{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T20:35:44Z","timestamp":1790454944130,"version":"4.1.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100014717","name":"National Outstanding Youth Science Fund Project of National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82103714"],"award-info":[{"award-number":["82103714"]}],"id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflamm. Res."],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s00011-025-02111-7","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T08:53:21Z","timestamp":1761123201000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Piezo1 exacerbates psoriasis by promoting macrophage M1 polarization and inhibits autophagy via activating PI3K\/AKT signaling pathway"],"prefix":"10.1007","volume":"74","author":[{"given":"Xiaoke","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simo","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxiong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youdong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,22]]},"reference":[{"issue":"3","key":"2111_CR1","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/s12016-016-8535-x","volume":"50","author":"Y Deng","year":"2016","unstructured":"Deng Y, Chang C, Lu Q. The inflammatory response in psoriasis: a comprehensive review. Clin Rev Allergy Immunol. 2016;50(3):377\u201389.","journal-title":"Clin Rev Allergy Immunol"},{"issue":"22","key":"2111_CR2","doi-asserted-by":"publisher","first-page":"84","DOI":"10.3390\/ijms242216095","volume":"24","author":"AM Man","year":"2023","unstructured":"Man AM, Or\u0103san MS, Hoteiuc OA, et al. Inflammation and psoriasis: a comprehensive review. Int J Mol Sci. 2023;24(22):84.","journal-title":"Int J Mol Sci"},{"issue":"6","key":"2111_CR3","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1684\/ejd.2020.3769","volume":"30","author":"MK An","year":"2020","unstructured":"An MK, Yoon JH, Park EJ, et al. Differential histopathological and immunohistochemical findings between palmar psoriasis and chronic hand eczema. Eur J Dermatol. 2020;30(6):710\u20135.","journal-title":"Eur J Dermatol"},{"key":"2111_CR4","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.jaut.2015.07.008","volume":"64","author":"JL Harden","year":"2015","unstructured":"Harden JL, Krueger JG, Bowcock AM. The immunogenetics of psoriasis: a comprehensive review. J Autoimmun. 2015;64:66\u201373.","journal-title":"J Autoimmun"},{"key":"2111_CR5","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20184347","author":"K Kamiya","year":"2019","unstructured":"Kamiya K, Kishimoto M, Sugai J, et al. Risk factors for the development of psoriasis. Int J Mol Sci. 2019. https:\/\/doi.org\/10.3390\/ijms20184347.","journal-title":"Int J Mol Sci"},{"key":"2111_CR6","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1111\/j.1600-065X.2008.00714.x","volume":"226","author":"K Boniface","year":"2008","unstructured":"Boniface K, Blom B, Liu YJ, et al. From interleukin-23 to T-helper 17 cells: human T-helper cell differentiation revisited. Immunol Rev. 2008;226:132\u201346.","journal-title":"Immunol Rev"},{"key":"2111_CR7","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.637829","volume":"12","author":"C Schinocca","year":"2021","unstructured":"Schinocca C, Rizzo C, Fasano S, et al. Role of the IL-23\/IL-17 pathway in rheumatic diseases: an overview. Front Immunol. 2021;12:637829.","journal-title":"Front Immunol"},{"key":"2111_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2024.101306","volume":"99","author":"S Park","year":"2024","unstructured":"Park S, Jang J, Kim HJ, et al. Unveiling multifaceted roles of myeloid innate immune cells in the pathogenesis of psoriasis. Mol Aspects Med. 2024;99:101306.","journal-title":"Mol Aspects Med"},{"issue":"1","key":"2111_CR9","doi-asserted-by":"publisher","DOI":"10.1186\/s12950-023-00360-z","volume":"20","author":"T Xia","year":"2023","unstructured":"Xia T, Fu S, Yang R, et al. Advances in the study of macrophage polarization in inflammatory immune skin diseases. J Inflamm. 2023;20(1):33.","journal-title":"J Inflamm"},{"issue":"1","key":"2111_CR10","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/s11033-023-09014-y","volume":"51","author":"E Apeku","year":"2024","unstructured":"Apeku E, Tantuoyir MM, Zheng R, et al. Exploring the polarization of M1 and M2 macrophages in the context of skin diseases. Mol Biol Rep. 2024;51(1):269.","journal-title":"Mol Biol Rep"},{"issue":"3","key":"2111_CR11","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1038\/s41577-018-0095-2","volume":"19","author":"AJ Clarke","year":"2019","unstructured":"Clarke AJ, Simon AK. Autophagy in the renewal, differentiation and homeostasis of immune cells. Nat Rev Immunol. 2019;19(3):170\u201383.","journal-title":"Nat Rev Immunol"},{"key":"2111_CR12","doi-asserted-by":"publisher","first-page":"1343987","DOI":"10.3389\/fimmu.2024.1343987","volume":"15","author":"Y Lin","year":"2024","unstructured":"Lin Y, Wu X, Yang Y, et al. The multifaceted role of autophagy in skin autoimmune disorders: a guardian or culprit? Front Immunol. 2024;15:1343987.","journal-title":"Front Immunol"},{"issue":"12","key":"2111_CR13","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1111\/1346-8138.16185","volume":"48","author":"C Liu","year":"2021","unstructured":"Liu C, Gu L, Ding J, et al. Autophagy in skin barrier and immune-related skin diseases. J Dermatol. 2021;48(12):1827\u201337.","journal-title":"J Dermatol"},{"issue":"4","key":"2111_CR14","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1016\/j.semarthrit.2018.06.001","volume":"48","author":"W Zhou","year":"2019","unstructured":"Zhou W, Chandran V, Cook R, et al. The association between occupational-related mechanical stress and radiographic damage in psoriatic arthritis. Semin Arthritis Rheum. 2019;48(4):638\u201343.","journal-title":"Semin Arthritis Rheum"},{"issue":"1","key":"2111_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2024.103711","volume":"24","author":"A Muhsen","year":"2025","unstructured":"Muhsen A, Hertz A, Amital H. The association between physical trauma and autoimmune articular and dermatological disorders. Autoimmun Rev. 2025;24(1):103711.","journal-title":"Autoimmun Rev"},{"issue":"5","key":"2111_CR16","doi-asserted-by":"publisher","first-page":"62","DOI":"10.3390\/ijms25052756","volume":"25","author":"H Kim","year":"2024","unstructured":"Kim H, Choi MR, Jeon SH, et al. Pathophysiological roles of ion channels in epidermal cells, immune cells, and sensory neurons in psoriasis. Int J Mol Sci. 2024;25(5):62.","journal-title":"Int J Mol Sci"},{"key":"2111_CR17","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.745572","volume":"13","author":"J He","year":"2022","unstructured":"He J, Shan S, Li Q, et al. Mechanical stretch triggers epithelial-mesenchymal transition in keratinocytes through Piezo1 channel. Front Physiol. 2022;13:745572.","journal-title":"Front Physiol"},{"issue":"1","key":"2111_CR18","doi-asserted-by":"publisher","first-page":"3256","DOI":"10.1038\/s41467-021-23482-5","volume":"12","author":"H Atcha","year":"2021","unstructured":"Atcha H, Jairaman A, Holt JR, et al. Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing. Nat Commun. 2021;12(1):3256.","journal-title":"Nat Commun"},{"key":"2111_CR19","doi-asserted-by":"publisher","DOI":"10.3390\/cells11132026","author":"MS Shutova","year":"2022","unstructured":"Shutova MS, Boehncke WH. Mechanotransduction in skin inflammation. Cells. 2022. https:\/\/doi.org\/10.3390\/cells11132026.","journal-title":"Cells"},{"issue":"23","key":"2111_CR20","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202402088R","volume":"38","author":"S Shan","year":"2024","unstructured":"Shan S, Jin R, Cheng X, et al. Mechano-induced arachidonic acid metabolism promotes keratinocyte proliferation through cPLA2 activity regulation. FASEB J. 2024;38(23):e70226.","journal-title":"FASEB J"},{"issue":"5","key":"2111_CR21","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1161\/HYPERTENSIONAHA.121.18750","volume":"79","author":"Y He","year":"2022","unstructured":"He Y, Deng B, Liu S, et al. Myeloid Piezo1 deletion protects renal fibrosis by restraining macrophage infiltration and activation. Hypertension. 2022;79(5):918\u201331.","journal-title":"Hypertension"},{"key":"2111_CR22","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.259544","author":"K Chen","year":"2022","unstructured":"Chen K, Man Q, Miao J, et al. Kir2.1 channel regulates macrophage polarization via the Ca2+\/CaMK II\/ERK\/NF-\u03baB signaling pathway. J Cell Sci. 2022. https:\/\/doi.org\/10.1242\/jcs.259544.","journal-title":"J Cell Sci"},{"issue":"1","key":"2111_CR23","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s12974-019-1398-3","volume":"16","author":"Q Liu","year":"2019","unstructured":"Liu Q, Zhang Y, Liu S, et al. Cathepsin c promotes microglia M1 polarization and aggravates neuroinflammation via activation of Ca(2+)-dependent PKC\/p38MAPK\/NF-\u03baB pathway. J Neuroinflammation. 2019;16(1):10.","journal-title":"J Neuroinflammation"},{"key":"2111_CR24","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12030689","author":"M Perin","year":"2023","unstructured":"Perin M, CHINIG\u00f2 G, Genova T, et al. The impact of plasma membrane ion channels on bone remodeling in response to mechanical stress, oxidative imbalance, and acidosis. Antioxidants. 2023. https:\/\/doi.org\/10.3390\/antiox12030689.","journal-title":"Antioxidants"},{"key":"2111_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2024.116050","volume":"222","author":"H Liu","year":"2024","unstructured":"Liu H, Zhou L, Wang X, et al. Dexamethasone upregulates macrophage PIEZO1 via SGK1, suppressing inflammation and increasing ROS and apoptosis. Biochem Pharmacol. 2024;222:116050.","journal-title":"Biochem Pharmacol"},{"issue":"4","key":"2111_CR26","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1016\/j.jaci.2023.08.017","volume":"153","author":"B Kim","year":"2024","unstructured":"Kim B, Rothenberg ME, Sun X, et al. Neuroimmune interplay during type 2 inflammation: symptoms, mechanisms, and therapeutic targets in atopic diseases. J Allergy Clin Immunol. 2024;153(4):879\u201393.","journal-title":"J Allergy Clin Immunol"},{"issue":"9","key":"2111_CR27","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1016\/j.jid.2019.11.023","volume":"140","author":"D Jeong","year":"2020","unstructured":"Jeong D, Qomaladewi NP, Lee J, et al. The role of autophagy in skin fibroblasts, keratinocytes, melanocytes, and epidermal stem cells. J Invest Dermatol. 2020;140(9):1691\u20137.","journal-title":"J Invest Dermatol"},{"key":"2111_CR28","doi-asserted-by":"publisher","first-page":"1486627","DOI":"10.3389\/fimmu.2024.1486627","volume":"15","author":"S Xue","year":"2024","unstructured":"Xue S, Lin Y, Chen H, et al. Mechanisms of autophagy and their implications in dermatological disorders. Front Immunol. 2024;15:1486627.","journal-title":"Front Immunol"},{"issue":"12","key":"2111_CR29","doi-asserted-by":"publisher","first-page":"2838","DOI":"10.1016\/j.jid.2021.05.016","volume":"141","author":"K Klapan","year":"2021","unstructured":"Klapan K, Frange\u017e \u017d, Markov N, et al. Evidence for lysosomal dysfunction within the epidermis in psoriasis and atopic dermatitis. J Invest Dermatol. 2021;141(12):2838-48.e4.","journal-title":"J Invest Dermatol"},{"issue":"31","key":"2111_CR30","doi-asserted-by":"publisher","first-page":"50682","DOI":"10.18632\/oncotarget.9330","volume":"7","author":"L Li","year":"2016","unstructured":"Li L, Chen X, Gu H. The signaling involved in autophagy machinery in keratinocytes and therapeutic approaches for skin diseases. Oncotarget. 2016;7(31):50682\u201397.","journal-title":"Oncotarget"},{"issue":"3","key":"2111_CR31","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1016\/j.jid.2020.07.012","volume":"141","author":"D Verma","year":"2021","unstructured":"Verma D, Fekri SZ, Sigurdardottir G, et al. Enhanced inflammasome activity in patients with psoriasis promotes systemic inflammation. J Invest Dermatol. 2021;141(3):586-95.e5.","journal-title":"J Invest Dermatol"},{"key":"2111_CR32","doi-asserted-by":"publisher","first-page":"278","DOI":"10.3389\/fphar.2017.00278","volume":"8","author":"G Fenini","year":"2017","unstructured":"Fenini G, Contassot E, French LE. Potential of IL-1, IL-18 and inflammasome inhibition for the treatment of inflammatory skin diseases. Front Pharmacol. 2017;8:278.","journal-title":"Front Pharmacol"},{"issue":"6","key":"2111_CR33","doi-asserted-by":"publisher","first-page":"118","DOI":"10.31083\/j.fbl2806118","volume":"28","author":"A Blagov","year":"2023","unstructured":"Blagov A, Sukhorukov V, Guo S, et al. The role of oxidative stress in the induction and development of psoriasis. Front Biosci (Landmark Ed). 2023;28(6):118.","journal-title":"Front Biosci (Landmark Ed)"},{"issue":"5 Pt A","key":"2111_CR34","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1016\/j.bbadis.2018.02.003","volume":"1864","author":"P Varshney","year":"2018","unstructured":"Varshney P, Saini N. PI3K\/AKT\/mTOR activation and autophagy inhibition plays a key role in increased cholesterol during IL-17A mediated inflammatory response in psoriasis. Biochim Biophys Acta Mol Basis Dis. 2018;1864(5 Pt A):1795\u2013803.","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"4","key":"2111_CR35","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1080\/15569527.2022.2127750","volume":"41","author":"Y Ren","year":"2022","unstructured":"Ren Y, Dong H, Jin R, et al. TRIM22 actives PI3K\/Akt\/mTOR pathway to promote psoriasis through enhancing cell proliferation and inflammation and inhibiting autophagy. Cutan Ocul Toxicol. 2022;41(4):304\u20139.","journal-title":"Cutan Ocul Toxicol"},{"key":"2111_CR36","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.665647","volume":"8","author":"L Mercurio","year":"2021","unstructured":"Mercurio L, Albanesi C, Madonna S. Recent updates on the involvement of PI3K\/AKT\/mTOR molecular cascade in the pathogenesis of hyperproliferative skin disorders. Front Med Lausanne. 2021;8:665647.","journal-title":"Front Med Lausanne"}],"container-title":["Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-025-02111-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00011-025-02111-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00011-025-02111-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T16:53:52Z","timestamp":1767200032000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00011-025-02111-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,22]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["2111"],"URL":"https:\/\/doi.org\/10.1007\/s00011-025-02111-7","relation":{},"ISSN":["1023-3830","1420-908X"],"issn-type":[{"value":"1023-3830","type":"print"},{"value":"1420-908X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,22]]},"assertion":[{"value":"22 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 September 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. The study was conducted in accordance with the Declaration of Helsinki (as revised in 2013). The study was approved by the Institutional Review Board of Shanghai Tenth People\u2019s Hospital Affiliated to Tongji University, Tongji University School of Medicine. All the study subjects provided informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"149"}}