{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:31:42Z","timestamp":1792794702220,"version":"4.5.0"},"reference-count":271,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflamm. Res."],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s00011-025-02052-1","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T20:38:39Z","timestamp":1748896719000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The relationship between neurodevelopmental disorders (NDDs) and NLRP3 inflammasome"],"prefix":"10.1007","volume":"74","author":[{"given":"Abbas","family":"Shahi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Firoozi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghaidaa Raheem Lateef","family":"Al-awsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebrahim","family":"Mirzaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hojjat","family":"Shahbazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Rezaee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Mohammadisoleimani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaser","family":"Mansoori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Moravej","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,3]]},"reference":[{"issue":"4","key":"2052_CR1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S2215-0366(16)30376-5","volume":"4","author":"A Thapar","year":"2017","unstructured":"Thapar A, Cooper M, Rutter M. Neurodevelopmental disorders. Lancet Psychiatry. 2017;4(4):339\u201346.","journal-title":"Lancet Psychiatry"},{"issue":"8","key":"2052_CR2","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.tins.2020.05.004","volume":"43","author":"I Parenti","year":"2020","unstructured":"Parenti I, et al. Neurodevelopmental disorders: from genetics to functional pathways. Trends Neurosci. 2020;43(8):608\u201321.","journal-title":"Trends Neurosci"},{"issue":"3","key":"2052_CR3","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.ncl.2009.04.011","volume":"27","author":"J Jimenez-Shahed","year":"2009","unstructured":"Jimenez-Shahed J. Tourette syndrome. Neurol Clin. 2009;27(3):737\u201355.","journal-title":"Neurol Clin"},{"issue":"3","key":"2052_CR4","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/mp.2013.16","volume":"19","author":"AS Cristino","year":"2014","unstructured":"Cristino AS, et al. Neurodevelopmental and neuropsychiatric disorders represent an interconnected molecular system. Mol Psychiatry. 2014;19(3):294\u2013301.","journal-title":"Mol Psychiatry"},{"issue":"1","key":"2052_CR5","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1101\/gr.178855.114","volume":"25","author":"F Hormozdiari","year":"2015","unstructured":"Hormozdiari F, et al. The discovery of integrated gene networks for autism and related disorders. Genome Res. 2015;25(1):142\u201354.","journal-title":"Genome Res"},{"issue":"6","key":"2052_CR6","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1089\/brain.2014.0324","volume":"5","author":"JK Kern","year":"2015","unstructured":"Kern JK, et al. Shared brain connectivity issues, symptoms, and comorbidities in autism spectrum disorder, attention deficit\/hyperactivity disorder, and tourette syndrome. Brain Connect. 2015;5(6):321\u201335.","journal-title":"Brain Connect"},{"issue":"10258","key":"2052_CR7","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","volume":"396","author":"T Vos","year":"2020","unstructured":"Vos T, et al. Global burden of 369 diseases and injuries in 204 countries and territories, 1990\u20132019: a systematic analysis for the Global Burden of Disease Study 2019. The Lancet. 2020;396(10258):1204\u201322.","journal-title":"The Lancet"},{"issue":"1","key":"2052_CR8","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1093\/oxfordjournals.epirev.a036164","volume":"17","author":"A Jablensky","year":"1995","unstructured":"Jablensky A. Schizophrenia: recent epidemiologic issues. Epidemiol Rev. 1995;17(1):10\u201320.","journal-title":"Epidemiol Rev"},{"key":"2052_CR9","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3389\/fnins.2014.00019","volume":"8","author":"A Schmitt","year":"2014","unstructured":"Schmitt A, et al. The impact of environmental factors in severe psychiatric disorders. Front Neurosci. 2014;8:19.","journal-title":"Front Neurosci"},{"issue":"3 Suppl","key":"2052_CR10","doi-asserted-by":"crossref","first-page":"1s","DOI":"10.1016\/0893-133X(95)00199-N","volume":"14","author":"DR Weinberger","year":"1996","unstructured":"Weinberger DR. On the plausibility of \u201cthe neurodevelopmental hypothesis\u201d of schizophrenia. Neuropsychopharmacology. 1996;14(3 Suppl):1s\u201311s.","journal-title":"Neuropsychopharmacology"},{"key":"2052_CR11","unstructured":"Weinberger D, Nasrallah H. The neurology of schizophrenia. 1986."},{"issue":"3","key":"2052_CR12","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00702-022-02567-5","volume":"130","author":"A Schmitt","year":"2023","unstructured":"Schmitt A, Falkai P, Papiol S. Neurodevelopmental disturbances in schizophrenia: evidence from genetic and environmental factors. J Neural Transm (Vienna). 2023;130(3):195\u2013205.","journal-title":"J Neural Transm (Vienna)"},{"key":"2052_CR13","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2022.880568","volume":"13","author":"EA Ermakov","year":"2022","unstructured":"Ermakov EA, et al. Immune system abnormalities in schizophrenia: an integrative view and translational perspectives. Front Psychiatry. 2022;13: 880568.","journal-title":"Front Psychiatry"},{"issue":"2\u20133","key":"2052_CR14","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1159\/000356538","volume":"21","author":"N M\u00fcller","year":"2014","unstructured":"M\u00fcller N. Immunology of schizophrenia. NeuroImmunoModulation. 2014;21(2\u20133):109\u201316.","journal-title":"NeuroImmunoModulation"},{"issue":"1","key":"2052_CR15","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/npp.2016.211","volume":"42","author":"BJ Miller","year":"2017","unstructured":"Miller BJ, Goldsmith DR. Towards an immunophenotype of schizophrenia: progress, potential mechanisms, and future directions. Neuropsychopharmacology. 2017;42(1):299\u2013317.","journal-title":"Neuropsychopharmacology"},{"issue":"6","key":"2052_CR16","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/da.20699","volume":"27","author":"DJ Stein","year":"2010","unstructured":"Stein DJ, et al. Should OCD be classified as an anxiety disorder in DSM-V? Depress Anxiety. 2010;27(6):495\u2013506.","journal-title":"Depress Anxiety"},{"issue":"13","key":"2052_CR17","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1017\/S0033291721001744","volume":"51","author":"B Mahjani","year":"2021","unstructured":"Mahjani B, et al. Genetics of obsessive-compulsive disorder. Psychol Med. 2021;51(13):2247\u201359.","journal-title":"Psychol Med"},{"key":"2052_CR18","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s11689-016-9170-9","volume":"8","author":"MJ Gazzellone","year":"2016","unstructured":"Gazzellone MJ, et al. Uncovering obsessive-compulsive disorder risk genes in a pediatric cohort by high-resolution analysis of copy number variation. J Neurodev Disord. 2016;8:36.","journal-title":"J Neurodev Disord"},{"issue":"3","key":"2052_CR19","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S1056-4993(18)30163-9","volume":"8","author":"AH Zohar","year":"1999","unstructured":"Zohar AH. The epidemiology of obsessive-compulsive disorder in children and adolescents. Child Adolesc Psychiatr Clin N Am. 1999;8(3):445\u201360.","journal-title":"Child Adolesc Psychiatr Clin N Am"},{"issue":"4","key":"2052_CR20","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1001\/jamapsychiatry.2014.2650","volume":"72","author":"ME Hirschtritt","year":"2015","unstructured":"Hirschtritt ME, et al. Lifetime prevalence, age of risk, and genetic relationships of comorbid psychiatric disorders in Tourette syndrome. JAMA Psychiat. 2015;72(4):325\u201333.","journal-title":"JAMA Psychiat"},{"issue":"1","key":"2052_CR21","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/s41572-019-0102-3","volume":"5","author":"DJ Stein","year":"2019","unstructured":"Stein DJ, et al. Obsessive\u2013compulsive disorder. Nat Rev Dis Primers. 2019;5(1):52.","journal-title":"Nat Rev Dis Primers"},{"issue":"12","key":"2052_CR22","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1038\/npp.2009.77","volume":"34","author":"S Bhattacharyya","year":"2009","unstructured":"Bhattacharyya S, et al. Anti-brain autoantibodies and altered excitatory neurotransmitters in obsessive-compulsive disorder. Neuropsychopharmacology. 2009;34(12):2489\u201396.","journal-title":"Neuropsychopharmacology"},{"issue":"11","key":"2052_CR23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0141703","volume":"10","author":"SM Meier","year":"2015","unstructured":"Meier SM, et al. Obsessive-compulsive disorder and autism spectrum disorders: longitudinal and offspring risk. PLoS ONE. 2015;10(11): e0141703.","journal-title":"PLoS ONE"},{"issue":"2","key":"2052_CR24","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.schres.2004.03.002","volume":"71","author":"RM Murray","year":"2004","unstructured":"Murray RM, et al. A developmental model for similarities and dissimilarities between schizophrenia and bipolar disorder. Schizophr Res. 2004;71(2):405\u201316.","journal-title":"Schizophr Res"},{"issue":"1","key":"2052_CR25","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/npp.1993.46","volume":"9","author":"LS Pilowsky","year":"1993","unstructured":"Pilowsky LS, Kerwin RW, Murray RM. Schizophrenia: a neurodevelopmental perspective. Neuropsychopharmacology. 1993;9(1):83\u201391.","journal-title":"Neuropsychopharmacology"},{"key":"2052_CR26","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.neubiorev.2014.12.003","volume":"49","author":"M Debnath","year":"2015","unstructured":"Debnath M, Venkatasubramanian G, Berk M. Fetal programming of schizophrenia: select mechanisms. Neurosci Biobehav Rev. 2015;49:90\u2013104.","journal-title":"Neurosci Biobehav Rev"},{"issue":"3","key":"2052_CR27","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.cell.2008.10.015","volume":"135","author":"CA Walsh","year":"2008","unstructured":"Walsh CA, Morrow EM, Rubenstein JLR. Autism and brain development. Cell. 2008;135(3):396\u2013400.","journal-title":"Cell"},{"issue":"3","key":"2052_CR28","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.neubiorev.2010.10.001","volume":"35","author":"M Berk","year":"2011","unstructured":"Berk M, et al. Pathways underlying neuroprogression in bipolar disorder: focus on inflammation, oxidative stress and neurotrophic factors. Neurosci Biobehav Rev. 2011;35(3):804\u201317.","journal-title":"Neurosci Biobehav Rev"},{"issue":"4","key":"2052_CR29","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.neubiorev.2007.10.005","volume":"32","author":"F Kapczinski","year":"2008","unstructured":"Kapczinski F, et al. Allostatic load in bipolar disorder: Implications for pathophysiology and treatment. Neurosci Biobehav Rev. 2008;32(4):675\u201392.","journal-title":"Neurosci Biobehav Rev"},{"issue":"2","key":"2052_CR30","doi-asserted-by":"crossref","first-page":"pyuo19","DOI":"10.1093\/ijnp\/pyu019","volume":"18","author":"MG Gottschalk","year":"2015","unstructured":"Gottschalk MG, et al. Proteomic enrichment analysis of psychotic and affective disorders reveals common signatures in presynaptic glutamatergic signaling and energy metabolism. Int J Neuropsychopharmacology. 2015;18(2):pyuo19.","journal-title":"Int J Neuropsychopharmacology"},{"key":"2052_CR31","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.pnpbp.2014.01.006","volume":"51","author":"H Yu","year":"2014","unstructured":"Yu H, et al. A hypothesis-driven pathway analysis reveals myelin-related pathways that contribute to the risk of schizophrenia and bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2014;51:140\u20135.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"5","key":"2052_CR32","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/bdi.12205","volume":"16","author":"A Bechdolf","year":"2014","unstructured":"Bechdolf A, et al. The predictive validity of bipolar at-risk (prodromal) criteria in help-seeking adolescents and young adults: a prospective study. Bipolar Disord. 2014;16(5):493\u2013504.","journal-title":"Bipolar Disord"},{"issue":"7","key":"2052_CR33","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1176\/appi.ajp.2015.15040414","volume":"173","author":"DM Hafeman","year":"2016","unstructured":"Hafeman DM, et al. Toward the definition of a bipolar prodrome: dimensional predictors of bipolar spectrum disorders in at-risk youths. Am J Psychiatry. 2016;173(7):695\u2013704.","journal-title":"Am J Psychiatry"},{"issue":"Suppl_2","key":"2052_CR34","doi-asserted-by":"crossref","first-page":"S138","DOI":"10.1093\/schbul\/sbt198","volume":"40","author":"C Arango","year":"2014","unstructured":"Arango C, Fraguas D, Parellada M. Differential neurodevelopmental trajectories in patients with early-onset bipolar and schizophrenia disorders. Schizophrenia Bull. 2014;40(Suppl_2):S138\u201346.","journal-title":"Schizophrenia Bull"},{"issue":"3","key":"2052_CR35","doi-asserted-by":"crossref","first-page":"6464","DOI":"10.3390\/ijms16036464","volume":"16","author":"MG Butler","year":"2015","unstructured":"Butler MG, Rafi SK, Manzardo AM. High-resolution chromosome ideogram representation of currently recognized genes for autism spectrum disorders. Int J Mol Sci. 2015;16(3):6464\u201395.","journal-title":"Int J Mol Sci"},{"issue":"12","key":"2052_CR36","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.3390\/ijms17122070","volume":"17","author":"KS Ho","year":"2016","unstructured":"Ho KS, et al. Chromosomal microarray analysis of consecutive individuals with autism spectrum disorders using an ultra-high resolution chromosomal microarray optimized for neurodevelopmental disorders. Int J Mol Sci. 2016;17(12):2070.","journal-title":"Int J Mol Sci"},{"issue":"4","key":"2052_CR37","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1097\/GIM.0b013e3181ff67ba","volume":"13","author":"JH Miles","year":"2011","unstructured":"Miles JH. Autism spectrum disorders\u2013a genetics review. Genet Med. 2011;13(4):278\u201394.","journal-title":"Genet Med"},{"issue":"4","key":"2052_CR38","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1136\/jmg.2004.024646","volume":"42","author":"MG Butler","year":"2005","unstructured":"Butler MG, et al. Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations. J Med Genet. 2005;42(4):318\u201321.","journal-title":"J Med Genet"},{"issue":"3","key":"2052_CR39","doi-asserted-by":"crossref","first-page":"677","DOI":"10.3390\/genes14030677","volume":"14","author":"A Genovese","year":"2023","unstructured":"Genovese A, Butler MG. The autism spectrum: behavioral, psychiatric and genetic associations. Genes (Basel). 2023;14(3):677.","journal-title":"Genes (Basel)"},{"issue":"21","key":"2052_CR40","doi-asserted-by":"crossref","first-page":"8290","DOI":"10.3390\/ijms21218290","volume":"21","author":"E Masini","year":"2020","unstructured":"Masini E, et al. An overview of the main genetic, epigenetic and environmental factors involved in autism spectrum disorder focusing on synaptic activity. Int J Mol Sci. 2020;21(21):8290.","journal-title":"Int J Mol Sci"},{"issue":"2","key":"2052_CR41","doi-asserted-by":"crossref","first-page":"141","DOI":"10.31887\/DCNS.2008.10.2\/maescamilla","volume":"10","author":"MA Escamilla","year":"2008","unstructured":"Escamilla MA, Zavala JM. Genetics of bipolar disorder. Dialogues Clin Neurosci. 2008;10(2):141\u201352.","journal-title":"Dialogues Clin Neurosci"},{"issue":"1","key":"2052_CR42","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.biopsych.2013.01.007","volume":"74","author":"A Modabbernia","year":"2013","unstructured":"Modabbernia A, et al. Cytokine alterations in bipolar disorder: a meta-analysis of 30 studies. Biol Psychiatry. 2013;74(1):15\u201325.","journal-title":"Biol Psychiatry"},{"issue":"9","key":"2052_CR43","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.jpsychires.2013.05.018","volume":"47","author":"K Munkholm","year":"2013","unstructured":"Munkholm K, et al. Cytokines in bipolar disorder vs. healthy control subjects: a systematic review and meta-analysis. J Psychiatr Res. 2013;47(9):1119\u201333.","journal-title":"J Psychiatr Res"},{"issue":"5","key":"2052_CR44","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/s41593-018-0128-y","volume":"21","author":"MD Rudolph","year":"2018","unstructured":"Rudolph MD, et al. Maternal IL-6 during pregnancy can be estimated from newborn brain connectivity and predicts future working memory in offspring. Nat Neurosci. 2018;21(5):765\u201372.","journal-title":"Nat Neurosci"},{"issue":"1","key":"2052_CR45","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.immuni.2018.11.016","volume":"50","author":"GN Pronovost","year":"2019","unstructured":"Pronovost GN, Hsiao EY. Perinatal interactions between the microbiome, immunity, and neurodevelopment. Immunity. 2019;50(1):18\u201336.","journal-title":"Immunity"},{"issue":"1","key":"2052_CR46","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.bbi.2009.08.001","volume":"24","author":"AM Enstrom","year":"2010","unstructured":"Enstrom AM, et al. Differential monocyte responses to TLR ligands in children with autism spectrum disorders. Brain Behav Immun. 2010;24(1):64\u201371.","journal-title":"Brain Behav Immun"},{"issue":"1","key":"2052_CR47","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1186\/1742-2094-10-38","volume":"10","author":"V Napolioni","year":"2013","unstructured":"Napolioni V, et al. Plasma cytokine profiling in sibling pairs discordant for autism spectrum disorder. J Neuroinflammation. 2013;10(1):813.","journal-title":"J Neuroinflammation"},{"issue":"7","key":"2052_CR48","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/s41577-020-00487-7","volume":"21","author":"KE Zengeler","year":"2021","unstructured":"Zengeler KE, Lukens JR. Innate immunity at the crossroads of healthy brain maturation and neurodevelopmental disorders. Nat Rev Immunol. 2021;21(7):454\u201368.","journal-title":"Nat Rev Immunol"},{"key":"2052_CR49","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.699563","volume":"12","author":"E Jentho","year":"2021","unstructured":"Jentho E, Weis S. DAMPs and innate immune training. Front Immunol. 2021;12: 699563.","journal-title":"Front Immunol"},{"issue":"12","key":"2052_CR50","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a016287","volume":"6","author":"MR de Zoete","year":"2014","unstructured":"de Zoete MR, et al. Inflammasomes. Cold Spring Harb Perspect Biol. 2014;6(12): a016287.","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"6","key":"2052_CR51","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","volume":"140","author":"K Schroder","year":"2010","unstructured":"Schroder K, Tschopp J. The inflammasomes. Cell. 2010;140(6):821\u201332.","journal-title":"Cell"},{"issue":"1","key":"2052_CR52","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/s41392-021-00687-0","volume":"6","author":"D Li","year":"2021","unstructured":"Li D, Wu M. Pattern recognition receptors in health and diseases. Signal Transduct Target Ther. 2021;6(1):291.","journal-title":"Signal Transduct Target Ther"},{"issue":"2","key":"2052_CR53","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","volume":"10","author":"F Martinon","year":"2002","unstructured":"Martinon F, Burns K, Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell. 2002;10(2):417\u201326.","journal-title":"Mol Cell"},{"issue":"6","key":"2052_CR54","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1083\/jcb.201602089","volume":"213","author":"D Sharma","year":"2016","unstructured":"Sharma D, Kanneganti T-D. The cell biology of inflammasomes: mechanisms of inflammasome activation and regulation. J Cell Biol. 2016;213(6):617\u201329.","journal-title":"J Cell Biol"},{"issue":"5","key":"2052_CR55","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.cell.2014.04.007","volume":"157","author":"M Lamkanfi","year":"2014","unstructured":"Lamkanfi M, Vishva M. Dixit, mechanisms and functions of inflammasomes. Cell. 2014;157(5):1013\u201322.","journal-title":"Cell"},{"issue":"5","key":"2052_CR56","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.cell.2011.04.022","volume":"145","author":"E Elinav","year":"2011","unstructured":"Elinav E, et al. NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell. 2011;145(5):745\u201357.","journal-title":"Cell"},{"issue":"5","key":"2052_CR57","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.chom.2011.04.008","volume":"9","author":"N Kerur","year":"2011","unstructured":"Kerur N, et al. IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to kaposi sarcoma-associated herpesvirus infection. Cell Host Microbe. 2011;9(5):363\u201375.","journal-title":"Cell Host Microbe"},{"issue":"3","key":"2052_CR58","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.immuni.2012.02.001","volume":"36","author":"S Khare","year":"2012","unstructured":"Khare S, et al. An NLRP7-containing inflammasome mediates recognition of microbial lipopeptides in human macrophages. Immunity. 2012;36(3):464\u201376.","journal-title":"Immunity"},{"issue":"7","key":"2052_CR59","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1002\/glia.22499","volume":"61","author":"J Minkiewicz","year":"2013","unstructured":"Minkiewicz J, de Rivero Vaccari JP, Keane RW. Human astrocytes express a novel NLRP2 inflammasome. Glia. 2013;61(7):1113\u201321.","journal-title":"Glia"},{"issue":"1","key":"2052_CR60","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.immuni.2012.07.006","volume":"37","author":"GI Vladimer","year":"2012","unstructured":"Vladimer GI, et al. The NLRP12 inflammasome recognizes yersinia pestis. Immunity. 2012;37(1):96\u2013107.","journal-title":"Immunity"},{"issue":"9","key":"2052_CR61","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1038\/sj.cdd.4402194","volume":"14","author":"T Fernandes-Alnemri","year":"2007","unstructured":"Fernandes-Alnemri T, et al. The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation. Cell Death Differ. 2007;14(9):1590\u2013604.","journal-title":"Cell Death Differ"},{"issue":"2","key":"2052_CR62","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","volume":"10","author":"F Martinon","year":"2002","unstructured":"Martinon F, Burns K, Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-\u03b2. Mol Cell. 2002;10(2):417\u201326.","journal-title":"Mol Cell"},{"key":"2052_CR63","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1146\/annurev.immunol.021908.132612","volume":"27","author":"CA Dinarello","year":"2009","unstructured":"Dinarello CA. Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol. 2009;27:519\u201350.","journal-title":"Annu Rev Immunol"},{"issue":"5","key":"2052_CR64","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1002\/eji.201141550","volume":"41","author":"CA Dinarello","year":"2011","unstructured":"Dinarello CA. A clinical perspective of IL-1\u03b2 as the gatekeeper of inflammation. Eur J Immunol. 2011;41(5):1203\u201317.","journal-title":"Eur J Immunol"},{"issue":"6552","key":"2052_CR65","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/378088a0","volume":"378","author":"H Okamura","year":"1995","unstructured":"Okamura H, et al. Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature. 1995;378(6552):88\u201391.","journal-title":"Nature"},{"issue":"1","key":"2052_CR66","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41584-023-01053-w","volume":"20","author":"E Landy","year":"2024","unstructured":"Landy E, et al. Biological and clinical roles of IL-18 in inflammatory diseases. Nat Rev Rheumatol. 2024;20(1):33\u201347.","journal-title":"Nat Rev Rheumatol"},{"issue":"1","key":"2052_CR67","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s41392-021-00507-5","volume":"6","author":"P Yu","year":"2021","unstructured":"Yu P, et al. Pyroptosis: mechanisms and diseases. Signal Transduct Target Ther. 2021;6(1):128.","journal-title":"Signal Transduct Target Ther"},{"issue":"4","key":"2052_CR68","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.tibs.2022.10.002","volume":"48","author":"J Xu","year":"2023","unstructured":"Xu J, N\u00fa\u00f1ez G. The NLRP3 inflammasome: activation and regulation. Trends Biochem Sci. 2023;48(4):331\u201344.","journal-title":"Trends Biochem Sci"},{"issue":"10","key":"2052_CR69","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/s41583-018-0055-7","volume":"19","author":"MT Heneka","year":"2018","unstructured":"Heneka MT, McManus RM, Latz E. Inflammasome signalling in brain function and neurodegenerative disease. Nat Rev Neurosci. 2018;19(10):610\u201321.","journal-title":"Nat Rev Neurosci"},{"issue":"8","key":"2052_CR70","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","volume":"19","author":"KV Swanson","year":"2019","unstructured":"Swanson KV, Deng M, Ting JPY. The NLRP3 inflammasome: molecular activation and regulation to therapeutics. Nat Rev Immunol. 2019;19(8):477\u201389.","journal-title":"Nat Rev Immunol"},{"key":"2052_CR71","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev-immunol-081022-021207","volume":"41","author":"J Fu","year":"2023","unstructured":"Fu J, Wu H. Structural mechanisms of NLRP3 inflammasome assembly and activation. Annu Rev Immunol. 2023;41:301\u201316.","journal-title":"Annu Rev Immunol"},{"issue":"13","key":"2052_CR72","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.3390\/cells12131766","volume":"12","author":"D Bult\u00e9","year":"2023","unstructured":"Bult\u00e9 D, et al. Inflammasomes: mechanisms of action and involvement in human diseases. Cells. 2023;12(13):1766.","journal-title":"Cells"},{"issue":"2","key":"2052_CR73","doi-asserted-by":"crossref","first-page":"787","DOI":"10.4049\/jimmunol.0901363","volume":"183","author":"FG Bauernfeind","year":"2009","unstructured":"Bauernfeind FG, et al. Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J Immunol. 2009;183(2):787\u201391.","journal-title":"J Immunol"},{"issue":"13","key":"2052_CR74","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.3390\/ijms20133328","volume":"20","author":"N Kelley","year":"2019","unstructured":"Kelley N, et al. The NLRP3 inflammasome: an overview of mechanisms of activation and regulation. Int J Mol Sci. 2019;20(13):3328.","journal-title":"Int J Mol Sci"},{"issue":"7081","key":"2052_CR75","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature04516","volume":"440","author":"F Martinon","year":"2006","unstructured":"Martinon F, et al. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature. 2006;440(7081):237\u201341.","journal-title":"Nature"},{"issue":"2","key":"2052_CR76","doi-asserted-by":"crossref","first-page":"411","DOI":"10.4049\/jimmunol.1500530","volume":"195","author":"T Eigenbrod","year":"2015","unstructured":"Eigenbrod T, Dalpke AH. Bacterial RNA: an underestimated stimulus for innate immune responses. J Immunol. 2015;195(2):411\u20138.","journal-title":"J Immunol"},{"key":"2052_CR77","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202006194","author":"PI Seoane","year":"2020","unstructured":"Seoane PI, et al. The NLRP3\u2013inflammasome as a sensor of organelle dysfunction. J Cell Biol. 2020. https:\/\/doi.org\/10.1083\/jcb.202006194.","journal-title":"J Cell Biol"},{"issue":"7081","key":"2052_CR78","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nature04515","volume":"440","author":"S Mariathasan","year":"2006","unstructured":"Mariathasan S, et al. Cryopyrin activates the inflammasome in response to toxins and ATP. Nature. 2006;440(7081):228\u201332.","journal-title":"Nature"},{"issue":"21","key":"2052_CR79","doi-asserted-by":"crossref","first-page":"15195","DOI":"10.1016\/S0021-9258(17)36591-2","volume":"269","author":"D Perregaux","year":"1994","unstructured":"Perregaux D, Gabel CA. Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity. J Biol Chem. 1994;269(21):15195\u2013203.","journal-title":"J Biol Chem"},{"issue":"10","key":"2052_CR80","doi-asserted-by":"crossref","first-page":"5120","DOI":"10.4049\/jimmunol.164.10.5120","volume":"164","author":"I Walev","year":"2000","unstructured":"Walev I, et al. Potassium regulates IL-1 beta processing via calcium-independent phospholipase A2. J Immunol. 2000;164(10):5120\u20134.","journal-title":"J Immunol"},{"issue":"6","key":"2052_CR81","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.immuni.2013.05.016","volume":"38","author":"R Mu\u00f1oz-Planillo","year":"2013","unstructured":"Mu\u00f1oz-Planillo R, et al. K+ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter. Immunity. 2013;38(6):1142\u201353.","journal-title":"Immunity"},{"issue":"4","key":"2052_CR82","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.immuni.2016.08.010","volume":"45","author":"CJ Gro\u00df","year":"2016","unstructured":"Gro\u00df CJ, et al. K+ efflux-independent NLRP3 inflammasome activation by small molecules targeting mitochondria. Immunity. 2016;45(4):761\u201373.","journal-title":"Immunity"},{"issue":"7575","key":"2052_CR83","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/nature15541","volume":"526","author":"N Kayagaki","year":"2015","unstructured":"Kayagaki N, et al. Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature. 2015;526(7575):666\u201371.","journal-title":"Nature"},{"issue":"7575","key":"2052_CR84","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature15514","volume":"526","author":"J Shi","year":"2015","unstructured":"Shi J, et al. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature. 2015;526(7575):660\u20135.","journal-title":"Nature"},{"issue":"4","key":"2052_CR85","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.immuni.2016.01.012","volume":"44","author":"MM Gaidt","year":"2016","unstructured":"Gaidt MM, et al. Human monocytes engage an alternative inflammasome pathway. Immunity. 2016;44(4):833\u201346.","journal-title":"Immunity"},{"issue":"1","key":"2052_CR86","doi-asserted-by":"crossref","first-page":"334","DOI":"10.4049\/jimmunol.1202737","volume":"190","author":"Y He","year":"2013","unstructured":"He Y, Franchi L, N\u00fa\u00f1ez G. TLR agonists stimulate Nlrp3-dependent IL-1\u03b2 production independently of the purinergic P2X7 receptor in dendritic cells and in vivo. J Immunol. 2013;190(1):334\u20139.","journal-title":"J Immunol"},{"issue":"7590","key":"2052_CR87","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/nature16959","volume":"530","author":"Y He","year":"2016","unstructured":"He Y, et al. NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux. Nature. 2016;530(7590):354\u20137.","journal-title":"Nature"},{"issue":"3","key":"2052_CR88","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/ni.3333","volume":"17","author":"H Shi","year":"2016","unstructured":"Shi H, et al. NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component. Nat Immunol. 2016;17(3):250\u20138.","journal-title":"Nat Immunol"},{"key":"2052_CR89","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111822","volume":"185","author":"X Zhang","year":"2020","unstructured":"Zhang X, et al. Development of small molecule inhibitors targeting NLRP3 inflammasome pathway for inflammatory diseases. Eur J Med Chem. 2020;185: 111822.","journal-title":"Eur J Med Chem"},{"issue":"5","key":"2052_CR90","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.3390\/ijms23052810","volume":"23","author":"A Vall\u00e9e","year":"2022","unstructured":"Vall\u00e9e A. Neuroinflammation in Schizophrenia: the key role of the WNT\/\u03b2-catenin pathway. Int J Mol Sci. 2022;23(5):2810.","journal-title":"Int J Mol Sci"},{"key":"2052_CR91","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.bbi.2016.03.009","volume":"57","author":"M Saresella","year":"2016","unstructured":"Saresella M, et al. Multiple inflammasome complexes are activated in autistic spectrum disorders. Brain Behav Immun. 2016;57:125\u201333.","journal-title":"Brain Behav Immun"},{"key":"2052_CR92","volume":"2015","author":"HK Kim","year":"2015","unstructured":"Kim HK, Chen W, Andreazza AC. The potential role of the NLRP3 Inflammasome as a link between mitochondrial complex i dysfunction and inflammation in bipolar disorder. Neural Plast. 2015;2015: 408136.","journal-title":"Neural Plast"},{"issue":"1","key":"2052_CR93","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13229-023-00558-1","volume":"14","author":"Y Xie","year":"2023","unstructured":"Xie Y, et al. Personalized estimates of brain cortical structural variability in individuals with Autism spectrum disorder: the predictor of brain age and neurobiology relevance. Mol Autism. 2023;14(1):27.","journal-title":"Mol Autism"},{"issue":"3\u20134","key":"2052_CR94","doi-asserted-by":"crossref","first-page":"236","DOI":"10.2298\/SARH1204236S","volume":"140","author":"M Stankovi\u0107","year":"2012","unstructured":"Stankovi\u0107 M, Laki\u0107 A, Ili\u0107 N. Autism and autistic spectrum disorders in the context of new DSM-V classification, and clinical and epidemiological data. Srp Arh Celok Lek. 2012;140(3\u20134):236\u201343.","journal-title":"Srp Arh Celok Lek"},{"key":"2052_CR95","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.cortex.2023.09.001","volume":"169","author":"K Furley","year":"2023","unstructured":"Furley K, et al. Developmental regression in children: current and future directions. Cortex. 2023;169:5\u201317.","journal-title":"Cortex"},{"issue":"6","key":"2052_CR96","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.jaac.2017.03.013","volume":"56","author":"R Loomes","year":"2017","unstructured":"Loomes R, Hull L, Mandy WPL. What is the male-to-female ratio in autism spectrum disorder? a systematic review and meta-analysis. J Am Acad Child Adolesc Psychiatry. 2017;56(6):466\u201374.","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"6","key":"2052_CR97","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1192\/bjp.bp.115.174649","volume":"209","author":"TS Brugha","year":"2016","unstructured":"Brugha TS, et al. Epidemiology of autism in adults across age groups and ability levels. Br J Psychiatry. 2016;209(6):498\u2013503.","journal-title":"Br J Psychiatry"},{"issue":"1","key":"2052_CR98","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41572-019-0138-4","volume":"6","author":"C Lord","year":"2020","unstructured":"Lord C, et al. Autism spectrum disorder. Nat Rev Dis Primers. 2020;6(1):5.","journal-title":"Nat Rev Dis Primers"},{"key":"2052_CR99","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s13229-017-0121-4","volume":"8","author":"A Modabbernia","year":"2017","unstructured":"Modabbernia A, Velthorst E, Reichenberg A. Environmental risk factors for autism: an evidence-based review of systematic reviews and meta-analyses. Mol Autism. 2017;8:13.","journal-title":"Mol Autism"},{"issue":"6","key":"2052_CR100","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.neuron.2015.09.016","volume":"87","author":"SJ Sanders","year":"2015","unstructured":"Sanders SJ, et al. Insights into autism spectrum disorder genomic architecture and biology from 71 risk loci. Neuron. 2015;87(6):1215\u201333.","journal-title":"Neuron"},{"issue":"1","key":"2052_CR101","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/acps.12666","volume":"135","author":"S Wu","year":"2017","unstructured":"Wu S, et al. Advanced parental age and autism risk in children: a systematic review and meta-analysis. Acta Psychiatr Scand. 2017;135(1):29\u201341.","journal-title":"Acta Psychiatr Scand"},{"issue":"16","key":"2052_CR102","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1001\/jama.2013.2270","volume":"309","author":"J Christensen","year":"2013","unstructured":"Christensen J, et al. Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism. JAMA. 2013;309(16):1696\u2013703.","journal-title":"JAMA"},{"issue":"8","key":"2052_CR103","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1097\/DBP.0000000000000341","volume":"37","author":"F Xie","year":"2016","unstructured":"Xie F, Peltier M, Getahun D. Is the risk of autism in younger siblings of affected children moderated by sex, race\/ethnicity, or gestational age? J Dev Behav Pediatr. 2016;37(8):603\u20139.","journal-title":"J Dev Behav Pediatr"},{"issue":"2","key":"2052_CR104","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/aur.2057","volume":"12","author":"GC Windham","year":"2019","unstructured":"Windham GC, et al. Maternal pre-pregnancy body mass index and gestational weight gain in relation to autism spectrum disorder and other developmental disorders in offspring. Autism Res. 2019;12(2):316\u201327.","journal-title":"Autism Res"},{"issue":"2","key":"2052_CR105","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1542\/peds.2010-2371","volume":"127","author":"K Cheslack-Postava","year":"2011","unstructured":"Cheslack-Postava K, Liu K, Bearman PS. Closely spaced pregnancies are associated with increased odds of autism in California sibling births. Pediatrics. 2011;127(2):246\u201353.","journal-title":"Pediatrics"},{"issue":"3","key":"2052_CR106","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.bbi.2011.08.007","volume":"26","author":"C Onore","year":"2012","unstructured":"Onore C, Careaga M, Ashwood P. The role of immune dysfunction in the pathophysiology of autism. Brain Behav Immun. 2012;26(3):383\u201392.","journal-title":"Brain Behav Immun"},{"key":"2052_CR107","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.984678","volume":"13","author":"M Da\u00ebron","year":"2022","unstructured":"Da\u00ebron M. The immune system as a system of relations. Front Immunol. 2022;13: 984678.","journal-title":"Front Immunol"},{"issue":"8","key":"2052_CR108","doi-asserted-by":"crossref","first-page":"6387","DOI":"10.1007\/s12035-017-0822-x","volume":"55","author":"D G\u0142adysz","year":"2018","unstructured":"G\u0142adysz D, Krzywdzi\u0144ska A, Hozyasz KK. Immune abnormalities in autism spectrum disorder-could they hold promise for causative treatment? Mol Neurobiol. 2018;55(8):6387\u2013435.","journal-title":"Mol Neurobiol"},{"issue":"5","key":"2052_CR109","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.biopsych.2015.08.007","volume":"81","author":"P Krakowiak","year":"2017","unstructured":"Krakowiak P, et al. Neonatal cytokine profiles associated with autism spectrum disorder. Biol Psychiatry. 2017;81(5):442\u201351.","journal-title":"Biol Psychiatry"},{"issue":"11","key":"2052_CR110","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s11910-018-0887-6","volume":"18","author":"HK Hughes","year":"2018","unstructured":"Hughes HK, Rose D, Ashwood P. The gut microbiota and dysbiosis in autism spectrum disorders. Curr Neurol Neurosci Rep. 2018;18(11):81.","journal-title":"Curr Neurol Neurosci Rep"},{"issue":"1","key":"2052_CR111","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1192\/bjp.bp.108.051672","volume":"195","author":"H Gardener","year":"2009","unstructured":"Gardener H, Spiegelman D, Buka SL. Prenatal risk factors for autism: comprehensive meta-analysis. Br J Psychiatry. 2009;195(1):7\u201314.","journal-title":"Br J Psychiatry"},{"issue":"6","key":"2052_CR112","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.mehy.2011.02.038","volume":"76","author":"MR Buehler","year":"2011","unstructured":"Buehler MR. A proposed mechanism for autism: an aberrant neuroimmune response manifested as a psychiatric disorder. Med Hypotheses. 2011;76(6):863\u201370.","journal-title":"Med Hypotheses"},{"key":"2052_CR113","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.bbi.2016.06.005","volume":"58","author":"HY Jiang","year":"2016","unstructured":"Jiang HY, et al. Maternal infection during pregnancy and risk of autism spectrum disorders: a systematic review and meta-analysis. Brain Behav Immun. 2016;58:165\u201372.","journal-title":"Brain Behav Immun"},{"issue":"7","key":"2052_CR114","first-page":"1546","volume":"44","author":"K Lyall","year":"2014","unstructured":"Lyall K, et al. Maternal immune-mediated conditions, autism spectrum disorders, and developmental delay. J Autism Dev Disord. 2014;44(7):1546\u201355.","journal-title":"J Autism Dev Disord"},{"key":"2052_CR115","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.bbi.2022.01.015","volume":"101","author":"D Szab\u00f3","year":"2022","unstructured":"Szab\u00f3 D, et al. Maternal P2X7 receptor inhibition prevents autism-like phenotype in male mouse offspring through the NLRP3-IL-1\u03b2 pathway. Brain Behav Immun. 2022;101:318\u201332.","journal-title":"Brain Behav Immun"},{"issue":"1","key":"2052_CR116","doi-asserted-by":"crossref","first-page":"1057539","DOI":"10.1155\/2018\/1057539","volume":"2018","author":"B Lee","year":"2018","unstructured":"Lee B, et al. The efficacy and safety of acupuncture for the treatment of children with autism spectrum disorder: a systematic review and meta-analysis. Evid-Based Complement Altern Med. 2018;2018(1):1057539.","journal-title":"Evid-Based Complement Altern Med"},{"key":"2052_CR117","doi-asserted-by":"crossref","unstructured":"Wong VCN, Chu VLY, Cheuk DKL. Acupuncture in autism spectrum disorders, in Comprehensive Guide to Autism, V.B. Patel, V.R. Preedy, and C.R. Martin, Editors. 2014, Springer New York: New York, NY. P 2203\u20132231.","DOI":"10.1007\/978-1-4614-4788-7_136"},{"issue":"1","key":"2052_CR118","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1515\/tnsci-2021-0011","volume":"12","author":"T Su","year":"2021","unstructured":"Su T, Pei L. Acupuncture and oxytocinergic system: the promising treatment for autism. Transl Neurosci. 2021;12(1):96\u2013102.","journal-title":"Transl Neurosci"},{"issue":"2","key":"2052_CR119","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/jnen\/nlab132","volume":"81","author":"P Zhao","year":"2022","unstructured":"Zhao P, et al. Acupuncture at ST36 alleviates the behavioral disorder of autistic rats by inhibiting TXNIP-mediated activation of NLRP3. J Neuropathol Exp Neurol. 2022;81(2):127\u201334.","journal-title":"J Neuropathol Exp Neurol"},{"issue":"2","key":"2052_CR120","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/ni.1831","volume":"11","author":"R Zhou","year":"2010","unstructured":"Zhou R, et al. Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat Immunol. 2010;11(2):136\u201340.","journal-title":"Nat Immunol"},{"key":"2052_CR121","doi-asserted-by":"crossref","first-page":"955128","DOI":"10.3389\/fimmu.2022.955128","volume":"13","author":"N Jiang","year":"2022","unstructured":"Jiang N, et al. Thioredoxin-interacting protein: a new therapeutic target in bone metabolism disorders? Front Immunol. 2022;13:955128.","journal-title":"Front Immunol"},{"key":"2052_CR122","doi-asserted-by":"publisher","DOI":"10.3390\/nu16040549","author":"M Suprunowicz","year":"2024","unstructured":"Suprunowicz M, et al. Between dysbiosis, maternal immune activation and autism: is there a common pathway? Nutrients. 2024. https:\/\/doi.org\/10.3390\/nu16040549.","journal-title":"Nutrients"},{"issue":"2","key":"2052_CR123","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jtcme.2022.03.001","volume":"13","author":"A Mehra","year":"2023","unstructured":"Mehra A, et al. Gut microbiota and autism spectrum disorder: from pathogenesis to potential therapeutic perspectives. J Tradit Complement Med. 2023;13(2):135\u201349.","journal-title":"J Tradit Complement Med"},{"issue":"1","key":"2052_CR124","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s40168-016-0225-7","volume":"5","author":"D-W Kang","year":"2017","unstructured":"Kang D-W, et al. Microbiota transfer therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study. Microbiome. 2017;5(1):10.","journal-title":"Microbiome"},{"issue":"2","key":"2052_CR125","first-page":"131","volume":"21","author":"FWD Tai","year":"2021","unstructured":"Tai FWD, McAlindon ME. Non-steroidal anti-inflammatory drugs and the gastrointestinal tract. Clin Med (Lond). 2021;21(2):131\u20134.","journal-title":"Clin Med (Lond)"},{"key":"2052_CR126","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2022.108327","volume":"241","author":"ZS Z\u00e1dori","year":"2023","unstructured":"Z\u00e1dori ZS, et al. Interactions between NSAIDs, opioids and the gut microbiota\u2014future perspectives in the management of inflammation and pain. Pharmacol Ther. 2023;241: 108327.","journal-title":"Pharmacol Ther"},{"key":"2052_CR127","doi-asserted-by":"crossref","first-page":"1268126","DOI":"10.3389\/fncel.2023.1268126","volume":"17","author":"DI Mohamed","year":"2023","unstructured":"Mohamed DI, et al. Unveiling the interplay between NSAID-induced dysbiosis and autoimmune liver disease in children: insights into the hidden gateway to autism spectrum disorders. Evidence from ex vivo, in vivo, and clinical studies. Front Cell Neurosci. 2023;17:1268126.","journal-title":"Front Cell Neurosci"},{"key":"2052_CR128","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jaut.2015.10.006","volume":"66","author":"Q Wang","year":"2016","unstructured":"Wang Q, et al. The clinical phenotypes of autoimmune hepatitis: a comprehensive review. J Autoimmun. 2016;66:98\u2013107.","journal-title":"J Autoimmun"},{"issue":"1","key":"2052_CR129","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/s41392-022-01081-0","volume":"7","author":"C-C Jiang","year":"2022","unstructured":"Jiang C-C, et al. Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications. Signal Transduct Target Ther. 2022;7(1):229.","journal-title":"Signal Transduct Target Ther"},{"issue":"3","key":"2052_CR130","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s00221-022-06541-1","volume":"241","author":"KA Ayriyants","year":"2023","unstructured":"Ayriyants KA, et al. A comparison of stress reactivity between BTBR and C57BL\/6J mice: an impact of early-life stress. Exp Brain Res. 2023;241(3):687\u201398.","journal-title":"Exp Brain Res"},{"key":"2052_CR131","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2021.113489","volume":"414","author":"VV Reshetnikov","year":"2021","unstructured":"Reshetnikov VV, et al. Sex-specific behavioral and structural alterations caused by early-life stress in C57BL\/6 and BTBR mice. Behav Brain Res. 2021;414: 113489.","journal-title":"Behav Brain Res"},{"key":"2052_CR132","volume":"9","author":"S Bachiller","year":"2020","unstructured":"Bachiller S, et al. Maternal separation leads to regional hippocampal microglial activation and alters the behavior in the adolescence in a sex-specific manner. Brain Behav Immun Health. 2020;9: 100142.","journal-title":"Brain Behav Immun Health"},{"issue":"3","key":"2052_CR133","doi-asserted-by":"crossref","first-page":"125","DOI":"10.22317\/jcms.v5i3.601","volume":"5","author":"K Khodamoradi","year":"2019","unstructured":"Khodamoradi K, et al. Maternal separation can affect the reproductive system by inflammasome activation in female mice. J Contemp Med Sci. 2019;5(3):125\u201330.","journal-title":"J Contemp Med Sci"},{"key":"2052_CR134","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2020.172953","volume":"196","author":"L Zhou","year":"2020","unstructured":"Zhou L, et al. Long-term maternal separation potentiates depressive-like behaviours and neuroinflammation in adult male C57\/BL6J mice. Pharmacol Biochem Behav. 2020;196: 172953.","journal-title":"Pharmacol Biochem Behav"},{"key":"2052_CR135","volume":"84","author":"NO Al-Harbi","year":"2020","unstructured":"Al-Harbi NO, et al. Elevated expression of toll-like receptor 4 is associated with NADPH oxidase-induced oxidative stress in B cells of children with autism. Int Immunopharmacol. 2020;84: 106555.","journal-title":"Int Immunopharmacol"},{"issue":"2","key":"2052_CR136","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/jdn.10310","volume":"84","author":"V Reisi-Vanani","year":"2024","unstructured":"Reisi-Vanani V, et al. Maternal separation stress through triggering of the neuro-immune response in the hippocampus induces autistic-like behaviors in male mice. Int J Dev Neurosci. 2024;84(2):87\u201398.","journal-title":"Int J Dev Neurosci"},{"key":"2052_CR137","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110112","volume":"118","author":"M Farzan","year":"2023","unstructured":"Farzan M, et al. Protective effects of vanillic acid on autistic-like behaviors in a rat model of maternal separation stress: behavioral, electrophysiological, molecular and histopathological alterations. Int Immunopharmacol. 2023;118: 110112.","journal-title":"Int Immunopharmacol"},{"issue":"2","key":"2052_CR138","first-page":"104","volume":"2","author":"SV Faraone","year":"2003","unstructured":"Faraone SV, et al. The worldwide prevalence of ADHD: is it an American condition? World Psychiatry. 2003;2(2):104\u201313.","journal-title":"World Psychiatry"},{"key":"2052_CR139","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3389\/fnhum.2019.00042","volume":"13","author":"Y Luo","year":"2019","unstructured":"Luo Y, et al. A review of heterogeneity in attention deficit\/hyperactivity disorder (ADHD). Front Hum Neurosci. 2019;13:42.","journal-title":"Front Hum Neurosci"},{"key":"2052_CR140","first-page":"7400","volume":"2013","author":"S Rodrak","year":"2013","unstructured":"Rodrak S, Wongsawat Y. EEG brain mapping and brain connectivity index for subtypes classification of attention deficit hyperactivity disorder children during the eye-opened period. Annu Int Conf IEEE Eng Med Biol Soc. 2013;2013:7400\u20133.","journal-title":"Annu Int Conf IEEE Eng Med Biol Soc"},{"issue":"3","key":"2052_CR141","first-page":"189","volume":"3","author":"JR Morrison","year":"1971","unstructured":"Morrison JR, Stewart MA. A family study of the hyperactive child syndrome. Biol Psychiatry. 1971;3(3):189\u201395.","journal-title":"Biol Psychiatry"},{"issue":"1","key":"2052_CR142","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.psc.2009.12.004","volume":"33","author":"SV Faraone","year":"2010","unstructured":"Faraone SV, Mick E. Molecular genetics of attention deficit hyperactivity disorder. Psychiatr Clin North Am. 2010;33(1):159\u201380.","journal-title":"Psychiatr Clin North Am"},{"issue":"14","key":"2052_CR143","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1001\/jama.288.14.1740","volume":"288","author":"FX Castellanos","year":"2002","unstructured":"Castellanos FX, et al. Developmental trajectories of brain volume abnormalities in children and adolescents with attention-deficit\/hyperactivity disorder. JAMA. 2002;288(14):1740\u20138.","journal-title":"JAMA"},{"issue":"7","key":"2052_CR144","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1097\/chi.0b013e318054e724","volume":"46","author":"S Pliszka","year":"2007","unstructured":"Pliszka S. Practice parameter for the assessment and treatment of children and adolescents with attention-deficit\/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2007;46(7):894\u2013921.","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"7\u20138","key":"2052_CR145","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.neuropharm.2009.07.026","volume":"57","author":"G Tripp","year":"2009","unstructured":"Tripp G, Wickens JR. Neurobiology of ADHD. Neuropharmacology. 2009;57(7\u20138):579\u201389.","journal-title":"Neuropharmacology"},{"key":"2052_CR146","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2017-1645","author":"AP Franz","year":"2018","unstructured":"Franz AP, et al. Attention-deficit\/hyperactivity disorder and very preterm\/very low birth weight: a meta-analysis. Pediatrics. 2018. https:\/\/doi.org\/10.1542\/peds.2017-1645.","journal-title":"Pediatrics"},{"issue":"3","key":"2052_CR147","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1159\/000079976","volume":"50","author":"VL Misener","year":"2004","unstructured":"Misener VL, et al. Replication test for association of the IL-1 receptor antagonist gene, IL1RN, with attention-deficit\/hyperactivity disorder. Neuropsychobiology. 2004;50(3):231\u20134.","journal-title":"Neuropsychobiology"},{"issue":"4","key":"2052_CR148","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s12402-011-0062-2","volume":"3","author":"RD Oades","year":"2011","unstructured":"Oades RD. An exploration of the associations of pregnancy and perinatal features with cytokines and tryptophan\/kynurenine metabolism in children with attention-deficit hyperactivity disorder (ADHD). Atten Defic Hyperact Disord. 2011;3(4):301\u201318.","journal-title":"Atten Defic Hyperact Disord"},{"issue":"21","key":"2052_CR149","doi-asserted-by":"crossref","first-page":"13054","DOI":"10.3390\/ijms232113054","volume":"23","author":"JH Park","year":"2022","unstructured":"Park JH. Potential inflammatory biomarker in patients with attention deficit hyperactivity disorder. Int J Mol Sci. 2022;23(21):13054.","journal-title":"Int J Mol Sci"},{"key":"2052_CR150","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1744-9081-6-29","volume":"6","author":"RD Oades","year":"2010","unstructured":"Oades RD, et al. Attention-deficit hyperactivity disorder (ADHD) and glial integrity: S100B, cytokines and kynurenine metabolism\u2013effects of medication. Behav Brain Funct. 2010;6:29.","journal-title":"Behav Brain Funct"},{"issue":"1\u20132","key":"2052_CR151","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/0006-8993(94)90006-X","volume":"643","author":"S Zalcman","year":"1994","unstructured":"Zalcman S, et al. Cytokine-specific central monoamine alterations induced by interleukin-1, -2 and -6. Brain Res. 1994;643(1\u20132):40\u20139.","journal-title":"Brain Res"},{"issue":"1\u20132","key":"2052_CR152","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0006-8993(96)00460-X","volume":"731","author":"H Anisman","year":"1996","unstructured":"Anisman H, Kokkinidis L, Merali Z. Interleukin-2 decreases accumbal dopamine efflux and responding for rewarding lateral hypothalamic stimulation. Brain Res. 1996;731(1\u20132):1\u201311.","journal-title":"Brain Res"},{"issue":"8","key":"2052_CR153","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.3390\/ph15081012","volume":"15","author":"HA Salem","year":"2022","unstructured":"Salem HA, et al. Neuroprotective effect of morin hydrate against attention-deficit\/hyperactivity disorder (ADHD) induced by MSG and\/or protein malnutrition in rat pups: effect on oxidative\/monoamines\/inflammatory balance and apoptosis. Pharmaceuticals (Basel). 2022;15(8):1012.","journal-title":"Pharmaceuticals (Basel)"},{"key":"2052_CR154","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113799","volume":"155","author":"K Abu-Elfotuh","year":"2022","unstructured":"Abu-Elfotuh K, et al. The protective effect of thymoquinone or\/and thymol against monosodium glutamate-induced attention-deficit\/hyperactivity disorder (ADHD)-like behavior in rats: Modulation of Nrf2\/HO-1, TLR4\/NF-\u03baB\/NLRP3\/caspase-1 and Wnt\/\u03b2-Catenin signaling pathways in rat model. Biomed Pharmacother. 2022;155: 113799.","journal-title":"Biomed Pharmacother"},{"issue":"16","key":"2052_CR155","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1021\/acschemneuro.1c00308","volume":"12","author":"SG G\u00fcrgen","year":"2021","unstructured":"G\u00fcrgen SG, et al. The effect of monosodium glutamate on neuronal signaling molecules in the hippocampus and the neuroprotective effects of omega-3 fatty acids. ACS Chem Neurosci. 2021;12(16):3028\u201337.","journal-title":"ACS Chem Neurosci"},{"issue":"10","key":"2052_CR156","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/j.1745-7599.2006.00160.x","volume":"18","author":"M Freeman","year":"2006","unstructured":"Freeman M. Reconsidering the effects of monosodium glutamate: a literature review. J Am Assoc Nurse Pract. 2006;18(10):482\u20136.","journal-title":"J Am Assoc Nurse Pract"},{"issue":"8","key":"2052_CR157","doi-asserted-by":"crossref","first-page":"868","DOI":"10.3923\/pjbs.2021.868.880","volume":"24","author":"M Khaled Abd-Elhaleim El Azazy","year":"2021","unstructured":"Khaled Abd-Elhaleim El Azazy M, et al. Omega-3 rich oils attenuate ADHD-like behaviour induced by dietary monosodium glutamate in rats. Pak J Biol Sci. 2021;24(8):868\u201380.","journal-title":"Pak J Biol Sci"},{"issue":"2","key":"2052_CR158","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1134\/S0006297920020042","volume":"85","author":"NK Isaev","year":"2020","unstructured":"Isaev NK, et al. Thymoquinone as a potential neuroprotector in acute and chronic forms of cerebral pathology. Biochem Mosc. 2020;85(2):167\u201376.","journal-title":"Biochem Mosc"},{"issue":"5","key":"2052_CR159","doi-asserted-by":"crossref","first-page":"1","DOI":"10.9734\/ARRB\/2018\/40165","volume":"25","author":"H Khither","year":"2018","unstructured":"Khither H, et al. In-vitro antioxidant effect of thymoquinone. Annu Res Rev Biol. 2018;25(5):1\u20139.","journal-title":"Annu Res Rev Biol"},{"issue":"1","key":"2052_CR160","doi-asserted-by":"crossref","first-page":"52","DOI":"10.2174\/1871529X18666180212114816","volume":"18","author":"H Shaterzadeh-Yazdi","year":"2018","unstructured":"Shaterzadeh-Yazdi H, et al. Immunomodulatory and anti-inflammatory effects of thymoquinone. Cardiovasc Hematol Disord Drug Targets. 2018;18(1):52\u201360.","journal-title":"Cardiovasc Hematol Disord Drug Targets"},{"key":"2052_CR161","doi-asserted-by":"crossref","first-page":"236","DOI":"10.3389\/fneur.2018.00236","volume":"9","author":"IA Fouad","year":"2018","unstructured":"Fouad IA, et al. Neuromodulatory effect of thymoquinone in attenuating glutamate-mediated neurotoxicity targeting the amyloidogenic and apoptotic pathways. Front Neurol. 2018;9:236.","journal-title":"Front Neurol"},{"issue":"4","key":"2052_CR162","doi-asserted-by":"crossref","first-page":"408","DOI":"10.3390\/ph15040408","volume":"15","author":"FH Pottoo","year":"2022","unstructured":"Pottoo FH, et al. Thymoquinone: review of its potential in the treatment of neurological diseases. Pharmaceuticals. 2022;15(4):408.","journal-title":"Pharmaceuticals"},{"key":"2052_CR163","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.bbr.2015.04.052","volume":"291","author":"X-Y Deng","year":"2015","unstructured":"Deng X-Y, et al. Thymol produces an antidepressant-like effect in a chronic unpredictable mild stress model of depression in mice. Behav Brain Res. 2015;291:12\u20139.","journal-title":"Behav Brain Res"},{"issue":"3","key":"2052_CR164","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/FBP.0b013e3283534301","volume":"23","author":"Z Azizi","year":"2012","unstructured":"Azizi Z, et al. Cognitive-enhancing activity of thymol and carvacrol in two rat models of dementia. Behav Pharmacol. 2012;23(3):241\u20139.","journal-title":"Behav Pharmacol"},{"issue":"7","key":"2052_CR165","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.3390\/ijms20071538","volume":"20","author":"H Javed","year":"2019","unstructured":"Javed H, et al. Neuroprotective effects of thymol, a dietary monoterpene against dopaminergic neurodegeneration in rotenone-induced rat model of parkinson\u2019s disease. Int J Mol Sci. 2019;20(7):1538.","journal-title":"Int J Mol Sci"},{"issue":"2","key":"2052_CR166","doi-asserted-by":"crossref","first-page":"L155","DOI":"10.1152\/ajplung.00449.2016","volume":"312","author":"H Zhao","year":"2017","unstructured":"Zhao H, et al. The role of nuclear factor-erythroid 2 related factor 2 (Nrf-2) in the protection against lung injury. Am J Physiol Lung Cell Mol Physiol. 2017;312(2):L155-l162.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"7","key":"2052_CR167","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1161\/STROKEAHA.115.009398","volume":"46","author":"X Zhao","year":"2015","unstructured":"Zhao X, et al. Dimethyl fumarate protects brain from damage produced by intracerebral hemorrhage by mechanism involving Nrf2. Stroke. 2015;46(7):1923\u20138.","journal-title":"Stroke"},{"key":"2052_CR168","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/978-1-60761-738-9_3","volume-title":"Transcription factors: methods and protocols","author":"A Giudice","year":"2010","unstructured":"Giudice A, Arra C, Turco MC. Review of molecular mechanisms involved in the activation of the Nrf2-ARE signaling pathway by chemopreventive agents. In: Higgins PJ, editor. Transcription factors: methods and protocols. Totowa, NJ: Humana Press; 2010. p. 37\u201374."},{"issue":"8","key":"2052_CR169","doi-asserted-by":"crossref","first-page":"4926","DOI":"10.1007\/s12035-022-02889-1","volume":"59","author":"N Mehterov","year":"2022","unstructured":"Mehterov N, et al. Interactions among brain-derived neurotrophic factor and neuroimmune pathways are key components of the major psychiatric disorders. Mol Neurobiol. 2022;59(8):4926\u201352.","journal-title":"Mol Neurobiol"},{"issue":"6","key":"2052_CR170","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.devcel.2016.08.011","volume":"38","author":"KM Loh","year":"2016","unstructured":"Loh KM, van Amerongen R, Nusse R. Generating cellular diversity and spatial form: Wnt signaling and the evolution of multicellular animals. Dev Cell. 2016;38(6):643\u201355.","journal-title":"Dev Cell"},{"issue":"2","key":"2052_CR171","doi-asserted-by":"crossref","first-page":"230","DOI":"10.3390\/cells10020230","volume":"10","author":"A Vall\u00e9e","year":"2021","unstructured":"Vall\u00e9e A, Vall\u00e9e J-N, Lecarpentier Y. Parkinson\u2019s disease: potential actions of lithium by targeting the WNT\/\u03b2-catenin pathway, oxidative stress, inflammation and glutamatergic pathway. Cells. 2021;10(2):230.","journal-title":"Cells"},{"key":"2052_CR172","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.lfs.2016.06.024","volume":"158","author":"R Libro","year":"2016","unstructured":"Libro R, Bramanti P, Mazzon E. The role of the Wnt canonical signaling in neurodegenerative diseases. Life Sci. 2016;158:78\u201388.","journal-title":"Life Sci"},{"issue":"12","key":"2052_CR173","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1007\/s00210-018-1552-y","volume":"391","author":"HI Ahmed","year":"2018","unstructured":"Ahmed HI, Abdel-Sattar SA, Zaky HS. Vinpocetine halts ketamine-induced schizophrenia-like deficits in rats: impact on BDNF and GSK-3\u03b2\/\u03b2-catenin pathway. Naunyn Schmiedebergs Arch Pharmacol. 2018;391(12):1327\u201338.","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"2052_CR174","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00063","author":"L Song","year":"2017","unstructured":"Song L, et al. NLRP3 inflammasome in neurological diseases, from functions to therapies. Front Cell Neurosci. 2017. https:\/\/doi.org\/10.3389\/fncel.2017.00063.","journal-title":"Front Cell Neurosci"},{"issue":"6","key":"2052_CR175","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.neubiorev.2008.03.003","volume":"32","author":"KCF Fone","year":"2008","unstructured":"Fone KCF, Porkess MV. Behavioural and neurochemical effects of post-weaning social isolation in rodents\u2014Relevance to developmental neuropsychiatric disorders. Neurosci Biobehav Rev. 2008;32(6):1087\u2013102.","journal-title":"Neurosci Biobehav Rev"},{"key":"2052_CR176","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.bbi.2022.02.022","volume":"102","author":"A Hamilton","year":"2022","unstructured":"Hamilton A, et al. The immunomodulatory effects of social isolation in mice are linked to temperature control. Brain Behav Immun. 2022;102:179\u201394.","journal-title":"Brain Behav Immun"},{"issue":"22","key":"2052_CR177","doi-asserted-by":"crossref","first-page":"1900574","DOI":"10.1002\/mnfr.201900574","volume":"63","author":"B Kang","year":"2019","unstructured":"Kang B, et al. Punicalagin, a pomegranate-derived ellagitannin, suppresses obesity and obesity-induced inflammatory responses via the Nrf2\/Keap1 signaling pathway. Mol Nutr Food Res. 2019;63(22):1900574.","journal-title":"Mol Nutr Food Res"},{"key":"2052_CR178","doi-asserted-by":"publisher","DOI":"10.3390\/nu12051516","author":"X An","year":"2020","unstructured":"An X, et al. Punicalagin protects diabetic nephropathy by inhibiting pyroptosis based on TXNIP\/NLRP3 pathway. Nutrients. 2020. https:\/\/doi.org\/10.3390\/nu12051516.","journal-title":"Nutrients"},{"issue":"5","key":"2052_CR179","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1089\/fpd.2016.2226","volume":"14","author":"Y Xu","year":"2017","unstructured":"Xu Y, et al. Antimicrobial activity of punicalagin against staphylococcus aureus and its effect on biofilm formation. Foodborne Pathog Dis. 2017;14(5):282\u20137.","journal-title":"Foodborne Pathog Dis"},{"key":"2052_CR180","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.biopha.2018.04.074","volume":"103","author":"X Cheng","year":"2018","unstructured":"Cheng X, et al. Punicalagin induces senescent growth arrest in human papillary thyroid carcinoma BCPAP cells via NF-\u03baB signaling pathway. Biomed Pharmacother. 2018;103:490\u20138.","journal-title":"Biomed Pharmacother"},{"issue":"12","key":"2052_CR181","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1038\/nn.3263","volume":"15","author":"J Liu","year":"2012","unstructured":"Liu J, et al. Impaired adult myelination in the prefrontal cortex of socially isolated mice. Nat Neurosci. 2012;15(12):1621\u20133.","journal-title":"Nat Neurosci"},{"key":"2052_CR182","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.122252","volume":"335","author":"K Abu-Elfotuh","year":"2023","unstructured":"Abu-Elfotuh K, et al. In silico and in vivo analysis of the relationship between ADHD and social isolation in pups rat model: implication of redox mechanisms, and the neuroprotective impact of Punicalagin. Life Sci. 2023;335: 122252.","journal-title":"Life Sci"},{"issue":"1","key":"2052_CR183","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12888-023-05469-2","volume":"24","author":"Y Wang","year":"2024","unstructured":"Wang Y, et al. Systemic inflammatory biomarkers in Schizophrenia are changed by ECT administration and related to the treatment efficacy. BMC Psychiatry. 2024;24(1):53.","journal-title":"BMC Psychiatry"},{"issue":"2","key":"2052_CR184","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1192\/apt.bp.113.011452","volume":"20","author":"R Upthegrove","year":"2014","unstructured":"Upthegrove R, Barnes NM. The immune system and schizophrenia: an update for clinicians. Adv Psychiatr Treat. 2014;20(2):83\u201391.","journal-title":"Adv Psychiatr Treat"},{"key":"2052_CR185","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114336","volume":"151","author":"Z Huang","year":"2025","unstructured":"Huang Z, et al. Urolithin A ameliorates schizophrenia-like behaviors and cognitive impairments in female rats by modulating NLRP3 signaling. Int Immunopharmacol. 2025;151: 114336.","journal-title":"Int Immunopharmacol"},{"issue":"Pt A","key":"2052_CR186","volume":"142","author":"T Wang","year":"2024","unstructured":"Wang T, et al. \u03b1-linolenic acid mitigates microglia-mediated neuroinflammation of schizophrenia in mice by suppressing the NF-\u03baB\/NLRP3 pathway via binding GPR120-\u03b2-arrestin 2. Int Immunopharmacol. 2024;142(Pt A): 113047.","journal-title":"Int Immunopharmacol"},{"key":"2052_CR187","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.euroneuro.2021.06.009","volume":"52","author":"PM Talukdar","year":"2021","unstructured":"Talukdar PM, et al. A proof-of-concept study of maternal immune activation mediated induction of Toll-like receptor (TLR) and inflammasome pathways leading to neuroprogressive changes and schizophrenia-like behaviours in offspring. Eur Neuropsychopharmacol. 2021;52:48\u201361.","journal-title":"Eur Neuropsychopharmacol"},{"issue":"6","key":"2052_CR188","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1017\/neu.2020.27","volume":"32","author":"L Ventura","year":"2020","unstructured":"Ventura L, et al. Involvement of NLRP3 inflammasome in schizophrenia-like behaviour in young animals after maternal immune activation. Acta Neuropsychiatr. 2020;32(6):321\u20137.","journal-title":"Acta Neuropsychiatr"},{"issue":"3","key":"2052_CR189","doi-asserted-by":"crossref","first-page":"543","DOI":"10.24272\/j.issn.2095-8137.2022.389","volume":"44","author":"RJ Ni","year":"2023","unstructured":"Ni RJ, et al. Depletion of microglia with PLX3397 attenuates MK-801-induced hyperactivity associated with regulating inflammation-related genes in the brain. Zool Res. 2023;44(3):543\u201355.","journal-title":"Zool Res"},{"issue":"2","key":"2052_CR190","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1093\/ijnp\/pyab087","volume":"25","author":"Y Su","year":"2022","unstructured":"Su Y, et al. Prenatal poly I: C challenge affects behaviors and neurotransmission via elevated neuroinflammation responses in female juvenile rats. Int J Neuropsychopharmacol. 2022;25(2):160\u201371.","journal-title":"Int J Neuropsychopharmacol"},{"issue":"10","key":"2052_CR191","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1002\/dneu.22044","volume":"72","author":"M Michel","year":"2012","unstructured":"Michel M, Schmidt MJ, Mirnics K. Immune system gene dysregulation in autism and schizophrenia. Dev Neurobiol. 2012;72(10):1277\u201387.","journal-title":"Dev Neurobiol"},{"key":"2052_CR192","volume":"12","author":"R Liu","year":"2021","unstructured":"Liu R, et al. NLRP3 influences cognitive function in schizophrenia in Han Chinese. Front Genet. 2021;12: 781625.","journal-title":"Front Genet"},{"issue":"4","key":"2052_CR193","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.jaci.2009.07.044","volume":"124","author":"Y Hitomi","year":"2009","unstructured":"Hitomi Y, et al. Associations of functional NLRP3 polymorphisms with susceptibility to food-induced anaphylaxis and aspirin-induced asthma. J Allergy Clin Immunol. 2009;124(4):779\u201385.","journal-title":"J Allergy Clin Immunol"},{"key":"2052_CR194","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.bbi.2024.11.030","volume":"124","author":"A Szabo","year":"2025","unstructured":"Szabo A, et al. NLRP3 inflammasome mediates astroglial dysregulation of innate and adaptive immune responses in schizophrenia. Brain Behav Immun. 2025;124:144\u201356.","journal-title":"Brain Behav Immun"},{"issue":"2","key":"2052_CR195","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1080\/13651501.2022.2106245","volume":"27","author":"G Ozdamar Unal","year":"2023","unstructured":"Ozdamar Unal G, Hekimler Ozturk K, Inci HE. Increased NLRP3 inflammasome expression in peripheral blood mononuclear cells of patients with schizophrenia: a case-control study. Int J Psychiatry Clin Pract. 2023;27(2):111\u20137.","journal-title":"Int J Psychiatry Clin Pract"},{"key":"2052_CR196","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.coviro.2017.06.006","volume":"25","author":"A Hayward","year":"2017","unstructured":"Hayward A. Origin of the retroviruses: when, where, and how? Curr Opin Virol. 2017;25:23\u20137.","journal-title":"Curr Opin Virol"},{"key":"2052_CR197","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1007\/s11262-017-1479-2","volume":"53","author":"C Liu","year":"2017","unstructured":"Liu C, et al. HBV X Protein induces overexpression of HERV-W env through NF-\u03baB in HepG2 cells. Virus Genes. 2017;53:797\u2013806.","journal-title":"Virus Genes"},{"key":"2052_CR198","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s11262-013-0939-6","volume":"47","author":"C Liu","year":"2013","unstructured":"Liu C, et al. Activation of elements in HERV-W family by caffeine and aspirin. Virus Genes. 2013;47:219\u201327.","journal-title":"Virus Genes"},{"issue":"4","key":"2052_CR199","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S1074-7613(01)00212-6","volume":"15","author":"Y Stauffer","year":"2001","unstructured":"Stauffer Y, et al. Interferon-\u03b1-induced endogenous superantigen: a model linking environment and autoimmunity. Immunity. 2001;15(4):591\u2013601.","journal-title":"Immunity"},{"issue":"11","key":"2052_CR200","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1007\/s13258-024-01546-2","volume":"46","author":"JM Yi","year":"2024","unstructured":"Yi JM. Epigenetic regulation of HERVs: Implications for cancer immunotherapy. Genes Genom. 2024;46(11):1303\u201312.","journal-title":"Genes Genom"},{"issue":"5","key":"2052_CR201","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1093\/schbul\/sbp166","volume":"37","author":"W Huang","year":"2011","unstructured":"Huang W, et al. Implication of the env gene of the human endogenous retrovirus W family in the expression of BDNF and DRD3 and development of recent-onset schizophrenia. Schizophr Bull. 2011;37(5):988\u20131000.","journal-title":"Schizophr Bull"},{"key":"2052_CR202","doi-asserted-by":"crossref","first-page":"422","DOI":"10.3389\/fpsyt.2018.00422","volume":"9","author":"X Wang","year":"2018","unstructured":"Wang X, Huang J, Zhu F. Human endogenous retroviral envelope protein syncytin-1 and inflammatory abnormalities in neuropsychological diseases. Front Psych. 2018;9:422.","journal-title":"Front Psych"},{"issue":"8","key":"2052_CR203","doi-asserted-by":"crossref","first-page":"4634","DOI":"10.1073\/pnas.061021998","volume":"98","author":"H Karlsson","year":"2001","unstructured":"Karlsson H, et al. Retroviral RNA identified in the cerebrospinal fluids and brains of individuals with schizophrenia. Proc Natl Acad Sci. 2001;98(8):4634\u20139.","journal-title":"Proc Natl Acad Sci"},{"issue":"3","key":"2052_CR204","doi-asserted-by":"crossref","first-page":"3000","DOI":"10.3390\/ijms24033000","volume":"24","author":"X Li","year":"2023","unstructured":"Li X, et al. HERV-W ENV induces innate immune activation and neuronal apoptosis via linc01930\/cGAS axis in recent-onset schizophrenia. Int J Mol Sci. 2023;24(3):3000.","journal-title":"Int J Mol Sci"},{"issue":"11","key":"2052_CR205","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1016\/j.cell.2023.04.025","volume":"186","author":"KC Barnett","year":"2023","unstructured":"Barnett KC, et al. A 360 view of the inflammasome: mechanisms of activation, cell death, and diseases. Cell. 2023;186(11):2288\u2013312.","journal-title":"Cell"},{"issue":"2","key":"2052_CR206","doi-asserted-by":"crossref","first-page":"520","DOI":"10.3390\/ijms26020520","volume":"26","author":"C Jia","year":"2025","unstructured":"Jia C, et al. HERV-W env induces neuron pyroptosis via the NLRP3\u2013CASP1\u2013GSDMD pathway in recent-onset schizophrenia. Int J Mol Sci. 2025;26(2):520.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"2052_CR207","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1186\/s12888-023-05182-0","volume":"23","author":"X-L Zhao","year":"2023","unstructured":"Zhao X-L, et al. Abnormal expression of miR-3653-3p, caspase 1, IL-1\u03b2 in peripheral blood of schizophrenia. BMC Psychiatry. 2023;23(1):822.","journal-title":"BMC Psychiatry"},{"issue":"5","key":"2052_CR208","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/j.1399-5618.2009.00717.x","volume":"11","author":"JF Wang","year":"2009","unstructured":"Wang JF, et al. Increased oxidative stress in the anterior cingulate cortex of subjects with bipolar disorder and schizophrenia. Bipolar Disord. 2009;11(5):523\u20139.","journal-title":"Bipolar Disord"},{"issue":"7329","key":"2052_CR209","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09663","volume":"469","author":"R Zhou","year":"2011","unstructured":"Zhou R, et al. A role for mitochondria in NLRP3 inflammasome activation. Nature. 2011;469(7329):221\u20135.","journal-title":"Nature"},{"issue":"3","key":"2052_CR210","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.immuni.2012.01.009","volume":"36","author":"K Shimada","year":"2012","unstructured":"Shimada K, et al. Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity. 2012;36(3):401\u201314.","journal-title":"Immunity"},{"key":"2052_CR211","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jpsychires.2015.10.015","volume":"72","author":"HK Kim","year":"2016","unstructured":"Kim HK, et al. Nod-like receptor pyrin containing 3 (NLRP3) in the post-mortem frontal cortex from patients with bipolar disorder: a potential mediator between mitochondria and immune-activation. J Psychiatr Res. 2016;72:43\u201350.","journal-title":"J Psychiatr Res"},{"key":"2052_CR212","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.eurpsy.2017.09.007","volume":"47","author":"L Garc\u00eda-\u00c1lvarez","year":"2018","unstructured":"Garc\u00eda-\u00c1lvarez L, et al. Regulation of inflammatory pathways in schizophrenia: a comparative study with bipolar disorder and healthy controls. Eur Psychiatry. 2018;47:50\u20139.","journal-title":"Eur Psychiatry"},{"key":"2052_CR213","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.bbi.2021.10.017","volume":"99","author":"A Szabo","year":"2022","unstructured":"Szabo A, et al. Increased circulating IL-18 levels in severe mental disorders indicate systemic inflammasome activation. Brain Behav Immun. 2022;99:299\u2013306.","journal-title":"Brain Behav Immun"},{"issue":"11","key":"2052_CR214","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1093\/jnen\/nlae066","volume":"83","author":"R Gober","year":"2024","unstructured":"Gober R, et al. Increased inflammasome protein expression identified in microglia from postmortem brains with schizophrenia. J Neuropathol Exp Neurol. 2024;83(11):951\u201366.","journal-title":"J Neuropathol Exp Neurol"},{"issue":"3","key":"2052_CR215","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1093\/schbul\/sbac191","volume":"49","author":"SB Jensen","year":"2023","unstructured":"Jensen SB, et al. Elevated systemic levels of markers reflecting intestinal barrier dysfunction and inflammasome activation are correlated in severe mental illness. Schizophr Bull. 2023;49(3):635\u201345.","journal-title":"Schizophr Bull"},{"issue":"1","key":"2052_CR216","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1176\/appi.ajp.2020.20111601","volume":"178","author":"WK Goodman","year":"2021","unstructured":"Goodman WK, Storch EA, Sheth SA. Harmonizing the neurobiology and treatment of obsessive-compulsive disorder. Am J Psychiatry. 2021;178(1):17\u201329.","journal-title":"Am J Psychiatry"},{"issue":"12","key":"2052_CR217","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1176\/appi.ajp.2008.08020320","volume":"165","author":"MH Bloch","year":"2008","unstructured":"Bloch MH, et al. Meta-analysis of the symptom structure of obsessive-compulsive disorder. Am J Psychiatry. 2008;165(12):1532\u201342.","journal-title":"Am J Psychiatry"},{"issue":"1","key":"2052_CR218","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/mp.2008.94","volume":"15","author":"AM Ruscio","year":"2010","unstructured":"Ruscio AM, et al. The epidemiology of obsessive-compulsive disorder in the national comorbidity survey replication. Mol Psychiatry. 2010;15(1):53\u201363.","journal-title":"Mol Psychiatry"},{"issue":"4","key":"2052_CR219","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1097\/00004583-199804000-00020","volume":"37","author":"D Geller","year":"1998","unstructured":"Geller D, et al. Is juvenile obsessive-compulsive disorder a developmental subtype of the disorder? A review of the pediatric literature. J Am Acad Child Adolesc Psychiatry. 1998;37(4):420\u20137.","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"12","key":"2052_CR220","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1111\/j.1469-7610.2011.02434.x","volume":"52","author":"E Nakatani","year":"2011","unstructured":"Nakatani E, et al. Children with very early onset obsessive-compulsive disorder: clinical features and treatment outcome. J Child Psychol Psychiatry. 2011;52(12):1261\u20138.","journal-title":"J Child Psychol Psychiatry"},{"issue":"2","key":"2052_CR221","doi-asserted-by":"crossref","first-page":"149","DOI":"10.31887\/DCNS.2010.12.2\/dpauls","volume":"12","author":"DL Pauls","year":"2010","unstructured":"Pauls DL. The genetics of obsessive-compulsive disorder: a review. Dialogues Clin Neurosci. 2010;12(2):149\u201363.","journal-title":"Dialogues Clin Neurosci"},{"issue":"8","key":"2052_CR222","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/j.cpr.2011.09.008","volume":"31","author":"S Taylor","year":"2011","unstructured":"Taylor S. Etiology of obsessions and compulsions: a meta-analysis and narrative review of twin studies. Clin Psychol Rev. 2011;31(8):1361\u201372.","journal-title":"Clin Psychol Rev"},{"issue":"8","key":"2052_CR223","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/sj.mp.4001847","volume":"11","author":"YY Shugart","year":"2006","unstructured":"Shugart YY, et al. Genomewide linkage scan for obsessive-compulsive disorder: evidence for susceptibility loci on chromosomes 3q, 7p, 1q, 15q, and 6q. Mol Psychiatry. 2006;11(8):763\u201370.","journal-title":"Mol Psychiatry"},{"issue":"3","key":"2052_CR224","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1176\/ajp.2007.164.3.493","volume":"164","author":"J Samuels","year":"2007","unstructured":"Samuels J, et al. Significant linkage to compulsive hoarding on chromosome 14 in families with obsessive-compulsive disorder: results from the OCD Collaborative Genetics Study. Am J Psychiatry. 2007;164(3):493\u20139.","journal-title":"Am J Psychiatry"},{"issue":"5","key":"2052_CR225","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/ajmg.10519","volume":"114","author":"GL Hanna","year":"2002","unstructured":"Hanna GL, et al. Genome-wide linkage analysis of families with obsessive-compulsive disorder ascertained through pediatric probands. Am J Med Genet. 2002;114(5):541\u201352.","journal-title":"Am J Med Genet"},{"issue":"4","key":"2052_CR226","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.pbb.2011.10.007","volume":"100","author":"K Wu","year":"2012","unstructured":"Wu K, et al. The role of glutamate signaling in the pathogenesis and treatment of obsessive-compulsive disorder. Pharmacol Biochem Behav. 2012;100(4):726\u201335.","journal-title":"Pharmacol Biochem Behav"},{"issue":"11","key":"2052_CR227","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.biopsych.2011.06.032","volume":"70","author":"M Zarei","year":"2011","unstructured":"Zarei M, et al. Changes in gray matter volume and white matter microstructure in adolescents with obsessive-compulsive disorder. Biol Psychiatry. 2011;70(11):1083\u201390.","journal-title":"Biol Psychiatry"},{"issue":"5","key":"2052_CR228","volume":"97","author":"C Jiang","year":"2018","unstructured":"Jiang C, et al. Association between TNF-\u03b1-238G\/A gene polymorphism and OCD susceptibility: a meta-analysis. Medicine (Baltimore). 2018;97(5): e9769.","journal-title":"Medicine (Baltimore)"},{"issue":"1","key":"2052_CR229","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41398-021-01700-4","volume":"12","author":"D Endres","year":"2022","unstructured":"Endres D, et al. Immunological causes of obsessive-compulsive disorder: is it time for the concept of an \u201cautoimmune OCD\u201d subtype? Transl Psychiatry. 2022;12(1):5.","journal-title":"Transl Psychiatry"},{"issue":"4","key":"2052_CR230","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s00127-018-1622-y","volume":"54","author":"LY Wang","year":"2019","unstructured":"Wang LY, et al. Systemic autoimmune diseases are associated with an increased risk of obsessive-compulsive disorder: a nationwide population-based cohort study. Soc Psychiatry Psychiatr Epidemiol. 2019;54(4):507\u201316.","journal-title":"Soc Psychiatry Psychiatr Epidemiol"},{"key":"2052_CR231","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.neubiorev.2016.09.025","volume":"71","author":"A P\u00e9rez-Vigil","year":"2016","unstructured":"P\u00e9rez-Vigil A, et al. The link between autoimmune diseases and obsessive-compulsive and tic disorders: a systematic review. Neurosci Biobehav Rev. 2016;71:542\u201362.","journal-title":"Neurosci Biobehav Rev"},{"issue":"3","key":"2052_CR232","first-page":"248","volume":"17","author":"M Foroughipour","year":"2012","unstructured":"Foroughipour M, et al. Frequency of obsessive-compulsive disorder in patients with multiple sclerosis: a cross-sectional study. J Res Med Sci. 2012;17(3):248\u201353.","journal-title":"J Res Med Sci"},{"issue":"1","key":"2052_CR233","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1192\/bjp.bp.113.137018","volume":"205","author":"DM Pearlman","year":"2014","unstructured":"Pearlman DM, et al. Anti-basal ganglia antibodies in primary obsessive-compulsive disorder: systematic review and meta-analysis. Br J Psychiatry. 2014;205(1):8\u201316.","journal-title":"Br J Psychiatry"},{"issue":"6","key":"2052_CR234","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.4049\/jimmunol.159.6.2994","volume":"159","author":"BB Mittleman","year":"1997","unstructured":"Mittleman BB, et al. Cerebrospinal fluid cytokines in pediatric neuropsychiatric disease. J Immunol. 1997;159(6):2994\u20139.","journal-title":"J Immunol"},{"issue":"3","key":"2052_CR235","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/s11920-012-0272-0","volume":"14","author":"SM Gray","year":"2012","unstructured":"Gray SM, Bloch MH. Systematic review of proinflammatory cytokines in obsessive-compulsive disorder. Curr Psychiatry Rep. 2012;14(3):220\u20138.","journal-title":"Curr Psychiatry Rep"},{"issue":"3","key":"2052_CR236","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1007\/s40473-020-00207-4","volume":"7","author":"T Feng","year":"2020","unstructured":"Feng T, Tripathi A, Pillai A. Inflammatory pathways in psychiatric disorders: the case of schizophrenia and depression. Curr Behav Neurosci Rep. 2020;7(3):128\u201338.","journal-title":"Curr Behav Neurosci Rep"},{"issue":"5","key":"2052_CR237","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1001\/jamapsychiatry.2022.0407","volume":"79","author":"JA Williams","year":"2022","unstructured":"Williams JA, et al. Inflammation and brain structure in schizophrenia and other neuropsychiatric disorders: a mendelian randomization study. JAMA Psychiat. 2022;79(5):498\u2013507.","journal-title":"JAMA Psychiat"},{"issue":"1","key":"2052_CR238","doi-asserted-by":"crossref","first-page":"75","DOI":"10.5505\/kpd.2022.72687","volume":"25","author":"M Tetik","year":"2022","unstructured":"Tetik M, et al. Relation of ASC and IL-1beta with neurocognitive parameters in patients with obsessive compulsive disorder (eng). J Clin Psy. 2022;25(1):75\u201383.","journal-title":"J Clin Psy"},{"issue":"1","key":"2052_CR239","doi-asserted-by":"crossref","first-page":"18008","DOI":"10.1038\/nrdp.2018.8","volume":"4","author":"E Vieta","year":"2018","unstructured":"Vieta E, et al. Bipolar disorders. Nat Rev Dis Primers. 2018;4(1):18008.","journal-title":"Nat Rev Dis Primers"},{"key":"2052_CR240","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jad.2016.06.063","volume":"205","author":"B Cullen","year":"2016","unstructured":"Cullen B, et al. Prevalence and correlates of cognitive impairment in euthymic adults with bipolar disorder: a systematic review. J Affect Disord. 2016;205:165\u201381.","journal-title":"J Affect Disord"},{"issue":"3","key":"2052_CR241","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1001\/archgenpsychiatry.2011.12","volume":"68","author":"KR Merikangas","year":"2011","unstructured":"Merikangas KR, et al. Prevalence and correlates of bipolar spectrum disorder in the world mental health survey initiative. Arch Gen Psychiatry. 2011;68(3):241\u201351.","journal-title":"Arch Gen Psychiatry"},{"key":"2052_CR242","doi-asserted-by":"crossref","first-page":"18008","DOI":"10.1038\/nrdp.2018.8","volume":"4","author":"E Vieta","year":"2018","unstructured":"Vieta E, et al. Bipolar disorders. Nat Rev Dis Primers. 2018;4:18008.","journal-title":"Nat Rev Dis Primers"},{"issue":"2","key":"2052_CR243","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S2215-0366(15)00505-2","volume":"3","author":"D Vigo","year":"2016","unstructured":"Vigo D, Thornicroft G, Atun R. Estimating the true global burden of mental illness. Lancet Psychiatry. 2016;3(2):171\u20138.","journal-title":"Lancet Psychiatry"},{"issue":"2\u20133","key":"2052_CR244","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1159\/000356539","volume":"21","author":"IG Barbosa","year":"2014","unstructured":"Barbosa IG, et al. The immunology of bipolar disorder. NeuroImmunoModulation. 2014;21(2\u20133):117\u201322.","journal-title":"NeuroImmunoModulation"},{"issue":"6","key":"2052_CR245","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1111\/j.1399-5618.2010.00853.x","volume":"12","author":"WW Eaton","year":"2010","unstructured":"Eaton WW, et al. Autoimmune diseases, bipolar disorder, and non-affective psychosis. Bipolar Disord. 2010;12(6):638\u201346.","journal-title":"Bipolar Disord"},{"issue":"6","key":"2052_CR246","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1002\/art.24519","volume":"61","author":"EA Bachen","year":"2009","unstructured":"Bachen EA, Chesney MA, Criswell LA. Prevalence of mood and anxiety disorders in women with systemic lupus erythematosus. Arthritis Rheum. 2009;61(6):822\u20139.","journal-title":"Arthritis Rheum"},{"issue":"5","key":"2052_CR247","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1191\/1352458504ms1087oa","volume":"10","author":"LJ Edwards","year":"2004","unstructured":"Edwards LJ, Constantinescu CS. A prospective study of conditions associated with multiple sclerosis in a cohort of 658 consecutive outpatients attending a multiple sclerosis clinic. Mult Scler. 2004;10(5):575\u201381.","journal-title":"Mult Scler"},{"issue":"5","key":"2052_CR248","volume":"14","author":"AA Farooqui","year":"2022","unstructured":"Farooqui AA, et al. No NLRP3 inflammasome expression in the ouabain animal model of bipolar disorder. Cureus. 2022;14(5): e24765.","journal-title":"Cureus"},{"key":"2052_CR249","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jad.2023.08.039","volume":"340","author":"XY Zhou","year":"2023","unstructured":"Zhou XY, et al. Mitochondrial health, NLRP3 inflammasome activation, and white matter integrity in adolescent mood disorders: A pilot study. J Affect Disord. 2023;340:149\u201359.","journal-title":"J Affect Disord"},{"issue":"7","key":"2052_CR250","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1038\/s41386-018-0293-4","volume":"44","author":"G Scaini","year":"2019","unstructured":"Scaini G, et al. TSPO upregulation in bipolar disorder and concomitant downregulation of mitophagic proteins and NLRP3 inflammasome activation. Neuropsychopharmacology. 2019;44(7):1291\u20139.","journal-title":"Neuropsychopharmacology"},{"issue":"5","key":"2052_CR251","doi-asserted-by":"crossref","first-page":"e1111","DOI":"10.1038\/tp.2017.83","volume":"7","author":"G Scaini","year":"2017","unstructured":"Scaini G, et al. Perturbations in the apoptotic pathway and mitochondrial network dynamics in peripheral blood mononuclear cells from bipolar disorder patients. Transl Psychiatry. 2017;7(5):e1111\u2013e1111.","journal-title":"Transl Psychiatry"},{"issue":"6","key":"2052_CR252","doi-asserted-by":"crossref","first-page":"247","DOI":"10.5152\/alphapsychiatry.2023.231281","volume":"24","author":"T Huang","year":"2023","unstructured":"Huang T, et al. Circulating toll-like receptor 4, Nucleotide-binding oligomerization domain-like receptor protein 3, and cytokines in patients with bipolar depression: a case-control study. Alpha Psychiatry. 2023;24(6):247\u201351.","journal-title":"Alpha Psychiatry"},{"issue":"S1","key":"2052_CR253","doi-asserted-by":"crossref","first-page":"S604","DOI":"10.1192\/j.eurpsy.2023.1261","volume":"66","author":"R Aronica","year":"2023","unstructured":"Aronica R, et al. Association between diffusion Tensor Imaging, inflammation and immunological alterations in unipolar and bipolar depression: a review. Eur Psychiatry. 2023;66(S1):S604\u2013S604.","journal-title":"Eur Psychiatry"},{"issue":"4","key":"2052_CR254","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1080\/07853890801923753","volume":"40","author":"L Shao","year":"2008","unstructured":"Shao L, et al. Mitochondrial involvement in psychiatric disorders. Ann Med. 2008;40(4):281\u201395.","journal-title":"Ann Med"},{"issue":"3","key":"2052_CR255","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3892\/mmr.2022.12810","volume":"26","author":"KH \u00d6zt\u00fcrk","year":"2022","unstructured":"\u00d6zt\u00fcrk KH, \u00dcnal G. Novel splice-site variants c.393G>A, c.278_2A>G in exon 2 and Q705K variant in exon 3 of NLRP3 gene are associated with bipolar I disorder. Mol Med Rep. 2022;26(3):293.","journal-title":"Mol Med Rep"},{"issue":"4","key":"2052_CR256","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s00018-022-04211-7","volume":"79","author":"AC Pereira","year":"2022","unstructured":"Pereira AC, et al. ER-mitochondria communication is involved in NLRP3 inflammasome activation under stress conditions in the innate immune system. Cell Mol Life Sci. 2022;79(4):213.","journal-title":"Cell Mol Life Sci"},{"issue":"22","key":"2052_CR257","doi-asserted-by":"crossref","first-page":"12513","DOI":"10.3390\/ijms222212513","volume":"22","author":"X Zhou","year":"2021","unstructured":"Zhou X, et al. Characterizing the NLRP3 inflammasome in mood disorders: overview, technical development, and measures of peripheral activation in adolescent patients. Int J Mol Sci. 2021;22(22):12513.","journal-title":"Int J Mol Sci"},{"issue":"4","key":"2052_CR258","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s40474-016-0099-1","volume":"3","author":"A Kumar","year":"2016","unstructured":"Kumar A, Trescher W, Byler D. Tourette syndrome and comorbid neuropsychiatric conditions. Curr Dev Disord Rep. 2016;3(4):217\u201321.","journal-title":"Curr Dev Disord Rep"},{"key":"2052_CR259","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10112479","author":"K Ueda","year":"2021","unstructured":"Ueda K, Black KJ. A comprehensive review of tic disorders in children. J Clin Med. 2021. https:\/\/doi.org\/10.3390\/jcm10112479.","journal-title":"J Clin Med"},{"issue":"6","key":"2052_CR260","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.neubiorev.2012.10.010","volume":"37","author":"PJ Hoekstra","year":"2013","unstructured":"Hoekstra PJ, et al. Environmental factors in tourette syndrome. Neurosci Biobehav Rev. 2013;37(6):1040\u20139.","journal-title":"Neurosci Biobehav Rev"},{"issue":"4","key":"2052_CR261","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nrneurol.2012.26","volume":"8","author":"H Deng","year":"2012","unstructured":"Deng H, Gao K, Jankovic J. The genetics of tourette syndrome. Nat Rev Neurol. 2012;8(4):203\u201313.","journal-title":"Nat Rev Neurol"},{"issue":"1","key":"2052_CR262","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1471-2393-14-53","volume":"14","author":"T-K Chao","year":"2014","unstructured":"Chao T-K, Hu J, Pringsheim T. Prenatal risk factors for tourette syndrome: a systematic review. BMC Pregnancy Childbirth. 2014;14(1):53.","journal-title":"BMC Pregnancy Childbirth"},{"issue":"9","key":"2052_CR263","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1002\/mds.22504","volume":"24","author":"D Martino","year":"2009","unstructured":"Martino D, et al. Immunopathogenic mechanisms in tourette syndrome: a critical review. Mov Disord. 2009;24(9):1267\u201379.","journal-title":"Mov Disord"},{"issue":"4","key":"2052_CR264","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s12640-019-00059-1","volume":"36","author":"L Hongyan","year":"2019","unstructured":"Hongyan L, et al. Rhynchophylline attenuates neurotoxicity in tourette syndrome rats. Neurotox Res. 2019;36(4):679\u201387.","journal-title":"Neurotox Res"},{"issue":"5","key":"2052_CR265","doi-asserted-by":"crossref","first-page":"e270","DOI":"10.1016\/S2665-9913(20)30065-5","volume":"2","author":"V Kl\u00fcck","year":"2020","unstructured":"Kl\u00fcck V, et al. Dapansutrile, an oral selective NLRP3 inflammasome inhibitor, for treatment of gout flares: an open-label, dose-adaptive, proof-of-concept, phase 2a trial. Lancet Rheumatol. 2020;2(5):e270\u201380.","journal-title":"Lancet Rheumatol"},{"key":"2052_CR266","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.bbi.2023.11.031","volume":"116","author":"A Naeem","year":"2024","unstructured":"Naeem A, et al. MCC950 reduces autophagy and improves cognitive function by inhibiting NLRP3-dependent neuroinflammation in a rat model of Alzheimer\u2019s disease. Brain Behav Immun. 2024;116:70\u201384.","journal-title":"Brain Behav Immun"},{"key":"2052_CR267","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/bs.apha.2024.10.004","volume":"102","author":"B Kaur","year":"2025","unstructured":"Kaur B, et al. Biological and therapeutic significance of targeting NLRP3 inflammasome in the brain and the current efforts to develop brain-penetrant inhibitors. Adv Pharmacol. 2025;102:103\u201357.","journal-title":"Adv Pharmacol"},{"issue":"5","key":"2052_CR268","doi-asserted-by":"crossref","DOI":"10.1111\/cts.13789","volume":"17","author":"E Gatlik","year":"2024","unstructured":"Gatlik E, et al. First-in-human safety, tolerability, and pharmacokinetic results of DFV890, an oral low-molecular-weight NLRP3 inhibitor. Clin Transl Sci. 2024;17(5): e13789.","journal-title":"Clin Transl Sci"},{"key":"2052_CR269","first-page":"23","volume":"16","author":"A Torres","year":"2018","unstructured":"Torres A, et al. De novo ATP1A3 and compound heterozygous NLRP3 mutations in a child with autism spectrum disorder, episodic fatigue and somnolence, and muckle-wells syndrome. Mol Genet Metab Rep. 2018;16:23\u20139.","journal-title":"Mol Genet Metab Rep"},{"issue":"1","key":"2052_CR270","first-page":"28","volume":"60","author":"M Tetik","year":"2023","unstructured":"Tetik M, et al. Associations between blood levels of NLRP3 inflammasome components and obsessive compulsive disorder. Noro Psikiyatr Ars. 2023;60(1):28\u201336.","journal-title":"Noro Psikiyatr Ars"},{"issue":"4","key":"2052_CR271","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/s00213-023-06505-5","volume":"241","author":"K Sakrajda","year":"2024","unstructured":"Sakrajda K, et al. Abelson helper integration site 1 haplotypes and peripheral blood expression associates with lithium response and immunomodulation in bipolar patients. Psychopharmacology. 2024;241(4):727\u201338.","journal-title":"Psychopharmacology"}],"container-title":["Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-025-02052-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00011-025-02052-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-025-02052-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T16:55:13Z","timestamp":1767200113000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00011-025-02052-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,3]]},"references-count":271,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["2052"],"URL":"https:\/\/doi.org\/10.1007\/s00011-025-02052-1","relation":{},"ISSN":["1023-3830","1420-908X"],"issn-type":[{"value":"1023-3830","type":"print"},{"value":"1420-908X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,3]]},"assertion":[{"value":"7 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 April 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 May 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"The authors consent to publication.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"90"}}