007","volume":"74","author":[{"given":"Cheng","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingdi","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aie","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuquan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaoni","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,29]]},"reference":[{"key":"2035_CR1","doi-asserted-by":"publisher","first-page":"986918","DOI":"10.3389\/fimmu.2022.986918","volume":"13","author":"Y Feng","year":"2022","unstructured":"Feng Y, Lu Y. Advances in vitiligo: update on therapeutic targets. Front Immunol. 2022;13:986918. https:\/\/doi.org\/10.3389\/fimmu.2022.986918.","journal-title":"Front Immunol"},{"issue":"3","key":"2035_CR2","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1111\/bjd.15199","volume":"177","author":"YC Lai","year":"2017","unstructured":"Lai YC, Yew YW, Kennedy C, Schwartz RA. Vitiligo and depression: a systematic review and meta-analysis of observational studies. Br J Dermatol. 2017;177(3):708\u201318. https:\/\/doi.org\/10.1111\/bjd.15199.","journal-title":"Br J Dermatol"},{"key":"2035_CR3","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1146\/annurev-clinpsy-072220-021440","volume":"18","author":"SM Monroe","year":"2022","unstructured":"Monroe SM, Harkness KL. Major depression and its recurrences: life course matters. Ann Rev Clin Psychol. 2022;18:329\u201357. https:\/\/doi.org\/10.1146\/annurev-clinpsy-072220-021440.","journal-title":"Ann Rev Clin Psychol"},{"issue":"11","key":"2035_CR4","doi-asserted-by":"publisher","first-page":"e0241445","DOI":"10.1371\/journal.pone.0241445","volume":"15","author":"A Kussainova","year":"2020","unstructured":"Kussainova A, Kassym L, Akhmetova A, et al. Vitiligo and anxiety: A systematic review and meta-analysis. PLoS ONE. 2020;15(11):e0241445. https:\/\/doi.org\/10.1371\/journal.pone.0241445.","journal-title":"PLoS ONE"},{"issue":"3","key":"2035_CR5","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1159\/000069731","volume":"72","author":"A Picardi","year":"2003","unstructured":"Picardi A, Pasquini P, Cattaruzza MS, et al. Stressful life events, social support, attachment security and alexithymia in vitiligo. A case-control study. Psychother Psychosom. 2003;72(3):150\u20138. https:\/\/doi.org\/10.1159\/000069731.","journal-title":"Psychother Psychosom"},{"issue":"6","key":"2035_CR6","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1046\/j.1365-2230.1998.00384.x","volume":"23","author":"L Papadopoulos","year":"1998","unstructured":"Papadopoulos L, Bor R, Legg C, Hawk JL. Impact of life events on the onset of vitiligo in adults: preliminary evidence for a psychological dimension in aetiology. Clin Exp Dermatol. 1998;23(6):243\u20138. https:\/\/doi.org\/10.1046\/j.1365-2230.1998.00384.x.","journal-title":"Clin Exp Dermatol"},{"issue":"4","key":"2035_CR7","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1111\/bjd.16049","volume":"178","author":"O Osinubi","year":"2018","unstructured":"Osinubi O, Grainge MJ, Hong L, et al. The prevalence of psychological comorbidity in people with vitiligo: a systematic review and meta-analysis. Br J Dermatol. 2018;178(4):863\u201378. https:\/\/doi.org\/10.1111\/bjd.16049.","journal-title":"Br J Dermatol"},{"key":"2035_CR8","doi-asserted-by":"publisher","first-page":"1454947","DOI":"10.3389\/fpsyg.2024.1454947","volume":"15","author":"C Cao","year":"2024","unstructured":"Cao C, Lin F, Jin R, et al. Anxiety-depression: a pivotal mental factor for accelerating disease progression and reducing curative effect in vitiligo patients. Front Psychol. 2024;15:1454947. https:\/\/doi.org\/10.3389\/fpsyg.2024.1454947.","journal-title":"Front Psychol"},{"key":"2035_CR9","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.pnpbp.2014.01.013","volume":"53","author":"JD Rosenblat","year":"2014","unstructured":"Rosenblat JD, Cha DS, Mansur RB, McIntyre RS. Inflamed moods: a review of the interactions between inflammation and mood disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2014;53:23\u201334. https:\/\/doi.org\/10.1016\/j.pnpbp.2014.01.013.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"8","key":"2035_CR10","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1038\/mp.2008.59","volume":"13","author":"ML Wong","year":"2008","unstructured":"Wong ML, Dong C, Maestre-Mesa J, Licinio J. Polymorphisms in inflammation-related genes are associated with susceptibility to major depression and antidepressant response. Mol Psychiatry. 2008;13(8):800\u201312. https:\/\/doi.org\/10.1038\/mp.2008.59.","journal-title":"Mol Psychiatry"},{"issue":"3","key":"2035_CR11","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1152\/physrev.2000.80.3.979","volume":"80","author":"A Slominski","year":"2000","unstructured":"Slominski A, Wortsman J, Luger T, Paus R, Solomon S. Corticotropin releasing hormone and Proopiomelanocortin involvement in the cutaneous response to stress. Physiol Rev. 2000;80(3):979\u20131020. https:\/\/doi.org\/10.1152\/physrev.2000.80.3.979.","journal-title":"Physiol Rev"},{"key":"2035_CR12","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.jsbmb.2013.02.006","volume":"137","author":"A Slominski","year":"2013","unstructured":"Slominski A, Zbytek B, Nikolakis G, et al. Steroidogenesis in the skin: implications for local immune functions. J Steroid Biochem Mol Biol. 2013;137:107\u201323. https:\/\/doi.org\/10.1016\/j.jsbmb.2013.02.006.","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"8","key":"2035_CR13","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1016\/j.jid.2024.02.007","volume":"144","author":"Y Wu","year":"2024","unstructured":"Wu Y, Yang Y, Lin Y, et al. Emerging role of fibroblasts in vitiligo: a formerly underestimated rising star. J Invest Dermatol. 2024;144(8):1696\u2013706. https:\/\/doi.org\/10.1016\/j.jid.2024.02.007.","journal-title":"J Invest Dermatol"},{"issue":"2","key":"2035_CR14","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s00403-016-1713-0","volume":"309","author":"S Rani","year":"2017","unstructured":"Rani S, Bhardwaj S, Srivastava N, Sharma VL, Parsad D, Kumar R. Senescence in the lesional fibroblasts of non-segmental vitiligo patients. Arch Dermatol Res. 2017;309(2):123\u201332. https:\/\/doi.org\/10.1007\/s00403-016-1713-0.","journal-title":"Arch Dermatol Res"},{"issue":"8","key":"2035_CR15","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1097\/01.asw.0000758600.40793.89","volume":"34","author":"RG Sibbald","year":"2021","unstructured":"Sibbald RG, Ayello EA. Psychophysiology: connecting skin, wounds, aging, and depression. Adv Skin Wound Care. 2021;34(8):399. https:\/\/doi.org\/10.1097\/01.asw.0000758600.40793.89.","journal-title":"Adv Skin Wound Care"},{"key":"2035_CR16","doi-asserted-by":"publisher","first-page":"111779","DOI":"10.1097\/01.asw.0000758600.40793.89","volume":"211","author":"BQ Dong","year":"2023","unstructured":"Dong BQ, Liao ZK, Le Y et al. Acceleration of melanocyte senescence by the Proinflammatory cytokines IFN\u03b3 and TNF\u03b1 impairs the repigmentation response of vitiligo patients to narrowband ultraviolet B (NBUVB) phototherapy. Mech Ageing Dev. 2023;211:111779. https:\/\/doi.org\/10.1016\/j.mad.2023.111779","journal-title":"Mech Ageing Dev"},{"issue":"6","key":"2035_CR17","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1111\/exd.13868","volume":"28","author":"E Bastonini","year":"2019","unstructured":"Bastonini E, Bellei B, Filoni A, Kovacs D, Iacovelli P, Picardo M. Involvement of non-melanocytic skin cells in vitiligo. Exp Dermatol. 2019;28(6):667\u201373. https:\/\/doi.org\/10.1111\/exd.13868.","journal-title":"Exp Dermatol"},{"key":"2035_CR18","doi-asserted-by":"publisher","first-page":"109130","DOI":"10.1016\/j.intimp.2022.109130","volume":"111","author":"M Aliyu","year":"2022","unstructured":"Aliyu M, Zohora FT, Anka AU, et al. Interleukin-6 cytokine: an overview of the immune regulation, immune dysregulation, and therapeutic approach. Int Immunopharmacol. 2022;111:109130. https:\/\/doi.org\/10.1016\/j.intimp.2022.109130.","journal-title":"Int Immunopharmacol"},{"issue":"10","key":"2035_CR19","doi-asserted-by":"publisher","first-page":"a016295","DOI":"10.1101\/cshperspect.a016295","volume":"6","author":"T Tanaka","year":"2014","unstructured":"Tanaka T, Narazaki M, Kishimoto T. IL-6 in inflammation, immunity, and disease. Cold Spring Harb Perspect Biol. 2014;6(10):a016295. https:\/\/doi.org\/10.1101\/cshperspect.a016295.","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"8","key":"2035_CR20","doi-asserted-by":"publisher","first-page":"e15653","DOI":"10.15252\/emmm.202115653","volume":"14","author":"M Paldor","year":"2022","unstructured":"Paldor M, Levkovitch-Siany O, Eidelshtein D, et al. Single-cell transcriptomics reveals a senescence-associated IL-6\/CCR6 axis driving radiodermatitis. EMBO Mol Med. 2022;14(8):e15653. https:\/\/doi.org\/10.15252\/emmm.202115653.","journal-title":"EMBO Mol Med"},{"issue":"3","key":"2035_CR21","doi-asserted-by":"publisher","first-page":"e15040","DOI":"10.1111\/exd.15040","volume":"33","author":"Y Kawakami","year":"2024","unstructured":"Kawakami Y, Kajita A, Hasui KI, Matsuda Y, Iwatsuki K, Morizane S. Elevated expression of interleukin-6 (IL-6) and serum amyloid A (SAA) in the skin and the serum of recessive dystrophic epidermolysis Bullosa: skin as a possible source of IL-6 through Toll-like receptor ligands and SAA. Exp Dermatol. 2024;33(3):e15040. https:\/\/doi.org\/10.1111\/exd.15040.","journal-title":"Exp Dermatol"},{"key":"2035_CR22","doi-asserted-by":"publisher","first-page":"154384","DOI":"10.1016\/j.phymed.2022.154384","volume":"105","author":"X Hu","year":"2022","unstructured":"Hu X, Qi C, Feng F, et al. Combining network pharmacology, RNA-seq, and metabolomics strategies to reveal the mechanism of cimicifugae Rhizoma\u2014Smilax glabra Roxb herb pair for the treatment of psoriasis. Phytomed Int J Phytother Phytopharmacol. 2022;105:154384. https:\/\/doi.org\/10.1016\/j.phymed.2022.154384.","journal-title":"Phytomed Int J Phytother Phytopharmacol"},{"key":"2035_CR23","doi-asserted-by":"publisher","first-page":"101697","DOI":"10.1016\/j.arr.2022.101697","volume":"80","author":"L Forcina","year":"2022","unstructured":"Forcina L, Franceschi C, Musar\u00f2 A. The hormetic and hermetic role of IL-6. Ageing Res Rev. 2022;80:101697. https:\/\/doi.org\/10.1016\/j.arr.2022.101697.","journal-title":"Ageing Res Rev"},{"key":"2035_CR24","doi-asserted-by":"publisher","first-page":"154680","DOI":"10.1016\/j.phymed.2023.154680","volume":"112","author":"D Han","year":"2023","unstructured":"Han D, Gong H, Wei Y, et al. Hesperidin inhibits lung fibroblast senescence via IL-6\/STAT3 signaling pathway to suppress pulmonary fibrosis. Phytomedicine: Int J Phytotherapy Phytopharmacology. 2023;112:154680. https:\/\/doi.org\/10.1016\/j.phymed.2023.154680.","journal-title":"Phytomed Int J Phytother Phytopharmacol"},{"key":"2035_CR25","doi-asserted-by":"publisher","unstructured":"Marek-Jozefowicz L, Czajkowski R, Borkowska A, et al. The brain-skin axis in psoriasis-psychological, psychiatric, hormonal, and dermatological aspects. Int J Mol Sci. 2022;23(2). https:\/\/doi.org\/10.3390\/ijms23020669.","DOI":"10.3390\/ijms23020669"},{"issue":"1","key":"2035_CR26","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.rcp.2017.07.002","volume":"48","author":"H Tohid","year":"2019","unstructured":"Tohid H, Shenefelt PD, Burney WA, Aqeel N. Psychodermatology: an association of primary psychiatric disorders with skin. Rev Colomb Psiquiatr (Engl Ed). 2019;48(1):50\u20137. https:\/\/doi.org\/10.1016\/j.rcp.2017.07.002.","journal-title":"Rev Colomb Psiquiatr (Engl Ed)"},{"key":"2035_CR27","doi-asserted-by":"publisher","first-page":"e60686","DOI":"10.2196\/60686","volume":"7","author":"A Molla","year":"2024","unstructured":"Molla A, Jannadi R, Alayoubi H, Altouri H, Balkhair M, Hafez D. Assessing the relationship between vitiligo and major depressive disorder severity: Cross-Sectional study. JMIR Dermatol. 2024;7:e60686. https:\/\/doi.org\/10.2196\/60686.","journal-title":"JMIR Dermatol"},{"issue":"1","key":"2035_CR28","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s12974-021-02100-7","volume":"18","author":"E Roohi","year":"2021","unstructured":"Roohi E, Jaafari N, Hashemian F. On inflammatory hypothesis of depression: what is the role of IL-6 in the middle of the chaos? J Neuroinflamm. 2021;18(1):45. https:\/\/doi.org\/10.1186\/s12974-021-02100-7.","journal-title":"J Neuroinflamm"},{"key":"2035_CR29","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.bbi.2021.02.019","volume":"95","author":"KM Kelly","year":"2021","unstructured":"Kelly KM, Smith JA, Mezuk B. Depression and interleukin-6 signaling: a Mendelian randomization study. Brain Behav Immun. 2021;95:106\u201314. https:\/\/doi.org\/10.1016\/j.bbi.2021.02.019.","journal-title":"Brain Behav Immun"},{"issue":"4","key":"2035_CR30","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1111\/1523-1747.ep12289743","volume":"108","author":"HS Yu","year":"1997","unstructured":"Yu HS, Chang KL, Yu CL, et al. Alterations in IL-6, IL-8, GM-CSF, TNF-alpha, and IFN-gamma release by peripheral mononuclear cells in patients with active vitiligo. J Invest Dermatol. 1997;108(4):527\u20139. https:\/\/doi.org\/10.1111\/1523-1747.ep12289743.","journal-title":"J Invest Dermatol"},{"issue":"1","key":"2035_CR31","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1111\/jocd.12517","volume":"18","author":"S Sushama","year":"2019","unstructured":"Sushama S, Dixit N, Gautam RK, Arora P, Khurana A, Anubhuti A. Cytokine profile (IL-2, IL-6, IL-17, IL-22, and TNF-\u03b1) in vitiligo-New insight into pathogenesis of disease. J Cosmet Dermatol. 2019;18(1):337\u201341. https:\/\/doi.org\/10.1111\/jocd.12517.","journal-title":"J Cosmet Dermatol"},{"issue":"3","key":"2035_CR32","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1042\/bj2650621","volume":"265","author":"PC Heinrich","year":"1990","unstructured":"Heinrich PC, Castell JV, Andus T. Interleukin-6 and the acute phase response. Biochem J. 1990;265(3):621\u201336. https:\/\/doi.org\/10.1042\/bj2650621.","journal-title":"Biochem J"},{"key":"2035_CR33","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1146\/annurev.immunol.021908.132710","volume":"27","author":"T Korn","year":"2009","unstructured":"Korn T, Bettelli E, Oukka M, Kuchroo VK. IL-17 and Th17 cells. Annu Rev Immunol. 2009;27:485\u2013517. https:\/\/doi.org\/10.1146\/annurev.immunol.021908.132710.","journal-title":"Annu Rev Immunol"},{"issue":"7090","key":"2035_CR34","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/nature04753","volume":"441","author":"E Bettelli","year":"2006","unstructured":"Bettelli E, Carrier Y, Gao W, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 2006;441(7090):235\u20138. https:\/\/doi.org\/10.1038\/nature04753.","journal-title":"Nature"},{"issue":"9","key":"2035_CR35","doi-asserted-by":"publisher","first-page":"4335","DOI":"10.1111\/jcmm.13723","volume":"22","author":"Q Zhang","year":"2018","unstructured":"Zhang Q, Cui T, Chang Y, et al. HO-1 regulates the function of Treg: association with the immune intolerance in vitiligo. J Cell Mol Med. 2018;22(9):4335\u201343. https:\/\/doi.org\/10.1111\/jcmm.13723.","journal-title":"J Cell Mol Med"},{"key":"2035_CR36","doi-asserted-by":"publisher","DOI":"10.1007\/s40744-024-00699-6","author":"Q Zheng","year":"2024","unstructured":"Zheng Q, Wang Z, Tan Y, Zhu K, Lu M. Over activation of IL-6\/STAT3 signaling pathway in juvenile dermatomyositis. Rheumatol Ther. 2024. https:\/\/doi.org\/10.1007\/s40744-024-00699-6.","journal-title":"Rheumatol Ther"},{"key":"2035_CR37","doi-asserted-by":"publisher","first-page":"2399","DOI":"10.2147\/ccid.s423922","volume":"16","author":"Z Cai","year":"2023","unstructured":"Cai Z, Zeng Y, Liu Z, Zhu R, Wang W. Curcumin alleviates epidermal Psoriasis-Like dermatitis and IL-6\/STAT3 pathway of mice. Clin Cosmet Investig Dermatol. 2023;16:2399\u2013408. https:\/\/doi.org\/10.2147\/ccid.s423922.","journal-title":"Clin Cosmet Investig Dermatol"},{"issue":"1","key":"2035_CR38","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1080\/13880209.2022.2163406","volume":"61","author":"L Peng","year":"2023","unstructured":"Peng L, Lu Y, Gu Y, et al. Mechanisms of action of Lycium barbarum polysaccharide in protecting against vitiligo mice through modulation of the STAT3-Hsp70-CXCL9\/CXCL10 pathway. Pharm Biol. 2023;61(1):281\u20137. https:\/\/doi.org\/10.1080\/13880209.2022.2163406.","journal-title":"Pharm Biol"},{"issue":"5","key":"2035_CR39","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1080\/13685538.2020.1806814","volume":"23","author":"E Karagn","year":"2020","unstructured":"Karagn E, Baysak S. Levels of TNF-\u03b1, IL-6, IL-17, IL-37 cytokines in patients with active vitiligo. Aging Male. 2020;23(5):1487\u201392. https:\/\/doi.org\/10.1080\/13685538.2020.1806814.","journal-title":"Aging Male"},{"issue":"6","key":"2035_CR40","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1016\/j.jaci.2013.02.029","volume":"131","author":"A Berroth","year":"2013","unstructured":"Berroth A, Khnl J, Kurschat N, et al. Role of fibroblasts in the pathogenesis of atopic dermatitis. J Allergy Clin Immunol. 2013;131(6):1547\u201354. https:\/\/doi.org\/10.1016\/j.jaci.2013.02.029.","journal-title":"J Allergy Clin Immunol"},{"issue":"7","key":"2035_CR41","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1016\/j.biocel.2010.03.023","volume":"42","author":"MV Schiaffino","year":"2010","unstructured":"Schiaffino MV. Signaling pathways in melanosome biogenesis and pathology. Int J Biochem Cell Biol. 2010;42(7):1094\u2013104. https:\/\/doi.org\/10.1016\/j.biocel.2010.03.023.","journal-title":"Int J Biochem Cell Biol"},{"issue":"7891","key":"2035_CR42","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1038\/s41586-021-04221-8","volume":"601","author":"Z Xu","year":"2022","unstructured":"Xu Z, Chen D, Hu Y, et al. Anatomically distinct fibroblast subsets determine skin autoimmune patterns. Nature. 2022;601(7891):118\u201324. https:\/\/doi.org\/10.1038\/s41586-021-04221-8.","journal-title":"Nature"}],"container-title":["Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-025-02035-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00011-025-02035-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-025-02035-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T16:54:10Z","timestamp":1767200050000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00011-025-02035-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,29]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["2035"],"URL":"https:\/\/doi.org\/10.1007\/s00011-025-02035-2","relation":{},"ISSN":["1023-3830","1420-908X"],"issn-type":[{"value":"1023-3830","type":"print"},{"value":"1420-908X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,29]]},"assertion":[{"value":"11 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 April 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"72"}}